cid Telangana train accident: Goods train derails near Peddapalli. Check full list of cancelled, diverted trains today | Today News - Mint By news.google.com Published On :: Wed, 13 Nov 2024 02:52:43 GMT Telangana train accident: Goods train derails near Peddapalli. Check full list of cancelled, diverted trains today | Today News MintGoods train derails in Telangana's Peddapalli; 20 trains cancelled, 10 diverted The Economic Times11 coaches of goods train derail in Telangana The Times of IndiaGoods train derailment in Telangana affects rail traffic between Delhi and Chennai Telangana TodayGoods train derails in Telangana's Peddapalli; 30 trains cancelled, several diverted The Hindu Full Article
cid Lucid Air cop car tested by California Highway Patrol By www.greencarreports.com Published On :: Tue, 12 Nov 2024 11:56:00 -0500 Lucid Motors is pitching its Air electric sedan as a potential police cruiser. On Sunday the automaker posted photos of an Air decked out in police equipment on X (formerly Twitter). Lucid said the car had recently participated in California Highway Patrol testing, but did not provide any other details. We've reached out to Lucid with questions... Full Article
cid La felicidad es… A By feeds.gracia.org Published On :: Mon, 27 Nov 2023 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid La felicidad es… B By feeds.gracia.org Published On :: Tue, 28 Nov 2023 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid ¿Qué hace que los cristianos estén más agradecidos? A By feeds.gracia.org Published On :: Thu, 14 Mar 2024 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid ¿Qué hace que los cristianos estén más agradecidos? B By feeds.gracia.org Published On :: Fri, 15 Mar 2024 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid La armadura de Dios: El cinturón de la veracidad y la coraza de la justicia By feeds.gracia.org Published On :: Fri, 30 Aug 2024 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid La armadura de Dios: El cinturón de la veracidad y la coraza de la justicia By feeds.gracia.org Published On :: Mon, 02 Sep 2024 00:00:00 PST La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.Click the icon below to listen. Full Article
cid Worker sues Casio over slapping incident By www.philstar.com Published On :: Wed, 13 Nov 2024 00:00:00 +0800 A business process outsourcing employee who was slapped by relieved Presidential Anti-Organized Crime Commission spokesman Winston John Casio during a raid on a suspected Philippine offshore gaming operator hub in Bagac, Bataan has filed criminal charges against the official. Full Article
cid Will Ukraine Commit Economic Suicide? By Published On :: Fri, 10 Oct 2014 13:50:00 GMT Ukraine's crippling 55 percent tax on private gas producers threatens to damage the economy, scare off investors and decimate gas production. Full Article
cid Rwanda: 20th Anniversary of the Genocide By Published On :: Wed, 09 Apr 2014 20:10:00 GMT Rwandans should be proud of the immense progress they have made since the genocide, but economic inequality and political abuses still plague the country. Full Article
cid Court to decide on taking Thaksin case by Nov 22 By www.bangkokpost.com Published On :: Wed, 13 Nov 2024 05:02:00 +0700 The attorney general has submitted documents to the Constitutional Court regarding the case in which former prime minister Thaksin Shinawatra is accused of asserting influence over the Pheu Thai Party. Full Article
cid Saudi crown prince condemns Israel's attacks on Palestinians as 'genocide' By www.jpost.com Published On :: Mon, 11 Nov 2024 17:17:39 GMT Saudi Arabia's crown prince condemned Israel's "genocide" in Gaza at a Riyadh summit, stressing support for Palestine and pausing US-led normalization talks after recent violent escalations. Full Article Saudi Arabia Islamism Mohammed bin Salman Israel-Hamas War
cid Farming in Crisis: Suicides and Climate Change Threaten India’s Agrarian Future By www.ipsnews.net Published On :: Mon, 11 Nov 2024 12:51:44 +0000 “Farming is in my blood, and I can’t imagine doing anything else,” said Mahim Mazumder, a farmer from Assam. “Even though the past three to five years have seen drastic changes—with temperatures rising so much that even sitting under a tree no longer offers relief—I will keep farming, even if it only yields a small […] Full Article Asia-Pacific Climate Change COP29 Environment Featured Food and Agriculture Headlines Human Rights Sustainable Development Goals TerraViva United Nations India IPS UN Bureau IPS UN Bureau Report
cid Fifteen-year-old in serious accident in Xylophagou By cyprus-mail.com Published On :: 2024-11-13T08:09:51+02:00 A 15-year-old was seriously injured while riding a moped overnight in the Famagusta district. According to the police, the accident happened around 9pm on Tuesday in Xylophagou, when a 35-year-old woman driving on Anastassi Manoli Street, under circumstances that are being investigated, ran over and injured the 15-year-old boy. The 15-year-old was initially taken by […] Full Article Main minor moped serious accident xylophagou
cid to write an autobiographical incident essay By english.al-akhbar.com Published On :: to write an autobiographical incident essay Full Article
cid Consumer insecticides are useless for fighting cockroach infestations By www.newscientist.com Published On :: Wed, 14 Aug 2024 16:00:39 +0100 Lab-reared German cockroaches are susceptible to consumer insecticide sprays, allowing manufacturers to pass US regulatory tests, but insects taken from real-world infestations are able to shrug off the products Full Article
cid Fish size themselves up in a mirror to decide if they can win a fight By www.newscientist.com Published On :: Wed, 11 Sep 2024 11:00:10 +0100 Cleaner wrasse use their reflection to build a mental image of their body size, which they use to compare themselves to rivals before picking a fight Full Article
cid Antidote to deadly pesticides boosts bee survival By www.newscientist.com Published On :: Fri, 13 Sep 2024 18:00:18 +0100 Feeding bees edible bits of hydrogel increases their odds of surviving pesticide exposure by 30 per cent Full Article
cid Next 10,000 years of Greenland ice sheet could be decided this century By www.newscientist.com Published On :: Wed, 29 Mar 2023 22:30:53 +0100 Carbon emissions within the next 50 years could lead to a tipping point where large parts of the Greenland ice sheet melt over the next 10,000 years Full Article
cid Pesticide Exposure Linked to ADHD Risk By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Pesticide Exposure Linked to ADHD RiskCategory: Health NewsCreated: 8/23/2010 10:57:00 AMLast Editorial Review: 8/23/2010 10:57:27 AM Full Article
cid Sledding Accidents Land Thousands of Kids in ER By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Sledding Accidents Land Thousands of Kids in ERCategory: Health NewsCreated: 8/24/2010 11:02:00 AMLast Editorial Review: 8/24/2010 11:02:36 AM Full Article
cid New Test Helps Decide if Heart Patient Needs Stent By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: New Test Helps Decide if Heart Patient Needs StentCategory: Health NewsCreated: 8/29/2012 11:00:00 AMLast Editorial Review: 8/29/2012 12:00:00 AM Full Article
cid Suicide a Danger for Some Women During Pregnancy: Study By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Suicide a Danger for Some Women During Pregnancy: StudyCategory: Health NewsCreated: 8/28/2017 12:00:00 AMLast Editorial Review: 8/29/2017 12:00:00 AM Full Article
cid U.S. Deaths From Suicide, Drugs Surpass Diabetes By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: U.S. Deaths From Suicide, Drugs Surpass DiabetesCategory: Health NewsCreated: 8/27/2018 12:00:00 AMLast Editorial Review: 8/28/2018 12:00:00 AM Full Article
cid Soldiers' Suicide Attempts Often Come Without Prior Mental Health Diagnosis By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Soldiers' Suicide Attempts Often Come Without Prior Mental Health DiagnosisCategory: Health NewsCreated: 8/29/2018 12:00:00 AMLast Editorial Review: 8/30/2018 12:00:00 AM Full Article
cid Restless Legs Syndrome Might Raise Risk of Suicide, Self-Harm By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Restless Legs Syndrome Might Raise Risk of Suicide, Self-HarmCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/26/2019 12:00:00 AM Full Article
cid What Treatments Work Best to Prevent Suicide? By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: What Treatments Work Best to Prevent Suicide?Category: Health NewsCreated: 8/27/2019 12:00:00 AMLast Editorial Review: 8/27/2019 12:00:00 AM Full Article
cid GERD (Acid Reflux) in Infants and Children By www.medicinenet.com Published On :: Thu, 18 Aug 2022 00:00:00 PDT Title: GERD (Acid Reflux) in Infants and ChildrenCategory: Diseases and ConditionsCreated: 1/31/2005 12:00:00 AMLast Editorial Review: 8/18/2022 12:00:00 AM Full Article
cid Association between a recalled positive airway pressure device and incident cancer: a population-based study By erj.ersjournals.com Published On :: 2024-11-07T00:35:55-08:00 Background The real-world consequences of a Philips Respironics recall for positive airway pressure (PAP) devices distributed between 2009 and 2021 are unknown. Methods We conducted a retrospective population-based study using health administrative databases (Ontario, Canada) on all new adult PAP users identified through the provincial funding system, free of cancer at baseline, who initiated (claimed) PAP treatment between 2012 and 2018. Everyone was followed from the PAP claim date to the earliest of incident cancer diagnosis, death or end of follow-up (March 2022). We used inverse probability of treatment weighting to balance baseline characteristics between individuals on recalled devices and those on devices from other manufacturers. Weighted hazard ratios of incident cancer were compared between groups. Results Of 231 692 individuals identified, 58 204 (25.1%) claimed recalled devices and 173 488 (74.9%) claimed devices from other manufacturers. A meaningful baseline difference between groups (standardised difference ≥0.10) was noted only by location-relevant covariates; other variables were mostly equally distributed (standardised differences ≤0.06). Over a median (interquartile range) follow-up of 6.3 (4.9–8.0) years, 11 166 (4.8%) developed cancer: unadjusted rates per 10 000 person-years of 78.8 (95% CI 76.0–81.7) in the recall group versus 74.0 (95% CI 72.4–75.6) in others (p=0.0034). Propensity score weighting achieved excellent balance in baseline characteristics between groups (standardised differences ≤0.07). On a weighted sample, there was no statistical difference in the hazard of incident cancer between groups: cause-specific hazard ratio (recalled versus others) 0.97 (95% CI 0.89–1.06). Conclusion In our real-world population study, compared to other manufacturers and adjusting for confounders, recalled Philips Respironics PAP devices do not appear to be independently associated with developing cancer. Full Article
cid CYP8B1 Catalyzes 12alpha-Hydroxylation of C27 Bile Acid: In Vitro Conversion of Dihydroxycoprostanic Acid into Trihydroxycoprostanic Acid [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Sterol 12α-hydroxylase (CYP8B1) is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along the bile acid (BA) synthesis pathway. Despite the long history of BA metabolism studies, it is unclear whether CYP8B1 catalyzes 12α-hydroxylation of C27 BAs, the key intermediates shuttling between mitochondria and peroxisomes. This work provides robust in vitro evidence that both microsomal and recombinant CYP8B1 enzymes catalyze the 12α-hydroxylation of dihydroxycoprostanic acid (DHCA) into trihydroxycoprostanic acid (THCA). On the one hand, DHCA 12α-hydroxylation reactivity is conservatively detected in liver microsomes of both human and preclinical animals. The reactivity of human tissue fractions conforms well with the selectivity of CYP8B1 mRNA expression, while the contribution of P450 enzymes other than CYP8B1 is excluded by reaction phenotyping in commercial recombinant enzymes. On the other hand, we prepared functional recombinant human CYP8B1 proteins according to a recently published protocol. Titration of the purified CYP8B1 proteins with either C4 (7α-hydroxy-4-cholesten-3-one) or DHCA yields expected blue shifts of the heme Soret peak (type I binding). The recombinant CYP8B1 proteins efficiently catalyze 12α-hydroxylation of both DHCA and C4, with substrate concentration occupying half of the binding sites of 3.0 and 1.9 μM and kcat of 3.2 and 2.6 minutes–1, respectively. In summary, the confirmed role of CYP8B1 in 12α-hydroxylation of C27 BAs has furnished the forgotten passageway in the BA synthesis pathway. The present finding might have opened a new window to consider the biology of CYP8B1 in glucolipid metabolism and to evaluate CYP8B1 inhibition as a therapeutic approach of crucial interest for metabolic diseases. SIGNIFICANCE STATEMENT The academic community has spent approximately 90 years interpreting the synthesis of bile acids. However, the 12α-hydroxylation of intermediates catalyzed by CYP8B1 is not completely mapped on the classic pathway, particularly for the C27 bile acids, the pivotal intermediates shuttling between mitochondria and peroxisomes. This work discloses the forgotten 12α-hydroxylation pathway from dihydroxycoprostanic acid into trihydroxycoprostanic acid. The present finding may facilitate evaluating CYP8B1 inhibition as a therapeutic approach of crucial interest for metabolic diseases. Full Article
cid Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5 [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC50 and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC50 values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms. SIGNIFICANCE STATEMENT These findings provide valuable insight regarding in vitro testing conditions to investigate the metabolism of new drug candidates and help determine drug safety in neonates. The results presented here also clearly demonstrate the effect that probe selection may have on CYP3A cytochrome P450 inhibition studies. Full Article
cid Inhibitory Actions of Potentiating Neuroactive Steroids in the Human {alpha}1{beta}3{gamma}2L {gamma}-Aminobutyric Acid Type A Receptor [Article] By molpharm.aspetjournals.org Published On :: 2024-10-17T05:12:59-07:00 The -aminobutyric acid type A (GABAA) receptor is modulated by a number of neuroactive steroids. Sulfated steroids and 3β-hydroxy steroids inhibit, while 3α-hydroxy steroids typically potentiate the receptor. Here, we have investigated inhibition of the α1β32L GABAA receptor by the endogenous neurosteroid 3α-hydroxy-5β-pregnan-20-one (3α5βP) and the synthetic neuroactive steroid 3α-hydroxy-5α-androstane-17β-carbonitrile (ACN). The receptors were expressed in Xenopus oocytes. All experiments were done using two-electrode voltage-clamp electrophysiology. In the presence of low concentrations of GABA, 3α5βP and ACN potentiate the GABAA receptor. To reveal inhibition, we conducted the experiments on receptors activated by the combination of a saturating concentration of GABA and propofol to fully activate the receptors and mask potentiation, or on mutant receptors in which potentiation is ablated. Under these conditions, both steroids inhibited the receptor with IC50s of ~13 μM and maximal inhibitory effects of 70–90%. Receptor inhibition by 3α5βP was sensitive to substitution of the α1 transmembrane domain (TM) 2-2' residue, previously shown to ablate inhibition by pregnenolone sulfate. However, results of coapplication studies and the apparent lack of state dependence suggest that pregnenolone sulfate and 3α5βP inhibit the GABAA receptor independently and through distinct mechanisms. Mutations to the neurosteroid binding sites in the α1 and β3 subunits statistically significantly, albeit weakly and incompletely, reduced inhibition by 3α5βP and ACN. SIGNIFICANCE STATEMENT The heteromeric GABAA receptor is inhibited by sulfated steroids and 3β-hydroxy steroids, while 3α-hydroxy steroids are considered to potentiate the receptor. We show here that 3α-hydroxy steroids have inhibitory effects on the α1β32L receptor, which are observed in specific experimental settings and are expected to manifest under different physiological conditions. Full Article
cid Arachidonic Acid Directly Activates the Human DP2 Receptor [Article] By molpharm.aspetjournals.org Published On :: 2024-10-17T05:12:59-07:00 Aberrant type 2 inflammatory responses are the underlying cause of the pathophysiology of allergic asthma, allergic rhinitis, and other atopic diseases, with an alarming prevalence in relevant parts of the Western world. A bulk of evidence points out the important role of the DP2 receptor in these inflammation processes. A screening of different polyunsaturated fatty acids at a fluorescence resonance energy transfer–based DP2 receptor conformation sensor expressed in human embryonic kidney (HEK) cells revealed an agonistic effect of the prostaglandin (PG)-D2 precursor arachidonic acid on DP2 receptor activity of about 80% of the effect induced by PGD2. In a combination of experiments at the conformation sensor and using a bioluminescence resonance energy transfer–based G protein activation sensor expressed together with DP2 receptor wild type in HEK cells, we found that arachidonic acid acts as a direct activator of the DP2 receptor, but not the DP1 receptor, in a concentration range considered physiologically relevant. Pharmacological inhibition of cyclooxygenases and lipoxygenases as well as cytochrome P450 did not lead to a diminished arachidonic acid response on the DP2 receptor, confirming a direct action of arachidonic acid on the receptor. SIGNIFICANCE STATEMENT This study identified the prostaglandin precursor arachidonic acid to directly activate the DP2 receptor, a G protein–coupled receptor that is known to play an important role in type 2 inflammation. Full Article
cid Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Although acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is causally linked to many diseases. Macrophages are a major cell type that orchestrates inflammatory processes. During inflammation, macrophages undergo polarization and activation, thereby mobilizing pro-inflammatory and anti-inflammatory transcriptional programs that regulate ensuing macrophage functions. Fatty acid binding protein 5 (FABP5) is a lipid chaperone highly expressed in macrophages. FABP5 deletion is implicated in driving macrophages toward an anti-inflammatory phenotype, yet signaling pathways regulated by macrophage-FABP5 have not been systematically profiled. We leveraged proteomic and phosphoproteomic approaches to characterize pathways modulated by FABP5 in M1 and M2 polarized bone marrow-derived macrophages (BMDMs). Stable isotope labeling by amino acids-based analysis of M1 and M2 polarized wild-type and FABP5 knockout BMDMs revealed numerous differentially regulated proteins and phosphoproteins. FABP5 deletion impacted downstream pathways associated with inflammation, cytokine production, oxidative stress, and kinase activity. Toll-like receptor 2 (TLR2) emerged as a novel target of FABP5 and pharmacological FABP5 inhibition blunted TLR2-mediated activation of downstream pathways, ascribing a novel role for FABP5 in TLR2 signaling. This study represents a comprehensive characterization of the impact of FABP5 deletion on the proteomic and phosphoproteomic landscape of M1 and M2 polarized BMDMs. Loss of FABP5 altered pathways implicated in inflammatory responses, macrophage function, and TLR2 signaling. This work provides a foundation for future studies seeking to investigate the therapeutic potential of FABP5 inhibition in pathophysiological states resulting from dysregulated inflammatory signaling. SIGNIFICANCE STATEMENT This research offers a comprehensive analysis of fatty acid binding protein 5 (FABP5) in macrophages during inflammatory response. The authors employed quantitative proteomic and phosphoproteomic approaches to investigate this utilizing bone marrow-derived macrophages that were M1 and M2 polarized using lipopolysaccharide with interferon and interleukin-4, respectively. This revealed multiple pathways related to inflammation that were differentially regulated due to the absence of FABP5. These findings underscore the potential therapeutic significance of macrophage-FABP5 as a candidate for addressing inflammatory-related diseases. Full Article
cid Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development [Review Article] By pharmrev.aspetjournals.org Published On :: 2024-10-16T07:40:25-07:00 Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates biliary secretion of lipids, endogenous metabolites, and xenobiotics. In intestine, bile acids facilitate the digestion and absorption of dietary lipids and fat-soluble vitamins. Through activation of nuclear receptors and G protein-coupled receptors and interaction with gut microbiome, bile acids critically regulate host metabolism and innate and adaptive immunity and are involved in the pathogenesis of cholestasis, metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, type-2 diabetes, and inflammatory bowel diseases. Bile acids and their derivatives have been developed as potential therapeutic agents for treating chronic metabolic and inflammatory liver diseases and gastrointestinal disorders. Significance Statement Bile acids facilitate biliary cholesterol solubilization and dietary lipid absorption, regulate host metabolism and immunity, and modulate gut microbiome. Targeting bile acid metabolism and signaling holds promise for treating metabolic and inflammatory diseases. Full Article
cid Glatiramer Acetate for the Treatment of Multiple Sclerosis: From First-Generation Therapy to Elucidation of Immunomodulation and Repair [Review Article] By pharmrev.aspetjournals.org Published On :: 2024-10-16T07:40:25-07:00 Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS), with a putative autoimmune origin and complex pathogenesis. Modification of the natural history of MS by reducing relapses and slowing disability accumulation was first attained in the 1990 s with the development of the first-generation disease-modifying therapies. Glatiramer acetate (GA), a copolymer of L-alanine, L-lysine, L-glutamic acid, and L-tyrosine, was discovered due to its ability to suppress the animal model of MS, experimental autoimmune encephalomyelitis. Extensive clinical trials and long-term assessments established the efficacy and the safety of GA. Furthermore, studies of the therapeutic processes induced by GA in animal models and in MS patients indicate that GA affects various levels of the innate and the adaptive immune response, generating deviation from proinflammatory to anti-inflammatory pathways. This includes competition for binding to antigen presenting cells; driving dendritic cells, monocytes, and B-cells toward anti-inflammatory responses; and stimulating T-helper 2 and T-regulatory cells. The immune cells stimulated by GA reach the CNS and secrete in situ anti-inflammatory cytokines alleviating the pathological processes. Furthermore, cumulative findings reveal that in addition to its immunomodulatory effect, GA promotes neuroprotective repair processes such as neurotrophic factors secretion, remyelination, and neurogenesis. This review aims to provide an overview of MS pathology diagnosis and treatment as well as the diverse mechanism of action of GA. Significance Statement Understanding the complex MS immune pathogenesis provided multiple targets for therapeutic intervention, resulting in a plethora of agents, with various mechanisms of action, efficacy, and safety profiles. However, promoting repair beyond the body’s limited spontaneous extent is still a major challenge. GA, one of the first approved disease-modifying therapies, induces diverse immunomodulatory effects. Furthermore, GA treatment results in elevated neurotrophic factors secretion, remyelination and neurogenesis, supporting the notion that immunomodulatory treatment can support in situ a growth-promoting and repair environment. Full Article
cid Prevalence of Rathke Cleft and Other Incidental Pituitary Gland Findings on Contrast-Enhanced 3D Fat-Saturated T1 MPRAGE at 7T MRI [CLINICAL PRACTICE] By www.ajnr.org Published On :: 2024-11-07T15:14:12-08:00 BACKGROUND AND PURPOSE: A cleftlike nonenhancing hypointensity was observed repeatedly in the pituitary gland at the adenohypophysis/neurohypophysis border on contrast-enhanced 3D fat-saturated T1-MPRAGE using clinical 7T MRI. Our primary goal was to assess the prevalence of this finding. The secondary goals were to evaluate the frequency of other incidental pituitary lesions, MRI artifacts, and their effect on pituitary imaging on the contrast-enhanced 3D fat-saturated T1 MPRAGE at 7T. MATERIALS AND METHODS: One hundred patients who underwent 7T neuroimaging between October 27, 2021, and August 10, 2023, were included. Each case was evaluated for cleftlike pituitary hypointensity, pituitary masses, and artifacts on contrast-enhanced 3D fat-saturated T1 MPRAGE. Follow-up examinations were evaluated if present. The average prevalence for each finding was calculated, as were descriptive statistics for age and sex. RESULTS: A cleftlike hypointensity was present in 66% of 7T MRIs. There were no significant differences between the "cleftlike present" and "cleftlike absent" groups regarding sex (P = .39) and age (P = .32). The cleftlike hypointensity was demonstrated on follow-up MRIs in 3/3 patients with 7T, 1/12 with 3T, and 1/5 with 1.5T. A mass was found in 22%, while 75% had no mass and 3% were indeterminate. A mass was found in 18 (27%) of the cleftlike present and 4 (13%) of the cleftlike absent groups. The most common mass types were Rathke cleft cyst in 7 (31.8%) patients, "Rathke cleft cyst versus entrapped CSF" in 6 (27.3%), and microadenoma in 6 (22.2%) in the cleftlike present group. There were no significant differences in the mass types between the cleftlike present and cleftlike absent groups (P = .23). Susceptibility and/or motion artifacts were frequent using contrast-enhanced 3D fat-saturated T1 MPRAGE (54%). Artifact-free scans were significantly more frequent in the cleftlike present group (P = .03). CONCLUSIONS: A cleftlike nonenhancing hypointensity was frequently seen on the contrast-enhanced 3D fat-saturated T1 MPRAGE images at 7T MRI, which most likely represents a normal embryologic Rathke cleft remnant and cannot be seen in lower-field-strength MRIs. Susceptibility and motion artifacts are common in the sella. They may affect image quality, and the artifacts at 7T may lead to an underestimation of the prevalence of the Rathke cleft and other incidental findings. Full Article
cid Roadside serendipity: an accident can lead to a rare diagnosis By breathe.ersjournals.com Published On :: 2024-11-12T00:25:08-08:00 Full Article
cid New research to better understand the biological factors of suicidal behaviour By www.heraldscotland.com Published On :: Tue, 12 Nov 2024 06:30:00 +0000 New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour. Full Article
cid Gary Lineker replacement decided as BBC tipped for rogue MOTD appointment By www.express.co.uk Published On :: Tue, 12 Nov 2024 09:34:00 +0000 Express Sport writers have decided who should replace Gary Lineker Full Article Football
cid CBD shows promise as pesticide for mosquitoes By www.newscientist.com Published On :: Fri, 27 Sep 2024 23:00:33 +0100 Mosquito larvae die after consuming hemp leaves because they react strongly to the cannabidiol in the foliage. The discovery might lead to the development of a new pesticide to control mosquito numbers Full Article
cid Trump's first Cabinet picks decidedly not isolationists: Ukraine, Israel breathe a sigh of relief By www.foxnews.com Published On :: Tue, 12 Nov 2024 16:49:18 -0500 Despite his own isolationist musings, the first picks of President-elect Donald Trump's incoming administration hail from a decidedly more traditionalist wing of the Republican Party. Full Article 25699a50-8609-594d-a947-d5270f093d29 fnc Fox News fox-news/politics/foreign-policy/secretary-of-state fox-news/politics/executive/national-security fox-news/politics/elections/presidential/trump-transition fox-news/person/donald-trump fox-news/politics article
cid Voters across the country decide on state ballot measures By www.foxnews.com Published On :: Tue, 12 Nov 2024 18:54:44 -0500 While many states focused on issues like abortion and immigration throughout this election cycle, voters in California and Colorado approved tougher crime laws. Full Article ebad90d5-8234-502e-8d58-7ebb010d2b66 fnc Fox News fox-news/politics/elections fox-news/politics/voting fox-news/us/us-regions/west/california fox-news/us/us-regions/west/colorado fox-news/us/crime fox-news/great-outdoors/hunting fox-news/politics article
cid FSAI warns of rise in ‘complex’ food incidents in annual report By www.foodsafetynews.com Published On :: Wed, 06 Nov 2024 05:03:00 +0000 In its annual report, the Food Safety Authority of Ireland (FSAI) warned that food incidents are becoming more complex and often serious. FSAI marked its 25th anniversary in 2023. External challenges impacting food safety include the potential for supply disruption due to political unrest in the Middle East and the... Continue Reading Full Article Government Agencies World annual report food fraud food incidents Food Safety Authority of Ireland (FSAI) official controls Salmonella
cid Photos of bus crash in India misrepresented as 'road accident in Bangladesh' By www.yahoo.com Published On :: 2024-11-13T06:15:58Z Full Article
cid 'America's Got Talent': How the Show Addressed Simon Cowell's Absence Following His Bike Accident By feedproxy.google.com Published On :: Tue, 11 Aug 2020 17:43:28 PDT Kelly Clarkson filled in for Cowell as he recuperates from back surgery. [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article TV
cid How a stubborn computer scientist accidentally launched the deep learning boom By arstechnica.com Published On :: Mon, 11 Nov 2024 12:00:09 +0000 "You’ve taken this idea way too far," a mentor told Prof. Fei-Fei Li. Full Article AI Features Science AlexNet deep learning Fei-Fei Li Geoffrey Hinton Jensen Huang Yann LeCun
cid Colorado scrambles to change voting-system passwords after accidental leak By arstechnica.com Published On :: Thu, 31 Oct 2024 21:28:05 +0000 "The goal is to complete the password updates by this evening," government says. Full Article Biz & IT Policy colorado elections voting system passwords