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See the Tools and Gadgets From Julia Child’s Kitchen That Reveal How the Beloved Chef Cooked

From the microwave to the food processor, the book author and television personality tried many appliances and devices to figure out the best ways to use them for her audience




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Crisis-hit farmers receive seeds and tools in Central African Republic

A major operation to distribute seeds and tools has been launched in the Central African Republic to support [...]





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Anne Kelly Knowles Uses GIS Tools to Re-Write History

The American Ingenuity Award winner is using geographic information systems to map history's most iconic landscapes




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To Divine the Future, the Ancients Relied on These Chance-Based Fortune-Telling Tools

Texts like the "Sortes Astrampsychi" promised insights on clients' love lives, career prospects, financial woes and families




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PEAK Surgical Uses SolidWorks Software to Develop Low-Temperature Surgical Cutting and Coagulation Tools

Pioneering Technology Allows Surgeons to Cut Precisely and Control Bleeding Without Causing Heat Damage to Tissue




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Spanish Engineering Students Get the Professional Tools They Deserve: SolidWorks

Intuitive 3D CAD Software, Used So Often by Professionals, Prepares EUSS Students for Success




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SolidWorks signs 1,000th partner as it continues to integrate key tools that help engineers design better products faster

SolidWorks provides the industry's most comprehensive list of partner product solutions




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DS SolidWorks Helps Bring Lifesaving Artery Tool to Reality

SolidWorks Design, Simulation, and Publishing Software Contribute to Halving of Design Cycle, 20 Percent Materials Saving, and Paperless Assembly




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Leatherman Tool Group switches to SOLIDWORKS software for 3D design of multipurpose tools and knives

Software will ease design of complex surfaces, speed innovations to market




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Hyphen Design, Ltd. cuts development time for mobile phones, power tools, etc. with SOLIDWORKS software

UK consultancy reduces design cycles by weeks, cuts prototyping costs, and designs better products for global clients like Virgin Mobile and Hasbro




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An amazing God-given tool

An amazing God-given tool to mobilise and inspire people to make a difference: Global Village.




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This Tool Can Help Identify 'STEM Deserts.' But It Needs Your Feedback

The National Math and Science Initiative's new tool aims to help the field look for patterns in STEM data, so educators and policy folks can fill in holes.




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Multimedia Tool: Teaching the Presidential Campaign

The Newseum in Washington has just launched Decision 2012: Exploring Elections and the Media, an online resource for teaching about the presidential campaign and election.




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NASA grant to support free tool to improve astrophysical simulations

David Radice, associate professor of physics and of astronomy and astrophysics, has been selected to receive a Sustainment Award from NASA to advance an open-source code called AthenaK for computational astrophysicists. The grant will provide nearly $920,000 over three years.




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VR goggles, decompression room part of counseling toolkit at Wilkes-Barre campus

Virtual reality goggles with a choice of soothing environments or guided meditations, a color-changing bubble wall, a prayer area, Zen garden and massage chair: These are all options provided by Penn State Wilkes-Barre’s Counseling Services to help students relax and stay calm.




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Sewage Surveillance Might Be a Powerful Tool to Fight Antimicrobial Resistance, New Study Reveals

Sewage surveillance is emerging as a crucial method in combating antimicrobial resistance (AMR), according to new research from Virginia Tech. Published in Nature Water, the study demonstrates that monitoring wastewater provides a more efficient and comprehensive approach to tracking antibiotic-resistant bacteria than testing individuals. This method holds particular promise for underserved communities, where access to healthcare is limited, and AMR-related diseases are most prevalent. The research team, led by experts such as Dr. Leigh-Anne Krometis and Dr. Marc Edwards, explored sewage samples from 62 countries and found significant correlations between AMR levels and socioeconomic factors, such as healthcare accessibility. By examining wastewater, public health officials could gain early insights into AMR spread, allowing them to take targeted actions to protect vulnerable populations. This approach could revolutionise AMR monitoring, particularly in rural and low-income areas, where AMR poses a growing threat.




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Google ‘Learn About’ Experimental AI Tool With Educational Style Responses Released

Google released a new experimental artificial intelligence (AI) tool on Monday aimed at helping users learn about new topics. Dubbed Learn About, the tool is different from the Mountain View-based tech giant's usual AI offerings, such as Gemini or AI Overviews. The experimental tool shows the information in a visual and interactive style and picks the data from educational sources.




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Delaware Libraries Announces Northstar Digital Literacy Tool

Thursday August 26, 2021 Dover, DE – Delaware Libraries are pleased to announce the launch of Northstar Digital Literacy, an online training tool for basic computer skills. Northstar Digital Literacy provides digital literacy assessments and tutorials in basic computer skills and tips for how to use technology in daily life. Delaware Libraries and Literacy Delaware […]




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DPH Launches QR Tool Giving Delawareans Convenient Access to Their COVID-19 Vaccine Record

DOVER, DE (Dec. 21, 2021) – The Delaware Division of Public Health (DPH) announced today that individuals vaccinated in Delaware will now have access to a QR code when downloading their COVID-19 vaccination record. The digital COVID-19 vaccination card now includes the QR code and is available through the DelVAX Public Portal, a site where those who were […]



  • Delaware Health and Social Services
  • Division of Public Health
  • Coronavirus
  • Covid Vaccine
  • Delaware Department of Health and Social Services
  • Delaware Division of Public Health
  • DelVax

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DNREC Prioritizes Equity in Community Environmental Project Fund Grants, Launches New Mapping Tool

DNREC announced today the 2025 Community Environmental Project Fund (CEPF) grants will have a focus on equity. This change comes after the CEPF grant process was revamped to better address community needs and strengthen partnerships.




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Navigating Chiplet-Based Automotive Electronics Design with Advanced Tools and Flows

In the rapidly evolving landscape of automotive electronics, traditional monolithic design approaches are giving way to something more flexible and powerful—chiplets. These modular microchips, which are themselves parts of a whole silicon system, offer unparalleled potential for improving system performance, reducing manufacturing costs, and accelerating time-to-market in the automotive sector. However, the transition to working with chiplets in automotive electronics is not without its challenges.

Designers must now grapple with a new set of considerations, such as die-to-die interconnect standards, complex processes, and the integration of diverse IPs. Advanced toolsets and standardized design approaches are required to meet these challenges head-on and elevate the potential of chiplets in automotive innovation. In the following discourse, we will explore in detail the significance of chiplets in the context of automotive electronics, the obstacles designers face when working with this paradigm, and how Cadence comprehensive suite of IPs, tools, and flows is pioneering solutions to streamline the chiplet design process.

Unveiling Chiplets in Automotive Electronics

For automotive electronics, chiplets offer a methodology to modularize complex functionalities, integrate different chiplets into a package, and significantly enhance scalability and manufacturability. By breaking down semiconductor designs into a collection of chiplets, each fulfilling specific functions, automotive manufacturers can mix and match chiplets to rapidly prototype new designs, update existing ones, and specialize for the myriad of use cases found in vehicles today.

The increasing significance of chiplets in automotive electronics comes as a response to several industry-impacting phenomena. The most obvious among these is the physical restriction of Moore's Law, as large die sizes lead to poor yields and escalating production costs. Chiplets with localized process specialization can offer superior functionality at a more digestible cost, maintaining a growth trajectory where monolithic designs cannot. Furthermore, chiplets support the assembly of disparate technologies onto a single subsystem, providing a comprehensive yet adaptive solution to the diverse demands present in modern vehicles, such as central computing units, advanced driver-assistance systems (ADAS), infotainment units, and in-vehicle networks. This chiplet-based approach to functional integration in automotive electronics necessitates intricate design, optimization, and validation strategies across multiple domains.

The Complexity Within Chiplets

Yet, with the promise of chiplets comes a series of intricate design challenges. Chiplets necessitate working across multiple substrates and technologies, rendering the once-familiar 2-dimensional design space into the complex reality of multi-layered, sometimes even three-dimensional domains. The intricacies embedded within this design modality mandate devoting considerable attention to partitioning trade-offs, signal integrity across multiple substrates, thermal behavior of stacked dies, and the emergence of new assembly design kits to complement process design kits (PDKs).

To effectively address these complexities, designers must wield sophisticated tools that facilitate co-design, co-analysis, and the creation of a robust virtual platform for architectural exploration. Standardizations like the Universal Chip Interconnect Express (UCIe) have been influential, providing a die-to-die interconnect foundation for chiplets that is both standardized and automotive-ready. The availability of UCIe PHY and controller IP from Cadence and other leading developers further eases the integration of chiplets in automotive designs.

The Role of Foundries and Packaging in Chiplets

Foundries have also pivoted their services to become a vital part of the chiplet process, providing specialized design kits that cater to the unique requirements of chiplets. In tandem, packaging has morphed from being a mere logistical afterthought to a value-added aspect of chiplets. Organizations now look to packaging to deliver enhanced performance, reduced power consumption, and the integrity required by the diverse range of technologies encompassed in a single chip or package. This shift requires advanced multiscale design and analysis strategies that resonate across a spectrum of design domains.

Tooling Up for Chiplets with Cadence

Cadence exemplifies the rise of comprehensive tooling and workflows to facilitate chiplet-based automotive electronics design. Their integrations address the challenges that chiplet-based SoCs present, ensuring a seamless design process from the initial concept to production. The Cadence suite of tools is tailored to work across design domains, ensuring coherence and efficiency at every step of the chiplet integration process.

For instance, Cadence Virtuoso RF subflows have become critical in navigating radio frequency (RF) challenges within the chiplets, while tools such as the Integrity 3D-IC Platform and the Allegro Advanced Multi-Die Package Design Solution have surfaced to enable comprehensive multi-die package designs. The Integrity Signal Planner extends its capabilities into the chiplet ecosystem, providing a centralized platform where system-wide signal integrity can be proactively managed. Sigrity and Celsius, on the other hand, offer universally applicable solutions that take on the challenges of chiplets in signal integrity and thermal considerations, irrespective of the design domain. Each of these integrated analysis solutions underscores the intricate symphony between technology, design, and packaging essential in unlocking the potential of chiplets for automotive electronics.

Cadence portfolio includes solutions for system analysis, optimization, and signoff to complement these domain-specific tools, ensuring that the challenges of chiplet designs don't halt progress toward innovative automotive electronics. Cadence enables designers to engage in power- and thermal-aware design practices through their toolset, a necessity as automotive systems become increasingly sophisticated and power-efficient.

A Standardized Approach to Success with Chiplets

Cadence’s support for UCIe underscores the criticality of standardized approaches for heterogeneous integration by conforming to UCIe standards, which numerous industry stakeholders back. By co-chairing the UCIe Automotive working group, Cadence ensures that automotive designs have a universal and standardized Die-to-Die (D2D) high-speed interface through which chiplets can intercommunicate, unleashing the true potential of modular design.

Furthermore, Cadence champions the utilization of virtual platforms by providing transaction-level models (TLMs) for their UCIe D2D IP to simulate the interaction between chiplets at a higher level of abstraction. Moreover, individual chiplets can be simulated within a chiplet-based SoC context leveraging virtual platforms. Utilizing UVM or SCE-MI methodologies, TLMs, and virtual platforms serve as first lines of defense in identifying and addressing issues early in the design process before physical silicon even enters the picture.

Navigating With the Right Tools

The road to chiplet-driven automotive electronics is one paved with complexity, but with a commitment to standards, it is a path that promises significant rewards. By leveraging Cadence UCIe Design and Verification IP, tools, and methodologies, automotive designers are empowered to chart a course toward chiplets and help to establish a chiplet ecosystem. With challenges ranging from die-to-die interconnect to standardization, heterogeneous integration, and advanced packaging, the need for a seamless integrated flow and highly automated design approaches has never been more apparent. Companies like Cadence are tackling these challenges, providing the key technology for automotive designers seeking to utilize chiplets for the next-generation E/E architecture of vehicular technology.

In summary, chiplets have the potential to revolutionize the automotive electronics industry, breathing new life into the way vehicles are designed, manufactured, and operated. By understanding the significance of chiplets and addressing the challenges they present, automotive electronics is poised for a paradigm shift—one that combines the art of human ingenuity with the power of modular and scalable microchips to shape a future that is not only efficient but truly intelligent.

Learn more about how Cadence can help to enable automakers and OEMs with various aspects of automotive design.




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Tool to create *.lib and *.db files for designs made in Innovus

Hi all, 

I have made a custom cell in Innovus that I will be instantiating into a bigger block, which I will also be using Innovus to do the Place & Route. 

I understand that I can generate a *.lef file and a *.lib file using Innovus. However, I need to also create a *.db file (these format of files are often used in DC Compiler synthesis tool). 

Is there a way to create the *.db file from Innovus? Or, is there a tool that I can use to create this *.db file? 

Thank you for your time. 




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Disappearing toolbar or docked menu

Disappearing toolbar or docked menu

Is there a way for the toolbar or floating menu from disappearing when a cells tab is added to a window?

I have created a skill toolbar and it disappeared when I add another cell or tab to a window.

The only toolbars that stay are the ones I have defined in the Layout.toolbar file.

Do I have to add a trigger to keep the toolbars visible or not disappearing from the window?

Cadence version IC23.1-64b.ISR7.27

Paul




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Request information on Tools

We are looking for suitable tools that could be used for RTL design, IP-XACT based  integration (third party IP) and RTL design verification ( SV / UVM based methodology).

Request to share details on the different Cadence tools that is most suitable for these activities.




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which tools support Linting for early stages of Digital Design flow?

I am trying to understand the Linting process. I know that mainly JasperGold is the tool for this purpose. Though I think JasperGold is more suited for later stages of the design. As a RTL Design Engineer, I want to make sure that if another tool has the capability of doing Linting earlier in the flow. for example, does Xcelium, Genus or Confomal support linting. I have seen some contradicting information online regarding this topic, though I can't find anything related to Linting on any of these tools.

Thanks




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Archive of Tools Classification Analysis (Xcelium)

Hi,

Current and valid TCAs for Functional Safety are readily available at the FuSa "one-stop shop".

But I have not been able to find any archive repository for access to the obsoleted versions.

I would need to have also v1.4 of Xcelum TCA to investigate exact changes wrt previous projects.

Anyone knows how to find it?

Best regards,  Lars




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ce_tools directory no longer shipped with Specman

Hello All,

starting with version 8.1 the contents of the ce_tools directory will no longer
be shipped with Specman. The directory contains some unsupported AE/R&D
ware and has not been updated for several releases (i.e. most of those old
packages don't work with the latest release).
 
Attached is the contents of this directory. Please read the README before
using any of the packages.


Regards,
-hannes


Originally posted in cdnusers.org by hannes




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Socionext Accelerates SoC Design Breakthroughs with Cadence Signoff Tools

Socionext, a leader in SoC design, recently made significant strides in enhancing its design efficiency for a complex billion-gate project. Faced with the initial challenges of lengthy eight-day iterations and a protracted two-month timing signoff process, the objective was to reduce the iteration cycle to just three days. By integrating Cadence's cutting-edge solutions—Certus Closure Solution, Tempus Timing Solution, and Quantus Extraction Solution—Socionext achieved remarkable improvements.

Notably, the Tempus DSTA tool dramatically cut timing closure time by 73%, outperforming conventional single-machine STA methods. This achievement, combined with the synergistic use of Cadence's Certus Closure and Tempus Timing solutions, allowed Socionext to meet their ambitious three-day iteration target and double productivity. Additionally, integrating these solutions significantly decreased both human and machine resource needs, slashing memory and disk costs by up to 90% and halving engineering resources during the optimization and signoff phases.

For more on this collaboration, check out the "Designed with Cadence" success story video on Cadence's website and YouTube channel.

Also, don't miss the on-demand webinar "Fast, Accurate STA for Large-Scale Design Challenges," which provides a deeper dive into Socionext's breakthroughs and the innovative solutions that powered their success.




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Get Plugged In: How to Use Generative AI Tools in Obsidian

As generative AI evolves and accelerates industry, a community of AI enthusiasts is experimenting with ways to integrate the powerful technology into common productivity workflows.




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NVIDIA Advances Robot Learning and Humanoid Development With New AI and Simulation Tools

Robotics developers can greatly accelerate their work on AI-enabled robots, including humanoids, using new AI and simulation tools and workflows that NVIDIA revealed this week at the Conference for Robot Learning (CoRL) in Munich, Germany. The lineup includes the general availability of the NVIDIA Isaac Lab robot learning framework; six new humanoid robot learning workflows Read Article





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How Bamboo can be Developed as a Tool for Climate Action and Financial Inclusion

Bamboo value chain can be developed and scaled up to support climate action, create green jobs, resilient businesses, and financial health, especially for the region's rural communities.




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Before the Stone Age: Were the first tools made from plants not rocks?

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age




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Before the Stone Age: Were the first tools made from plants not rocks?

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age




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Mammoth tusk tool may have been used to make ropes 37,000 years ago

Experiments with a replica suggest that a piece of mammoth ivory with carved holes found in a cave in Germany was used by ancient humans to make ropes




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Neanderthal cooking skills put to the test with birds and stone tools

In an effort to understand ancient Neanderthal food preparation techniques, researchers butchered five wild birds using flint stone tools and roasted them




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Extremely rare Bronze Age wooden tool found in English trench

In a wetland on the south coast of England, archaeologists dug up one of the oldest and most complete wooden tools ever found in Britain, which is around 3500 years old




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Before the Stone Age: Were the first tools made from plants not rocks?

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age




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Tools Test Debunks 'Dumb Neanderthals' Theory

Title: Tools Test Debunks 'Dumb Neanderthals' Theory
Category: Health News
Created: 8/27/2008 2:00:00 AM
Last Editorial Review: 8/27/2008 12:00:00 AM




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Evidence-based management of symptoms in serious respiratory illness: what is in our toolbox?

Extract

Living with a respiratory illness requires patients to manage a wide range of symptoms, many of which will worsen as a disease progresses. Breathlessness is a hallmark feature of respiratory conditions, occurring in almost all individuals with COPD and interstitial lung disease (ILD) [1, 2]. Cough is present in 78% of people with ILD and is frequently distressing, with physical, social and emotional impacts [1, 3].




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Adapting the Social Norms Exploration Tool in the Democratic Republic of the Congo to Identify Social Norms for Behavior Change

ABSTRACTIn the Democratic Republic of the Congo (DRC), male engagement, social norms, and social networks mitigate family planning behavior. We discuss the adaptation of the Social Norms Exploration Tool (SNET), which identifies relevant social norms and community members upholding these norms, to inform the development of family planning interventions in the DRC. The SNET provides activity tools and templates to guide users through the following steps: (1) plan and prepare, (2) identify reference groups, (3) explore social norms, (4) analyze results, and (5) apply findings.The SNET approach resulted in discussion of social norms, particularly around birth spacing and gender norms framing the man as the decision-maker. However, despite applying a methodology specifically designed to identify social norms, other factors limiting use of contraceptive methods were identified in the process, including lack of education, rumors, and misconceptions. Adaptations were needed to include the full range of reference groups due to narrow phrasing of primary questions, and some of the participatory methods were overly complicated. Feedback from experienced data collectors suggested that the social norms framework is not intuitive, is difficult to apply correctly, and may require that data collectors have a stronger foundation in the relevant concepts to produce valid and actionable results.Although the SNET provides language for discussing normative factors and techniques to identify reference groups and social norms, modifications to the implementation process are recommended when adapting the tool for research.




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Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRABeCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.

SIGNIFICANCE STATEMENT

Cannabis has been used by humans as an effective medicine for millennia, including for pain management. Recent evidence emphasizes the therapeutic potential of compounds that modulate endocannabinoid signaling. Specifically, cannabidiol and inhibitors of the enzyme ABHD6 represent promising strategies to achieve pain relief by modulating endocannabinoid signaling in pain pathways via distinct, nonintoxicating mechanisms of action.




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MIRD Pamphlet No. 30: MIRDfit--A Tool for Fitting of Biodistribution Time-Activity Data for Internal Dosimetry

In nuclear medicine, estimating the number of radioactive decays that occur in a source organ per unit administered activity of a radiopharmaceutical (i.e., the time-integrated activity coefficient [TIAC]) is an essential task within the internal dosimetry workflow. TIAC estimation is commonly derived by least-squares fitting of various exponential models to organ time–activity data (radiopharmaceutical biodistribution). Rarely, however, are methods used to objectively determine the model that best characterizes the data. Additionally, the uncertainty associated with the resultant TIAC is generally not evaluated. As part of the MIRDsoft initiative, MIRDfit has been developed to offer a biodistribution fitting software solution that provides the following essential features and advantages for internal dose assessment: nuclear medicine–appropriate fit functions; objective metrics for guiding best-fit selection; TIAC uncertainty calculation; quality control and data archiving; integration with MIRDcalc software for dose calculation; and a user-friendly Excel-based interface. For demonstration and comparative validation of MIRDfit’s performance, TIACs were derived from serial imaging studies involving 18F-FDG and 177Lu-DOTATATE using MIRDfit. These TIACs were then compared with TIAC estimates obtained using other software. In most cases, the TIACs agreed within approximately 10% between MIRDfit and the other software. MIRDfit has been endorsed by the MIRD Committee of the Society of Nuclear Medicine and Molecular Imaging and has been integrated into the MIRDsoft suite of free dosimetry software; it is available for download at no user cost (https://mirdsoft.org/).




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Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities [75th Anniversary Celebration Collection Special Section]

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.

Significance Statement

Studies have implicated the kynurenine pathway of tryptophan in the pathophysiology of neurologic and psychiatric diseases. Key enzymes of the kynurenine pathway regulate brain metabolism in both health and disease, making them promising targets for treating these disorders. Therefore, understanding the distribution, cellular expression, and regulation of these enzymes and metabolites in the brain is critical for developing effective therapeutic strategies. This review endeavors to describe these processes in detail.:




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New Tools Take Whole-Person Approach to Obesity Care [Family Medicine Updates]




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Chest Pain in Primary Care: A Systematic Review of Risk Stratification Tools to Rule Out Acute Coronary Syndrome [Systematic Review]

PURPOSE

Chest pain frequently poses a diagnostic challenge for general practitioners (GPs). Utilizing risk stratification tools might help GPs to rule out acute coronary syndrome (ACS) and make appropriate referral decisions. We conducted a systematic review of studies evaluating risk stratification tools for chest pain in primary care settings, both with and without troponin assays. Our aims were to assess the performance of tools for ruling out ACS and to provide a comprehensive review of the current evidence.

METHODS

We searched PubMed and Embase for articles up to October 9, 2023 concerning adult patients with acute chest pain in primary care settings, for whom risk stratification tools (clinical decision rules [CDRs] and/or single biomarker tests) were used. To identify eligible studies, a combination of active learning and backward snowballing was applied. Screening, data extraction, and quality assessment (following the Quality Assessment of Diagnostic Accuracy Studies-2 tool) were performed independently by 2 researchers.

RESULTS

Of the 1,204 studies screened, 14 were included in the final review. Nine studies validated 7 different CDRs without troponin. Sensitivities ranged from 75.0% to 97.0%, and negative predictive values (NPV) ranged from 82.4% to 99.7%. None of the CDRs outperformed the unaided judgment of GP’s. Five studies reported on strategies using troponin measurements. Studies using high-sensitivity troponin showed highest diagnostic accuracy with sensitivity 83.3% to 100% and NPV 98.8% to 100%.

CONCLUSION

Clinical decision rules without troponin and the use of conventional troponin showed insufficient sensitivity to rule out ACS in primary care and are not recommended as standalone tools. High-sensitivity troponin strategies are promising, but studies are limited. Further prospective validation in primary care is needed before implementation.




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How ten years of Game Maker’s Toolkit’s design analysis informed Mind Over Magnet

"A lot of puzzle games can leave you staring at the same static screen for ages, but here, I’m always pushing you forward," says Mark Brown of Game Maker’s Toolkit. For a decade now, Brown has been releasing accessible deep dives on game design for his popular YouTube channel, like "How Game Designers Protect Players From Themselves" and "The Two Types of Random in Game Design." This week, he’s releasing his own for the first time.

Read more




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Google tool makes AI-generated writing easily detectable

Google DeepMind has been using its AI watermarking method on Gemini chatbot responses for months – and now it’s making the tool available to any AI developer




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Stool test could provide a simpler way to diagnose endometriosis

A chemical produced by gut bacteria could be the basis for a non-invasive test for endometriosis – and mouse experiments suggest it might also help treat the condition