Bayberry candle-making, grave sites of notable New Castle veterans and early recordings of classical music among topics to be explored.

Vintage 1950s-era New Castle ice cream stand still dishing up soft serve.

Events to take place at sites across Delaware.

Highlights include a program on William Penn’s role in the founding of Dover, activities celebrating Martin Luther King Jr. Day and a concert by CoroAllegro.

Museums closed on Christmas Eve, Christmas Day and New Year’s Day.

Program explores beaches and resorts that African Americans could visit without fear of discrimination or violence during the segregation era.

Eight of the programs celebrate African American History Month.

Delaware’s farming future and long agricultural heritage were both recognized today in a ceremony honoring the newest participants in the state’s Young Farmers Program and the latest inductees into the Century Farm Program, with the announcement that 10 young farmers would be receiving no-interest loans from the First State’s new innovative assistance program, now in its second year.

A partnership with the Delaware State Police and the Fish & Wildlife Natural Resources Police is helping the Delaware Forest Service reopen its historic picnic pavilion at Redden State Forest that was closed in early 2017 due to persistent illegal activity. The parking lot and rest area – popular with hikers and horseback riders – now features bright lighting, 24-hour video surveillance, and regular patrols by both marked and undercover law enforcement personnel. Along with these enhanced security measures, new signage reminds visitors that the site is closed from dusk to dawn.

The Florence and Isaac Budovitch House, and the Newark Union Church and Cemetery, are both located in New Castle County north of Wilmington.

The post Two additional Delaware properties listed in the National Register of Historic Places appeared first on Division of Historical and Cultural Affairs - State of Delaware.

On Saturday, September 14, at 10:30 a.m. the Delaware Public Archives will celebrate the cinematic history of Delaware's movie theaters with a special program presented by author Michael Nazarewycz.

The post Historic Movie Theaters of Delaware appeared first on Delaware Public Archives - State of Delaware.

Even while the government and Reserve Bank of India (RBI) have provided some stimulus, further support may be required to help real estate and for the economy to stay afloat during the crisis.

The national average price of wind power purchase agreements dropped to below 2 cents/kWh in 2018, according to the annual Wind Technologies Market Report released by the U.S. Department of Energy.

Exxon Mobil Corp. will use renewable energy to produce oil in West Texas.

The 130-MW Les Cedres generating station in Canada is a landmark in the history of Quebec hydropower. Hydro-Quebec recently celebrated the station's 100th year of operation, as well as its induction into the Hydro Hall of Fame.

The national average price of wind power purchase agreements dropped to below 2 cents/kWh in 2018, according to the annual Wind Technologies Market Report released by the U.S. Department of Energy.

HONG KONG - Holdout anti-government protesters remained in control of a major arterial road in Hong Kong on Monday a day after organisers said two million people flooded the streets in a historic rebuke of the city's pro-Beijing leader.

An ancient marine reptile that swam the oceans nearly 250 million years ago had unusual pebble-like teeth which it used to crush hard-shelled prey, scientists believe. The creature, named Cartorhynchus lenticarpus, belongs to an extinct group of reptiles known as ichthyosaurs. Not much is known about the ancestry...

The mayor of the western Turkish town of İznik, which is a key venue in the history of Christianity, has launched a campaign against those who paint the historic city walls with graffiti despite repeated warnings. Click through for the story in photos...

The Labor Department's monthly employment report also showed the unemployment rate surging to 14.7% last month, shattering the post-World War II record of 10.8% touched in November 1982.

With shops and factories closed nationwide due to the coronavirus pandemic, nearly all of the jobs created in the US economy in the last decade were wiped out in a single month.An unprecedented 20.5 million jobs were destroyed in April in the world’s largest economy, driving the unemployment rate to 14.7 per cent compared to 4.4 per cent in March, the Labour Department said in its monthly report, the first to capture the impact of a full month of the lockdowns.The US is home to the world’s…

In the United States, 20.5 million jobs were wiped out in April -- the most ever reported .

A former Pakistani child bride, who was wrongly accused of killing her husband at 13 and subsequently spent almost two decades in prison, is making history by being the first victim of a miscarriage of justice to seek compensation from the state, say legal human rights experts.   This March, Rani Tanveer, who was released in […]

The post Former Child Bride Holds Pakistan to Account for Wrongful Imprisonment in Historic Legal Challenge appeared first on Inter Press Service.

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The United States recorded Friday its steepest job losses in history over the coronavirus pandemic as Europe moved to keep its borders shut for another month.

The coronavirus lockdown wiped out 20.5 million US jobs in April, destroying nearly all the positions created in the previous decade in the world's largest economy, the country's labour department reported on Friday.

The unprecedented collapse drove the unemployment rate to 14.7 per cent — well beyond the peak hit in late 2009 during the global financial crisis — from 4.4pc in March.

And job losses in March were worse than initially reported, falling 870,000 even though the business closures mostly happened in the second half of the month.

The plunge in non-farm payroll employment was the largest ever recorded since 1939, while the jobless rate was the highest and the biggest increase since 1948, the report said.

Employment fell sharply in all major industry sectors, with particularly heavy job losses in leisure and hospitality, the first sector hit and the one bearing the brunt of the impact of the lockdowns.

However, the labour department noted that the some workers were misclassified in the report as employed when they should have been counted as laid off.

Had they been listed properly, the unemployment rate would have been nearly five percentage points higher.

Meanwhile, US President Donald Trump downplayed unprecedented US job losses, saying they were not a surprise.

“It's fully expected, there's no surprise. Somebody said, 'oh look at this,'” he said on Fox News minutes after the labour department published the figures.

“I'll bring it back,” he said.

Stocks on Wall Street jumped Friday despite historic job losses suffered by the economy. Fred Katayama reports.

Stocks on Wall Street jumped Friday despite historic job losses suffered by the economy. Fred Katayama reports.

ABSTRACT

The Candida albicans high-affinity phosphate transporter Pho84 is required for normal Target of Rapamycin (TOR) signaling, oxidative stress resistance, and virulence of this fungal pathogen. It also contributes to C. albicans’ tolerance of two antifungal drug classes, polyenes and echinocandins. Echinocandins inhibit biosynthesis of a major cell wall component, beta-1,3-glucan. Cells lacking Pho84 were hypersensitive to other forms of cell wall stress beyond echinocandin exposure, while their cell wall integrity signaling response was weak. Metabolomics experiments showed that levels of phosphoric intermediates, including nucleotides like ATP and nucleotide sugars, were low in pho84 mutant compared to wild-type cells recovering from phosphate starvation. Nonphosphoric precursors like nucleobases and nucleosides were elevated. Outer cell wall phosphomannan biosynthesis requires a nucleotide sugar, GDP-mannose. The nucleotide sugar UDP-glucose is the substrate of enzymes that synthesize two major structural cell wall polysaccharides, beta-1,3- and beta-1,6-glucan. Another nucleotide sugar, UDP-N-acetylglucosamine, is the substrate of chitin synthases which produce a stabilizing component of the intercellular septum and of lateral cell walls. Lack of Pho84 activity, and phosphate starvation, potentiated pharmacological or genetic perturbation of these enzymes. We posit that low substrate concentrations of beta-d-glucan- and chitin synthases, together with pharmacologic inhibition of their activity, diminish enzymatic reaction rates as well as the yield of their cell wall-stabilizing products. Phosphate import is not conserved between fungal and human cells, and humans do not synthesize beta-d-glucans or chitin. Hence, inhibiting these processes simultaneously could yield potent antifungal effects with low toxicity to humans.

IMPORTANCE Candida species cause hundreds of thousands of invasive infections with high mortality each year. Developing novel antifungal agents is challenging due to the many similarities between fungal and human cells. Maintaining phosphate balance is essential for all organisms but is achieved completely differently by fungi and humans. A protein that imports phosphate into fungal cells, Pho84, is not present in humans and is required for normal cell wall stress resistance and cell wall integrity signaling in C. albicans. Nucleotide sugars, which are phosphate-containing building block molecules for construction of the cell wall, are diminished in cells lacking Pho84. Cell wall-constructing enzymes may be slowed by lack of these building blocks, in addition to being inhibited by drugs. Combined targeting of Pho84 and cell wall-constructing enzymes may provide a strategy for antifungal therapy by which two sequential steps of cell wall maintenance are blocked for greater potency.

Current health inequities are rooted in more than simple systems failures and inefficiencies. Historical legacy has corrupted health outcomes, and resolution requires both acknowledgment and intention.

Studies of the former NE England coalfield in Tyneside demonstrated that heat flow perturbations in boreholes were due to the entrainment and lateral dispersion of heat from deeper in the subsurface through flooded mine workings. This work assesses the influence of historical mining on geothermal observations across Greater Glasgow. The regional heat flow for Glasgow is 60 mW m^–2 and, after correction for palaeoclimate, is estimated as c. 80 mW m^–2. An example of reduced heat flow above mine workings is observed at Hallside (c. 10 km SE of Glasgow), where the heat flow through a 352 m deep borehole is c. 14 mW m^–2. Similarly, the heat flow across the 199 m deep GGC01 borehole in the Glasgow Geothermal Energy Research Field Site is c. 44 mW m^–2. The differences between these values and the expected regional heat flow suggest a significant component of horizontal heat flow into surrounding flooded mine workings. This deduction also influences the quantification of deeper geothermal resources, as extrapolation of the temperature gradient above mine workings would underestimate the temperature at depth. Future projects should consider the influence of historical mining on heat flow when temperature datasets such as these are used in the design of geothermal developments.

Supplementary material: Background information on the chronology of historical mining at each borehole location and a summary of groundwater flow in mine workings beneath Glasgow are available at https://doi.org/10.6084/m9.figshare.c.4681100

Thematic collection: This article is part of the ‘Early Career Research’ available at: https://www.lyellcollection.org/cc/SJG-early-career-research

The development of pastoralism transformed human diets and societies in grasslands worldwide. The long-term success of cattle herding in Africa has been sustained by dynamic food systems, consumption of a broad range of primary and secondary livestock products, and the evolution of lactase persistence (LP), which allows digestion of lactose...

Cowen et al. (1) leverage modern gains in data science to describe impressive cross-cultural similarities in the perception of musical affect and do so in unprecedented detail. Their approach is innovative and fundamentally empirical. As such, it should have important applications for prediction in the field of affective computing, which...

As anticipated due to the COVID-19 pandemic, Windsor’s unemployment rate closed in on historic levels in April as it reached 12.9 per cent of the labour force, according to the latest numbers released Friday by Statistics Canada. There were 21,800 people in the Windsor area recorded as being unemployed in the latest StatsCan survey. But […]

In the memoir Uncanny Valley, Anna Wiener examines the collective hyperconfidence that has enabled the tech sector’s meteoric growth

Roy “Captain Roy D” Davis has devoted much of the last three years to the QAnon conspiracy theory, writing books pitching the concept to new fans and getting his car repainted with an enormous “Q” on the hood. Through it all, he’s been utterly convinced that former Trump national security adviser Michael Flynn—a central figure to much of the Q community—was the victim of an anti-Trump cabal orchestrated by the leaders of the deep state. He corresponded with other Flynn supporters following his legal case, and donated proceeds from one of his books to Flynn’s legal fund. 

So when Davis saw on Thursday that the Justice Department would drop its charges against Flynn for lying to the FBI, Davis was euphoric.

“He’s a hero of mine,” Davis said. “I wouldn’t do all of these things just out of the blue.”

Read more at The Daily Beast.

The Oscar-winning sword-and-sandals Russell Crowe vehicle refreshed old cliches, before ushering in a spate of copycats

“Joey, do you like movies about gladiators?” the creepy pilot asks the small boy in Airplane!. To younger audiences, the joke no longer makes any sense. In Airplane!’s day, sword-and-sandals movies had become an outdated, unwittingly homoerotic joke. But then came Gladiator, and the joke was on us. Released 20 years ago this month, Ridley Scott’s Roman epic gave the old cliches a new lease of life. It was all here: Colosseum action! Rippling man-flesh! Tigers! But Gladiator had its cheesecake and ate it. It served up crowd-pleasing spectacle and airline-ad visuals but also solemn, Oscar-worthy drama (and, in retrospect, a fair degree of camp).

Related: The Guide: Staying In – sign up for our home entertainment tips

More than 20 million Americans lost their jobs in the last month, and unemployment among African-Americans has hit 16.7 percent.

NASA announced last week that they will be embarking on...

The post NASA Asks People To Watch The Historic SpaceX Launch From Home appeared first on Man's World India.

A new study of ancient climate has a dire warning about today's dry conditions

Major U.S. stock indexes jumped on Friday and logged solid gains for the week after data on historic job losses due to the coronavirus crisis showed they were slightly fewer than feared.

Follow our live updates HERE Coronavirus: The symptoms

A family firm that runs one of the historic Dunkirk Little Ships as a Thames passenger service is appealing for help to survive the lockdown.

Europeans will see the worst economic shock since the Great Depression due to coronavirus, the European Union predicted.