The 25th April 2012 marked the implementation of the first  phase of amendments to the Licensing Act 2003 (‘the Licensing Act’) ...

2020 looks set to be a significant year for privacy, cyber security and Internet content reforms in China and Hong Kong. On 20 December 2019, the Cyberspace Administration of China released the “Regulation on Governance of Internet Information...

On 4 February 2015, the government launched a consultation on draft regulations implementing the cap on care costs contained in the Care Act 2014. The consultation also sought views on the need for new appeals system in relation to local authorities...

On 17 September 2015, the House of Lords EU Internal Market Sub-Committee (“the Committee”) launched an inquiry into the regulation of online platforms in the EU. The Committee intends to gather evidence on the benefits and problems online platforms...

Selective Distribution – Some recent developments in the adidas case: when can sales via online platforms be restricted? On 18 November 2015, the Autorité de la concurrence (the “French Competition Authority” or “...

How does the communication within a team take place in the home office? Due to the increasing intensity of preventive measures against the spread of corona, more and more companies are closing down their locations and, where possible, relocating bus...

The text version of this document in not available. You can...

The text version of this document in not available. You can...

Russia's Red Army Choir shot a video at home playing notes from the Ottoman military band Mehter in support of Turkey's fight with the novel coronavirus.

In its response to COVID-19, the UK Government has also been listening to business and seeking to provide further support mechanisms to help those businesses that have been forced to close in the short term. This has included the prohibition on land...

The Covid-19 crisis has exposed weaknesses in Chinese health care system despite some impressive reforms over the past two decades, witnesses told an advisory arm of the US Congress on Thursday.China has strengthened its Centre for Disease Control and Prevention (CDC) to improve the monitoring of outbreaks and better coordinate local public health authorities, US experts on international health care told the United States-China Economic and Security Review Commission.This happened after the…

The graduation approach provides a sequenced intervention designed to overcome multiple barriers that prevent the extreme poor from breaking out of poverty.

ISLAMABAD: Chief Justice of the Islamabad High Court (IHC) Justice Athar Minallah on Friday converted the matter relating to delay in administration of justice into public interest litigation and sought reports from the interior secretary, the chief commissioner of Islamabad and judges of trial courts working within the IHC’s jurisdiction.

Chief Justice Minallah asked the police, district administration and federal government to explain why police reforms could not be enforced in the federal capital even though the law had been promulgated some 18 years ago.

The court framed six questions to be answered by these authorities, including why Police Order 2002 could not be implemented in Islamabad; why proper investigation training was not imparted to investigation officers; whether the code of criminal procedure 1898 and Qanoon-i-Shahadat [Evidence Act] of 1984 were still applicable; whether the state was responsible for delay in administration of justice and whether victims of delayed justice could seek remedy from any forum.

The court appointed criminologist Dr Shoaib Suddle, Kamaluddin Tippu, director general of the National Police Bureau, superintendent of Adiala Jail and vice chairmen of the Pakistan Bar Council and Islamabad Bar Council as amici curiae in the matter.

Further hearing was adjourned to May 14.

During the hearing, the inspector general of Islamabad police submitted a report on the problems arising during investigation of crimes which hindered administration of justice.

In the report, the IG said that the investigation officer (IO) of a case had to pay Rs5,000 parcel fee from his own pocket to send evidence to a forensic laboratory for analysis.

“There should not be any laboratory fee or it should be responsibility of the district administration [to pay the fee],” he said.

The IG noted that it took around two months to send evidence to laboratory for analysis. “An IO should be given the authority to send evidence to a laboratory without waiting for the approval of high officials,” he suggested.

Similarly, he said, an IO paid Rs15,000 for preparation of a sketch of a suspect believed to have committed a crime. “Such a sketch should be prepared within two days.”

The report said that plaintiffs did not cooperate with police after registration of first information reports.

The absence of a forensic laboratory in Islamabad, lawyers’ strikes and deployment of police personnel for special duties also delayed investigation process and subsequently trials, the report said.

Earlier, acquitting a murder suspect Chief Justice Minallah had observed that the existing criminal justice system had failed to deliver and it was on the verge of collapse.

The court had observed that the existing criminal justice system failed to prevent and prosecute crime and it was perpetuating miscarriages of justice.

It had noted that low-paid investigating officers did not have sufficient resources to visit the crime scene when a crime was reported, let alone sending the sealed samples and arranging the payment of the fee to a laboratory for conducting forensic examinations.

Published in Dawn, May 9th, 2020

With the Narendra Modi government taking charge on Tuesday, real estate players hope the sector will get due priority, which will help bring the economy back to 8-9 percent growth. “The new government will pave way for realty reforms and take concrete steps to implement its promise given in the BJP manifesto to ensure housing for all in eight years,” Confederation of Real Estate Developers’ Associations of India (Credai) Lalit Kumar Jain said. The merger of Housing and Urban Development Department will ensure coordination and proper control, he said. “The new government will bring in a positive change to developers and buyers in the otherwise dark era that has been […]

Regulatory reforms should focus on building up market competition, which indirectly forces state-owned enterprises to improve their operation toward efficiency.

Regulatory reforms should focus on building up market competition, which indirectly forces state-owned enterprises to improve their operation toward efficiency.

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

Peptidoglycan, the sugar-amino acid polymer that composes the bacterial cell wall, requires a significant expenditure of energy to synthesize and is highly immunogenic. To minimize the loss of an energetically expensive metabolite and avoid host detection, bacteria often recycle their peptidoglycan, transporting its components back into the cytoplasm, where they can be used for subsequent rounds of new synthesis. The peptidoglycan-recycling substrate binding protein (SBP) MppA, which is responsible for recycling peptidoglycan fragments in Escherichia coli, has not been annotated for most intracellular pathogens. One such pathogen, Chlamydia trachomatis, has a limited capacity to synthesize amino acids de novo and therefore must obtain oligopeptides from its host cell for growth. Bioinformatics analysis suggests that the putative C. trachomatis oligopeptide transporter OppABCDF (OppABCDF_Ct) encodes multiple SBPs (OppA1_Ct, OppA2_Ct, and OppA3_Ct). Intracellular pathogens often encode multiple SBPs, while only one, OppA, is encoded in the E. coli opp operon. We hypothesized that the putative OppABCDF transporter of C. trachomatis functions in both oligopeptide transport and peptidoglycan recycling. We coexpressed the putative SBP genes (oppA1_Ct, oppA2_Ct, oppA3_Ct) along with oppBCDF_Ct in an E. coli mutant lacking the Opp transporter and determined that all three chlamydial OppA subunits supported oligopeptide transport. We also demonstrated the in vivo functionality of the chlamydial Opp transporter in C. trachomatis. Importantly, we found that one chlamydial SBP, OppA3_Ct, possessed dual substrate recognition properties and is capable of transporting peptidoglycan fragments (tri-diaminopimelic acid) in E. coli and in C. trachomatis. These findings suggest that Chlamydia evolved an oligopeptide transporter to facilitate the acquisition of oligopeptides for growth while simultaneously reducing the accumulation of immunostimulatory peptidoglycan fragments in the host cell cytosol. The latter property reflects bacterial pathoadaptation that dampens the host innate immune response to Chlamydia infection.

Human activities and population growth have increased the natural burden of reactive nitrogen (N) in the environment. Excessive N deposition on Earth’s surface leads to adverse feedbacks on ecosystems and humans. Similar to that of air pollution, emission control is recognized as an efficient means to control acid deposition. Control...

Genome-wide association studies have implicated thousands of noncoding variants across common human phenotypes. However, they cannot directly inform the cellular context in which disease-associated variants act. Here, we use open chromatin profiles from discrete mouse cell populations to address this challenge. We applied stratified linkage disequilibrium score regression and evaluated heritability enrichment in 64 genome-wide association studies, emphasizing schizophrenia. We provide evidence that mouse-derived human open chromatin profiles can serve as powerful proxies for difficult to obtain human cell populations, facilitating the illumination of common disease heritability enrichment across an array of human phenotypes. We demonstrate that signatures from discrete subpopulations of cortical excitatory and inhibitory neurons are significantly enriched for schizophrenia heritability with maximal enrichment in cortical layer V excitatory neurons. We also show that differences between schizophrenia and bipolar disorder are concentrated in excitatory neurons in cortical layers II-III, IV, and V, as well as the dentate gyrus. Finally, we leverage these data to fine-map variants in 177 schizophrenia loci nominating variants in 104/177. We integrate these data with transcription factor binding site, chromatin interaction, and validated enhancer data, placing variants in the cellular context where they may modulate risk.

A team of researchers at the Massachusetts Institute of Technology (MIT) has demonstrated that single-celled microorganisms such as Escherichia coli and Saccharomyces cerevisiae that normally do not inhabit hydrogen-rich environments can survive and grow in a 100% hydrogen atmosphere. “There’s a diversity of habitable worlds out there, and we have confirmed that Earth-based life can [...]

During these long, mundane physically-distant days, stretching on into an uncertain future like an ever-lengthening beigeish corridor, it’s impossible not to miss hanging out with friends. Especially the kind of hanging out where you’re not really doing anything in particular, not talking about any one thing—just kind of being. As we continue to stay physically […]

Follow our live coronavirus updates HERE Coronavirus: The symptoms

A former top Government adviser has launched a group that will offer coronavirus advice as an alternative from the official Government committee.

The Census Bureau says it plans to continue its relaunch of limited 2020 census operations on May 13, when the next round of workers is set to resume hand-delivering paper forms in rural communities.

The Census Bureau says it plans to continue its relaunch of limited 2020 census operations on May 13, when the next round of workers is set to resume hand-delivering paper forms in rural communities.

Sia's video stars dancer Maddie Ziegler and stylist Tonya Brewer

Rolling Stone can herd sheep, chop vegetables, and perform a few repairs

From coding to engineering challenges, these apps and platforms will keep kids busy

In its desperate attempt to flatten the curve, India is flattening something else: its notorious air pollution.

Sarah Ferguson is never one to do things by halves and to mark VE Day on Friday, the...

There is no baseball being played in the US because of coronavirus, but a manufacturer of the uniforms worn in the Major League is now using the same fabric to make protective clothing in the fight against the pandemic.

Manufacturer and designer, Placon, has introduced the Face Shield Alliance to provide healthcare workers and first responders with adequate Personal Protective Equipment (PPE) during the Covid-19 pandemic.

Shares of Danish allergy immunotherapy specialist ALK Abello were up almost 10% at 1,788.00 Danish kroner…

The new directive is part of a larger Justice Department initiative to create better communication and coordination to fight crime and promote justice in Indian Country.

A former Guatemalan special forces soldier was arrested today in Palm Beach County, Fla., for lying on his naturalization application about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.

A former Guatemalan special forces soldier was indicted today by a federal grand jury in Palm Beach County, Fla., for lying on his naturalization application about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.

The Department has filed a stipulated settlement agreement resolving a portion of its lawsuit against Erie County, N.Y, regarding the limited issue of suicide prevention and related mental health care.

Gilberto Jordan, 54, a former Guatemalan special forces soldier, pleaded guilty today in Fort Lauderdale, Fla., to a federal charge of unlawfully procuring his U.S. citizenship, admitting that he lied on his naturalization application about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.

A Las Vegas federal grand jury has indicted Thanh Viet Jeremy Cao, a resident of Orange County, Calif., for filing false liens against federal employees and corruptly obstructing the administration of the federal tax laws.

Gilberto Jordan, a former Guatemalan special forces soldier, was sentenced today by U.S. District Judge William J. Zloch in the Southern District of Florida to 10 years in prison for unlawfully procuring his U.S. citizenship by lying about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.

Kenneth H. Nix and Velma I. Salinas-Nix, both of Boerne, Texas, were indicted by a federal grand jury in San Antonio on a multi-count indictment alleging tax fraud and false statements to the U.S. government.

Maxim Healthcare Services Inc., one of the nation’s leading providers of home healthcare services, has entered into a settlement to resolve criminal and civil charges relating to a nationwide scheme to defraud Medicaid programs and the Veterans Affairs program of more than $61 million.

Richard Jaensch, a self-employed plumber residing from Annandale, Va., was found guilty today by a federal jury sitting in Alexandria, Va., of one count of corruptly endeavoring to impede the Internal Revenue Service (IRS), one count of filing a false claim for a refund, and four counts of failing to file tax returns for 2004 through 2007.

Richard Jaensch, 54, of Annandale, Va., was sentenced today to 36 months in prison by U.S. District Judge Gerald Bruce Lee, the Justice Department and Internal Revenue Service (IRS) announced. Jaensch had been found guilty on Dec. 7, 2011, by a federal jury sitting in Alexandria, Va., of corruptly endeavoring to impede the IRS, filing a false claim for a refund and four counts of failing to file tax returns for 2004 through 2007. Judge Lee also sentenced Jaensch to three years supervised release and ordered him to pay $197,984 in restitution to the IRS.

The United States has entered into a comprehensive, cooperative agreement with the city of Seattle to implement sustainable reforms within the Seattle Police Department (SPD), the Justice Department announced today. The agreement seeks to resolve issues raised by the Justice Department’s investigation into SPD through federal court oversight of reform efforts to ensure effective and constitutional policing in Seattle. The agreement includes a settlement agreement and stipulated order of resolution (settlement agreement), filed in federal court in Seattle today, that is subject to an independent monitor and court oversight, and separately a memorandum of understanding (MOU) to be enforced by the parties with community oversight and the assistance of the monitor.

The United States and the city of Portland, Ore., announced today that they have reached a preliminary agreement to make changes to Portland Police Bureau policies, practices, training and supervision. This agreement was reached following a comprehensive investigation. Together with the agreement, the Justice Department today announced its findings that the Portland Police Bureau (PPB) has engaged in an unconstitutional pattern or practice of excessive force against people with mental illness. The Justice Department delivered a letter detailing the findings to Portland Mayor Sam Adams and Police Chief Michael Reese, who were cooperative throughout the department’s investigation.

The Justice Department has reached an agreement with the county of Los Angeles to extend critical reforms at the Los Angeles County Juvenile Probation Camps that were set to expire later this month. The agreement amends a memorandum of agreement (MOA) entered into in 2008 to resolve the department’s investigation into conditions of confinement at the juvenile camps.

Velma I. Salinas-Nix and Kenneth H. Nix, of Boerne, Texas, were sentenced today to serve 20 months in prison and 30 months in prison, respectively, for filing false tax returns and making false statements to the U.S. Army by filing false financial ethics disclosure forms.