Trump to appoint hardliners Rubio and Waltz as foreign policy chiefs, reports claim

Russian warship armed with hypersonic missiles trains in English Channel, state media reports

Queen Camilla has sparked a surge of support for a cause close to her heart, following in the footsteps of Prince William with a powerful new documentary. Her Majesty The Queen: Behind Closed Doors, which aired on ITV on Monday evening, offered a deeply personal look at her first year as...

Inclusive sports can empower women with disabilities, and foster accessibility, social integration, and gender equality in the Pacific. Recent Paralympic milestones and policy examples illustrate the ongoing need for supportive infrastructures and greater representation to create equitable opportunities in sports.

The TA is proposed to develop Bhutan's overall power dispatch options and strategies for domestic electricity consumption and international power trade. It will look into strategic views to maximize power export from various potential energy sources of hydropower, solar power, and wind power while meeting growing domestic electricity consumption.

Horses experience hyperflexion, or rollkur, when their necks bend far towards their chests – it could place the animal at a greater risk of physical discomfort and stress

Feedback is intrigued by new research into how major sports tournaments "were associated with increases in the number of babies born" nine months later - but only for supporters of the winning teams

Title: New Policy Supports Choice for Male Circumcision
Category: Health News
Created: 8/27/2012 11:00:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: What Parents Need to Know About Sports Participation
Category: Health News
Created: 8/24/2014 9:35:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM

Title: Excessive Sports Training Hurts Kids, Expert Warns
Category: Health News
Created: 8/21/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: One Activity Causes 4 Out of 5 Sports-Linked Spinal Injuries
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

Title: New Reports on Polio: How Worried Should We Be?
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Title: Get Moving! Any Sports Can Lower Seniors' Odds of Early Death
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

Secretary of State Rex Tillerson speaks at the Center for Strategic and International Studies on Wednesday.

WASHINGTON — Secretary of State Rex Tillerson is condemning reported atrocities committed against Rohingya Muslims in Myanmar, and he says those responsible — perhaps the country’s military — will be held accountable.

Tillerson says accounts of the suffering of the Rohingya are “heartbreaking” — and that if those reports are true, then “someone is going to be held to account for that.”

Tillerson — who’s set to visit South Asia next week — is urging the Myanmar government to improve humanitarian access to the population in western Rakhine state.

Amnesty International has accused Myanmar’s security forces of killing hundreds of men, women and children during a systematic campaign to expel the Rohingya. More than 580,000 refugees have fled to neighboring Bangladesh since late August.

“We really hold the military leadership accountable for what’s happening,” Tillerson said at the Center for Strategic and International Studies, a Washington think tank. “What’s most important to us is that the world can’t just stand idly by and be witness to the atrocities that are being reported in that area.”

He also called Wednesday for the U.S. and India to expand strategic ties. He pointedly criticized China, which he accused of challenging international norms needed for global stability.

He said the world needed the U.S. and India to have a strong partnership. The two nations share goals of security, free navigation, free trade and fighting terrorism in the Indo-Pacific, and serve as “the eastern and western beacons” for an international rules-based order which is increasingly under strain, he said.

Both India and China had benefited from that order, but Tillerson said India had done so while respecting rules and norms, while China had “at times” undermined them. To make his point, he alluded to China’s island building and expansive territorial claims in seas where Beijing has long-running disputes with Southeast Asian neighbors.

“China’s provocative actions in the South China Sea directly challenge the international law and norms that the United States and India both stand for,” Tillerson said in an address at the Center for Strategic and International Studies, a Washington think tank.

He added that the U.S. seeks constructive relations with China but “won’t shrink” from the challenges it poses when it “subverts the sovereignty of neighboring countries, and disadvantages the U.S. and our friends.”

U.S.-India relations have generally prospered in the past decade, in part because of their shared concerns about the rise of China. While President Donald Trump has looked to deepen cooperation with China on addressing the nuclear threat from North Korea, he’s also sought a closer relationship with India, which shares U.S. worries on Islamic extremism.

“In this period of uncertainty and angst, India needs a reliable partner on the world stage. I want to make clear: with our shared values and vision for global stability, peace and prosperity, the United States is that partner,” Tillerson said.

Tillerson said the U.S. wants to help improve India’s military capabilities, and also improve security cooperation among the region’s major democracies, which included Japan and Australia.

Tillerson said the U.S. and India were leading regional efforts on counterterrorism. He called for India’s archrival Pakistan “to take decisive action against terrorist groups based within their own borders that threaten its own people and the broader region.”

The post Tillerson: ‘Heartbreaking’ reports of suffering in Myanmar appeared first on PBS NewsHour.

EA Sports FC 25 has debuted in first place on the Canadian charts for September 2024, according to data from Circana (formerly The NPD Group) reported by the Entertainment Software Association of Canada (ESA).

There were four other new releases in the top 10 with NHL 25 debuting in second place, The Legend of Zelda: Echoes of Wisdom in third place, Astro Bot in fourth place, and NBA 2K25 in 10th place.

Star Wars: Outlaws is in fifth place, Hogwarts Legacy is in sixth place, and Madden NFL 25 is in seventh place. God of War: Ragnarök is in eighth place following the release of the PC version and Elden Ring is in ninth place.

Top 10 best-selling games in Canada:

1. EA Sports FC 25 - NEW
2. NHL 25 - NEW
3. The Legend of Zelda: Echoes of Wisdom* - NEW
4. Astro Bot - NEW
5. Star Wars: Outlaws
6. Hogwarts Legacy
7. Madden NFL 25
8. God of War: Ragnarök
9. Elden Ring
10. NBA 2K25* - NEW

*Digital sales not included

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463027/ea-sports-fc-25-debuts-in-1st-on-the-canadian-charts/

BioWare currently has no plans for Dragon Age: The Veilguard expansions, according to reports. Instead the studio will support the fantasy RPG with smaller updates and otherwise turn their full attention towards Mass Effect 5.

Read more

The finale doesn’t look to provide a definitive answer to what drove Aaron’s actions, much to the show’s credit.

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

Emma Raducanu has been crowned BBC Sports Personality of the Year on another history-defining night for Britain’s teenage phenomenon.

By Tom Garry, in Salford

Mary Earps said she felt “very honoured and humbled” to receive “the ultimate all-round sporting accolade”, after being named as the BBC’s Sports Personality of the year ahead of runner-up Stuart Broad to continue women’s sport’s strong recent run in the event.

The Biden administration will support a United Nations treaty this week that will create a new cybercrime convention, including China and Russia, which has not sat well with some lawmakers and critics.

Xbox hardware sales dropped 29 percent, but that barely made a dent.

Shop stylish diaper bags that busy moms won't mind carrying.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

Diesel equipment will be replaced with hydrogen- or electric-power gear.

When thinking about the classics or games I’d recommend people play on mobile, Mini Metro is one of the best …

Continue reading "Exclusive: Dinosaur Polo Club Interview – CEO Amie Wolken on Mini Metro, Mini Motorways, the Team, Free DLC, Working With Apple, Ports, and More"

Madden NFL has been around for almost 40 years (really) so it’s high time the gaming franchise got the documentary treatment. Prime Video has got you covered. The platform just announced that It’s in the Game: Madden NFL will stream on November 26, which is just ahead of Thanksgiving.

The four-part docuseries will explore “one of the biggest video games of all time” that “became a worldwide phenomenon, spanning generations.” The show will explore Madden’s “archaic 8-bit origins to its success as an annual must have.” Prime Video says EA Sports has given it access to the vaults, so there should be plenty of new footage for diehard fans.

As the story goes, EA founder Trip Hawkins approached commentator John Madden back in 1984 for his endorsement and expertise, but the game took four long years of development before coming out in 1988. This extended development time was allegedly due to Madden himself, who demanded a realistic football experience. I’m sure the documentary will get into all of that.

Formerly known as John Madden Football, the franchise became an annual event in 1990 and changed its name to Madden NFL in 1993. These games have sold over 130 million copies worldwide since 1988. The latest iteration, Madden NFL 25, released back in August to fairly middling reviews.

Le ministre du Travail, Steven MacKinnon, ordonne la reprise des activités dans les ports au pays qui sont à l’arrêt en raison de conflits de travail.

Ottawa aurait laissé trop de liberté aux syndicats, en leur donnant «carte blanche» pour déclencher des grèves dans les ports du pays.

Labour Minister Steven MacKinnon has sent labour disputes at ports in Quebec and British Columbia to binding arbitration and has ordered people back to work after the disputes reached what he called a "total impasse."

A Canada Border Services Agency superintendent is speaking out after being targeted by the Indian government with allegations of murder and terrorism — allegations Canadian authorities say are not backed by any evidence.

The Arctic territory hopes that three new airports will pave the way for direct flights from the US and Europe.