Songbirds swarm their predators and seals appreciate a good rhythm

Bantam Tools Acquires Evil Mad Scientist to Accelerate Development of Next Generation Art and Handwriting Machines Windell Oskay and Lenore Edman of Evil Mad Scientist named CTO and COO of Bantam Tools  PEEKSKILL, N.Y, January 16, 2024 — Bantam Tools, the desktop CNC manufacturer that builds exceptional computer controlled machines for innovators, is excited to … Continue reading Bantam Tools Acquires Evil Mad Scientist →

Bantam Tools proudly unveils its latest advancement in proven plotter technology with the launch of the new Bantam Tools NextDraw™ series of drawing and handwriting machines. Engineered for artists, innovators, and educators seeking exceptional versatility and performance, Bantam Tools now offers a trio of new models designed for drawing and handwriting. “The Evil Mad Scientist … Continue reading Introducing the Bantam Tools NextDraw™ →

NEWS—The Ray Studio hand vise seems like the perfect tool for hobbyists who like to paint small figures, glue small parts, and more. The weighted handle provides a grip for one hand or you can place it on a table. Or you can remove the handle altogether. The split vise features slots for rods to […]

In light of a recent series of fires in high-rise buildings with combustible facades, including the Grenfell tower fire, the National Fire Protection Association (NFPA) has initiated a project to develop a fire risk assessment tool for these types of buildings to assist local authorities globally with fire safety in their communities.

“Power Grid” by Ram Joshi is licensed via CC BY-NC-ND 2.0. We’re proud to announce Creative Commons’ Legal Tools have been reviewed and accepted into the Digital Public Goods Alliance (DPGA) DPG Registry. The DPGA is a multi-stakeholder initiative, endorsed by the United Nations Secretary-General, that is working to accelerate the attainment of the UN…

The post CC Legal Tools Recognized as Digital Public Goods appeared first on Creative Commons.

Explore tips and techniques for deep-cleaning your kitchen tools and gadgets. Learn how to sanitize your everyday cooking utensils effectively, ensuring a healthier cooking environment and longer-lasting kitchenware. Perfect for home cooks and hygiene enthusiasts.

The post How to Clean and Sanitize Kitchen Gadgets and Tools: Your Ultimate Guide appeared first on Unclutterer.

Uncover the top cleaning tools for every kitchen task in our detailed guide. From scrub brushes to microfiber cloths, we outline the best ways to keep your kitchen spotless. Learn how to clean smarter, not harder, with these proven tips and tricks.

The post The Best Cleaning Tools for Every Kitchen Task: Your Ultimate Guide appeared first on Unclutterer.

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An analysis looking at the hand bones of australopithecines, apes and humans reveals that tool use likely evolved before the Homo genus arose.

Show notes for Episode #2: Subscribe to the Internet Musician Podcast with iTunes: In this episode, I present “Music Tools for the Indie Artist”, a topic that I recently presented to a local songwriting group.  Specifically, I present the tools and process I use to capture and preserve those moments of musical inspiration–no matter whether they strike […]

Google said it discovered a zero-day vulnerability in the SQLite open-source database engine using its large language model (LLM) assisted framework called Big Sleep (formerly Project Naptime). The tech giant described the development as the "first real-world vulnerability" uncovered using the artificial intelligence (AI) agent. "We believe this is the first public example of an AI agent finding

This week was a total digital dumpster fire! Hackers were like, "Let's cause some chaos!" and went after everything from our browsers to those fancy cameras that zoom and spin. (You know, the ones they use in spy movies? ????️‍♀️) We're talking password-stealing bots, sneaky extensions that spy on you, and even cloud-hacking ninjas! ???? It's enough to make you want to chuck your phone in the ocean.

High-profile entities in India have become the target of malicious campaigns orchestrated by the Pakistan-based Transparent Tribe threat actor and a previously unknown China-nexus cyber espionage group dubbed IcePeony. The intrusions linked to Transparent Tribe involve the use of a malware called ElizaRAT and a new stealer payload dubbed ApoloStealer on specific victims of interest, Check Point

Cybersecurity researchers have uncovered nearly two dozen security flaws spanning 15 different machine learning (ML) related open-source projects. These comprise vulnerabilities discovered both on the server- and client-side, software supply chain security firm JFrog said in an analysis published last week. The server-side weaknesses "allow attackers to hijack important servers in the

⚠️ Imagine this: the very tools you trust to protect you online—your two-factor authentication, your car’s tech system, even your security software—turned into silent allies for hackers. Sounds like a scene from a thriller, right? Yet, in 2024, this isn’t fiction; it’s the new cyber reality. Today’s attackers have become so sophisticated that they’re using our trusted tools as secret pathways,

Cybersecurity researchers are calling attention to a new sophisticated tool called GoIssue that can be used to send phishing messages at scale targeting GitHub users. The program, first marketed by a threat actor named cyberdluffy (aka Cyber D' Luffy) on the Runion forum earlier this August, is advertised as a tool that allows criminal actors to extract email addresses from public GitHub

We are excited to announce the release of beta version of a new and long-awaited tool – Personal Feeds. In its first iteration it will allow you to create personal feeds and add items from other content feeds. You may have already used custom feeds for that in our Feeds Reader. But the main difference […]

The post Personal feeds – a tool with a personal touch… appeared first on RSSground.com.

They say if voting made any difference they wouldn’t let us do it. That’s not entirely true. We, at RSS Ground, completely depend on what our users request and require. That’s why we always ask you for your feedback. Please take part in our traditional poll and help us draw up a plan for future […]

The post Vote For New RSS Ground Tools And Features appeared first on RSSground.com.

The NOVA Universe Revealed Community Outreach Toolkit contains strategies for organizing events around the content of the five-part series as well as examples of hands-on activities and a wide range of multimedia educational resources aligned to the content of each episode.

NASA scientists used a neural network called ExoMiner to examine data from Kepler, increasing the total tally of confirmed exoplanets in the universe.

Use this toolkit to organize community screenings which educate the public, provide a space to discuss local impacts, and brainstorm community solutions.

Use the Secrets in Your Data Outreach Toolkit to organize screenings and events in your community about personal data privacy and security online.

velocityconf: New #velocityconf speaker interview w/ @sascha_d http://t.co/zg4tzDzIlH Config Management: It's Not About the Tool

Yu Xue
Sep 1, 2008; 7:1598-1608
Research

Eiji Kinoshita
Apr 1, 2006; 5:749-757
Technology

Visual Abstract

Eugen Netz
Dec 1, 2020; 19:2157-2167
Technological Innovation and Resources

Protein quality control is maintained by a number of integrated cellular pathways that monitor the folding and functionality of the cellular proteome. Defects in these pathways lead to the accumulation of misfolded or faulty proteins that may become insoluble and aggregate over time. Protein aggregates significantly contribute to the development of a number of human diseases such as amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease. In vitro, imaging-based, cellular studies have defined key biomolecular components that recognize and clear aggregates; however, no unifying method is available to quantify cellular aggregates, limiting our ability to reproducibly and accurately quantify these structures. Here we describe an ImageJ macro called AggreCount to identify and measure protein aggregates in cells. AggreCount is designed to be intuitive, easy to use, and customizable for different types of aggregates observed in cells. Minimal experience in coding is required to utilize the script. Based on a user-defined image, AggreCount will report a number of metrics: (i) total number of cellular aggregates, (ii) percentage of cells with aggregates, (iii) aggregates per cell, (iv) area of aggregates, and (v) localization of aggregates (cytosol, perinuclear, or nuclear). A data table of aggregate information on a per cell basis, as well as a summary table, is provided for further data analysis. We demonstrate the versatility of AggreCount by analyzing a number of different cellular aggregates including aggresomes, stress granules, and inclusion bodies caused by huntingtin polyglutamine expansion.

You encounter this issue when the table metadata matches the data source. In this scenario, no metadata update is required.

Cross-linking MS (XL-MS) has been recognized as an effective source of information about protein structures and interactions. In contrast to regular peptide identification, XL-MS has to deal with a quadratic search space, where peptides from every protein could potentially be cross-linked to any other protein. To cope with this search space, most tools apply different heuristics for search space reduction. We introduce a new open-source XL-MS database search algorithm, OpenPepXL, which offers increased sensitivity compared with other tools. OpenPepXL searches the full search space of an XL-MS experiment without using heuristics to reduce it. Because of efficient data structures and built-in parallelization OpenPepXL achieves excellent runtimes and can also be deployed on large compute clusters and cloud services while maintaining a slim memory footprint. We compared OpenPepXL to several other commonly used tools for identification of noncleavable labeled and label-free cross-linkers on a diverse set of XL-MS experiments. In our first comparison, we used a data set from a fraction of a cell lysate with a protein database of 128 targets and 128 decoys. At 5% FDR, OpenPepXL finds from 7% to over 50% more unique residue pairs (URPs) than other tools. On data sets with available high-resolution structures for cross-link validation OpenPepXL reports from 7% to over 40% more structurally validated URPs than other tools. Additionally, we used a synthetic peptide data set that allows objective validation of cross-links without relying on structural information and found that OpenPepXL reports at least 12% more validated URPs than other tools. It has been built as part of the OpenMS suite of tools and supports Windows, macOS, and Linux operating systems. OpenPepXL also supports the MzIdentML 1.2 format for XL-MS identification results. It is freely available under a three-clause BSD license at https://openms.org/openpepxl.

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.

Intact glycopeptide identification has long been known as a key and challenging barrier to the comprehensive and accurate understanding the role of glycosylation in an organism. Intact glycopeptide analysis is a blossoming field that has received increasing attention in recent years. Mass spectrometry (MS)-based strategies and relative software tools are major drivers that have greatly facilitated the analysis of intact glycopeptides, particularly intact N-glycopeptides. This manuscript provides a systematic review of the intact glycopeptide identification process using mass spectrometry data generated in shotgun proteomic experiments, which typically focus on N-glycopeptide analysis. Particular attention is paid to the software tools that have been recently developed in the last decade for the interpretation and quality control of glycopeptide spectra acquired using different MS strategies. The review also provides information about the characteristics and applications of these software tools, discusses their advantages and disadvantages, and concludes with a discussion of outstanding tools.

The Chatham House Sustainable Laboratories Initiative: Prior Assessment Tool Other resource sysadmin 14 June 2019

Laboratories are critical for supporting effective infectious disease surveillance and outbreak response. This tool is meant to help structure a conversation between funding partners and recipient countries on how to most effectively establish or repurpose laboratories in low-resource environments.

Introduction

Laboratories are critical for supporting effective infectious disease surveillance and outbreak response, and lack of adequate laboratory capacity is a global challenge. As part of global health security initiatives, cooperative threat reduction efforts and international development programmes, sophisticated laboratories have been provided to mitigate biological threats and bolster a country’s capacity for detection, diagnosis and storage of high-consequence pathogens. Very often, these use the assumptions, standards and templates applied in high-income countries. However, it can be difficult or even impossible to sustain these facilities in low-resource environments. There can sometimes be limited local technical capacity and capability, which can result in a high reliance on imported expertise, skills, equipment and other resources. Sustainability can therefore be hard to achieve. In addition, when a funding partner withdraws, the laboratories can become disused, foundering without the trained personnel and financial resources to sustain them.

To help address this situation, a proposal gaining increasing support internationally is to adopt an approach based on a local risk assessment, whereby laboratories are appropriately and optimally tailored to the local risks and to the resources available, both in the short and longer term, without compromising biosafety and biosecurity.

A Chatham House workshop was convened in Abuja, Nigeria, in 2018 to explore what West African countries would find most appropriate in terms of building laboratory capacity, what the main challenges have been so far, and what needs to be done to improve the sustainability of laboratories in the region. It emerged that there was a need for a more structured conversation between the funding partner and recipient country early in the process – prior to embarking on the detailed planning phase for the establishment or repurposing of a laboratory. This should involve careful consideration and an assessment of existing and planned capacity, needs and contextual issues, together with proposals for how to address the issues revealed, so that any ensuing laboratory demonstrably supports the national strategy and therefore flourishes.

Gender, think-tanks and international affairs: A toolkit Other resource NCapeling 9 February 2021

Encouraging a more gender-sensitive approach for think-tank activities such as convening and debate, research and analysis, and communications and publishing.

Compiled by staff at Chatham House, the Centre for Feminist Foreign Policy and the British American Security Information Council, the toolkit provides think-tanks with guidance on ways of adapting organizational structures, activities and practices in order to embed greater awareness of gender issues and adopt gender-sensitive approaches throughout their work.

The toolkit is designed for all people working in international affairs think-tanks, regardless of role, experience or level of seniority. It will be particularly useful for those think-tanks that are just beginning the process of raising greater awareness of gender issues internally, as well as for those that have already begun to make changes but wish to expand this work further.

The work to develop the toolkit came as a response to the commonly gendered nature of think-tanks and their activities. The toolkit recognizes the discrimination and under-representation that women often experience within the sector, as well as the relative absence of women among executive leadership, governance structures and senior researcher positions in many think-tanks.

The toolkit’s focus on gender is a starting point for wider intersectional analysis and action within the think-tank community. Embedding inclusive research, convening and communication practices is not just ‘the right thing to do’. When diversity and inclusion initiatives succeed, organizations are more resilient, innovative and better at decision-making.

While there has already been incremental change within think-tanks, the toolkit’s authors intend that their work will build on the important body of research and practices that already exist by encouraging think-tanks to examine their own processes and develop ways of working that focus not just on women’s representation, but on the structures and systems that perpetuate biases and inequalities.

The law as a tool for EU integration could be ending Expert comment NCapeling 15 October 2021

Poland is not the only EU member state challenging the supremacy of European law, as historic change is happening in how European integration functions.

The Polish Constitutional Tribunal’s ruling that several articles of the European treaties are incompatible with the Polish constitution is prompting much debate, especially in terms of both the similarities and differences between it and rulings by the German constitutional court which have also challenged the European Court of Justice (ECJ).

Pro-Europeans are keen to draw a sharp distinction between the reasoning deployed by the two courts. They see the Polish court’s challenge as an exceptional case which the European Union (EU) cannot ‘tolerate’ because it would lead to the ‘demolition of the EU’s legal order from within’ and argue the EU must take a tough approach to Poland by re-asserting the supremacy of EU law.

But this view misses a bigger long-term shift in the EU. Both the German and Polish cases illustrate some of the basic conflicts within the EU’s legal system for decades. What is being challenged increasingly openly – even since the UK left the EU – is the idea of the EU as a de facto federation in which non-majoritarian institutions such as the ECJ have final say about the quality of democracy in member states.

ECJ’s quiet revolution

Historically ‘integration through law’ was central to the European project and the ECJ was a key institution driving forward integration – usually benefiting from what Erik Stein called ‘benign neglect by the powers that be and the mass media’. Even when European integration in the form of treaties stalled in the 1960s and 1970s, ‘judicial integration’ through the ECJ continued, including its notable 1964 decision that EU law was supreme.

This self-empowerment of the ECJ – what another scholar of European constitutionalism Joseph Weiler calls ‘a quiet revolution’ – was possible because there was a ‘permissive consensus’ in member states which allowed judicial integration to continue largely unchallenged. But this has now changed as both politicians and national courts are more willing to challenge what they see as judicial overreach.

There are important differences between the approach of the German and the Polish constitutional courts. The Law and Justice Party has politicized the Polish court, packing it with judges sympathetic to that party, whereas the German court is more independent.

In addition, whereas the German court made qualified and subdued objections to measures taken in response to the euro crisis during the past decade and, in particular, the steps towards the mutualization of eurozone debt – but often backed down with ‘all bark and no bite’ as Christoph Schmid put it – the Polish court is driven by political considerations and has challenged the supremacy of EU law in a more direct and general way.

However, the German court has made it clear it is the guardian of the German constitution and seeks to impose limits on the ECJ’s self-empowerment by arguing Europe is not a federation. According to the German court’s theory of ‘constitutional pluralism’, there is in effect a constant dialogue and accommodation between the national and EU level rather than a simple primacy of EU law over national law.

The court sees itself as the ultimate arbiter of whether steps in European integration are consistent with the German constitution, and is likely to challenge any further steps in fiscal integration even if the ECJ deems them in accordance with the treaties – as it did with the European Central Bank’s quantitative easing programme.

Supremacy of EU law is under pressure

Right across Europe, courts and politicians are increasingly challenging the ECJ and questioning the supremacy of EU law. Michel Barnier called for France to regain ‘legal sovereignty’ and should no longer be subject to the judgments of the ECJ – an extraordinary demand from the EU Brexit negotiator who regularly lectured the UK about the sanctity of the EU’s legal order.

Other possible French presidential candidates such as Valérie Pécresse and Eric Zemmour are also openly challenging the primacy of EU law. The UK, of course, is fighting its own battle with the EU about the ECJ’s role in the Northern Ireland Protocol.

It was not the current Polish government but the people of France and the Netherlands who blocked the attempt at explicit constitutionalisation of the EU in a referendum just one year after the 2004 enlargement. Whereas the Constitutional Treaty ‘would have codified the doctrine of EU legal supremacy’, that provision was dropped from its successor the Lisbon Treaty, again indicating consensus on EU legal supremacy is not as strong as is often claimed.

Sept. 23, 2024 — Altera, an Intel Company, today unveiled an array of FPGA hardware, software and development tools that make its programmable solutions more accessible across a broader range of […]

The post Intel’s Altera Unveils New FPGA Tools and Kits to Boost AI and Edge Applications appeared first on HPCwire.

Benchmarking is an important topic in quantum computing. There’s consensus it’s needed but opinions vary widely on how to go about it. Last week, IBM introduced a new tool — […]

The post IBM Develops New Quantum Benchmarking Tool — Benchpress appeared first on HPCwire.

COLUMBUS, Ohio, Nov. 7, 2024 — Alexander Hoover, an assistant professor in the Department of Mathematics and Statistics at Cleveland State University, has always been fascinated by marine organisms—the way […]

The post OSC Advances Marine Movement Research with Computational Tools for Bio-Inspired Robotics appeared first on HPCwire.

Nebraska's education department released an interactive instructional materials map last week, showing what curricula districts have adopted for English-language arts, math, and K-8 science.

The Urban Institute released a toolkit aimed at policymakers and investors interested in using private dollars to pay for public programs, such as prekindergarten.

Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and accuracy over ROI-based methods. We evaluated its performance against 145 cortical retrograde tracer injections in male and female marmosets that were used as ground truth cellular connectivity on a voxel-by-voxel basis. The receiver operating characteristic (ROC) curve was calculated for each injection, and we achieved area under the ROC curve of 0.95 for undirected and 0.942 for directed SCA in the case of high cell count threshold. This indicates that SCA can reliably estimate the strong cellular connections between voxels in fMRI data. We then used our directed SCA method to analyze the human default mode network (DMN) and found that dlPFC (dorsolateral prefrontal cortex) and temporal lobe were separated from other DMN regions, forming part of the language-network that works together with the core DMN regions. We also found that the cerebellum (Crus I-II) was strongly targeted by the posterior parietal cortices and dlPFC, but reciprocal connections were not observed. Thus, the cerebellum may not be a part of, but instead a target of, the DMN and language-network. Summarily, our novel directed SCA method, visualized with a new functional flat mapping technique, opens a new paradigm for whole-brain functional analysis.