National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

Though exports are banned, shipments of 64,000 tonnes were allowed under special bilateral pact

Nearly 40 flights operated by the Indian carriers have received bomb threats in the past few days which later turned out to be hoaxes

I&B Ministry stated that advertisements issued for products related to food and health sectors will be required to upload an annual self-certificate on the Broadcast Seva Portal and Press Council of India portal.  

ADHM is the latest in the brand of cinema that isn’t so much as plot driven as it is focused on characters, relationships and interactions.

New Zealand captain Tom Latham stated his troupe was confident it had heard two sounds.

After Prime Minister Narendra Modi accused the Congress government of collecting ₹700 crore from excise sources to fund the Maharashtra elections, it was the turn of N. Cheluvarayaswamy

Uttar Pradesh Yogi Adityanath alleged that the JMM-led government in Jharkhand fuelled corruption, anarchy and looting of natural resources.

Mr. Farage (52), later posted a picture on Facebook and Twitter of him with Mr. Trump, who gives a thumbs-up for the camera.

Eleven wagons of the goods train carrying iron ore derailed between Raghavapuram and Ramagundam

Many webmasters have realized the benefit of using RSS to dynamically update websites. This means that the website content automatically changes when the RSS feed is updated. This allows for webmasters to serve dynamic content or a mixture of static and dynamic content on their website.

Feed2HTML

Just as the second generation of search engines and directories evolved into niche topic specific portals we are seeing the same occur in the area of RSS feed directories and search engines. While some directories are admittedly more niche than others the trend is obvious.

Vertical search and niche directories are becoming authority sites in a crowded online world. These niche directories will help individuals in specific industries locate topics essential to their industries.

Vertical Marketing with RSS Feeds

Samsung remains number one with 23.4 per cent; in the overall PC market, Lenovo topped the rank with 21.6 per cent market share

HP OmniBook Ultra Flip comes with HP Wolf Security to protect it against cyber threats

The International Olympic Committee is a major business entity, generating $7.6 billion in the recent four-year cycle primarily through broadcast rights and sponsorships

Electrochemical system runs 15 times as long as best previous design

Zippy and comfortable, the Mini Convertible is a perfect car for short jaunts, but this isn't the ride you'd choose to take your entire family to the airport or pick for a long family excursion, says Pavan Lall.

The Rohit Shetty-directed Singham Again has crossed the domestic net collections of Hrithik Roshan and Deepika Padukone-starrer Fighter at the box office.

Marketers fear ‘racist’ Trump supporters, says head of Hispanic advertising group

The UK is tightening rules on sexist stereotyping in ad campaigns. Critics argue recruitment in the industry must change too

Members Event

Event participants

Professor Joseph S Nye, University Distinguished Service Professor, Harvard Kennedy School of Government
Chair: Gideon Rachman, Chief Foreign Affairs Commentator, Financial Times

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.

Wipro has signed a memorandum of understanding with the Maharashtra government under which it will repurpose one of its information technology campuses at Hinjewadi in Pune to a 450-bed intermediary care Covid-19 hospital in four weeks and hand it over to the state government by May 30.