Cancer patients from Mumbai to reach tomorrow

The diagnosis of cancer is a shock in itself and then comes another - the risk of infertility

The changes in protein expression common to several cancerous cell lines focus attention on cell spreading and focal adhesion kinase.

36 stranded Manipuri including 16 Cancer patients departs Mumbai for Imphal

"If cancer could do me no harm, what can Covid do?" This was the confidence that 74-year-old Yusuf Hotelwala exuded while leaving for the Covid care centre in Vadodara after testing positive a week ago. On Saturday, Hotelwala, who suffers from peritoneal mesothelioma and has already survived two heart attacks was beaming as doctors confirmed his recovery.

Little Richards died on Saturday at the age of 87

Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1 (myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy, through which normal apoptosis may be restored by inhibiting the protective function of Mcl-1. Here, the discovery and biophysical properties of an anti-Mcl-1 antibody fragment are described and the utility of both the scFv and Fab are demonstrated in generating an Mcl-1 crystal system amenable to iterative structure-guided drug design.

The stars move quickly because they are very close to each other, separated by only about one-fourth the distance from the Earth to the Moon. As a result, they share strong gravitational forces. They were once farther apart but have spiraled closer together over time. Billions of years from now, they will crash together and merge.

The post At 1,500,000 mph, twin stars in the constellation Cancer win speediest orbit award appeared first on Smithsonian Insider.

Eric Silver of SAO is pursuing innovative and interdisciplinary uses of his technique for chemical imaging at the cellular level.

The post Technology developed for X-ray astronomy is being adapted to study cancer cells appeared first on Smithsonian Insider.

Bald from snout to tail with baggy wrinkled skin and beady eyes, eastern African naked mole rats (Heterocephalus glaber) are subterranean mammals long credited with […]

The post Rare cancer cells discovered in naked mole rats appeared first on Smithsonian Insider.

Karolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen, and Gennady G. Yegutkin

Extracellular adenosine mediates diverse anti-inflammatory, angiogenic and vasoactive effects and becomes an important therapeutic target for cancer, which has been translated into clinical trials. This study was designed to comprehensively assess adenosine metabolism in prostate and breast cancer cells. We identified cellular adenosine turnover as a complex cascade, comprised of (a) the ectoenzymatic breakdown of ATP via sequential nucleotide pyrophosphatase/phosphodiesterase-1, ecto-5’-nucleotidase/CD73 and adenosine deaminase reactions, and ATP re-synthesis through counteracting adenylate kinase and nucleoside diphosphokinase; (b) the uptake of nucleotide-derived adenosine via equilibrative nucleoside transporters; and (c) the intracellular adenosine phosphorylation into ATP by adenosine kinase and other nucleotide kinases. The exposure of cancer cells to 1% O₂ for 24 hours triggered ~2-fold up-regulation of CD73, without affecting nucleoside transporters, adenosine kinase activity and cellular ATP content. The ability of adenosine to inhibit the tumor-initiating potential of breast cancer cells via receptor-independent mechanism was confirmed in vivo using a xenograft mouse model. The existence of redundant pathways controlling extracellular and intracellular adenosine provides a sufficient justification for reexamination of the current concepts of cellular purine homeostasis and signaling in cancer.

Ganlu Deng, Yihong Chen, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Yaojie Fu, Changjing Cai, Hong Shen, and Shan Zeng

Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with patient's poor prognosis. BMP4 was upregulated in GC cell lines and promoted EMT and metastasis of GC cells both in vitro and in vivo, while knockdown of BMP4 significantly inhibited EMT and metastasis of GC cells. Meanwhile, the inhibitor of DNA binding 1 (Id1) was identified as a downstream target of BMP4 by PCR arrays and upregulated via Smad1/5/8 phosphorylation. Id1 knockdown attenuated BMP4-induced EMT and invasion in GC cells. Moreover, Id1 overexpression in BMP4 knockdown cells restored the promotion of EMT and cell invasion. In summary, BMP4 induced EMT to promote GC metastasis by upregulating Id1 expression. Antagonizing BMP4 may be a potential therapeutic strategy in GC metastasis.

Smokers who are exposed to radon appear to be at even greater risk for lung cancer, because the effects of smoking and radon are more powerful when the two factors are combined, says a new report by a committee of the National Research Council.

Scientific evidence is insufficient to prove or disprove the theory that exposure to polio vaccine contaminated with a monkey virus between 1955 and 1963 has triggered cancer in humans, says a new report from the Institute of Medicine of the National Academies.

Ovarian cancer should not be categorized as a single disease, but rather as a constellation of different cancers involving the ovary, yet questions remain on how and where various ovarian cancers arise, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Current cancer control efforts in the United States typically are fragmented and uncoordinated, but taking a systems approach to establish a U.S. National Cancer Control Plan would address the challenge more holistically, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Patients with cancer have heightened risks of unintentional and intentional injuries during the diagnostic process, reveal findings from a large study published by The BMJ today.

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A new class of drugs called HIF-2 inhibitors is more effective and better tolerated than the standard of care drug sunitinib in treating kidney cancer, researchers with the Kidney Cancer Program at Harold C. Simmons Comprehensive Cancer Center have found.

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Recycling ships for scrap is a known asbestos exposure hazard, yet this study is one of few to trace asbestos-related cancer rates in shipbreaking workers. The results, obtained from former shipbreakers in Taiwan, show higher rates of cancer overall, especially oesophageal and lung cancers.

Long-term, low level exposure to arsenic in drinking water may increase a person’s risk of skin cancer, according to a new study conducted in Hungary, Romania and Slovakia. The study suggests that levels of inorganic arsenic previously thought to be harmless may have a carcinogenic effect over a longer period of time.

Our lifestyles determine how often we are exposed to cancer-causing chemicals, such as those in traffic emissions and cigarette smoke. A Swedish study reveals how exposure to these chemicals varies from person to person. Among its findings, the amount of time a person spends in traffic or refuelling their car significantly affects how much benzene and butadiene they could inhale.

Throughout history people have turned to nature for relief from illnesses and this remains true today. With new technologies, researchers have an even greater ability to identify natural products that may lead to treatment or prevention of a wide range of health problems.

The chemical 1,4-dioxane, a solvent suspected of causing cancer, is very difficult to clean up once it enters the environment. However, hope is offered by recent scientific developments that use plants, bacteria and fungi to decontaminate water resources. Scientists provided a round-up of these 1,4-dioxane bioremediation techniques in a recent analysis.

The post Using artificial intelligence to beat cancer appeared first on The Lead SA.

Why are California sea lions getting sick with cancer? Researchers suspect viruses, PCBs in the water and genetics.

Study found that men who ejaculated more than 21 times a month were significantly less likely to develop prostate cancer.

Cancer-causing human papilloma virus, or HPV, can be spread through kissing and oral sex.

Video: Could working the night shift alter a woman's body clock enough to cause breast cancer?

The Indian long pepper's use in traditional medicine dates back thousands of years.

For people living in areas neighboring the Fukushima nuclear power plants, the worst of the radiation exposure may have passed.

For my 23rd birthday, along with some shirts and books and other stuff, I got Hodgkin's disease.

Breast cancer survivors who practiced yoga for as little as 3 months reported significant improvement in several areas.

Yoga provides graded exercise that can be tailored for individuals, making it useful for all sorts of patients and their lifestyles.

New research seems to demonstrate that iridium, a rare metal found in meteorites, can kill cancer cells.

The reason red meat is linked to higher cancer risk is that it contains a sugar molecule called Neu5Gc that isn't naturally found in the human body.

Astronaut Janice Voss, a veteran of five spaceflights and a former science director for a NASA exoplanet-hunting spacecraft, has died after a battle with cancer

Outdoor air pollution has now been classified as 'carcinogenic to humans' by the United Nations.

An Armillaria gallica mushroom found in Michigan's Upper Peninsula is growing fast, and the secret to its phenomenal growth might hold the cure to cancer.

Experts believe that between one-third and one-half of cancers are preventable. Here's what you can do.

The latest, largest study finds talcum powder likely causes little risk for ovarian cancer.

Plus: Notes from around Hollywood.

New research finds that a relativity cheap and safe diabetes medication may help prevent breast cancer.

Metformin, an inexpensive and common diabetes drug, may fight ovarian cancer, according to a new study.

Resistance is not futile. In fact, it can stave off colon cancer and ease inflammatory bowel disease and other digestion problems.

Researchers find a strong association between elevated blood glucose levels and certain types of cancer.

Human trials are set to begin on the treatment, which cured 100 percent of mice during animal trials.

New studies on cancer are paving the way for faster diagnosis, better treatment — and more lives saved.

A device undergoing clinical trials in the U.K. may detect cancer by analyzing the compounds left by cells' biochemical reactions.

Airbnb is offering free housing for cancer patients and the people who care for them.

The Bush Administration buried a report showing a highly elevated risk of cancer for those living near coal ash. Why do we burn coal again?