It’s vital for wellness, full participation in society

Jaya is a woman of steel in the truest sense of the word.Despite being the first lady of filmdom, she's as real and rooted to the ground as anyone can get, notes Subhash K Jha on the actor-politician's 74th birthday.

Westminster : Nichols and Sons, 25 Parliament Street, MDCCCLXXXV [1885]

Ceramic artist Rahul Kumar’s tenth solo exhibition, The Untold Resides Somewhere, is a labyrinth of emotive, lexical and metaphorical expressions for “preserving the discarded”

At the end of Day 5 of the ongoing marquee event, India is at 15th position in the medal's tally with three gold, five silver, and seven bronze

Cell-penetrating assembly uncages hormone, turning on gene circuit

Reaction opens unstrained nitrogen rings furnishing alkyl fluorine compounds

Suspension that has fully acclimatised to Indian roads and handles potholes and bumps with ease, plush interiors that feel premium beyond just surface level, and aggressive and imposing design cues give this SUV a presence and profile that has little competition, says Pavan Lall.

The structure was produced by Turkish software company Etisan and is one of the club's main new hygiene measures to prevent the spread of the coronavirus at the training facilities.

Deepika Padukone is not only a prolific actress, who has been upping her acting game but she is also a saree connoisseur. With her resplendent sarees, the actress has inspired the young ladies of today to drape sarees. In

It was just a few days ago,when stylist Aastha Sharma shared a picture of Lisa Ray from the sets of Four More Shots Please!, where she was seen sporting a stunning white bridal ensemble by Gaurav Gupta. And now, recently,

The Union Health Minister Harsh Vardhan said the testing capacity for COVID-19 has been ramped up to around 95,000 tests per day and a total of over 15 lakh tests have been conducted so far across hundreds of government and private labs.

The state also reported death of 48 patients, taking the death toll to 779, said a health department official.

With the addition of 50 new cases, total number of coronavirus (Covid-19) positive cases in Andhra Pradesh has gone up to 1,980.According to governm

Tamil Nadu witnessed another spike in Covid-19 positive cases today with 669 to go past the 7,000-mark at 7,204.Chennai alone had recorded 509 new ca

Emacs "predates Linux, and was once far more popular," writes LWN.net, while adding that the text editor "has fallen into relative obscurity over the years." Then it reports on a "mega-thread" on the emacs-devel mailing list about how to make Emacs more appealing and attractive to users: The discussion started with a post from "ndame" asking why Emacs is "so square"; the appearance of things like buttons could be improved with rounded corners, they said. Richard Stallman, one of the original authors of Emacs, seemed somewhat dismissive in his reply: "Perhaps we should implement a mode that puts cosmetics on Emacs so it will appeal to those who judge by the surface of things." But Stefan Kangas thought there was more to it than that: I think it's unfortunate if we assume that this is all bells and whistles. Graphical design elements can also improve usability. I also don't know that it's helpful to assume that the rest of the world will take the enlightened stance.... He wondered if there was "any reason not to improve the default look". Stallman said that there are some technical barriers in finding someone interested in and capable of doing the work needed, but there is an overarching problem that needs to be addressed first: The code to interface Emacs to X-based GUIs needs rewriting by an expert, and has needed it for decades. Until it gets that rewrite, changes in it are likely to break something. Stallman did agree that the graphical design could improve usability, "but I have a feeling that the changes that would help are deeper issues than the shape of corners". It was a long and interesting discussion, touching on the popularity of both Vim and Visual Studio Code, while another post questioned whether Emacs should even be prioritizing its menu bar and tool bar. One post suggested "starter kits" to make the text editor more friendly to newcomers, another suggested making Cntrl-C cut-and-paste the default key binding, and one asked whether it was Emacs' terminology and keyboard shortcuts that might be confusing to users coming from Microsoft Word. "You are basically making a commitment to being or becoming a power user..." argued another post. "If you just want to do 'casual' text editing emacs is a very weird choice in 2020."

Read more of this story at Slashdot.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Instagram Live allows users to stream video to followers and engage with them in real time. Here are some cool tips to make your quarantine a little more interesting.

Japan has added 11,090 megawatts of clean energy capacity since July 2012, when it began an incentive program to encourage investment in renewables, according to the Ministry of Economy, Trade and Industry.

Japan has added 11,090 megawatts of clean energy capacity since July 2012, when it began an incentive program to encourage investment in renewables, according to the Ministry of Economy, Trade and Industry.