On October 20th, ICANN and Verisign renewed the agreement under which Verisign will continue to act as Root Zone Maintainer for the Domain Name System (DNS) for another 8-year term. The Root Zone sits atop the hierarchical architecture of the DNS and is essential to virtually all internet navigation, acting as the dynamic, cryptographically secure, […]

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Today, the latest issue of The Domain Name Industry Brief Quarterly Report was released by DNIB.com, showing the third quarter of 2024 closed with 362.3 million domain name registrations across all top-level domains (TLDs), a decrease of 0.1 million domain name registrations, or less than 0.05%, compared to the second quarter of 2024. Domain name […]

The post Domain Name Industry Brief Quarterly Report: DNIB.com Announces 362.3 Million Domain Name Registrations in the Third Quarter of 2024 appeared first on Verisign Blog.

The Group Managing Director of Nedcomoaks Group, Dr Ned Okonkwo, has stated that the adoption of electric vehicles will help reduce maintenance by almost 70 per cent. He stated this on Tuesday at the agreement signing ceremony for 2,000 EVs by CIG Motors, Nedcomoaks and Fidelity Bank in Lagos. He noted that the partnership was

TOKYO — Japanese Prime Minister Shigeru Ishiba, battered in parliamentary elections last month, has survived a rare runoff vote against the opposition to remain the country's leader but he still faces turmoil ahead. One of his top priorities is dealing with the aftermath of a major corruption scandal in the long-ruling Liberal Democratic Party, in which dozens of lawmakers from the party are alleged to have pocketed profits from event ticket sales as kickbacks. Ishiba also now has a much-emboldened, opposition eager to push through policies long stymied by the LDP. Support ratings for his Cabinet have fallen to about 30%. Here is a look at what's happening in Japan's tumultuous politics, and what it might mean for Ishiba and his government as they prepare to navigate a second term of U.S. President-elect Donald Trump. Why did the vote in parliament take place? A parliamentary vote for a new leader is mandatory within 30 days of a general election. In the past that was mostly ignored as the head of the LDP usually enjoyed a majority in the Lower House, the more powerful of Japan’s two-chamber parliament. This time, though, because Ishiba's LDP and its junior coalition partner lost its majority in the recent election, the runoff on Monday couldn't be avoided — the first in 30 years. What's next for the prime minister? Opposition's top leader, Yoshihiko Noda, has noted that nearly half of all lower house steering committees are now headed by the opposition. That’s a huge change from the pre-election domination of the LDP, which controlled all but three of the 27 committees. “We are going to have a new landscape in Japanese politics,” Noda said. Twelve of the committees in key areas, including budget, political reforms, national security and legal affairs, will be headed by Noda’s Constitutional Democratic Party of Japan and two other main opposition groups. What's certain is that the era of LDP’s one-sided rule is over, for now, and the opposition has a chance to achieve policies long opposed by the ruling conservatives, including on issues like gender equality and diversity. Noda last Friday said a legal committee that is now headed by his party’s gender equality chief, Chinami Nishimura, is aiming to achieve a civil code revision to allow married couples the option of keeping separate surnames. That change has been stalled by LDP conservatives for 30 years despite widespread support by the public and a United Nations panel on discrimination against women. Who is the opposition kingmaker? Yuichiro Tamaki is head of the conservative Democratic Party for the People, which quadrupled its seats to 28 in the election. The vote elevated his party from a fringe group to a major player. He is now being cast as a potential key to Ishiba’s survival. A Harvard-educated former Finance Ministry bureaucrat, the 55-year-old Tamaki has seen success by pushing for the raising of a basic tax-free income allowance and an increase of take-home wages. His messages on social media have appealed to younger voters, who have long been ignored by LDP policies catering to conservative elderly. Ishiba apparently seems to find Tamaki’s 28-member DPP an attractive partner to secure a majority. The two parties, which have common ground in some areas — including support for greater nuclear energy use and a stronger military — have started policy talks. Ishiba met with both Tamaki and Noda on Monday but Tamaki may be cautious about moving too close to a scandal-plagued LDP ahead of another election next year. Noda is struggling to form a unified opposition to force a change of government, which he says is his next goal. What does this mean for Ishiba's government? For Ishiba, the “hung parliament” requires him to win over opposition forces so he can push his policies. While considered unstable, it might also provide a chance for a more consensus-based policy making process, experts say. “I’m taking the current situation positively as a chance to get our opposition voice heard more carefully,” Tamaki said. Ishiba also faces challenges of restoring unity in his own party. A number of senior LDP lawmakers are waiting to overthrow Ishiba, though their priority is to resolidify their footholds, not infighting — and nobody is eager to do damage control at this difficult time anyway. “The [Ishiba] administration is quite unstable. ... He will have to get opposition parties' cooperation every time he wants to get a bill approved, which could stall policies,” said University of Tokyo political science professor Yu Uchiyama. And even if Ishiba survives politically in the coming months, there could be a call for his replacement ahead of next elections. “Japan is likely to return to a period of short-lived government,” Uchiyama said. How does this affect Japan's diplomacy, security and ties with Trump? Ishiba congratulated Trump hours after his victory and in a brief telephone conversation, they agreed to closely work together to further elevate their alliance. While experts say Trump understands the importance of U.S.-Japan relations, he may — as he did in his first administration — pressure Japan to pay more for the cost of 50,000 U.S. troops in Japan or to buy more expensive American weapons. Trump's possible tariff proposals could also hurt Japanese exporters. Ishiba on Saturday renewed his pledge to pursue an ongoing military buildup plan under a strategy that calls for a counter-strike capability with long-range cruise-missiles. He has long advocated a more equal Japan-U.S. security alliance but could face difficulty pursuing those plans. ‘’It will be a fantastic experiment to see if a national unity government can get Japan through until the next election,” said Michael Cucek, an expert in Japanese politics at Temple University in Japan.  

[Capital FM] Nairobi -- The Politics surrounding the control of the Sh10.5 billion Road Maintenance Levy Fund between MPs and Governors has continued to stall talks to iron out the stalemate over the equitable revenue share to the devolved units.

The United Nations continues to be virtually paralyzed – and remains politically impotent amidst two raging conflicts—as Russia and Israel keep defying the world body. The killings of civilians and the destruction of cities, particularly by Israel, are devastating and continue despite repeated warnings from the UN, its humanitarian agencies, the International Criminal Court (ICC), […]

IDF intelligence had been tracking these underground facilities for years, and over recent weeks, the air force focused on destroying them.

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A Neanderthal skeleton was discovered encased in rock in an Italian cave 30 years ago, but it hasn’t been studied much due to a long-running impasse about how to safely excavate it

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The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

Single maintenance and reliever therapy (SMART) is an asthma treatment approach that utilizes combined inhaled corticosteroids and long-acting β-agonists for maintenance and quick relief therapy. Despite the evidence for its benefits in asthma treatment and its adoption into American and international asthma guidelines and recommendations, SMART remains a practice of some debate. This article reviews the available evidence for SMART and offers guidance for its integration into comprehensive asthma management. Overall, short-acting β-agonist-only asthma therapy regimens should be avoided, regardless of condition severity (SOR A Recommendation). Family medicine clinicians should start SMART for patients requiring either GINA Step 3 or 4 therapy, especially if they have signs of poor adherence (SOR B Recommendation). Finally, use budesonide-formoterol over other inhaled corticosteroid/long-acting β-agonist combinations when implementing SMART (SOR B Recommendation).

Donald Trump pulled out of another mainstream interview Thursday–this time nixing a sit-down with NBC News.

The interview, CNN reported, would be in Philadelphia with NBC News' senior business correspondent, Christine Romans. CNN’s Brian Stelter said one source suggested that it had only been “postponed.”

It was the second time in a week that he had canceled a scheduled appearance outside the conservative news sphere, CNN’s Reliable Sources reported Thursday. He had canceled an in-studio appearance on the CNBC flagship show, Squawk Box, which was due on Friday.

Read more at The Daily Beast.

Trump would face little to no resistance in confirming his picks for Supreme Court justices in the majority-GOP Congress, but Alito has no plans to step down.

Other Windows Insider updates include new CPU instructions for Prism x86 emulator.

As a truck owner who’s watching every penny, you know how quickly maintenance expenses can get out of hand. There’s always another issue, another part to replace, another tool you didn’t know you needed. But there’s good news – plenty of ways exist to keep those trucks running smoothly without draining your wallet. With a […]

The post Maintenance Tips for Budget-Conscious Truck Owners ─ Keeping Costs Down appeared first on Chart Attack.

Imagine walking into your yard with a coffee in one hand, no lawn mower in sight, and the kind of lush greenery that looks effortlessly perfect. No frantic trimming or sweating under the summer sun. Sounds too good to be true? It’s possible when you pick the right low-maintenance grass. Let’s walk through some game-changing […]

The post Looking for Low-Maintenance Grasses? Discover the Best Choices for Busy Gardeners appeared first on Chart Attack.

Speculator swapped pricey domain for OpenAI shares instead of taking cash payment.

Combining DNA analysis, archeological techniques, and historical records overturns some assumptions of the people of Pompeii.

We all need to be fully aware who has access to our health data, when they can access it, what it’s being used for and the potential implications.

The post My Health Record: Remain in or opt out? appeared first on Star Observer.

It is often said that medicine is both an art and a science. In an imperfect world this is both inevitable and desirable. But it is extremely important that the two should not be confused with each other. In particular, because the “science” side of the equation has achieved overwhelming prestige and authority, it is...

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May 6, 2024

Joseph S. Nye advocates for identifying areas for cooperation between the United States and China such as climate change and public health.

State Farm: Spring Home Maintenance Tips

Be Prepared! Protect your home from sudden heating repairs with a home warranty from AHS this winter. Home warranties help homeowners control repair or replacement costs during a break down.

An aerial view of your mowing path helps you remember to switch up your pattern for optimum turf health.

Learn more about the 2016 PetSafe� Bark for Your Park� grant-giving program in this video.

The Hon'ble Madras High Court in the case of M/s S.R.S. Construction v. The State Tax Officer (Data Analytics) [Writ Petition (MD) Nos. 16214 & 16276 of 2024 dated July 19, 2024] set aside the orders which have been signed by the same officer in dual capacity, holding that such orders are liable to

China's Ministry of Finance and the State Administration of Taxation have issued a statement announcing tax relief from the Urban Maintenance and Construction Tax.