VOLUME 289 (2014) PAGES 6604–6618In Fig. 4G, in the foxi1 panel, the images in Fig. 4G, i and l, corresponding to “smad1 MO” and “smad5 MO + samd1/9 mRNA” samples, respectively, were inadvertently reused during figure preparation. This error has now been corrected using images pertaining to each treatment and sample. This correction does not affect the results or conclusions of the work.jbc;295/52/18650/F4F1F4Figure 4G.

Around 3% of people are thought to hear voices when there is no one talking.

The principal of a school in Washington, DC, describes a shift toward equity, diversity, and inclusion.

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical, and functional properties. In mouse visual cortex, they also differ in their modulation with an animal’s behavioral state, and this state modulation can be predicted from the first principal component (PC) of the gene expression matrix. Here, we ask whether this link between transcriptome and state-dependent processing generalizes across species. To this end, we analysed seven single-cell and single-nucleus RNA sequencing datasets from mouse, human, songbird, and turtle forebrains. Despite homology at the level of cell types, we found clear differences between transcriptomic PCs, with greater dissimilarities between evolutionarily distant species. These dissimilarities arise from two factors: divergence in gene expression within homologous cell types and divergence in cell-type abundance. We also compare the expression of cholinergic receptors, which are thought to causally link transcriptome and state modulation. Several cholinergic receptors predictive of state modulation in mouse interneurons are differentially expressed between species. Circuit modelling and mathematical analyses suggest conditions under which these expression differences could translate into functional differences.

FAO and China have signed a two-year tripartite cooperation agreement worth about N$10.5 million (US$1.5 million) that will boost the efforts of local farmers in Namibia. The agreement, which is [...]

The food security situation in Gaza is catastrophic. Famine is imminent in the Northern Governorates and there is a risk of famine across the rest of the Gaza Strip, according [...]

A new exhibition in Paris demonstrates the influence that the Spanish artist had on the young American painter who would help usher in the Abstract Expressionist movement

Geologists suggest the catastrophic impact of "S2" delivered key nutrients to the oceans, prompting microorganisms to thrive

Wildlife photographer Jason Leo Bantle recounts the moment he came across Banff’s most famous grizzly ‘The Boss,’ during the bear’s surprise visit to Canmore, Alta.

Chair Rick Petrella and trustees Dan Dignard, Bill Chopp and Mark Watson of the Brant Haldimand Norfolk Catholic District School Board were to Italy between July 8 and 15 to buy $100,000 in custom artwork for two new high schools. It's among trips by Ontario school boards that have come under scrutiny for the way public money is spent.

Ontario's Minister of Education has announced she will audit discretionary spending of all school boards in the province after reports of expensive trips by board officials in recent months.

CBC's Dalson Chen talks to Bob Reaume about a break in that resulted in an estimated $40,000 in merchandise taken just before the busy holiday season.

Global workholding product supplier increases sales, reduces development time and costs, and designs better products with 3D CAD software

Writer Nicole spent five days driving around Portugal this summer, hanging out with three Transform teams and listening to their stories.

Ministry opportunities in Hungary open up the mission experience for families with younger children.

Getting the whole family involved in a short term missions trip is an unforgettable experience!

Marcela (Argentina) experienced the power of God working through her while on a mission trip in Israel.

The care the head teacher of Chiyembekezo School shows to her pupils even outside the classroom has a ripple effect on the larger community.

South Africa's unemployment rate fell by more than expected in the third quarter, declining by 1.4 percentage points to 32.1%.

OM EAST responds to the need for Christian books in the Georgian language.

Olger Morales shares his testimony of how he came to work in OM full-time after participating in numerous short-term outreaches.

A Chicago-based former Little League team has filed a lawsuit against Little League International over the organization's decision to strip the team's United States championship earlier this year.

Penn State Health will collect unwanted, unneeded or expired medications, needles and syringes for safe disposal on Saturday, Oct. 26, as part of National Prescription Drug Take-Back Day.

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.

The mere threat of immigration enforcement could have severe consequences for students' mental health, school engagement, grades, and post-high school lives, a new study finds.

The mere threat of immigration enforcement could have severe consequences for students' mental health, school engagement, grades, and post-high school lives, a new study finds.

Education Week has teamed up with Roadtrip Nation to send a group of teachers across the country in a green RV. Here's what you need to know.

Books played an important role in Aslan's salvation. Now he provides literature to other Central Asians.

The first movie released in 2018 and featured Janhvi Kapoor and Ishaan Khatter in the lead roles

Archana's son also joined her on the trip

Crispy veg strips are a versatile and delicious snack that can be enjoyed by everyonewhether youre craving something light or want to impress guests at your next party.

Pankaj Tripathi revealed a surprising ingredient that he adds to his tea to make it special.

Delaware will hold its 22nd National DEA Prescription Drug Take-Back Day on Saturday, April 30, 2022. Delawareans can discard their expired or unused medications at locations statewide between 10:00 a.m. and 2:00 p.m. There will also be Sharps disposals for needle disposal at select locations, and overdose response education with free Narcan available at select locations.

DOVER, DE (Aug. 29, 2022) – The Delaware Division of Public Health’s (DPH) Office of Health Crisis Response (OHCR) is announcing it will begin including fentanyl test strips in Narcan kits it distributes to the public. The effort is part of a harm-reduction strategy aimed at preventing accidental overdoses due to fentanyl consumption.   Fentanyl is now the leading cause of […]

*Editor/Reporter note: We originally stated that five DEA National Prescription Drug Take Back locations would be offering Overdose Response Training and Narcan distribution to the public; there are only two – Milford and Middletown. We also erroneously stated that there are 23 locations currently participating in the National Prescription Drug Take Back event; there are 22.    […]

Los residentes de Delaware encontrarán más opciones en aseguradoras y planes, y subsidios federales incrementados continuos para ayudar con la asequibilidad; la registración se extiende hasta el 15 de Enero del 2023 NEW CASTLE (1º de Noviembre, 2022) – Saliendo de un año con sin precedentes por la inscripción en el Mercado de Seguros Médicos […]

The Delaware Division of Public Health (DPH) recently held its 24th Prescription Drug Take-Back Day event. Organized nationally by the Drug Enforcement Administration (DEA), Prescription Drug Take-Back Day is operated locally by DPH. The twice-a-year event (April and October) aims to reduce the risk of prescription medications being diverted for misuse and has resulted in 114,470 pounds of medication being collected in Delaware since 2010. […]

The Delaware Division of Public Health (DPH), in collaboration with the Delaware Division of Professional Regulation (DPR), announces important updates to the Mental Health and Substance Use Disorder section of the My Healthy Community (MHC) Dashboard.  These updates are located within this section’s Prescription Monitoring Program (PMP) tab and present trends in prescription drug dispensing in Delaware. The […]

NEW CASTLE – The Delaware Department of Health and Social Services (DHSS) announced today enhancements to the CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical and pharmacy claims in Delaware. […]

Amidst a shortage of prescription stimulants, concerns have been raised about the potential increase in illicit drug use. With many individuals relying on prescription stimulants to manage conditions such as attention-deficit/hyperactivity disorder (ADHD), the shortage has left many struggling to access the medication they need. This has led some individuals to turn to illicit drugs […]

Delaware will hold its 25th National DEA Prescription Drug Take-Back Day on Saturday, October 28, 2023. Delawareans can discard their expired or unused medications at locations statewide between 10:00 a.m. and 2:00 p.m. Sharps disposals for needle disposal will be available at select locations, as well as overdose response education with free Narcan available at […]

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained with an example, how to disable Browser Back Button after Logout using JavaScript in ASP.Net MVC.

DOVER, Del. (May 19, 2022) — The Delaware Office of Highway Safety (OHS) is reminding drivers about the lifesaving benefits of wearing a seat belt this spring, during the National Highway Traffic Safety Administration’s (NHTSA) national Click It or Ticket high-visibility enforcement effort. Delaware is joining the national seat belt campaign, which coincides with the […]