Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

The present invention provides a polymerizable compound represented by the following formula (I), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The polymerizable compound, polymerizable composition, and polymer have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.

The invention relates to a method for preparation of platinum siloxane compounds containing at least one CO ligand molecule (Pt carbonyl siloxanes). The method comprises reacting gaseous carbon monoxide (CO) with a platinum siloxane compound, preferably a platinum vinyl-cyclosiloxane compound, in solution with an organic solvent. The method is straightforward and applicable to industrial scale. With this method, specific isomers of platinum carbonyl vinylcyclosiloxanes are prepared, in which the two η-2-ethenyl groups coordinated to the Pt atom are bonded in trans-configuration relative to the cyclosiloxane backbone. The Pt compounds obtained by the method are used as catalysts for hydrosilylation and for crosslinking and curing of siloxanes and silanes.

The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

The present invention relates to a tin-containing organolithium compound which can be used as anionic polymerization initiators, represented by the following formula (1): R4−xSn(Ya—Zm—Yb—Li)x (1)Wherein R, Z and Y are defined as in the specification; x represents a value of 1 or 2; m represents a value of 0 or 1; a represents a value of 0 to 6, b represents a value of 0 to 6, a+b is from 0 to 6, provided that m=1 when x=1. The tin-containing organolithium compounds according to the present invention can be used as initiators to initiate the polymerization of conjugated dienes and/or monovinyl aromatic hydrocarbons, thereby synthesizing various linear, star or telechelic polymers. The present invention also relates to a method for preparing the tin-containing organolithium compounds according to the present invention.

A process for the purification of organometallic compounds or heteroatomic organic compounds from oxygen, water and from the compounds deriving from the reaction of water and oxygen with the organometallic or heteroatomic compounds whose purification is sought, comprising the operation of contacting the organometallic or heteroatomic compound to be purified in the liquid state or in form of vapor, pure or in a carrier gas, with a hydrogenated getter alloy, and optionally also with one or more gas sorber materials selected among palladium on porous supports and a mixture of iron and manganese supported on zeolites.

The invention relates to a process for preparing Grignard compounds of the formula I. The invention additionally relates to compounds of the formula I and to polymer-bound compounds of the formula Ia. The invention further relates to the use of the process for preparing substance libraries and to the use of the compounds of the formulae I and Ia in chemical synthesis.

A process for preparing alkyllithium compounds by reacting a sodium-lithium alloy with alkyl halides at temperatures of about 50 to 125° C.

Disclosed is a method for producing Alkyllithium compounds by reacting metallic lithium with an Alkyl halide in a solvent. The reaction is performed at a reduced pressure at the boiling point of the solvent.

In the process of synthesizing alkylborazine compound represented by the chemical formula 2, by a reaction of a halogenated borazine compound represented by the chemical formula 1 with a Grignard reagent, thus synthesized alkylborazine compound is washed with water, or subjected to sublimation purification or distillation purification at least three times, and/or subjected to distillation purification at least twice. In the formulas, R1 independently represents alkyl group; R2 independently represents alkyl group; and X represents halogen atom.

A method for the production of alkyl lithium compounds is disclosed, in which metallic lithium is reacted with an alkyl halide in a solvent, whereby the metallic lithium is introduced in the form of lithium particles, generated by spraying molten lithium into an inert atmosphere or into a vacuum.

The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

The invention relates to a method for producing Grignard compounds, according to which magnesium is reacted in a suitable fluid reaction medium in a protective atmosphere with hologen-substituted organic compounds by means of microwave radiation.

Pulverulent solid which consists essentially of at least one metal alkyl compound bound chemically and/or physically to a finely divided, porous, mechanically stable and chemically inert support, has a proportion by weight of metal alkyl compound of at least 5% by weight, based on the support, and has an angle of repose, determined in accordance with ISO 4324, of up to 48°. The solid allows trouble-free metering as active component into a reactor.

A process is described for preparing aryllithium compounds by reaction of metallic lithium in an ether-containing solvent with an aryl halide, wherein prior to or at the beginning of the reaction a catalyst is added, the catalyst containing a halogen-free, polynuclear aromatic (aryl catalyst) or consisting of such a compound.

[Problem] To provide a preparation process by which an organic alkali metal compound is obtained in a high yield and a process for preparing an organic transition metal compound using the organic alkali metal compound. [Means to solve the problem] A process for preparing an organic alkali metal compound, which is characterized by adding a compound represented by the following formula (2) in the reaction of an active proton-containing compound represented by the following formula (1) with an alkali metal compound. RHp (1) In the formula (1), R is a hydrocarbon group or an amino group and may contain a halogen atom, a silicon atom, an oxygen atom or a nitrogen atom, H is an active proton, and p is the number of hydrogen atoms abstracted in the reaction with the alkali metal compound. In the formula (2), Ra to Rc are each an atom or a group selected from a hydrogen atom, a hydrocarbon group, a heteroatom-containing group and a silicon-containing group and may be the same as or different from each other, and the neighboring substituents may be bonded to each other to form a ring.

A method of purifying crude organometallic compounds using a stripping column and a gas stream is provided. This method removes relatively more volatile impurities as compared to the organometallic compound.

Methods and systems are provided for converting methane in a feed stream to acetylene. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to nitrogen based hydrocarbon compounds such as pyridines. The method includes the reaction of acetylene with ammonia and controlling the ratio of acetylene to ammonia to generate the desired nitrogen based hydrocarbon compound.

An assembly includes a threaded hole, a threaded fastener, and a locking compound. The threaded fastener is positioned in the threaded hole with a portion of fastener threads mated with a corresponding portion of hole threads. The locking compound is between the mated fastener threads and hole threads. The locking compound includes an aluminum pigmented compound suspended in a water-based inorganic binder.

An integrated structure of compound semiconductor devices is disclosed. The integrated structure comprises from bottom to top a substrate, a first epitaxial layer, an etching-stop layer, a second epitaxial layer, a sub-collector layer, a collector layer, a base layer, and an emitter layer, in which the first epitaxial layer is a p-type doped layer, the second epitaxial layer is an n-type graded doping layer with a gradually increased or decreased doping concentration, and the sub-collector layer is an n-type doped layer. The integrated structure can be used to form an HBT, a varactor, or an MESFET.

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

Provided is a novel coated phosphor capable of effectively suppressing the adverse effects of hydrogen sulfide gas generated by the reaction between a sulfur-containing phosphor and moisture in the air. Provided is a sulfur-containing phosphor having a configuration in which ZnO compound containing Zn and O is present on the surface of a sulfur-containing phosphor having a host material which includes sulfur.

A transistor device includes a compound semiconductor body having a first surface and a two-dimensional charge carrier gas disposed below the first surface in the compound semiconductor body. The transistor device further includes a source in contact with the two-dimensional charge carrier gas and a drain spaced apart from the source and in contact with the two-dimensional charge carrier gas. A first passivation layer is in contact with the first surface of the compound semiconductor body, and a second passivation layer is disposed on the first passivation layer. The second passivation layer has a different etch rate selectivity than the first passivation layer. A gate extends through the second passivation layer into the first passivation layer.

Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability.

A layered compound-metal particle composite 3 is obtained by the addition, to an organically modified layered compound 1 formed by the intercalation of organic ions between layers of a layered compound, of both an aqueous colloidal metal solution 2 in which metal particles are dispersed as a metal colloid in water, and a nonaqueous solvent which is a poor solvent for the metal colloid and has an excellent ability to swell the organically modified layered compound 1.

An integrated self-supporting and deformation-resistant modular driver's cabin structure for mounting to the front end of a rail vehicle body and for providing a driver space and a windshield opening, is composed of a composite sandwich structure with a single, common, continuous outer skin layer, a single, common, continuous inner skin layer and an internal structure wholly covered with and bonded to the inner and outer skin layers, the internal structure comprising a plurality of core elements. The driver's cabin structure comprises at least: side pillars each having a lower end and an upper end, and an undercarriage structure at the lower end of each of the side pillars. The fiber-reinforced sandwich located in the side pillars is provided with several layers of fibers oriented to provide a high bending stiffness. The fiber-reinforced sandwich of the undercarriage structure is such to transfer static and crash loads without flexural buckling.

Disclosed is a method of producing a chemically pure and stably dispersed organic nanoparticle colloidal suspension using an ultrafast pulsed laser ablation process. The method comprises irradiating a target of an organic compound material in contact with a poor solvent with ultrashort laser pulses at a high repetition rate and collecting the nanoparticles of the organic compound produced. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beam, an organic compound target in contact with a poor solvent, and a solvent circulating system to cool the laser focal volume and collect the produced nanoparticle products. By controlling various laser parameters, and with optional poor solvent flow movement, the method provides stable colloids of dispersed organic nanoparticles in the poor solvent in the absence of any stabilizing agents.

Precursors for use in depositing antimony-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of Ge2Sb2Te5 chalcogenide thin films in the manufacture of nonvolatile Phase Change Memory (PCM) or for the manufacturing of thermoelectric devices, by deposition techniques such as chemical vapor deposition (CVD) and atomic layer deposition (ALD).

A non-aqueous drywall compound being the combination of a first component mixture of acetone, a non-aqueous liquid adhesive containing ethyl cyanoacrylate, and a powder containing calcium sulfate hemihydrate (plaster of Paris), the mixture being a pliable putty capable of adhering to gypsum wallboard or similar work surfaces. The second component of the drywall compound is an accelerator or activator containing acetone and toluene. The first component is applied to a defect in a work surface using a spreading tool and the second component is then applied to the exposed surface of the first component, such as by spraying or brushing, whereupon the drywall compound cures, hardens or sets within less than ten minutes to a state capable of being sanded into a smooth, hard surface and painted.

Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

Disclosed is an apparatus and related methods for facilitating the application of a cutting tool to a work-piece rotating on the axis of a lathe.

Integrated processes are provided for syngas refining and bioconversion of syngas to oxygenated organic compound. In the integrated processes ammonia contained in the syngas is recovered and used as a source of nitrogen and water for the fermentation. The integrated processes first remove tars from syngas by scrubbing using a first aqueous medium under conditions that ammonium bicarbonate is unstable. With tars removed, contact between the syngas and a second aqueous medium enables ammonia and carbon dioxide to be removed from the syngas without undue removal of components adverse to the fermentation, processing or oxygenated product such as benzene, toluene, xylene, ethylene, acetylene, and hydrogen cyanide. At least a portion of the second aqueous medium is supplied as a source of water and ammonia for the fermentation.

This invention relates to sulfur based compounds useful in methods of carbon dioxide or sulfur dioxide removal.

Compound action snips includes include first and second handles pivotally connected to each other, and first and second blades. The first handle includes first and second walls arranged opposite to each other. The second wall includes a recess. The first blade is mounted to the first handle. The second blade is mounted to the second handle. A fastener inserts through the first wall, the first blade, and the second wall. A fixing element is received into the recess and threaded onto the fastener, so that a top surface defined on the fixing element is not exposed out of the second wall of the first handle.

A method of making metal nanoparticles and carbon nanotubes is disclosed. A mixture of a transition metal compound and an aromatic polymer, a precursor of an aromatic polymer, or an aromatic monomer is heated to form a metal nanoparticle composition, optionally containing carbon nanotubes.

An improved apparatus strips HPNA's from hydroprocessed streams in a fractionation column having a split shell configuration. Only one vapor stripping feed is required to the split shell of the fractionation column. The resulting reduction in steam requirement provides a superior fractionation in the column.

A crude oil feedstream is treated to remove or reduce the content of known undesired heteroatomic and polynuclear aromatic compounds containing nitrogen and sulfur by contacting the feedstream with one or more solid adsorbent materials selected from attapulgus clay, alumina, silica gel and activated carbon in a mixing vessel for a time that is sufficient to optimize the adsorption of the undesired compounds from the crude oil, subjecting the mixture to atmospheric flash distillation and then to vacuum flash distillation to recover presorbed boiling ranges of products having a lowered content of the undesired compounds, and preferably regenerating at least a portion of the solid adsorbent material for reuse in the process.

The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

An esteramide compound of the following formula (I): R1OOC-A-CONR2R3 (I) is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

The invention relates to a fertilizing compound for application to plants and crops, especially fruits, intended for increasing the amount of calcium and subsequently improving the state of health of the plants and the preservation thereof after harvesting. The compound consists of a combination of components such as calcium nitrate, calcium lignosulfonate, organic acids, menadione sodium bisulphite, amino acids and water. The compound is in the form of a liquid preparation, packed in containers of between 20 and 1000 liters, is water-soluble and is applied by fertigation, spraying or in a localized form by border irrigation.

Provided herein are compositions comprising at least one estolide compound of formula: in which n is an integer equal to or greater than 0; m is an integer equal to or greater than 1; R1, independently for each occurrence, is selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R3 and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched. Also provided are uses of the compositions described herein.

An insect repellent compound that includes naturally occurring oil that emits an odor which repels insects is described. The compound is not harmful to animals, to humans or to the environment. The compound may be incorporated into materials such as yarn that is woven to form a mesh. The material may be used for making an animal mask, for screen doors and other applications. A method of making the compound and incorporating it into materials and products is described.

A method for forming a V-NAND device is disclosed. Specifically, the method involves deposition of at least one of semiconductive material, conductive material, or dielectric material to form a channel for the V-NAND device. In addition, the method may involve a pretreatment step where ALD, CVD, or other cyclical deposition processes may be used to improve adhesion of the material in the channel.

A method of treating a carbon structure is provided. The method may include the step of infiltrating the carbon structure with a ceramic preparation comprising yttrium oxides and zirconium oxides. The carbon structure may be densified by chemical vapor infiltration (CVI) and heat treated to form yttrium oxycarbides and/or carbides and zirconium oxycarbides and/or carbides. Heat treating the carbon structure may comprise a temperature ranging from 1000° C. to 1600° C.

Methods are disclosed for generating electrical power from a compound comprising carbon, oxygen, and hydrogen. Water is combined with the compound to produce a wet form of the compound. The wet form of the compound is transferred into a reaction processing chamber. The wet form of the compound is heated within the reaction chamber such that elements of the compound dissociate and react, with one reaction product comprising hydrogen gas. The hydrogen gas is processed to generate electrical power.

A system for diffusing one or more volatile compounds includes a base and a pod tray, carried by the base. At least one pod is carried by the pod tray. The pod has a housing holding a volatile compound mass, the housing and mass being moveable relative to one another. An actuator is carried by the base, the actuator being operable to engage the pod and move the housing and the volatile compound mass relative to one another. The pod and the actuator are positionable relative to one another such that one or both of the pod and the actuator can be positioned proximate to one another to enable the actuator to engage the pod and move the housing and the volatile compound mass relative to one another.

A compound tool formed preferably of a single piece, having a grip stem adapted to be gripped by the jaws of adjustable pliers received in a recess on the tool, and having a hammer head. Together the plier and tool are useable as a hammer.

A polymerizable liquid crystal compound represented by Chemical Formula 1: wherein in Chemical Formula 1, groups and variables are the same as defined in the detailed description.