The whitening and loss of brown adipose tissue (BAT) during obesity and aging promote metabolic disorders and related diseases. The imbalance of Ca²⁺ homeostasis accounts for the dysfunction and clearance of mitochondria during BAT whitening. Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear. In this study, we determined that the inhibitory effects of capsaicin on HFD-induced obesity and BAT whitening were dependent on the participation of SIRT3, a critical mitochondrial deacetylase. SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD. Mechanistically, SIRT3 inhibits mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium overload by reducing the H3K27ac level on the MCU promoter in an AMPK-dependent manner. In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin. Capsaicin intervention also inhibited aging-induced BAT whitening through this mechanism. In conclusion, this study emphasizes a critical role of the AMPK/SIRT3 pathway in the maintenance of BAT morphology and function and suggests that intervention in this pathway may be an effective target for preventing obesity- or age-related metabolic diseases.

If you're a patient in the UK, increasingly, your first interaction with the healthcare system won't be the traditional face to fact chat with your doctor - instead you'll have a telephone consultation. The prevalence of these telephone consultations is increasing, and being promoted by CCGs and private companies who administer them - usually as...

Led by vice president of home clubhouse operations Rick Stowe, who began working for the club in 1981 and became head of the clubhouse in 1997, the Reds have a well-oiled machine with regard to packing up and moving out.

The D-backs will work to compete in 2019 while continuing to build up the farm system, which has some pitching at the top end with better position players at the lower levels.

Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although ¹⁸F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with ¹⁸F-FDG can be serially imaged in the early stages of pressure-overload–induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n = 22), sham surgery (n = 12), or coronary ligation as an inflammation-positive control (n = 5). MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC. Immunostaining identified the extent of inflammatory leukocyte infiltration early in pressure overload. ¹⁸F-FDG PET scans were acquired at 3 and 7 d after TAC, under ketamine-xylazine anesthesia to suppress cardiomyocyte glucose uptake. Results: Pressure overload evoked rapid left ventricular dilation compared with sham (end-systolic volume, day 2: 40.6 ± 10.2 μL vs. 23.8 ± 1.7 μL, P < 0.001). Contractile function was similarly impaired (ejection fraction, day 2: 40.9% ± 9.7% vs. 59.2% ± 4.4%, P < 0.001). The severity of contractile impairment was proportional to histology-defined myocardial macrophage density on day 8 (r = –0.669, P = 0.010). PET imaging identified significantly higher left ventricular ¹⁸F-FDG accumulation in TAC mice than in sham mice on day 3 (10.5 ± 4.1 percentage injected dose [%ID]/g vs. 3.8 ± 0.9 %ID/g, P < 0.001) and on day 7 (7.8 ± 3.7 %ID/g vs. 3.0 ± 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression was variable among TAC mice. The ¹⁸F-FDG signal correlated with ejection fraction (r = –0.75, P = 0.01) and ventricular volume (r = 0.75, P < 0.01). Western immunoblotting demonstrated a 60% elevation of myocardial glucose transporter 4 expression in the left ventricle at 8 d after TAC, indicating altered glucose metabolism. Conclusion: TAC induces rapid changes in left ventricular geometry and contractile function, with a parallel modest infiltration of inflammatory macrophages. Metabolic remodeling overshadows inflammatory leukocyte signal using ¹⁸F-FDG PET imaging. More selective inflammatory tracers are requisite to identify the diffuse local inflammation in pressure overload.

Anastassios G. Pittas
Dec 1, 2005; 28:2939-2941
BR Clinical Care/Education/Nutrition

OBJECTIVE

Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study.

SOCIETY FOR JUDGMENT AND DECISION MAKING NEWSLETTER The quarterly Society for Judgment and Decision Making newsletter is available for download from the SJDM site: http://sjdm.org/newsletters/ It features announcements, conferences, jobs, and the 2019 Conference program. See y’all in Montreal (nobody ever says that but the 2019 SJDM meeting will take place in Montreal, November 15-18, […]

The post SJDM Newsletter is ready for download appeared first on Decision Science News.

Once known as “the gold of the Incas,” quinoa has been one of the world’s neglected crops but is currently becoming more and more popular. For centuries, quinoa remained a hidden treasure grown almost exclusively by indigenous communities in the Andean heights. Lately, quinoa has been growing in popularity with foodies and health-conscious consumers around the world. It was even [...]

The London institution's online offerings include 280,000 newly added Creative Commons images

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Latest SOLIDWORKS press releases, news, technical alerts and announcements. These feeds are seen on...

Latest SOLIDWORKS press releases, news, technical alerts and announcements. These feeds are seen on...

Latest SOLIDWORKS press releases, news, technical alerts and announcements. These feeds are seen on...

That killer app only helps you if you can find it on your iPhone when you need it. Productivity expert Jill Duffy tells you how to keep your apps tidy and organized so they're always at your fingertips.

Many parents are having to take on a variety of new roles, from playing IT help desk to becoming makeshift teaching assistants to supervising recess.

The UEFA Regions' Cup final tournament programme is available for download, with detailed information about the eight teams going for gold at the world's top amateur tournament.

Many parents are having to take on a variety of new roles, from playing IT help desk to becoming makeshift teaching assistants to supervising recess.

Computerized provider order entry (CPOE) has been recognized to enhance the efficiency, safety, and quality of medical work. Yet vendors and organizations have not determined best practices for customizations, resulting in systems that have poor usability and unintended consequences of use.

This study demonstrated that systematically developed order sets reduce cognitive workload and order variation in the context of improved system usability and guideline adherence. The concept of cognitive workload reduction is novel in the setting of computer order entry. (Read the full article)

Allostatic load (AL), a biomarker of cardiometabolic risk, predicts the onset of the chronic diseases of aging including cardiac disease, diabetes, hypertension, and stroke. Socioeconomic-related stressors, such as low family income, are associated with AL.

African American youth who grow up in neighborhoods in which poverty levels increase across adolescence evince high AL. The study also highlights the benefits of emotional support in ameliorating this association. (Read the full article)

The official UEFA Futsal EURO 2018 programme, featuring all you need to know about the teams plus interviews with the likes of Wissam Ben Yedder, is out now and available to download for free.

The official programme of the 2018 UEFA Youth League finals weekend is filled with interviews, statistics, team profiles and much more. Get your free copy now.

Get the lowdown on the last four and all you need to know about the event in Zaragoza in the official programme.

The official UEFA Futsal EURO 2018 review contains in-depth tactical analysis, interviews and all the stats from the finals in Slovenia.

Zoom has gained immense popularity in India despite the government warning against it, and advising users to opt for other alternatives. According to app intelligence firm Sensor Tower, India...

Aloo paratha is arguablythe most famous form stuffed paratha, but what if we told you can make your aloo paratha much more wholesome by stuffing a bit of paneer in it.

Police in Sweden are investigating after a pair of thugs opened fire on a McDonald’s restaurant with an AK-47 rifle. The shooting is one of two violent incidents at a McDonald’s outlet in the country in as many days.
Read Full Article at RT.com

High taxes, bad healthcare, police repression, lack of culture, poor education… Telegram founder Pavel Durov wants you to know he really doesn’t like Silicon Valley and thinks living or doing business in the US is a terrible idea.
Read Full Article at RT.com

  Youtube-dl is a fantastic little command line utility that lets you download videos from YouTube and a couple of other video hosting sites. Although the command line interface is off-putting at first,...

CureFit claims that as many as two lakh people are attending its live classes every day on the app.

India’s coronavirus disease contact-tracing app Aarogya Setu became the world’s fastest growing mobile app on Tuesday night with 50 million users in 13 days. It is to be highlighted that 11 million of these downloads were registered in a single day after Prime Minister Narendra Modi urged people to download the application in his third televised […]

The post Aarogya Setu Crosses 5 Crore Downloads In 13 Days; Becomes World’s Fastest Growing App first appeared on Trak.in . Trak.in Mobile Apps: Android | iOS.

Imagine you are on a vacation with your family, and suddenly, your phone starts buzzing. You pick it up and what are you looking at is a bunch of pending, unanswered e-mails. You start recollecting the checklist you had made before taking off only to realize that you haven’t put on the automatic replies! (read more)

I am working on some SKILL scripts which are loaded by allegro.ilinit at startup.

If I edit my .il-files how do I get them updated in Allegro?

Right now I restart the program but there must be a simpler way.

A newbie question, I know...  

Specman *search* command allows searching in all loaded modules, but only for a string.

Is there a way to search for a regexp or glob?

Alternatively, is there a way to simply get a list of all loaded files somehow? Then I could use either the "shell" command, or real shell together with grep.

Thanks

Please include a brief summary of how to use it.

Hi all 

Good day.

Can anyone tell me whether it is possible to view the signals once it is modified from its previous values without closing the simvision window. If possible kindly let me know the command for it(Linux).

 Is it possible to view the schematic for the code written?? Kindly instruct me.

 Thanks all.

S K S 

Qualys discovered a local privilege escalation in OpenBSD's dynamic loader (ld.so). This vulnerability is exploitable in the default installation (via the set-user-ID executable chpass or passwd) and yields full root privileges. They developed a simple proof of concept and successfully tested it against OpenBSD 6.6 (the current release), 6.5, 6.2, and 6.1, on both amd64 and i386; other releases and architectures are probably also exploitable.

This Metasploit module exploits a vulnerability in the OpenBSD ld.so dynamic loader (CVE-2019-19726). The _dl_getenv() function fails to reset the LD_LIBRARY_PATH environment variable when set with approximately ARG_MAX colons. This can be abused to load libutil.so from an untrusted path, using LD_LIBRARY_PATH in combination with the chpass set-uid executable, resulting in privileged code execution. This module has been tested successfully on OpenBSD 6.1 (amd64) and OpenBSD 6.6 (amd64).

FCKEditor version 2.6.8 ASP version suffers from a file upload protection bypass.

This Metasploit module exploits an arbitrary file upload vulnerability found in Kaseya versions below 6.3.0.2. A malicious user can upload an ASP file to an arbitrary directory without previous authentication, leading to arbitrary code execution with IUSR privileges.