The second installment in our weekly series spotlights titles that may have been lost in the news amid the COVID-19 pandemic

A woman found not criminally responsible for fatally stabbing a stranger in the heart at the makeup counter of a Toronto drugstore five years ago could ultimately be allowed to live in the community if the mental health facility where she is staying decides she can, the Ontario Review Board says.

A man in Kamloops, B.C., has died and two others are in hospital with life-threatening injuries after a stabbing at a party at an apartment complex Saturday night. 

Worker Ronaldo visits with a rabbi in Israel and discusses prophecies about the Messiah.

IRAQ’S prime ministerial merry-go-round continues to spin apace. Spy chief Mustafa al-Kadhimi, director of the country’s National Intelligence Service, is now the third prime minister designate this year, following the withdrawal of the two previous prospective candidates.

Penn State Schuylkill senior Abigayle Kaiser has embraced leadership roles on campus throughout her undergraduate experience. From Schuylkill Benefitting THON, to the Lion Ambassadors, the Blue & White Society and so much more, Kaiser is a student who did it all. As she nears graduation with a full-time marketing job secured, Kaiser reflects on her time as a Penn Stater.

Background: MRSA pose significant therapeutic challenges, related to their: frequency in clinical infections; innate virulence properties; and propensity for multi-antibiotic resistance. MRSA are among the most common causes of endovascular infections, including infective endocarditis (IE).

Objective: To employ transthoracic echocardiography (TTE) to evaluate the effect of exebacase, a novel direct lytic agent, in experimental aortic valve MRSA IE.

Study Design: TTE was utilized to evaluate the in vivo effect of exebacase on MRSA-infected vegetation progression when combined with daptomycin (vs daptomycin alone). Primary intravegetation outcomes were: maximum size; weights at sacrifice; and MRSA counts at infection baseline vs after 4 days of daptomycin treatment (alone or in addition to exebacase administered once on treatment Day 1).

Results: A single dose of exebacase in addition to daptomycin cleared significantly more intravegetation MRSA than daptomycin alone. This was associated with a statistical trend toward reduced maximum vegetation size in the exebacase + daptomycin vs the daptomycin-alone therapy groups (p = 0.07). Also, mean vegetation weights in the exebacase-treated group were significantly lower vs daptomycin-alone (p < 0.0001). Maximum vegetation size by TTE correlated with vegetation weight (p = 0.005). In addition, intravegetation MRSA counts in the combination group were significantly lower vs untreated controls (p<0.0001) and the daptomycin-alone group (p<0.0001).

Conclusion: This study suggests that exebacase has a salutary impact on MRSA-infected vegetation progression when combined with daptomycin, especially in terms of vegetation MRSA burden, size and weight. Moreover, TTE appears to be an efficient non-invasive tool to assess therapeutic efficacies in experimental MRSA IE.

FineReader 15 is the best all-round PDF-and-OCR app there is, with a smooth, modern interface, fast performance, and a deep feature set.

Accreditation is the highest recognition afforded to museums in the United States.

W.B. Simpson Elementary School 4th grader Latrell McGinnis spent last spring tending to his cabbage in hopes of growing the best-looking cabbage in Delaware. After all the judging was completed, McGinnis’s hard work paid off when he was announced as the state winner during a presentation at his school this week.

Electric truck by ABB showcased in Swiss capital, Bern.

The IDAL HTTP server CGI interface contains a URL, which allows an unauthenticated attacker to bypass authentication and gain access to privileged functions. In the IDAL CGI interface, there is a URL (/cgi/loginDefaultUser), which will create a session in an authenticated state and return the session ID along with the username and plaintext password of the user. An attacker can then login with the provided credentials or supply the string 'IDALToken=......' in a cookie which will allow them to perform privileged operations such as restarting the service with /cgi/restart.

The Uruguayan government agency Instituto Antarctico Uruguayo (IAU) is collaborating with ABB, Uruguayan utility company UTE and the Ministry of Industry, Energy and Mining (MIEM) to provide a second solar power installation at the IAU’s research base in the Antarctic.

As renewable energy proliferates, major players like Hitachi, ABB and GE are seeing value in combining grid and generation business units.

As renewable energy proliferates, major players like Hitachi, ABB and GE are seeing value in combining grid and generation business units.

Only time will tell whether this is right, but EV adoption is clearly rising both on the individual and fleet fronts. Utilities such as Southern California Edison and Ameren, among many others, are working to build EV charging infrastructure and align power distribution in a way to handle it.

ABB and Rolls-Royce on Tuesday announced a global partnership on microgrid technology and advanced automation. Together the two companies will offer a microgrid solution for utilities, commercial and industrial entities.

ABB is working with Italian utility Evolvere on how to use blockchain technology to deliver transparent and secure peer-to-peer energy transactions.

As renewable energy proliferates, major players like Hitachi, ABB and GE are seeing value in combining grid and generation business units.

Senator representing Adamawa North Senatorial district, Elisha Ishaku Abbo has accused governor Ahmadu Fintiri of making false claims over the donation of transformers to some communities in the State. The lawmaker said the transformers were donated by the newly established Northeast Development Commission (NEDC) through the intervention of his Committee. He frowned at the publication […]

Senator Abbo accuses Adamawa Governor of ‘false claims’ over NEDC projects

Police are investigating a house robbery in which a couple in Amanzimtoti, on the south coast of KwaZulu-Natal, believed to be in their 50s was stabbed. ......

(MENAFN - Nam News Network) RAMALLAH, May 9 (NNN-WAFA) - Palestinian President, Mahmoud Abbas, warned, on Friday, that measures will be taken against ... ......

PATTAYA: Three foreigners have been detained for violating the emergency decree after they were found swimming at a closed beach behind a hotel in this resort city on Saturday.

[Namibian] POLICE arrested 143 suspects for drug-related crimes in April, the latest police report on drug busts and arrests says.

[Daily Trust] What would have been mere enforcement of wearing of face mask in Anambra State on Monday turned into a tragedy as 22-year-old Cletus Chisom was stabbed to death by Mr. Ibuchi Nwoju, a security man.

[RSF] Reporters Without Borders (RSF) calls for a full and thorough investigation into the way a Somali journalist was stabbed to death on a Mogadishu street yesterday evening, because the initial evidence suggests that he was the victim of a premeditated murder.

“Keep in mind that Abbas is a status quo man. He does not like to rock the boat and this is not something that he would do easily, to do what he threatens to do,” said Professor Khalil Shikaki.

ISLAMABAD: Former Chairman Senate Mian Raza Rabbani Friday questioned the formation of the National Council for Minorities through notification and termed it violation of the judgement of the...

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State-owned enterprises, including power utilities, in many countries have collected a menagerie of assets unrelated to their core business. And they are selling cheap.

Reforming state-owned enterprises can be an extraordinarily complex activity but it is underpinned by a single clear goal.

With key reforms, Pacific states could move toward cleaner, more affordable sources of energy that eventually eliminate fossil fuels completely.

In the fragile energy scenario of small Pacific islands, contingency plans are crucial to keep the lights on during a crisis.

ISLAMABAD: Former Senate chairman Mian Raza Rabbani on Friday said that the National Council for Minorities nominated through a notification after a considerable delay was illegal because it had been formed in violation of a judgement announced by the then Chief Justice of Pakistan Tasaduq Hussain Jilani on June 19, 2014.

“The said act of violating the judgement of the Supreme Court is condemned,” the PPP leader said in a statement.

Mr Rabbani said that the Supreme Court’s judgement had come in the wake of a bomb blast in a Peshawar church in 2013 which left over a hundred members of the Christian community dead.

In a suo motu case, the then Chief Justice of Pakistan, in paragraph 37(iv) of the judgement, had ordered the setting up of the National Council for Minorities to monitor practical realisation of the rights and safeguards of members of minority communities provided in the 1973 Constitution.

The council was supposed to be mandated to frame policy recommendations for safeguarding and protecting minorities’ rights by the federal and provincial governments.

The judgement clearly mentioned eight steps that the governments were to take, including (i) reservation of quota in services, (ii) a special police force to protect places of worship, (iii) steps to discourage hate speeches, and (iv) revision of school curriculum to promote cultural and religious tolerance.

The PPP leader said that none of the steps had been taken so far by the governments.

He said that the federal government had, after the approval of the cabinet, constituted the council through a notification and the body had become controversial even before its birth and as a result the religious affairs ministry had to amend its summary.

The PPP leader said that the council should be constituted through an act of parliament.

Mr Rabbani said that the importance given to safeguarding the rights of the minorities in the country was evident from the fact that the white colour portion of the national flag represented minorities and in over 20 Articles of the Constitution, 1973, the rights of minorities had been guaranteed.

Published in Dawn, May 9th, 2020

ISLAMABAD: Former prime minister and senior leader of the Pakistan Muslim League-Nawaz (PML-N) Shahid Khaqan Abbasi will appear on Saturday (today) before the commission of inquiry investigating the recent shortage and price hike of sugar in the country.

Mr Abbasi told Dawn on Friday he would inform the commission how sugar scandals develop, in the light of his experience as a former chief executive of the country.

He said he had written a letter to the commission, offering his services to it by sharing his experiences in probing scams. “I wrote the letter to the commission, as under the Commission of Inquiry Act any citizen can assist such commissions in investigating such scams,” he said.

Upon receiving the letter, Mr Abbasi said, the commission asked him to provide a written statement, or any other document, that would help in investigating the scandal. “I told the commission that I will not give any written statement or document, but will assist it on the basis of my experience, I being a former member of the Economic Coordination Committee (of the cabinet) and former head of the federal cabinet,” he said.

Mr Abbasi, who served as the prime minister in the last PML-N government, said he would explain to the commission how the sugar crisis occurred.

When asked to share some of the reasons behind the crisis, the former premier said allowing export of the commodity was one of the main reasons. “The commission has to ascertain who gave the approval for export of sugar when its local demand had not been taken care of.”

He said he would request the commission to keep his meeting with its members open to all. Another PML-N leader and former defence minister Khurram Dastagir Khan would be accompanying Mr Abbasi to the meeting.

The commission is investigating the recent shortage of sugar and wheat in the country, in which some key members and allies of the ruling Pakistan Tehreek-i-Insaf were allegedly involved.

Published in Dawn, May 9th, 2020

The next season of the ABB FIA Formula E Championship kicks off in December 2018, and is already shaping up to be exceptional. Featuring new cars, a new race format, new cities, new power modes, new teams, and new drivers, season five promises to ramp up...

The fifth season of the ABB FIA Formula E Championship has kicked off in style in December 2018 with the SAUDIA Ad Diriyah E-Prix. Since then, the Championship’s 22 participating Gen2 electric cars and drivers have been crisscrossing the planet in 13...

The rabbit hemorrhagic disease virus (RHDV), which belongs to the family Caliciviridae and the genus Lagovirus, causes lethal fulminant hepatitis in rabbits. RHDV decreases the activity of antioxidant enzymes regulated by Nrf2 in the liver. Antioxidants are important for the maintenance of cellular integrity and cytoprotection. However, the mechanism underlying the regulation of the Nrf2-antioxidant response element (ARE) signaling pathway by RHDV remains unclear. Using isobaric tags for relative and absolute quantification (iTRAQ) technology, the current study demonstrated that RHDV inhibits the induction of ARE-regulated genes and increases the expression of the p50 subunit of the NF-B transcription factor. We showed that RHDV replication causes a remarkable increase in reactive oxygen species (ROS), which is simultaneously accompanied by a significant decrease in Nrf2. It was found that nuclear translocation of Keap1 plays a key role in the nuclear export of Nrf2, leading to the inhibition of Nrf2 transcriptional activity. The p50 protein partners with Keap1 to form the Keap1-p50/p65 complex, which is involved in the nuclear translocation of Keap1. Moreover, upregulation of Nrf2 protein levels in liver cell nuclei by tert-butylhydroquinone (tBHQ) delayed rabbit deaths due to RHDV infection. Considered together, our findings suggest that RHDV inhibits the Nrf2-dependent antioxidant response via nuclear translocation of Keap1-NF-B complex and nuclear export of Nrf2 and provide new insight into the importance of oxidative stress during RHDV infection.

IMPORTANCE Recent studies have reported that rabbit hemorrhagic disease virus (RHDV) infection reduced Nrf2-related antioxidant function. However, the regulatory mechanisms underlying this process remain unclear. The current study showed that the NF-B p50 subunit partners with Keap1 to form the Keap1-NF-B complex, which plays a key role in the inhibition of Nrf2 transcriptional activity. More importantly, upregulated Nrf2 activity delayed the death of RHDV-infected rabbits, strongly indicating the importance of oxidative damage during RHDV infection. These findings may provide novel insights into the pathogenesis of RHDV.

The world according to two of the scene’s most dedicated rave architects. Gabber Eleganza and HDMIRROR make a formidable duo on their new collaborative track ‘Frozen Dopamina’, which arrives with a video capturing the world at its most euphoric. The track is taken from The Real Life, a new collaborative release from the two producers […]

The post Gabber Eleganza & HDMIRROR chase euphoria on ‘Frozen Dopamina’ appeared first on FACT Magazine.

Long before NLP became a hot field in AI, people devised rules and machines to manipulate language

From tiny sunglasses to leather coats, the film’s costume designer Kym Barrett writes about why the film’s look feels so relevant in our uncertain world

• Read more from the spring/summer 2020 edition of The Fashion, our biannual style supplement

I never thought The Matrix would have the impact it has had on fashion. But from long leather coats to so-called “Matrix-style” sunglasses, the costumes I designed in the 90s continue to have influence to this day.

Part of the reason they are still in the ether is because they were so iconic. The silhouettes, for instance, had to be instantly recognisable so that viewers could tell who each character was, even in the dark. All of the costumes are fairly immune to period, which is what makes them relatable, even now.

The sixth installment in our weekly series spotlights titles that may have been lost in the news amid the COVID-19 crisis

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

A 16-year-old boy has suffered serious injuries after he was stabbed in a "senseless" attack in north-east London.

Read our live coronavirus updates HERE Coronavirus: The symptoms

7.45am update: Tragic pregnant mother's baby loses fight for life

John Lewis sales have plunged, despite a surge in online orders, after it was forced to shut stores in face of coronavirus.

A man in his 50s is fighting for his life after a stabbing in Notting Hill.

Police have been left "flabbergasted" after a man who coughed in an officer's face claiming to have Covid-19 was spared jail. .