The precise regulation of Ca²⁺ signals plays a crucial role in the physiological functions of neurons. Here, we investigated the rapid effect of glucocorticoids on Ca²⁺ signals in cultured hippocampal neurons from both female and male rats. In cultured hippocampal neurons, glucocorticoids inhibited the spontaneous somatic Ca²⁺ spikes generated by Kv2.1-organized Ca²⁺ microdomains. Furthermore, glucocorticoids rapidly reduced the cell surface expressions of Kv2.1 and Ca_V1.2 channels in hippocampal neurons. In HEK293 cells transfected with Kv2.1 alone, glucocorticoids significantly reduced the surface expression of Kv2.1 with little effect on K⁺ currents. In HEK293 cells transfected with Ca_V1.2 alone, glucocorticoids inhibited Ca_V1.2 currents but had no effect on the cell surface expression of Ca_V1.2. Notably, in the presence of wild-type Kv2.1, glucocorticoids caused a decrease in the surface expression of Ca_V1.2 channels in HEK293 cells. However, this effect was not observed in the presence of nonclustering Kv2.1S586A mutant channels. Live-cell imaging showed that glucocorticoids rapidly decreased Kv2.1 clusters on the plasma membrane. Correspondingly, Western blot results indicated a significant increase in the cytoplasmic level of Kv2.1, suggesting the endocytosis of Kv2.1 clusters. Glucocorticoids rapidly decreased the intracellular cAMP concentration and the phosphorylation level of PKA in hippocampal neurons. The PKA inhibitor H89 mimicked the effect of glucocorticoids on Kv2.1, while the PKA agonist forskolin abrogated the effect. In conclusion, glucocorticoids rapidly suppress Ca_V1.2-mediated Ca²⁺ signals in hippocampal neurons by promoting the endocytosis of Kv2.1 channel clusters through reducing PKA activity.

A slowed-down recording, made as part of a scientific study, shows one dog quickly mimicking another canine's expression during playtime in a park in Palermo. (Video courtesy Elisabetta Palagi)

The energetic streams are together 23 million light-years in length—roughly as long as 140 Milky Way galaxies lined end to end

Once the first primate made a break, the 42 others followed suit in a simple case of monkey-see, monkey-do

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Cometal builds on successful investment in COSMOS design analysis software

On a recent outreach to several towns in the Amazon jungle, OM Peru worked with the Presbyterian Church of Moyabamba and its annexes.

Penn State Shenango Physical Therapist Assistant students and faculty recently volunteered at the Medical Equipment Recycling Program in Farrell.

Emily Weider, a third-year student at Penn State Schuylkill, has always been drawn to business, growing up involved in her family's trucking company. Her Co-Op experience at Northeast Pennsylvania Manufacturers and Employers Association provided valuable hands-on learning, from managing databases to enhancing marketing efforts with Canva. The welcoming environment and the skills she gained have solidified her confidence in pursuing a future in business.

WILMINGTON – Despite COVID-19, Family Crisis Therapists with the Delaware Children’s Department have continued to engage families with targeted early intervention programming to further social and development skills this summer. The K-5 Family Crisis Therapists (FCTs), through the Division of Prevention and Behavioral Health Services, work in elementary schools across our state helping children and […]

Although cash should still be seen as a "trashy" asset class, investors do not have many other places to park their money, says an analyst.

Honor Magic 7 RSR Porsche Design will join the Honor Magic 7 series soon. As we await the formal launch of the handset, its key specifications have surfaced online. The Honor Magic 7 RSR Porsche Design is tipped to feature a 6.8-inch display with 1.5K resolution and a triple rear camera unit comprising a 200-megapixel periscope telephoto sensor.

Sudha Murty and Narayana Murthy appeared on the latest episode of The Great Indian Kapil Show  

The Great Indian Kapil Show episode featuring Navjot Singh Sidhu will premiere on Netflix on Saturday, November 16 

The Investor Protection Unit of the Delaware Department of Justice is encouraging anyone who invested with precious metals dealers Metals.com, Tower Equity, Chase Metals, or Barrick Capital to learn more about whether they may have been defrauded and the process for potentially recovering some of their losses. In September, the Investor Protection Unit joined the […]

Prosecutors have convicted Kwesi Hudson on 15 charges, including multiple felonies. Hudson, 50, was indicted in 2018 for a string of robberies, kidnappings, and sexual assault against three victims in February and March of 2017. “These heinous crimes victimized three women and terrorized an entire community for months,” said Attorney General Kathy Jennings. “I’m grateful […]

This afternoon President Trump ordered flags at all U.S. government buildings and facilities to be flown at half-staff until sunset on January 13, 2021 as a sign of respect for the service and sacrifice of United States Capitol Police Officers Brian D. Sicknick and Howard Liebengood, and all Capitol Police Officers and law enforcement across […]

As sign of respect for the service and sacrifice of the victims of the attack at the United States Capitol on Friday, April 2, 2021, President Biden ordered flags at all U.S. government buildings and facilities to be flown at half-staff until sunset on April 6, 2021. In concurrence with the President’s order, Governor Carney […]

The Delaware Judiciary welcomed its first “facility” or comfort dog to the Leonard L. Williams Justice Center in partnership with the Delaware Capitol Police.

Nathaniel McQueen Jr., Secretary of the Department of Safety and Homeland Security, announced Major Elmer C. Harris as the Chief of the Delaware Capitol Police. The Department of Safety and Homeland Security (DSHS) and the Delaware Capitol Police (DCP) held a ceremony to mark the start of Chief Elmer C. Harris’s role as Chief of […]

Today the Delaware Tourism Office announced awards to four Delaware sports facilities through the Sports Tourism Capital Investment Fund. Established through the Fiscal Year 2024 Bond and Capital Improvements Act, the fund provides financial support to new or existing sports facilities that hold events throughout the year to attract out-of-state visitors and contribute to the state and local economy.

On Aug. 1, the Delaware Tourism Office will reopen the Sports Tourism Capital Investment Fund for applications. Established through the FY24 Bond and Capital Improvements Act, the fund provides financial support to new or existing sports facilities that hold events throughout the year to attract out-of-state visitors and contribute to the state and local economy.

1. Delhi: India's capital chokes as air pollution turns 'severe'  BBC.com
2. Several flights diverted due to low visibility conditions at Delhi airport  The Times of India
3. Delhi's toxic air: Why you should not take your cough lightly  India Today
4. Delhi air pollution: Visibility near-zero amid thick smog; CPCB says AQI 'very poor', IQAir shows 'hazardous' | Details  Hindustan Times
5. Delhi's IGI airport sees flight diversions as season's first dense fog hits national capital  Moneycontrol

As vehicles transition into interconnected ecosystems, artificial intelligence and advanced technologies become increasingly crucial. Infotainment systems have evolved beyond mere music players to become central hubs for connectivity, entertainment, and navigation. With global demand for comfort, convenience, and safety rising, the automotive infotainment market is experiencing significant growth. Valued at USD14.99 billion in 2023, it is projected to grow at a compound annual growth rate (CAGR) of 9.9% from 2024 to 2030.

To keep pace with this evolution, infotainment systems must accommodate a range of workloads, including audio, voice, AI, and vision technologies. This requires a flexible, scalable Digital Signal Processor (DSP) solution that acts as an offload engine for the main application processor. Integrating a single DSP for varied functions offers a cost-effective solution for high-performance, low-power processing, which aligns well with the needs of Electric Vehicles (EVs).

If you missed the detailed presentation by Casey Ng, Product Marketing Director at Cadence at CadenceLIVE 2024, register at the CadenceLIVE On-Demand site to access it and other insightful presentations. Stay ahead of the curve and explore the future of innovative electronics with us.

Cadence Infotainment Solution: Leading the Charge

Cadence Tensilica HiFi DSPs play a crucial role in enhancing audio capabilities in vehicle infotainment systems. They support applications like voice recognition, hands-free calling, and deliver immersive audio experiences. This technology is also paramount for features such as active noise control, which reduces road and cabin noise, and acoustic event detection for identifying unusual sounds like broken glass. One notable innovation is the "audio bubble," enabling personalized audio zones within the vehicle, ensuring passengers enjoy distinct audio settings.

Cadence HiFi DSP technology enriches the driving experience for electric vehicles by mimicking traditional engine sounds, while its advanced audio processing ensures optimal performance across various digital radio standards. It significantly contributes to noise reduction, hence improving the cabin experience. Integrating a Double Precision Floating Point Unit (FPU) stands out, as it upgrades audio performance and Signal-to-Noise Ratio (SNR) through efficient 64-bit processing, allowing control over numerous speakers without hitches.

These advancements distinguish the DSP as an essential tool in evolving infotainment systems, offering unmatched performance and adaptability. Tensilica HiFi processors, crucial to advanced infotainment SoCs, serve as efficient offload processors, augmenting real-time execution and energy efficiency. Cadence’s ecosystem, with over 200 codecs and software partnerships, propels the evolution of innovative infotainment systems. Introducing the HiFi 5s DSP marks a new era in connected car experiences, setting the stage for groundbreaking advancements.

Exploring Tomorrow with HiFi 5s DSP Technology

The HiFi 5s represents the apex of audio and AI digital signal processing performance. Built on the Xtensa LX8 platform, it introduces capabilities like auto-vectorization, which allows standard C code to be automatically optimized for performance. This synergy of hardware and software co-design marks a significant step forward in DSP technology. By leveraging its extended Single Instruction, Multiple Data (SIMD) capabilities alongside features like a double-precision floating-point unit (DP_FPU), the HiFi 5s delivers unparalleled precision and speed improvements in signal and audio processing tasks. Equally notable are its branch prediction and L2 cache enhancements, which optimize system performance by refining the control code execution and recognizing codec efficiency. The application of such enhancements are particularly beneficial in real-world scenarios.

AI-Powered Audio

Cadence's focus on AI integration with the HiFi 5s demonstrates significant improvements in audio clarity through AI-powered solutions.

• AI models learn from real-world data and adapt dynamically, while classic DSP algorithms rely on fixed rules.
• AI can be fine-tuned for specific scenarios, whereas classic DSP lacks flexibility.
• AI handles extreme and marginal noise patterns better, generalizes well across different environments, and is robust against varying noise characteristics.

Cadence's dedication to artificial intelligence marks a pivotal shift in audio processing. Traditional DSP algorithms, bound by rigid rules, are eclipsed by AI's ability to learn dynamically from real-world data. This adaptability equips AI models to tackle challenging noise patterns and offer unmatched clarity even in noisy environments, making them ideal for automotive and consumer audio applications.

Realtime AI-Optimized Speech Enhancements by OmniSpeech and ai|coustics

OmniSpeech

Our partner, OmniSpeech, has advanced AI-based audio processing that enhances the performance of audio software, specifically for omnidirectional and dipole microphones. Impressively, their technology operates with less than 32MHz and requires only 418kB of memory.

Test results show that background noise is significantly reduced when AI employs a single omnidirectional microphone, outperforming non-AI solutions. Additionally, when using a dipole microphone with AI, there is a 3.5X improvement in the weighted Signal-to-Noise Ratio (SNR) and more than a 28% increase in the Global Mean Opinion Score (GMOS) across various background noise.

ai|coustics

ai|coustics, a Cadence partner specializing in advanced audio technologies, utilizes real-time AI-optimized speech enhancement algorithms. They leverage an extensive speech-quality dataset containing thousands of hours and 100 languages to transform low-quality audio into studio-grade audio. Their process includes:

• De-reverb, which eliminates room resonances, echoes, and reflections

• Removing artifacts from downsampling and codec compression

• Dynamic and adaptive background noise removal

• Reviving audio materials with analog and digital distortions

• Providing support for all languages, accents, and a variety of speakers

Applications include:

• Automotive: Enhances clarity of navigation commands and communication for driver safety

• Consumer audio: Improves voice clarity for better dialogue understanding in TV programs. Optimizes speech intelligibility in communication for both uplink and downlink audio streams

• Smart IoT: Boosts voice command detection and response quality

Performance Enhancements

The advancements in branch prediction and L2 cache integration have significantly boosted performance metrics across various systems. With HiFi 5s, branch prediction increases codec efficiency by an average of 5%, reaching up to 16% in optimal conditions. L2 cache improvements have drastically enhanced system-level performance, evidenced by a 2.3X boost in EVS decoder efficiency. Adding MACs and imaging ISA in imaging use cases has led to substantial advancements. When comparing HiFi 5s to HiFi 5, imaging ISA performance improvements range with >60% average performance improvements.

The Crescendo of the Future

As Cadence continues to blaze trails in DSP technology, the HiFi 5s emerges as the quintessential solution for consumer and automotive audio use cases. With a robust framework for auto-vectorization, an unmatched double-precision FPU, AI-driven audio solutions, and comprehensive system enhancements, Cadence is orchestrating the next era of audio processing, where every note is clearer, every sound richer, and every experience more engaging. It is not just the future of audio—it's the future of how we experience the world around us.

 Discover how Cadence Automotive Solutions can transform your business today!

A new Python library has been written to facilitate an interface between Python and AWR software using a command structure that adheres more closely to Python coding conventions. This library is labeled "pyawr-utils" and it is installed using the standard Python pip command. Comprehensive documentation for installing and using pyawr-utils is available.(read more)

London LEP and Thames Valley Berkshire LEP hold on to their respective first and second places in the Local Enterprise Partnership rankings, while Oxfordshire LEP jumps up eight places to third. 

Passion Capital's Eileen Burbidge talks to fDi about what fintech companies should consider when expanding internationally, and why London will always be a key market in the sector.

India’s 2020 budget continues the process of opening up to overseas investment.

Venture capital funding has reached record levels in recent years, enabling start-ups to expand across borders – but their ability to do this depends on their type of business, and where they are founded.

Australia’s proud mining history, the quality of its workers and high working standards were instrumental in bringing Canadian mining and exploration company Kirkland Lake Gold to the Victorian gold fields.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

MINNEAPOLIS, MINNESOTA — Huldah Momanyi Hiltsley made history November 5 by becoming the first Kenyan-born immigrant elected to the Minnesota House of Representatives. She describes her victory as a testament to resilience, determination and the realization of the American dream. Standing in the State Capitol for the first time on the morning of her orientation, Hiltsley told VOA she was overwhelmed with emotions and eager to start her journey as an elected official. “I am super excited,” Hiltsley said. “Today is orientation day for new legislators, and to be standing in this Capitol as an African immigrant woman is a tremendous honor. I’m just overexcited right now.” She said this milestone did not come easily. Her path to the Minnesota State Capitol was marked by struggles, including a fight against an immigration system that nearly led to her family’s deportation. She credits much of her success to the community support and the intervention of the late U.S. Senator Paul Wellstone, whose advocacy she said ultimately secured her family’s green cards and, later, citizenship. “Getting to this moment honestly is just a testament to the struggles that my family has gone through to be in this country,” she said. There has been a media frenzy surrounding Hiltsley’s victory and it has captured the attention of Kenyan media, with celebrations taking place in her hometown, Nyamemiso village, which is eight hours from Nairobi, Kenya's capital. Despite the attention, Hiltsley said she remains humble.  “I’m that little girl from that little village somewhere in the middle of Kenya, and now I’m in the spotlight of this media frenzy. And so, I’m still trying to really appreciate the magnitude of the moment,” she said. Hiltsley said she has a desire to inspire others, particularly young girls in Kenya and the United States. "It is still surreal,” she said, adding that “if I can make it to this point, I can be a role model to somebody to remind them that it is possible that our wildest dreams are possible. And that would be something that I would look back and say, wow, I’ve made a difference in somebody’s life.” Her legislative priorities Looking ahead, Hiltsley said she is committed to championing issues that matter to her constituents in Minnesota’s Legislative District 38A. Her priorities include community-centered public safety policies, affordable housing options, workers’ rights and support for small businesses — many of which are run by African immigrants. “The resources are out here,” she said, promising to empower her community. “It is my job to go back to my community and tell them, hey, there are resources here. This is how this system works. Let’s work together to mobilize and make sure that we are also taking a piece of the pie,” she said. As the first Kenyan American woman in Minnesota's Legislature, Hiltsley said she recognizes the weight and responsibility of her position. She described it as “an honor that I don’t take lightly.” “I don’t want to be the last,” she, adding that she hopes "this moment right here is a testimony that you can come to this country, work hard, take care of business, know your craft, stick to it, be consistent and get to where you want to.” Her message to those who have yet to succeed in their political campaigns is clear: Perseverance is key. “Be consistent. Keep going. There’s enough space in this Legislature for more people of color, especially immigrants, because that’s the voice that is missing,” Hiltsley said. Changing political scene Hiltsley shared her thoughts on the changing political landscape in Washington, particularly with the coming administration under President-elect Donald Trump. While acknowledging the challenges, she said she will stay focused on serving her constituents in Minnesota, regardless of politics. “We are here to serve the people, and it doesn’t matter if you are Democrat or Republican,” she said. “We are here as legislators to serve the people of Minnesota.” Hiltsley also shared her heartfelt message to fellow Kenyans who have been celebrating her historic achievement. “This is a historical moment, and I’m honored to be a Kenyan American,” she said. “Let’s continue celebrating this victory, but after that, we have work to do.” She said her eyes are set on not just her role in Minnesota, but also finding ways to collaborate with Kenya’s leaders to address issues facing the country, including corruption and a lack of strong leadership. “Kenya has unlimited potential,” she said. “It’s up to our leaders to do right by the people.” Hiltsley will officially take her seat in the Minnesota State House of Representatives and be sworn in on January 7. Representatives are elected to serve two-year terms. This story originated in VOA’s Swahili Service. Salem Solomon contributed to the report from Washington.

The Great Mosque, in all its majestic grandeur, is less enticing if you're an American woman who somehow finds herself inside it.

[African Development Bank (AfDB)] The world's largest annual climate conference opens in Baku, Azerbaijan, on Monday, with African nations ramping up efforts to tackle climate change. At COP29, the African Development Bank aims to mobilize additional resources for climate action in Africa and launch a bold new approach to assessing African economies by including their "green wealth."

On January 6, 2021, white insurrectionists stormed the U.S. Capitol, proudly displayed the confederate flag, and set up gallows on the Capitol grounds.