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Australia proposes social media ban for children under the age of 16

If the legislation is passed, social media platforms including X, TikTok, Instagram and Facebook would have one year to work out how to exclude Australian children.




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MechWarrior 5: Clans is supposed to be newbie-friendly, and I put it to the test

All the kit balancing, squad leading, and lore you could want, if you want it.




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Reynatis Interview: Creative Producer TAKUMI, Scenario Writer Kazushige Nojima, and Composer Yoko Shimomura discuss the game, coffee, and more

Later this month on September 27th, NIS America will release FuRyu’s action RPG Reynatis for Switch, Steam, PS5, and PS4 …




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Britain's soaring reliance on foreign power exposes great green energy scam...


Britain's soaring reliance on foreign power exposes great green energy scam...


(Third column, 5th story, link)





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Waiver of Informed Consent - proposed changes in the 21st Century Cures Act

Adam Feuerstein points out - and expresses considerable alarm over - an overlooked clause in the 21st Century Cures Act:


In another tweet, he suggests that the act will "decimate" informed consent in drug trials. Subsequent responses and retweets  did nothing to clarify the situation, and if anything tended to spread, rather than address, Feuerstein's confusion.

Below is a quick recap of the current regulatory context and a real-life example of where the new wording may be helpful. In short, though, I think it's safe to say:


  1. Waiving informed consent is not new; it's already permitted under current regs
  2. The standards for obtaining a waiver of consent are stringent
  3. They may, in fact, be too stringent in a small number of situations
  4. The act may, in fact, be helpful in those situations
  5. Feuerstein may, in fact, need to chill out a little bit


(For the purposes of this discussion, I’m talking about drug trials, but I believe the device trial situation is parallel.)

Section 505(i) - the section this act proposes to amend - instructs the Secretary of Health and Human Services to propagate rules regarding clinical research. Subsection 4 addresses informed consent:

…the manufacturer, or the sponsor of the investigation, require[e] that experts using such drugs for investigational purposes certify to such manufacturer or sponsor that they will inform any human beings to whom such drugs, or any controls used in connection therewith, are being administered, or their representatives, that such drugs are being used for investigational purposes and will obtain the consent of such human beings or their representatives, except where it is not feasible or it is contrary to the best interests of such human beings.

[emphasis  mine]

Note that this section already recognizes situations where informed consent may be waived for practical or ethical reasons.

These rules were in fact promulgated under 45 CFR part 46, section 116. The relevant bit – as far as this conversation goes – regards circumstances under which informed consent might be fully or partially waived. Specifically, there are 4 criteria, all of which need to be met:

 (1) The research involves no more than minimal risk to the subjects;
 (2) The waiver or alteration will not adversely affect the rights and welfare of the subjects;
 (3) The research could not practicably be carried out without the waiver or alteration; and
 (4) Whenever appropriate, the subjects will be provided with additional pertinent information after participation.

In practice, this is an especially difficult set of criteria to meet for most studies. Criterion (1) rules out most “conventional” clinical trials, because the hallmarks of those trials (use of an investigational medicine, randomization of treatment, blinding of treatment allocation) are all deemed to be more than “minimal risk”. That leaves observational studies – but even many of these cannot clear the bar of criterion (3).

That word “practicably” is a doozy.

Here’s an all-too-real example from recent personal experience. A drug manufacturer wants to understand physicians’ rationales for performing a certain procedure. It seems – but there is little hard data – that a lot of physicians do not strictly follow guidelines on when to perform the procedure. So we devise a study: whenever the procedure is performed, we ask the physician to complete a quick form categorizing why they made their decision. We also ask him or her to transcribe a few pieces of data from the patient chart.

Even though the patients aren’t personally identifiable, the collection of medical data qualifies this as a clinical trial.

It’s a minimal risk trial, definitely: the trial doesn’t dictate at all what the doctor should do, it just asks him or her to record what they did and why, and supply a bit of medical context for the decision. All told, we estimated 15 minutes of physician time to complete the form.

The IRB monitoring the trial, however, denied our request for a waiver of informed consent, since it was “practicable” (not easy, but possible) to obtain informed consent from the patient.  Informed consent – even with a slimmed-down form – was going to take a minimum of 30 minutes, so the length of the physician’s involvement tripled. In addition, many physicians opted out of the trial because they felt that the informed consent process added unnecessary anxiety and alarm for their patients, and provided no corresponding benefit.

The end result was not surprising: the budget for the trial more than doubled, and enrollment was far below expectations.

Which leads to two questions:

1.       Did the informed consent appreciably help a single patient in the trial? Very arguably, no. Consenting to being “in” the trial made zero difference in the patients’ care, added time to their stay in the clinic, and possibly added to their anxiety.
2.       Was less knowledge collected as a result? Absolutely, yes. The sponsor could have run two studies for the same cost. Instead, they ultimately reduced the power of the trial in order to cut losses.


Bottom line, it appears that the modifications proposed in the 21st Century Cures Act really only targets trials like the one in the example. The language clearly retains criteria 1 and 2 of the current HHS regs, which are the most important from a patient safety perspective, but cuts down the “practicability” requirement, potentially permitting high quality studies to be run with less time and cost.

Ultimately, it looks like a very small, but positive, change to the current rules.

The rest of the act appears to be a mash-up of some very good and some very bad (or at least not fully thought out) ideas. However, this clause should not be cause for alarm.




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Proposed law could mandate treatment for community disturbances linked to mental health

The Community Disputes Resolution Tribunals (CDRT) will be able to mandate mental health treatment for those who cause unreasonable interferences in the community if a bill to amend the Community Disputes Resolution Act (CDRA) goes through.  The bill was proposed in Parliament by Minister for Community, Culture and Youth Edwin Tong on Tuesday (Nov 12). The CDRT currently hears disputes under CDRA between neighbours involving acts of unreasonable interference with the enjoyment or use of places of residence. Under the bill, the tribunal will be able to issue Mandatory Treatment Orders (MTO) should there be a belief that the acts of disturbance stem from an underlying psychiatric condition. "In those cases, the issue therefore is not just a disamenity one," Minister Tong said. "Hence, the MTO is intended to address the root cause of certain acts that a resident may engage in." Tong added that their priority remains in persuading the resident to go for treatment voluntarily, and that the CDRT-issued MTO is a measure of last resort. There are also criteria that must be met for the MTO to be issued.




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‘Pakistan's actions at the UN may embolden other member states to oppose U.S. positions'

U.S. Mission in New York raised concerns about Pakistan's voting on key issues such as counterterrorism and human rights




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45425: India proposes US observer status at SAARC

In a surprise development, the GOI has told us that it would welcome US participation as an Observer to SAARC.




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CFPB’s Proposed Data Rules Would Improve Security, Privacy and Competition

The collection and sale of consumer data is too lucrative for companies to say no to participating in the data broker economy. New rules proposed by the Consumer Financial Protection Bureau may help eliminate the incentive for companies to buy and sell consumer data.





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Trump's Assassination Fantasy Has a Darker Purpose

Juliette Kayyem argues that Trump's stories of his own victimization make violence by his supporters far more likely.




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Strategic Myopia: The Proposed First Use of Tactical Nuclear Weapons to Defend Taiwan

David Kearn argues that the idea that the first use of nuclear weapons since 1945 would be by the United States in the defense of Taiwan against a conventional Chinese invasion would have significant, negative, and long-lasting, diplomatic ramifications. It is difficult to fathom the myriad potential consequences, but U.S. nuclear weapon use would almost certainly shatter the non-proliferation regime as a functioning entity, incentivize states (including China) to acquire or improve their existing nuclear arsenal, and damage America's standing globally.




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Why Realists Oppose the War in Gaza

Stephen Walt argues that realists oppose Israel's actions in Gaza (and U.S. complicity in them) because the combination is undermining the United States' global position and bringing the United States precisely zero strategic benefits.




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LG Gives Team Uniform Colors A New Purpose, Enlists Color Commentator Jay Bilas To Help NCAA March Madness Fans 'Do Game Day Right' - Jay Bilas shares his tips on how to do game day right.

ESPN College Basketball Analyst and LG Color Commentator Jay Bilas shares his tips on how to do game day right.




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Anti-Dumping Duty Imposed on Welded Stainless-Steel Pipes and Tubes from Thailand and Vietnam

GOVERNMENT OF INDIA MINISTRY OF FINANCE (DEPARTMENT OF REVENUE)




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Holding Multiple PANs May Impose Penalties

Do not hold multiple PAN as it may cost you.A fine amounting Rs. 10,000 may be imposed u/s 272B of the Income Tax Act for possessing multiple PANs or providing incorrect PAN info




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A Closer Look At The Photo Op Bible Trump Spilled Blood To Awkwardly Pose With

I Had Peaceful Protestors Gassed And Beaten So I Could Waddle To This Photo Op Like A Big Boy And All I Got Was This Prop Bible




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Bishop William Barber Endorses Harris, Says Faith Leaders Must Oppose Trump's Hate

“There can be no middle ground, not in this moment.” As the U.S. presidential race draws to a close, Bishop William Barber, the national co-chair of the Poor People’s Campaign, founding director of the Center for Public Theology and Public Policy at Yale Divinity School and co-author of White Poverty: How Exposing Myths About Race and Class Can Reconstruct American Democracy, explains why he is endorsing Kamala Harris for president in his personal capacity. In contrast to Donald Trump’s divisive rhetoric and policies that will benefit the rich, Barber says “we see clearly Harris trying to unify.” He makes a theological argument for opposing Trump and also discusses voting rights and access in his home state of North Carolina.




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Keeanga-Yamahtta Taylor: Democrats Demobilized Their Base. A Movement Is Now Needed to Oppose Trump

Donald Trump’s performance in the 2024 election surpassed expectations, with the candidate winning the key battleground states of Pennsylvania, North Carolina and Georgia and picking up larger shares of more diverse segments of the electorate, including Black and Latino male voters. Keeanga-Yamahtta Taylor, a professor of African American studies at Princeton University, says the blame lies squarely on the Harris campaign, which refused to differentiate itself from unpopular incumbent President Joe Biden. “The problem here is with the leadership of the Democratic Party,” adds John Nichols, national affairs correspondent for The Nation. Nichols and Taylor discuss how Democrats “demobilized” young voters and grassroots organizers, to their electoral detriment. “Donald Trump, as a president who has very few guardrails, has the potential to take horrific actions,” says Nichols. For those seeking to oppose him, says Taylor, “There’s a lot of rebuilding that has to be done.”




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NFRA Set to Propose Audit Norms for LLPs in 25th Nov Board Meeting

The National Financial Reporting Authority (NFRA) has convened a board meeting scheduled for November 25, where it will examine and potentially set audit standards for limited liability partnerships (LLPs), according to official sources. ...




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IT'S ALWAYS SUPPOSED TO BE A TACO




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Temple of Poseidon at Samikon is larger than expected

Archaeologists have uncovered more of the monumental Temple of Poseidon in Greece’s Peloponnese, revealing rare artifacts and unique architectural features that shed light on ancient religious practices .

Continue reading Temple of Poseidon at Samikon is larger than expected at The Wild Hunt.




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supposedly phone

Today on Toothpaste For Dinner: supposedly phone


This RSS feed is brought to you by Drew and Natalie's podcast Garbage Brain University. Our new series Everything Is Real explores the world of cryptids, aliens, quantum physics, the occult, and more. If you use this RSS feed, please consider supporting us by becoming a patron. Patronage includes membership to our private Discord server and other bonus material non-patrons never see!




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'He was a nightmare': Employee's savage review after quitting exposes entitled boss, leads to their termination

When you're applying for jobs, you're probably checking out every online review you can find to dodge any potential red flags. After all, who wants to go through multiple interviews only to discover that the company's run by an entitled boss who thinks coworkers should act like "family"? Hard pass. Sites that let employees rate companies are a goldmine for honest feedback—sometimes with details that make you grateful for the warning.

Well, after one employee spent six grueling months working under a new VP, they tried to clue in the higher-ups about just how awful the new boss was. When the owner didn't take their concerns seriously, they took things a step further, leaving a brutally honest review that laid everything bare. The best part is it worked. The entitled boss eventually got the boot, and the company's culture finally went back to normal. Unfortunately, the original employee who exposed the mess had already quit—but at least they left with a story of sweet, well-deserved karma.




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28-year-old employee flirts with supposedly single 40-year-old coworker, turns out she's been married for 16 years: 'She was lying about being single'

Here is another example of why one should never try to form a romantic attachment with a coworker. It never works out for a plethora of potential reasons. In this instance, however, the reasons had less to do with the professional side of things and more to do with this lying coworker's personal life.

The Redditor described how their close friend, a 28-year-old male employee at their company, had been engaging in continuous flirtations with his 40-year-old female coworker, who had led everyone in the office to believe that she was single. These weren't assumptions; she was actively advertising her single lifestyle to anyone who would listen. The younger employee even took her out on several dates, and the two seemed to be keeping their romantic lives and their professional lives separate.

Unfortunately for the younger guy, he and the Redditor discovered that she had been hiding her marriage of over 16 years. When the employee decided to get even with his coworker, things went south very quickly and HR ended up getting involved. Keep scrolling below for the full story. For more, check out this post about a company that tried to steal a job candidate's idea.




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Assisted dying bill: What is in proposed law?

The proposed law would allow some terminally ill adults to end their own lives. But there are requirements.




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Simmonds opposes Paralympic merger

Double Paralympic champion Eleanor Simmonds says she would not support any plan to combine the Olympic and Paralympic Games.




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Tax-News.com: France Proposes Additional COVID-19 Support Measures

In two recent speeches, French Finance Minister Bruno Le Maire has outlined plans to extend COVID-19 supports for French businesses.




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Increased Temperatures Pose Growing Dengue Risk

The escalating impact of climate change is anticipated to expand the reach of medlinkdengue/medlink, a mosquito-borne disease claiming thousands of




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Antibiotic Rifaximin Resistance Poses Growing Superbug Risk

Australian research has found that the widespread use of the antibiotic rifaximin is fueling the rise of a nearly untreatable superbug. (!--ref1--)




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"Painting With Light" Exposes the Visual Impact of Air Pollution

Collaborating researchers and artists have united to "paint with light," rendering invisible air pollution visible. Their efforts underscore the health




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Artificial Sweetener Sucralose Poses a Sweet Threat to the Environment

medlinkSucralose/medlink, an artificial sweetener found in many zero-calorie food and drink products, escapes during wastewater treatment and affects




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Indians Predisposed to Insulin Resistance More Prone to Fatty Liver Disease

Being highly predisposed to insulin resistance puts Indians at a higher risk of developing non-alcoholic fatty liver disease (NAFLD), suggest health experts.





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Indoor Vaping Exposes Children to Significantly Less Nicotine Than Smoking

medlinkChildren/medlink exposed to vaping indoors absorb significantly less nicotine compared to those exposed to indoor medlinksmoking/medlink,




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Hospital Disinfectant Fails Against Global Health Threat Posed by Antibiotic Resistance

Chlorine disinfectant used in hospitals proves ineffective against the leading cause of medlinkantibiotic/medlink-associated sickness globally as




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Lumbar Liquidators Flooring Pose Risk of Cancer: Centers for Disease Control and Prevention

The recent Centers for Disease Control and Prevention (CDC) report states that some types of laminate flooring made by the company, Lumber Liquidators




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Improvements to Prior Authorization in Medicare Advantage Proposed

A new study has revealed the pros and cons of prior authorization (PA) policies for Medicare and the impact these policies have on patients and clinicians.




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Budget 2024: Government to Propose Changes to Insurance Laws

In a significant move towards achieving 'Insurance for All by 2047', the government is set to introduce a bill seeking amendments to the Insurance Act, 1938, during the upcoming Budget session.




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Anushka Shetty is back! Poses with a cigar in the first look of Ghaati

Directed by Krish Jagarlamudi, Anushka Shetty is all set to conquer everyone's hearts yet again with her bold and fierce look of smoking a cigar and with an intense look on her face. 




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MrBeast & Logan Paul in Mumbai: Saif Ali Khan fulfils Jeh wish; Kareena Kapoor, Taimur, Malaika Arora, Arhaan pose with global stars

A video shows Saif Ali Khan carrying his son Jeh on his shoulders, while Taimur sits next to Kareena at a nearby table. Both Taimur and Jeh wore matching caps, while Kareena Kapoor and Saif Ali Khan twinned in black outfits. When the anchor asked who would like a picture with Logan Paul, Jeh raised his hand.




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Vote for Mahayuti for fast development, oppose MVA which will put brakes: PM tells Maha

Prime Minister Narendra Modi on Friday appealed to the voters of Maharashtra to re-elect the Mahayuti alliance comprising the BJP, Shiv Sena and NCP to increase the pace of development and oppose the Maha Vikas Aghadi (MVA) which will put brakes on the state's growth.




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Pakistan win exposes serious flaws in Australia's batting, says coach Gillespie

Following Pakistan's first ODI series win in Australia happening after 22 years, interim white-ball head coach Jason Gillespie said his bowlers exposed some flaws in the hosts' batting line-up.




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The social purpose market in Australia - 28 Apr

Every year Australia spends more than half a trillion dollars on social purpose goods and services directed at health, welfare and education, almost one third of the nation's GDP.




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Meta found to have exposed info on North Korean defectors to advertisers

Meta has added another privacy sanction to its extensive collection: South Korea’s data protection agency fined the social media giant around $15.7 million for processing sensitive user data and passing it to advertisers without a proper legal basis, Reuters reports. Seoul’s Personal Information Protection Commission (PIPC) found Facebook’s parent collected information from about 980,000 users, […]

© 2024 TechCrunch. All rights reserved. For personal use only.





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Greater Noida Man's 'High-Rise' Cannabis Operation Busted, Dark Web Dealings Exposed!

In a remarkable operation in Greater Noida, a man named Rahul Chaudhary been apprehended by the Uttar Pradesh Police for cultivating cannabis within his apartment and allegedly distributing it through the dark web. Chaudhary, holding an English degree, was reported to




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Silicon Valley's Dark Secret: Tech Giants' Green Claims Exposed As AI Gobbles Up Energy

In our technology driven world the movers and shakers of the tech industry always want to be on the right side of the law. They want to show their humane face to the global audiences. But is that the truth?A new




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Bigg Boss 18: Karan Veer Mehra gets jealous, proposes to Chum Darang indirectly, actress says 'yeh sunke hum...'

Did Karan Veer Mehra confess his feelings to Chum Darang? Here's how the actress reacted.




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Assessment of extracellular polymeric substances production and antioxidant defences in periphytic communities exposed to effluent contaminants

Environ. Sci.: Processes Impacts, 2024, Advance Article
DOI: 10.1039/D4EM00446A, Paper
Carlos Silva, Etelvina Figueira, Diana Matos, Carina Sá, Tânia Vidal, Fernando José Mendes Gonçalves, Nelson Abrantes, Joana Luísa Pereira
Periphyton is frequently used in the evaluation of the ecological status of aquatic ecosystems using diatoms as a proxy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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