Brain infections with Cryptococcus neoformans are associated with significant morbidity and mortality. Cryptococcosis typically presents as meningoencephalitis or fungal mass lesions called cryptococcomas. Despite frequent in vitro discoveries of promising novel antifungals, the clinical need for drugs that can more efficiently treat these brain infections remains. A crucial step in drug development is the evaluation of in vivo drug efficacy in animal models. This mainly relies on survival studies or post-mortem analyses in large groups of animals, but these techniques only provide information on specific organs of interest at predefined time points. In this proof-of-concept study, we validated the use of non-invasive preclinical imaging to obtain longitudinal information on the therapeutic efficacy of amphotericin B or fluconazole monotherapy in meningoencephalitis and cryptococcoma mouse models. Bioluminescence imaging (BLI) enabled the rapid in vitro and in vivo evaluation of drug efficacy while complementary high-resolution anatomical information obtained by magnetic resonance imaging (MRI) of the brain allowed a precise assessment of the extent of infection and lesion growth rates. We demonstrated a good correlation between both imaging readouts and the fungal burden in various organs. Moreover, we identified potential pitfalls associated with the interpretation of therapeutic efficacy based solely on post-mortem studies, demonstrating the added value of this non-invasive dual imaging approach compared to standard mortality curves or fungal load endpoints. This novel preclinical imaging platform provides insights in the dynamic aspects of the therapeutic response and facilitates a more efficient and accurate translation of promising antifungal compounds from bench to bedside.

The UK and Scottish Governments must work more closely together to ensure people get the benefits they are entitled to, a new report by the Scottish Parliament’s Social Security Committee has said.

DOVER (May 15, 2019) – During the 18th Prescription Drug Take-Back Day event on April 27, 2019, Delaware collected 5,385 pounds of unwanted or expired medicine, according to the U.S. Drug Enforcement Administration (DEA) and the Division of Public Health (DPH). That amount is approximately 1,600 pounds more than the 3,739 pounds collected in October. […]

NEW CASTLE (Sept. 25, 2019) – Department of Health and Social Services employees joined together with the Food Bank of Delaware, legislators and other volunteers to distribute 30,000 pounds of non-perishable food, fresh produce and dairy products to Delawareans in need during a drive-through event today at DHSS’ Herman Holloway Campus near New Castle. The […]

The UK Home Secretary will be asked to raise the recommended £30,000 minimum salary threshold for all latest international workers to defend lower-paid British workers.At the moment, the limitation only appeals to non-EU migrants, but it's assumed…

PM Boris Johnson is set to change the plan about the minimum £30,000 earning the threshold for migrants who aim to enter the UK after the exit of Britain from the EU.The Reasons Behind the DecisionThe proposal appears to not fit in with his plan to…

In the video, a TikTok user challenges viewers to solve the mystery of the missing pound while splitting a restaurant bill equally.

1 Seychellois Rupee = 88.1146 Lebanese Pound

1 Seychellois Rupee = 0.047 British Pound Sterling

1 Seychellois Rupee = 0.9065 Egyptian Pound

1 Trinidad and Tobago Dollar = 223.8615 Lebanese Pound

1 Trinidad and Tobago Dollar = 0.1193 British Pound Sterling

1 Trinidad and Tobago Dollar = 2.3031 Egyptian Pound

1 Swedish Krona = 154.8072 Lebanese Pound

1 Swedish Krona = 0.0825 British Pound Sterling

1 Swedish Krona = 1.5927 Egyptian Pound

1 Slovak Koruna = 68.1239 Lebanese Pound

1 Slovak Koruna = 0.0363 British Pound Sterling

1 Slovak Koruna = 0.7009 Egyptian Pound

1 Serbian Dinar = 13.9483 Lebanese Pound

1 Serbian Dinar = 0.0074 British Pound Sterling

1 Serbian Dinar = 0.1435 Egyptian Pound

1 Polish Zloty = 359.7741 Lebanese Pound

1 Polish Zloty = 0.1917 British Pound Sterling

1 Polish Zloty = 3.7014 Egyptian Pound

1 Qatari Rial = 415.4747 Lebanese Pound

1 Qatari Rial = 0.2214 British Pound Sterling

1 Qatari Rial = 4.2745 Egyptian Pound

1 Indian Rupee = 20.0355 Lebanese Pound

1 Indian Rupee = 0.0107 British Pound Sterling

1 Indian Rupee = 0.2061 Egyptian Pound

1 Pakistani Rupee = 9.4755 Lebanese Pound

1 Pakistani Rupee = 0.005 British Pound Sterling

1 Pakistani Rupee = 0.0975 Egyptian Pound

1 Sierra Leonean Leone = 0.1534 Lebanese Pound

1 Sierra Leonean Leone = 0.0001 British Pound Sterling

1 Sierra Leonean Leone = 0.0016 Egyptian Pound

1 New Taiwan Dollar = 50.6668 Lebanese Pound

1 New Taiwan Dollar = 0.027 British Pound Sterling

1 New Taiwan Dollar = 0.5213 Egyptian Pound

1 Thai Baht = 47.2436 Lebanese Pound

1 Thai Baht = 0.0252 British Pound Sterling

1 Thai Baht = 0.4861 Egyptian Pound

1 Turkish Lira = 213.3924 Lebanese Pound

1 Turkish Lira = 0.1137 British Pound Sterling

1 Turkish Lira = 2.1954 Egyptian Pound

1 Singapore Dollar = 1070.8289 Lebanese Pound

1 Singapore Dollar = 0.5706 British Pound Sterling

1 Singapore Dollar = 11.0169 Egyptian Pound

1 Mauritian Rupee = 38.0948 Lebanese Pound