There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group,RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—,W represents a single bond or a C1-3 alkylene group, andRing B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group,Y represents a nitrogen atom or the formula N+(RF),RF represents a C1-4 alkyl group, andm and n, which may be the same or different, each represent an integer of 0 or 1.

A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.

A description is given of N-(1,2,5-oxadiazol-3-yl)pyridinecarboxamides of the general formula (I) as herbicides. R in this formula (I) stands for radicals such as hydrogen, organic radicals, and other radicals such as halogen. W stands for a substituted pyridyl radical.

The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention.

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to mophinan compounds useful as μ, δ and/or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

The present invention provides compounds having the general structural formula (I), and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.

Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I). A crystal structure of an inhibitor cocrystallized with farnesyl pyrophosphate in the active site of rat FTase illustrates that the para-benzonitrile moiety is stabilized by a π-π stacking interaction with the Y361β residue, suggesting an importance of this component of the inhibitors.

Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

A fastening assembly includes a connecting member, a mounting member mounted to the connecting member, and a sliding member. The mounting member includes a first fixing portion. The sliding member is slidably received in the mounting member and the connecting member. The sliding member includes a first end exposed out of the first fixing portion, and a second end slidably received in the connecting member. The second end of the sliding member is operable to be extended out of or substantially coplanar with an end of the connecting member. The fastening assembly can be utilized to mount a heat sink to a board.

The present invention provides a method for manufacturing a fitting that has a configuration where a fitting plate and a blind nut are integrally formed and also provides a tap tool for use in this method. According to the present invention, performing tap processing to an internal diameter portion to integrally form a portion corresponding to the blind nut, when a tap tool having a protrusion at an end thereof is utilized to be inserted into the bag-like blind hole at a planned part of the blind nut and the tap processing is carried out, the protrusion provided at the end of the tap tool comes into contact with an inner wall at the end of the bag-like blind hole, and a pressed material thereby forms a convex shape on an outer side of the bag-like blind hole.

A fastener includes a t-nut having a barrel and a flange. The flange includes an opening which leads to a threaded barrel. The threaded barrel extends from the opening in the flange to a distal end portion thereof. An end cap has an annular recess on a first side thereof and has a raised annular ridge on a second side thereof. The raised annular ridge of the end cap is affixed to the flange of the t-nut by welding the end cap to the flange. Dirt, water and moisture cannot enter the barrel because the end cap is sealed to the flange. Additionally, the barrel may be relatively short as it is fully threaded prior to the affixation of the end cap to the flange.

Provided is a method for manufacturing an FRP member with insert which enables to reduce a machining time to improve productivity. First, a threaded hole 11 is formed in an insert 3. An FRP member 2 where at least the threaded hole 11 of the insert 3 is covered with a coating 4 made of FRP is molded. A counter-bored hole 31 that penetrates the coating 4 of the FRP member 2 to communicate with the threaded hole 11 of the insert 3 is formed, to thereby obtain an FRP component 1 with insert. Accordingly, a machining step after molding the FRP member 2 in which dry machining is required includes only the boring step of forming the counter-bored hole 31 in the FRP member 2. Thus, the machining time can be reduced, and the productivity can be improved.

In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.

A threading cutting insert achieves high shape accuracy of a screw to be processed, and saves on manufacturing cost. Therefore in the threading cutting insert, a plurality of tooth-shaped cutting edges are formed in a cross ridge line portion between a rake face and flanks formed in a cutting side face, wherein the plurality of mountain-shaped cutting edges provides at least one finishing cutting edge for transferring a shape of a screw, and at least one roughing cutting edge formed in a tooth shape smaller than that of the finishing cutting edge. A flank of the finishing cutting edge includes a first flank, and a second flank having a clearance angle larger than that of the first flank, wherein the finishing cutting edge, the first flank, and the second flank are sequentially provided in that order from the rake surface in a direction of a lower surface of the insert.

A pivoting split thread chasing die with fastener is disclosed. In one example, the fastener can include a retainer that captures the fastener within one half of the thread chasing die. The thread chasing die may make it easier for a user to refurbish threads of large bolts and studs.

A fastener suitable for use in airplane manufacture or repair that is coated with a pre-mixed moisture cure sealant. The sealant layer is coated with a frangible moisture barrier that will break apart when the fastener is installed, thus exposing the sealant to atmospheric moisture. Once exposed to moisture, the sealant will begin to cure. Preferred embodiments also provide a moisture indicator that provides a visual indication that the outer moisture resistant layer has been damaged.

An apparatus to produce a self-piercing and clinch nut includes a first forging die assembly, a second forging die assembly, a third forging die assembly, a transfer mechanism, and a controller. The first forging die assembly is configured to subject a blank to first processing. The second forging die assembly is adjacent to the first forging die assembly and configured to subject the blank to second processing after the blank has undergone the first processing in the first forging die assembly. The third forging die assembly is adjacent to the second forging die assembly and configured to subject the blank to third processing after the blank has undergone the second processing in the second forging die assembly. The controller is configured to control the first forging die assembly, the second forging die assembly, the third forging die assembly, and the transfer mechanism to operate.

A releasable lock nut assembly for securing a bearing on a threaded hub may include a thrust washer including a disk portion and a peripheral skirt extending axially away from the disk portion, the peripheral skirt having a plurality of openings and a characteristic diameter measured at an axial location of the openings, and a protuberance proximate to at least one of the openings. The assembly may also include a lock ring inserted into the thrust washer, where the lock ring includes a plurality of tangs that extend beyond a lock ring major diameter such that the tangs fit within the openings of the thrust washer. The protuberance may be deformed such that all of the peripheral skirt is within the characteristic diameter, and the protuberance may define an internal envelope of the thrust washer where the internal envelope is larger than the major diameter of the lock ring.

A method for manufacturing a bolting part, such as a screw or a nut. The bolting part having a head with a periphery having at least one shoulder extending in a radial plane. The method includes at least the following forming steps: shearing of a wire of material so as to obtain a part of determined length, calibration of the part so as to correct the geometry of the part, rough machining of the calibrated part so as to obtain the head of the bolting part, and finishing of the rough-machined part by means of a third punch so as to form a head having at least one shoulder. The calibration, rough machining and finishing steps being carried out only by cold heading.

A polishing pad, having a polishing layer comprising a thermoset polyurethane foam, wherein the polishing layer has an in-plane variation of 12 or less in microrubber A hardness, the variation being obtained by measuring the polishing layer from a polishing surface side of the layer, the thermoset polyurethane foam contains, as raw material components, an isocyanate component and active-hydrogen-containing compounds, and the active-hydrogen-containing compounds comprise a trifunctional polyol having at least one terminated hydroxyl group that is a secondary hydroxyl group, and having a hydroxyl group value of 150 to 1,000 mg KOH/g in an amount of 10 to 50 parts by weight for 100 parts by weight of the active-hydrogen-containing compounds.

The process and apparatus for mobile separation and recovery of used contaminants abrasive blasting material from a work site. Entrained contaminants within used blast material are removed by a self-contained mobile platform process using multiple stage cleaning system including dual cyclonic separation, multiple stage dust filters with large debris magnetic drum, airwash and vibratory separation in a flow through containment and blast media separation process.

A device for processing welding electrodes with a grinding surface driven by a driving motor with a shaft, which faces the motor and runs in a housing, wherein at least one opening is provided in the housing for guiding a welding electrode for grinding in a defined position relative to the grinding wheel. The housing is releasably fixed to a motor flange for bearing the shaft, and the grinding wheel is arranged on a side of the motor flange which is remote from the motor. The motor flange is formed by a sleeve, which is adapted to be stuck onto the housing in such a way, that at least one opening extends from the circumference of the housing towards the grinding surface facing the motor.

An abrasive tool including a CMP pad conditioner having a substrate including a first major surface, a second major surface opposite the first major surface, and a side surface extending between the first major surface and the second major, wherein a first layer of abrasive grains is attached to the first major surface and a second layer of abrasive grains is attached to the second major surface. The conditioner further includes a first sealing member extending in a peripheral direction along a portion of the side surface of the substrate.

A method of chemical mechanical polishing a substrate includes polishing a metal layer on the substrate at a polishing station, monitoring thickness of the metal layer during polishing at the polishing station with an eddy current monitoring system, and controlling pressures applied by a carrier head to the substrate during polishing of the metal layer at the polishing station based on thickness measurements of the metal layer from the eddy current monitoring system to reduce differences between an expected thickness profile of the metal layer and a target profile, wherein the metal layer has a resistivity greater than 700 ohm Angstroms.

A tool is disclosed for selective honing of the outer diameter of a cylinder using an abrasive belt in semi-circular contact upon the outer-diameter of a cylindrical work-piece to perform a similar function to honing the inner-diameter of a hollow cylinder. The belt is retained within the tool body by U-shaped restraint arms, and a slot in the tool body. A clamp block retains the ends of the belt which exit the slot. Springs on the arms, and contact of the block on the outside of the tool body, force the belt into a triangular shape inside the body. A cylindrical work-piece inserted within the triangular shaped belt causes the belt to deform into three semi-circular areas of contact between the belt and work-piece. When the work-piece is rotated, the belt abrades material from the work-piece.

A run-off securing device, in particular a run-off securing device of a handheld power tool, is configured to avoid running off of a clamping element and/or a tool from a spindle. The device has at least one transmission unit, which is removably coupled to the spindle and has at least one first transmission element and at least one second transmission element. The at least one second transmission element is movable in relation to the at least one first transmission element. The transmission unit has at least one movement changing unit, which at least partially transforms a first relative movement between the at least one first transmission element and the at least one second transmission element into a second relative movement in a braking mode.

The method for machining a series of workpieces (21) via at least one machining jet includes the following steps: each workpiece (21) is associated with an identifier for uniquely identifying the workpiece,during the machining of a respective workpiece, the temporal characteristic of the machining jet is detected by at least one sensor (30),the detected temporal characteristic is evaluated so as to obtain at least one comparative value, andfor detecting incorrect machining, the at least one comparative value is compared with at least one threshold value.

Particularly, a thin-film solar cell panel or the like is processed without necessity of attaching and detaching of mask and washing steps with respect to a workpiece in a fine blasting employing a fine abrasive. A negative pressure space (20) and an opposing negative pressure space (40) having openings (22, 42) are opposed by being spaced at a movement allowable interval of the workpiece such as a thin-film solar cell panel or the like and so as to face one side edge in the same direction as a moving direction of the workpiece. Further, a fine abrasive is injected while relatively moving the workpiece in a moving direction (T) with respect to a blast gun (30) in which an injection hole (31) is disposed within the negative pressure space (20), and the fine abrasive injected into the negative pressure space (20) and/or the opposing negative pressure space (40) and a cut and removed cut scrap such as a thin film layer or the like are sucked and recovered through the intermediary of suction devices (21a, 21b) and/or an opposing suction device (41) respectively communicating with the spaces (20) and/or (40).

An enclosed polishing apparatus include a housing, a fixing seat, a guiding mechanism, and a chain-driven polishing mechanism. The housing includes a bottom housing and a top housing connected to the bottom housing. The fixing seat is securely placed in the bottom housing. The guiding mechanism is placed in the top housing above the fixing seat. The polishing mechanism is movably mounted on the guiding mechanism above the fixing seat. The polishing mechanism is driven and guided by the guiding mechanism to follow a desired polishing contour on a workpiece.

The present invention provides transgenic soybean event MON87769, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a sample, methods for detecting the presence of said soybean event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event in a sample, growing the seeds of such soybean event into soybean plants, and breeding to produce soybean plants comprising DNA diagnostic for the soybean event.

The present invention provide a two-component anti-seizure agent for hot metal working process comprising the first aqueous solution and the second aqueous solution, wherein the first aqueous solution contains 10˜30 mass % of sodium silicate equivalent to anhydride to 100 mass % of total mass of the first aqueous solution, and the second aqueous solution contains at least one kind selected from a group consisting of: an organic acid and water-soluble amine salts thereof, an inorganic acid and water-soluble amine salts thereof, a water-soluble amine, a water-soluble alcohol, and a water-soluble metal chloride. When the two-component anti-seizure agent is applied onto disk-roll type guide shoes, it can be provided and maintained on the circumferential surface of the disk-roll type guide shoes without washed away by rolls' cooling water. Thereby, the anti-seizure agent does not adhere to rolls and the rolls and a pipe material do not cause slippage each other. Thus, it is capable to carry out piercing-rolling of the pipe material.

Provided for are lubricant base stocks with improved filterability. The lubricant base stock includes a bright stock and an effective amount of a heavy neutral. The filterability of the base stock as measured by the Membrane Filtration Method is less than or equal to 400 seconds. Also provided for are lubricating oils with improved filterability and methods of improving the filterability of lubricant base stocks.

Polymeric compositions and methods for making and using the same are provided. The polymeric composition can include a first ethylene-based copolymer and a second ethylene-based copolymer. The first ethylene-based copolymer can have a weight percent of ethylene-derived units based on a weight of the polymeric composition (EA) ranging from about 35 wt % to about 52 wt % and a weight-average molecular weight (MwA) of less than or equal to 130,000. The second ethylene-based copolymer can have a weight percent of ethylene-derived units based on the weight of the polymeric composition (EB) ranging from about 65 wt % to about 85 wt % and a weight-average molecular weight (MwB) of less than 130,000.

Disclosed are rheology modifiers comprising compositionally disperse polymeric compositions and/or crystallinity disperse polymeric compositions that may be useful in modifying the rheological properties of lubrication fluids, and methods for making such compositions. The compositionally disperse polymeric composition are formed from at least two discrete compositions of ethylene copolymers. The crystallinity disperse polymeric composition are formed from ethylene copolymers having at least two discrete values of residual crystallinity.

The lubricating base oil of the invention is characterized by satisfying at least one of the following conditions (a) or (b). (a) A saturated compound content of 95% by mass or greater, and a proportion of 0.1-10% by mass of cyclic saturated compounds among the saturated compounds.(b) The condition represented by the following formula (1). 1.435≦n20−0.002×kv100≦1.450 (1) wherein n20 represents the refractive index of the lubricating base oil at 20° C., and kv100 represents the kinematic viscosity (mm2/s) of the lubricating base oil at 100° C.

The invention provides a lubricant composition containing (A) an ionic liquid having an anion represented by formula 1: (Rf1-SO2) (Rf2-SO2) N− or formula 2: (Rf3) (Rf3) (Rf3) PF3− wherein Rf1 and Rf2 in formula 1 may be the same or different and are each F, CF3, C2F5, C3F7 or C4F9, and Rf3 in formula 2 may be the same or different and is CF3, C2F5, C3F7 or C4F9; and (B) a fatty acid amine salt in an amount of 0.1 to 5.0 mass %. The lubricant composition of the invention can favorably be used under a high vacuum or an ultra high vacuum, or under high temperatures, and exhibits excellent rust prevention properties.

Provided is a method for preparing a grease composition, which comprises mixing an amine in a lubricating bas oil and an isocyanate in a lubricating base oil under high pressure and high flow rate impingement. In one embodiment, the mixing and reaction occurs in a reaction injection molding device. The resulting grease composition is an extremely low noise grease, being virtually clear of any urea thickener particles.

The invention provides a grease composition for a hub unit bearing employing an angular contact ball bearing, containing (a) as a thickener a mixture of diurea compounds represented by formula (I): R1—NHCONH—R2—NHCONH—R1, formula (II): R1—NHCONH—R2—NHCONH—R3, and formula (III): R3—NHCONH—R2—NHCONH—R3 wherein R1 is cyclohexyl group, R2 is a divalent aromatic hydrocarbon group having 6 to 15 carbon atoms, R3 is a straight-chain or branched alkyl group having 12 to 20 carbon atoms, and (R1/(R1+R3))×100=85 to 95 mol %; (b) a base oil; (c) a molybdenum dialkyldithiocarbamate; and (d) a calcium sulfonate. The grease composition of the invention, when used in the hub unit bearing, shows minimum leakage, excellent anti-flaking properties and satisfactory bearing lubrication life.

Corrosion by ammonia/amine salts in hydrocarbon streams such as distillation overhead streams that contain a mineral acid and water can be prevented, avoided or minimized by adding certain strong amines to the streams. The amines have a pKa between about 10.5 to about 12 and include, but are not necessarily limited to, dimethylamine, diethylamine, dipropylamine, diisopropyl-amine, di-n-butylamine, diisobutylamine, di-sec-butylamine, di-tert-butylamine, pyrrolidine, piperidine, and combinations thereof. If the hydrocarbon stream further includes a nitrogen-containing compound such as ammonia, a tramp and/or a residual amine which can form a corrosive salt with the mineral acid, then the added amine is a stronger base than the tramp or residual amine, if present. The amount of added amine is greater than total amount of nitrogen-containing compound, so that any corrosive salts formed are less corrosive than the salts that would otherwise form from the ammonia and/or tramp amine.

Various esterified alkyl ketal ester or hydroxyalkyl ketal ester products are useful as components of organic polymer compositions. The ketal esters are produced in certain transesterifications between alkyl ketal esters and/or hydroxyalkyl ketal esters and polyols, aminoalcohols, polyamines, and/or polycarboxylic acids. The products are excellent plasticizers for a variety of organic polymers, notable poly(vinyl chloride) plastisols. The products are also very good lubricants for many lubrication applications.

Systems and methods are provided for hydroprocessing a petroleum fraction, such as a bottoms fraction from a fuels hydrocracking process, to generate a lubricant base oil. A fuels hydrocracking process typically has less stringent requirements for the sulfur and nitrogen content of a feed as compared to a lubricant base oil. Additionally, depending on the nature of the feed for the fuels hydrocracking process, the bottoms fraction may contain a relatively high level of aromatics compounds. The aromatic content of such a petroleum fraction can be reduced using a aromatic saturation stage with multiple catalyst beds, or alternatively using a reactor (or reactors) with multiple aromatic saturation stages. The catalysts in the various beds or stages can be selected to provide different types of aromatic saturation activity. An initial bed or stage can provide activity for saturation of 1-ring aromatics in the petroleum fraction. One or more subsequent beds or stages, operating at successively lower temperature, can then be used to reduce the multiple-ring aromatic content of the petroleum fraction.

A thickened grease composition is provided by process of heating a mineral oil and 12-hydroxystearic acid with lithium hydroxide and forming a simple lithium grease to which at least one component selected from the group comprising succinic acid, glutaric acid, adipic acid, 6-hydroxycaproic acid, dimethyl succinate, dimethyl glutarate, dimethyl adipate, methyl hydroxycaproate, cyclohexanediols, methyl 5-hydroxyvalerate, methyl valerate, gamma butyrolactone, and methyl levulinate or mixtures thereof.

It is known by the inventor that a universal synthetic lubricant additive that can greatly enhance the performance standards of existing lubricants, petroleum based or synthetic, imparts a new and desirable property not originally present in the existing oil or it reinforces a desirable property already possessed in some degree can greatly benefit the consumer. Although additives of many diverse types have been developed to meet special lubrication needs, their principal functions are relatively few in number. This universal synthetic lubricant additive (invention) with micro lubrication technology, when used as directed will reduce the oxidative or thermal degradation of the host oil, substantially reduce the deposition of harmful deposits in lubricated parts, minimize rust and corrosion, control frictional properties, reduce wear, temperature, sludge, varnishes and prevent destructive metal-to-metal contact, reduce fuel consumption and harmful emissions while improving performance through increased horsepower and torque.

Provided are a lubricant composition capable of reducing friction between sliding parts at least one of which contains an aluminum-based material in a lubrication section, and a method for lubricating an aluminum-based member with the composition. The lubricant composition is for use in a lubrication section having sliding parts at least one of which contains an aluminum-based material, and contains a lubricant base oil and at least one of a phosphorus-containing carboxylic compound and a metal salt thereof (component (A)) at 0.001 to 1 mass % of the composition in terms of phosphorus. The composition may suitably be used as lubricant such as drive train lubricant for automatic or manual transmissions, grease, wet brake oil, hydraulic actuation oil, turbine oil, compressor oil, bearing oil, refrigerant oil, and the like used in apparatus having the sliding parts.