The Blyth Festival will not be staging any plays this year.

Provincial police have located human remains in their search for a missing Meaford man, and one person has been taken into custody.

How much is likely to change in the Premier League table if the season is played to its conclusion? BBC Sport looks at the past 10 years for some hints.

A newly opened Delaware seafood restaurant has a unique item on its menu: robot servers. The machines are the latest example of intelligent machines working in the restaurant industry.

A team of researchers at the University of California at San Diego have created a soft robotic lens that responds to eye movements.

Japanese researchers at Keio University have unveiled a robotic tail that has been designed to be worn by elderly people who struggle to maintain their balance.

During the first five weeks of the season, NFL coaches, as a group, have made the choice to go for two points 47 times this year, 19 more than they did at this point of the season in 2017.

The Seahawks are barely over .500, but they measure up in a critical statistic that has helped narrow the field of likely Super Bowl teams.

Butler hasn't had much practice time with the 76ers, but he's already acclimating to their preferred way of playing and closing out wins.

The two teams in control of the NFC's wild-card slots battle head-to-head, while the rest of the NFL playoff picture got much clearer despite four of the AFC’s top teams losing.

The "Alias" actor was diagnosed with the disease as a child.

The former first daughter and her spouse welcomed a son on Monday.

Tom Bergeron tweeted that he thought the producers had agreed the show should be “free of inevitably divisive bookings from ANY party affiliations.”

The days of your family member sending you money in an envelope from overseas are decreasing due to the risk of this money getting lost in transit or removed from your letterbox before you’ve arrived home. While many merchants and everyday people are sending money to family and friends abroad using PayPal, TransferWise is, in […]

The post How to Send Money Overseas with TransferWise appeared first on Tips and Tricks HQ.

Discover the 7 essential things you need to know about Seabourn Cruises Entire cruise ship. Things you really need to know if you are interested in cruising on this luxury cruise ship. I tour all aspects of the ship and share my views on what os good and works less well. I explore many aspects of the ship including dining options, bars and lounges, fitness, entertainment, facilities and experience. Seabourn Cruises is one of the ultra-luxury cruise lines and Seabourn Encore was the first of a new class of ships for the cruise line. The sister ship is called Seabourn Ovation, and os basically the same ship.

Note: I travelled as a guest of the Seabourn Cruises before making this video. They had no input on the opinions or content of this video.

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

Follow Tips For Travellers on:
- Instagram: http://www.instagram.com/garybembridge
- Facebook: http://www.facebook.com/tipsfortravellers
- Twitter: http://www.twitter.com/garybembridge

#SeabournCruises #SeabournEncore #CruiseShipTour

What are the 4 Things You Really Need To Know Before Cruising with Seabourn Cruises? I explore the ultra-luxury Seabourn Cruise Line and discuss for essential things about them to help you decide if this is the best, or right, cruise line for your cruising vacation, including what Seabourn is, what they do better and the same as other ultra-luxury cruise lines, what your fare really gets (and does not get you) and who the line is best for.

Note: I travelled as a guest of the cruise line before making this video

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

Follow Tips For Travellers on:
- Instagram: http://www.instagram.com/garybembridge
- Facebook: http://www.facebook.com/tipsfortravellers
- Twitter: http://www.twitter.com/garybembridge

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There are several things which go into successful video marketing on YouTube. One of these things is the very often neglected YouTube SEO that’s so vital for getting viewers to actually find your video. Too many YouTube marketers are concerned with what’s going on in their videos to really push for better SEO, and it […]

The post How Web Media Developer can use YouTube SEO with Better Search Marketing to Rank Their Videos appeared first on SpyreStudios.

Keyword research is the backbone of your online presence. It’s common knowledge that this practice determines your rankings and visibility in the organic search. However, the way keyword research is done has changed over time. Today, using Google’s Keyword Planner to find phrases with a high search volume and optimizing your site for them is not […]

The post How to do Keyword Research for SEO appeared first on ReadWrite.

Local news publishers have struggled to monetize spike in consumer interest.

Please visit Search Engine Land for the full article.

The Rich Results Test tool now also supports SpecialAnnouncement markup.

Please visit Search Engine Land for the full article.

‘The idea that what’s happening with searcher behavior is not causing these shifts means that Google is in there writing that code for every intent, every day, and I can’t believe that’s what’s happening,’ said Dr. Pete Meyers on Live with Search Engine Land.

Please visit Search Engine Land for the full article.

If you are having indexing issues with your HTML or JavaScript-based website then you won’t want to miss this chat.

Please visit Search Engine Land for the full article.

Even the biggest sites on the internet can have problems with their SEO and Google.

Please visit Search Engine Land for the full article.

The suggestions surface for multiple intents for logged-in users.

Please visit Search Engine Land for the full article.

This is the first time Google says it has provided this kind of data to the public.

Please visit Search Engine Land for the full article.

This update was an “absolute monster” said Mordy Oberstein from RankRanger.

Please visit Search Engine Land for the full article.

Here is the latest news from around the world.

Seattle, Washington

Theme Cruise to Panama (Shakespeare at Sea / MacMania)

Hear about travel to Seattle, Washington as the Amateur Traveler talks to Mary Jo Manzanares from travelingwithmj.com about her hometown.

Hear about travel to the "Sea Islands" off the coats of Georgia and South Carolina as the Amateur Traveler talks to Ruby & Peter from ajourneywelove.com about their travels in this archipelago.

Hear about travel to Baja Sur in Mexico as the Amateur Traveler talks to   author and travel writer Stuart Gustafson about his love affair with the southern tip of the Baja Peninsula. 

As the coronavirus crisis built to pandemic levels in early March, a relatively unknown tech company confronted a defining opportunity. Zoom Video Communications, a fast-growing enterprise videoconferencing platform with roots in both Silicon Valley and China, had already seen its market cap grow from under $10 billion to nearly double that. As the coronavirus began … Continue reading "New Research Shows Why and How Zoom Could Become an Advertising Driven Business"

"They sing the song," writes Real Big Boys. "Thanks to the Melni Pinniped Choir for barking."

Previously. Read the rest

The Delivery Man Synopsis The Delivery Man is a comedy television series produced by ITV that premiered in April of 2015. The Delivery Man follows the story of Matthew (played by Darren Boyd – Spy), a police officer who decides to switch careers in his mid-thirties and becomes a midwife. The Delivery Man is currently […]

Other Space Synopsis Other Space is a Science Fiction comedy television series produced by Yahoo that premiered in April of 2015. Created by Paul Feig (Freaks and Geeks) Other Space is set in the early 22nd century and follows the story of the inexperienced crew aboard UMP Cruiser on a routine space exploratory mission. In […]

Peter Kay’s Car Share Synopsis Peter Kay’s Car Share is a situation comedy television series produced by BBC One that premiered in April of 2015. Peter Kay’s Car Share follows the story of John (played by Peter Kay), an assistant manager in a supermarket and his co-worker and promotions rep Kayleigh (played by Sian Gibson). […]

Meet the Smiths Synopsis Meet the Smiths is a scripted reality television series produced by TBS that premiered in April of 2015. Meet the Smiths follows the daily lives of Kenny Smith, an NBA analyst for TNT and his wife Gwendolyn Osborne-Smith, a model for The Price is Right. The couple has five children together […]

Arranged Synopsis Arranged is a reality television series produced by the FYI Network that premiered in April of 2015. Arranged follows the story of the three American couples who all come from different backgrounds, but their cultural traditions allow for arranged marriages. The series chronicles their lives in the lead up to the wedding and […]

Wayward Pines Synopsis Wayward Pines is a mystery thriller television series produced by Fox Network and set to premiere in May of 2015. Based on the book Pines written by Blake Crouch and produced by M. Night Shyamalan Wayward Pines follows the story of an FBI agent Ethan Bruke (played by Matt Dillon), who travels […]

Miles from Tomorrowland Synopsis Miles from Tomorrowland is an animated television series produced by the Disney Channel that premiered in February of 2015. Miles from Tomorrowland is an American animated TV series about the adventures of an inquisitive, if somewhat reckless boy named Miles who travels the universe with his family. Miles from Tomorrowland is […]

The Protectors (1972) Synopsis The Protectors (1972) was an action thriller television series produced by ITV that premiered in September of 1972. The Protectors (1972) was a British action thriller series created by Gerry Anderson (Thunderbirds) about an international group of rich troubleshooters. Contessa di Contini (played by Nyree Dawn Porter), Paul Buchet (played by […]

Wormwood Synopsis Wormwood was a children’s television series produced by Network Ten and ABC1 that premiered in October of 2007. Made as a joint Canadian-Australian production, Wormwood was a TV series about a quirky town where a group of kids investigated strange events. The series was based on the stories written by Paul Jennings. Wormwood […]

A Sharp Intake Of Breath Synopsis A Sharp Intake Of Breath was a situation comedy television series produced by ITV that premiered in February of 1978. Created by Ronnie Taylor A Sharp Intake Of Breath followed the story of Peter Barnes (played by David Jason – Only Fools And Horses), an ordinary man who made […]

Basecamp’s newest product HEY has lived on Kubernetes since development first began. While our applications are majestic monoliths, a product like HEY has numerous supporting services that run along-side the main app like our mail pipeline (Postfix and friends), Resque (and Resque Scheduler), and nginx, making Kubernetes a great orchestration option for us. As you… keep reading

An eight-year-old boy with good intentions sparked a missing person search on Tuesday.

Grey Bruce provincial police say the OPP canine unit found human remains in Meaford, and one person is under arrest.

The following article, Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself, was first published on 100PercentFedUp.com.

A 37-year-old China native and "outstanding researcher" at the University of Pittsburgh...

Continue reading: Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself ...

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.