The brain this morning does not want to function . One side is saying get up get moving get out . The other side replies in a negative fashion . Let me stay in bed a bit longer. My foot aches . Underneath and on top. Shoes are rubbing toes from so much

Jahvier Perez, 26, faces attempted murder, assault and child endangerment charges in the grisly Saturday morning attack, which may have left the two-year-old brain-damaged, police sources said.

Mamadou Bah, 19, an immigrant from Senegal who dreamt of playing pro basketball, died after he stumbled into Gentlemen’s Quarters Salon on Church Ave. near Ocean Ave. in Flatbush just before 10 p.m. Tuesday.

Researchers used rabbits and antidepressants to search for a link between orgasm and ovulation in female mammals.

The last thing L.A. County needs during a coronavirus pandemic is a turf battle between the sheriff and the Board of Supervisors.

"Never in my wildest dreams did I think it would be my brother until I saw everything the next day and saw his name," said Rosemary Gomez, 38. “I was like, ‘No, it can’t be him, it can’t be him.' Then his (estranged) wife called me. She was in a state of shock."

Four fire engines were at the scene

Taika Waititi's irreverent but humanist look at a boy in the Hitler Youth has been a major presence this awards season — for good and bad.

Find out if your favorite film, TV show or commercial won at the 22nd CDGAs, which were hosted by Mindy Kaling. Also honored were Charlize Theron, Adam McKay, Michael Kaplan and Mary Ellen Fields.

'Jojo Rabbit' costume designer Mayes C. Rubeo made her mark with Mel Gibson's 'Apocalypto.' For Taika Waititi, she turned to history and art for inspiration.

In Palm Desert, singer-actress Abbe Lane and her husband, theatrical agent Perry Leff, have sold their golf course retreat for $2.91 million.

'Bad Therapy' stars Michaela Watkins as a devious couples therapist preying on wealthy Westsiders.

The suspect is a 21-year-old Noblesville man who is facing three felony charges.

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Beneath that bland obfuscation, the momentum is all in one direction. The speed of decision making is seriously slowed by the friction of several concerns.

Some are worried about the legality of an apparent breach of an arms embargo. US Secretary of State Hillary Clinton isn't one of them. She says a transfer of arms would be legal.

With "flickers" of intelligence that the rebels may contain al-Qaeda supporters come deep concerns that Nato would be arming the enemy.

You don't have to be the CIA or SIS to know this is likely to be true. Libyan al-Qaeda fighters were active in Iraq, and the closely linked Islamic Fighting Group has been active in the past.

Defence Secretary Robert Gates may have some doubts about this path.

After all, he was one of the CIA officers involved in arming the mujahideen in the 1980s. That's right: the guys who became the Taliban, whom the Americans are fighting to this day.

But most of the discussion is missing a much bigger point.

"Arming the rebels" is a convenient shorthand, but anyone who thinks it is that simple is living in an exciting Boy's Own world of adventure that bears little relationship to real military conflict.

Former CIA officer Bruce Riedel, who chaired Mr Obama's review of Afghanistan and Pakistan policy, told me: "This is more complex than flying planes over and throwing AK-47s on the ground."

The sort of heavy weapons that would make the difference require months of intense training. But Mr Riedel thinks the path is set.

We are past the Rubicon. Barring a miracle, the situation looks like a stalemate. If we don't want to live with that, it means boots on the ground.

He says that as America boots are politically out of the question, that means the rebel forces will have to defeat Col Gaddafi. My BBC colleagues on the front line say while the rebels lack serious weaponry, what they lack even more is a coherent plan.

Mr Riedel says as well as training in specific weapons they need "organisation and discipline".

"It is about turning a rabble into an army," he says.

It seems to me that this is a slippery slope. You provide weapons, so you provide trainers. The trainers need protecting. The protectors needs supply lines. The supply lines need protecting. Before you know it there are more than just a few foreign boots on the ground.

Mr Riedel again:

Mission creep is inevitable. That is why you saw such an anguished debate. Those most reluctant, like the defence secretary, know that and will want a clarity of mission and more troops. The uniformed military have understood from the beginning once you start these things they snowball.

America does have experience in this field. There was another conflict where it sent a few people to oversee the supply of military equipment to local fighters and the French. That expanded to a few hundred advisers, to supply a little guidance and little training at a distance. Before long some more troops were sent. That's when it became known as the Vietnam War.

A Palm Desert man crashed his car, stabbed a good Samaritan who tried to free his daughter from the wreck and flung the girl off a cliff, killing her, according to the Riverside County Sheriff's Department.

Twelve people were injured by the blaze in a 49-storey residential building in Sharjah.

Police charge David Egan with the murder of Danny Pearce in Greenwich, south-east London.

Police are investigating a house robbery in which a couple in Amanzimtoti, on the south coast of KwaZulu-Natal, believed to be in their 50s was stabbed.

Six-time world champion Lewis Hamilton has said he feels "fresher than ever" following an unexpected break from Formula One.

The following article, Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place”, was first published on 100PercentFedUp.com.

Texas Governor Greg Abbott just changed the coronavirus order to free Salon A La Mode owner Shelley Luther from jail. Abbott tweeted out a comment about the poor treatment of the business owner: Throwing Texans in jail whose biz’s shut down through no fault of their own is wrong. I am eliminating jail for violating […]

Continue reading: Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place” ...

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

(Queensland University of Technology) It started life as the concept drawing for a mobile 'status update' tool only geeks could love. Now we cannot imagine a world without Twitter, its hashtags, and the worldwide movements it has helped create. A new book tracks its journey.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

1 onion, grated 1 cup Greek yoghurt 1/2 cup olive oil 1/2 lemon, juiced 2 cloves of garlic, crushed 1 tsp. smoked paprika 1/2 tsps. ground coriander 1/2 tsps. ground cumin 500g chicken thighs, cut in to 3 cm pieces 2 tbsps. sesame seeds, toasted tabbouleh 100g burghul 2 1/2 cups frozen peas 1 handful of flat leaf parsley, chopped 1 punnit of cherry tomatoes, halved 1 handful of mint leaves, lightly chopped 3 shallots, thinly sliced 200g Greek feta, crumbled 1/3 cup olive oil 1/2 lemon, juiced 1/2 tsp. ground cinnamon Good pinch of sea salt flakes and black pepper

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Phillippa Grogan. Phillippa's latest book is "Phillippa's Home Baking".

Cabbage at its best.

4 x 150 x g of pork loin steaks as your butcher to cut 3 x cup (210 g) Panko Breadcrumbs (Japanese bread crumb) 1/2 cup (80g) Plain flour Chopped flat leaf parsley, thyme, rosemary 2 Eggs, lightly beaten 1/2cup (80g) finely grated Parmesan CABBAGE SLAW 500 grams of Cabbage finely shredded Squeezed of Lemon juice 1/4 cup (60 ml) quality cider vinegar add to taste. May need less. 2 Tablespoon of Macadamia Oil 1 Tablespoon chop parsley Aioli just a little bit to bind Sea salt and cracked pepper 100 ml Macadamia oil for cooking 4 juicy lemon wedges to squeeze over Pork

Rabbi Lord Jonathan Sacks offers thoughts on how we can navigate the coronavirus pandemic with courage, hope and empathy. With wisdom and clarity, he speaks on leadership, fear, death, hope and how we could use this moment to build a more just world. Watch for a special, impromptu prayer about halfway through the conversation. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and head of curation Helen Walters. Recorded March 30, 2020)

From Trash to Treasure is an intensely honest account of a life powerfully redeemed and is a demonstration of the goodness of God. Lee Habbershaw's journey to recovery from sexual abuse moved me to tears - sometimes in compassion, but often in joy. The book is rich with the landmark of life events and Biblical truths which, layer by layer, led Lee into the powerful teaching and counselling ministry she operates in today. This book could change your life (page 7)

Stroud, G. J. (Gabrielle J.), 1977-

1968.

Leipzig : S. Hirzel, 1881.

Names, Personal -- England.

Names, Personal -- Welsh.

Names, Personal -- Scottish.

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination both in vitro and ex vivo models. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. These in vivo findings corroborate initial in vitro studies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.

SIGNIFICANCE STATEMENT This study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.