A method for processing workpieces with a laser processing machine including a laser processing head having a nozzle receiving member configured to receive a laser nozzle. The method includes holding a workpiece on a workpiece support plane of a workpiece support, transferring a laser nozzle between a nozzle magazine of a nozzle changing device located at a first side of the workpiece support and a nozzle receiving member of the laser processing head located at a second side of the workpiece support such that the laser nozzle is assembled on or disassembled from the nozzle receiving member, and moving the laser nozzle through a through-opening defined in the workpiece support along a transverse direction to the workpiece support.

A system for loading/unloading sheets is disclosed, some of which also being of metal, and handling method thereof, serving a laser cutting center. The system includes a pair of rails (1, 2), supported at a preset height above a feeding tray (T) of the cutting center, whereon at least one Cartesian robotized hand is movably mounted, capable of moving along horizontal axes X and Y as well as along a vertical axis Z, mutually orthogonal, and including at least two bridge cranes (3, 4) sliding along the rails (1, 2) each of which supports at least one pair of robotized hands (5-8), and the robotized hands (5-8) have an electromagnetic pick-up head which may be coupled with a suction-cup device (103). Feeding tray (T) consists of bars whereon small tesserae (204) of ceramic material are fitted.

A carriage is moved in a direction including a Y axis component in order to move a turning process tool that is attached to a tool spindle along a horizontal line that is perpendicular to a Z axis, and thus, a turning process is carried out on a workpiece which is attached to a workpiece spindle.

A subsea tool changer comprises a housing; a rotatable carousel rotatably mounted within the housing and adapted to receive a plurality of selectively removable tools; a tool changer that can select a predetermined one of the plurality of tools from the carousel; and a power drive adapted to provide a predetermined function to a tool selected by the tool changer, the power drive further comprising a first power drive interface. In typical use, a selectively removable tool is placed onto the rotatable carousel which is rotated so that a desired selectively removable tool is positioned adjacent to a tool driver which is then mated with the desired selectively removable tool. The tool changer and mated selected removable tool are moved outward toward an outer boundary of the housing and the tool changer extended at least partially outside the housing outward towards a predetermined tool working position. The tool changer is then pivoted to position the selected removable tool to its predetermined tool working position.

A cutting device includes a support base, a first slide module, a second slide module slidably connected to the first slide module, and a cutting module. The support base includes a support surface and a slide portion on the support surface. The first slide module is slidably positioned on the slide portion. The sliding direction of the second slide module is perpendicular to the sliding direction of the first slide module. The cutting module includes a fixed frame fixed on the second slide module, a driving device fixed on the fixed frame, and a cutter connected to the driving device. The driving device drives the cutter to rotate around a central axis of the cutter and move up and down along the central axis. The central axis is perpendicular to the support surface. The cutter includes a hollow cylindrical blade. An end surface of the blade faces the support surface.

A head tool changer for use with a deposition-based digital manufacturing system, the head tool changer comprising a tooling unit configured to retain a deposition head, a grip unit configured to engage with tooling unit and to relay electrical power to the tooling unit, and a master unit operably mounted to a gantry and configured to engage with the tooling unit and to relay electrical power to the tooling unit.

A section member drilling or milling machine comprises a machine bed for supporting a workpiece to be drilled, the machine bed including guides for controllably sliding thereon a support comprising precision vertical guides thereon a platform is engaged, the platform comprising parallel horizontal guides slidably supporting a carriage, in turn supporting a cantilever arm, including a driving motor for controllably driving a drilling and milling tool along parallel guides of the cantilever arm.

A network component comprising at least one processor coupled to a memory and configured to exchange security information using a plurality of attributes in a management entity (ME) in an optical network unit (ONU) via an ONU management control interface (OMCI) channel, wherein the attributes provide security features for the ONU and an optical line terminal (OLT). Also included is an apparatus comprising an ONU configured to couple to an OLT and comprising an OMCI ME, wherein the OMCI ME comprises a plurality of attributes that support a plurality of security features for transmissions between the ONU and the OLT, and wherein the attributes are communicated via an OMCI channel between the ONU and the OLT and provide the security features for the ONU and the OLT.

Methods and systems for decoding a signal include compensating for impairments in a received signal using at least carrier phase estimation, where residual phase error remains after compensation; calculating symbol log-likelihood ratios (LLRs) for symbols in the compensated signal using Monte Carlo integration; demapping the symbols in the compensated signal using the symbol LLRs and extrinsic information from signal decoding to produce one or more estimated codewords; and decoding each estimated codeword with a decoder that generates a decoded codeword and extrinsic information.

An undersea long-haul transmission system includes an optical fiber transmission span and a coherent detection and digital signal processing module for providing dispersion compensation. The transmission span includes at least one fiber pair comprising substantially equal lengths of a positive-dispersion first fiber and a negative-dispersion second fiber that are configured to provide a signal output at transmission distances greater than 10,000 km, in which the combined accumulated dispersion across the operating bandwidth does not exceed the dispersion-compensating capacity of the coherent detection and digital signal processing module. Further described is a fiber for use in an undersea long-haul transmission span. At a transmission wavelength of 1550 nm, the fiber has a dispersion coefficient in the range of −16 to −25 ps/nm·km, and a dispersion slope in the range of 0.04 to 0.02 ps/nm2·km.

Provided is a polarization separation device which converges filter coefficients used in polarization separating process more quickly. The polarization separation device according to the present invention comprises: a first filter means 11 which applies filtering process on each of first and second input signals, which are detected from an received optical signal, with elements of a characteristic matrix representing the inverse characteristics of an optical transmission path as filter coefficients, and uses each of the filtered signals to output a first output signal; a second filter means 12 which applies filtering process on each of the first and second input signals with the other elements of the characteristic matrix as filter coefficients, and uses each of the filtered signals to output a second output signal; a filter coefficient update means 13 which updates the first filter coefficients using a relation between the elements of the characteristic matrix so as to further reduce both error signals of the first and second output signals; and a filter coefficient update means 14 which updates the second filter coefficients using the relation between the elements of the characteristic matrix so as to further reduce both error signals to the first and second output signals.

A WDM optical signal is transmitted through a tunable optical filter and is polarization-nulled to find optical signal to noise ratio of individual WDM channels. The polarization nulling can be performed using a heuristic multipoint extrema search method, such as Nelder-Mead method. A plurality of checkpoints can be included in the search to verify the progress and to improve the overall robustness of a real-time polarization nulling.

An optical transport network system includes a plurality of NEs, each transmitting wavelength-multiplexed optical signals. Each NE includes a routing information DB that is used to store reachable area information, which contains identifiers of other NEs in a range within which the optical signals can be transmitted from the own NE without using an REG. A FROM NE includes a path candidate searching unit that searches for a plurality of path candidates for transmitting optical signals from the FROM NE to a TO NE. The TO NE includes a path selecting unit that selects a path for transmitting optical signals from among a plurality of path candidates. The path selecting unit obtains the number of times for which the REG is used for each of the plurality of path candidates; and, based on each number of times that is obtained, selects a path for transmitting the optical signals.

This invention relates to provisioning wavelength-selective switches and reconfigurable optical add-drop multiplexers to minimize the bandwidth narrowing effect from the optical filters. Novel architectures and methods are disclosed that can significantly reduce bandwidth-narrowing on channels in a reconfigurable WDM network where a large number of optical filter elements are cascaded. Instead of blocking unused channels as in the prior art, unused channels are selectively provisioned depending on the state of their adjacent channels. Unused adjacent channels of an active channel are provisioned to follow the same path as the active channels. As each channels is deployed, the channel frequency is selected so as to minimize bandwidth narrowing.

Optical fiber-based distributed communications systems that provide and support both RF communication services and digital data services are disclosed herein. The RF communication services and digital data services can be distributed over optical fiber to client devices, such as remote antenna units for example. In certain embodiments, digital data services can be distributed over optical fiber separate from optical fiber distributing RF communication services. In other embodiments, digital data services can be distributed over common optical fiber with RF communication services. For example, digital data services can be distributed over common optical fiber with RF communication services at different wavelengths through wavelength-division multiplexing (WDM) and/or at different frequencies through frequency-division multiplexing (FDM). Power distributed in the optical fiber-based distributed communications system to provide power to remote antenna units can also be accessed to provide power to digital data service components.

A laser relay module for free space optical communications including an optical telescope for receiving and transmitting optical beams; an optical diplexer for separating transmitting and received optical beams; an optical amplifier; a modulated beacon laser for line of sight control of a plurality of communicating remote network nodes; a beacon beam detector for detecting an incoming beacon optical beam for line of sight control of the optical telescope and receiving data from other network nodes; and means for inserting an output of the modulated beacon laser into the optical telescope for transmission to another network node, and for transporting the incoming beacon optical beam to the beacon detector.

An optical receiver circuit is disclosed in which a number of electrical signals are processed to extract data encoded therein. The electrical signals may be compared during the process to selectively remove one or more waveforms from one or more corresponding electrical signals. Various data signals, each including one or more waveforms, may then be processed to extract the encoded data. The optical receiver circuit reduces, or eliminates, electrical offsets which may be present in one or more of the electrical signals to reduce corresponding errors in the encoded data signals.

A cutting insert having a plurality of corner cutting edges has an upper face, a lower face, two longitudinal side faces and two transversal side faces connecting the upper face and the lower face. A through hole passes through central parts of the upper face and the lower face. The longitudinal side faces are opposite to each other and normal to both upper and lower faces, as are the transversal side faces. The upper face and the lower face are each provided with two chip discharge grooves, each chip discharge groove extending along a corresponding one of the transversal side faces, the two chip discharge grooves being inclined oppositely in the transverse direction so that the upper face and the lower face are each provided with two corner cutting edges at diagonally opposite corners. The longitudinal length of the insert is longer than the transversal length of the insert. The cutting insert can be mounted stably to a small-diametered cutter with a sufficient mounting surface.

A toolholder assembly includes a toolholder body having a coolant passage and a cutting insert seated within a recess of the body. The cutting insert includes an insert orifice extending between a top face and a bottom face that aligns with the coolant passage. A lock pin includes a lock pin orifice that aligns with and is in fluid communication with the coolant passage of the body. The lock pin orifice has an outlet port to allow the fluid to flow through the lock pin orifice and exit through the outlet port. A lock pin ring includes a coolant port in fluid communication with the outlet port of the lock pin to effectively discharge cooling fluid in the direction of a cutting area of the cutting insert.

A milling tool for slot milling includes a tool body and a plurality of separated first seats, which form root insert seats for root inserts arranged one after the other along a first line and a plurality of separated flank insert seats that includes a plurality of second seats for flank inserts . The plurality of second seats is arranged one after the other along a second line on a primary side of the root insert seats. A plurality of third seats for flank inserts is arranged one after the other along a third line on a secondary side of the root insert seats. Each flank insert seat includes a bottom surface, an inner side surface, and an outer side surface. Each flank insert includes an under side, an opposite upper side, and a circumferential edge side that forms a rake face connecting the upper side and the underside.

A cutting insert of the present invention includes an upper surface; a lower surface; a side surface; a cutting edge which is located along an intersection of the upper surface and the side surface, and comprises a major cutting edge, a flat cutting edge, and a minor cutting edge located between the major cutting edge and the flat cutting edge; and a land part located along the cutting edge on the upper surface. The land part includes a minor cutting edge land portion located correspondingly to the minor cutting edge. The minor cutting edge land portion is inclined downward toward a central part of the upper surface. The present invention also provides a cutting tool including the cutting insert, and a method of manufacturing a machined product by using the cutting tool.

A tool for both severing the end of a pipe and beveling the cut end includes a spiral cutting mill having an elongate end received in the bore of a frustoconical shell cutter. The shell cutter is locked for rotation with the cutting mill such that a single tool has two cutting surfaces, one for severing a length of pipe and one for beveling the outer edge thereof.

A cutting insert has at least first and second side surfaces, with a chip-control arrangement. The chip-control arrangement includes at least one projection disposed at an intersection of a corner of the cutting insert. When the chip-control arrangement includes two projections they can be disposed symmetrically on both sides of the intersection. Each of the at least one projections is elongated and extends longitudinally along an associated side surface.

A cutting insert is capable of boring or drilling without the formation of a prepared hole in a workpiece. A cutting edge includes a cutting edge portion extending from the outer peripheral side to the tool center axis side of a cutting tool body when the cutting insert is attached to a mounting seat, reaching a first plane including the tool center axis, and traversing from one side to the other side of a second plane which is perpendicular to the first plane and which includes the tool center axis.

A cutter insert assembly for a drill bit for boring into the earth, comprising a super-hard structure clampable to a support body by means of a clamp mechanism; the clamp mechanism comprising opposed or opposable compression members connected or connectable by a tension member capable of sustaining a clamping force between the compression members when the cutter insert assembly is in a clamped condition, in which condition the compression members exert opposing compressive forces on the super-hard structure and the support body, operable to clamp the super-hard structure to the support body, and in which condition the cutter insert assembly is self-supporting and capable of being mounted onto a drill bit body.

A cutting tool includes a polygonal cutter body and an end cutting insert for chipforming machining mounted in a serrated seat disposed at an axial end of the cutter body. A bottom surface of the insert has a plurality of parallel serrations meshing with corresponding serrations of the seat. The serrations extend transversely relative to the longitudinal axis for resisting axially rearward cutting forces applied to the insert. The seat is formed directly by the cutter body, or by a shim disposed beneath the insert. The shim is provided with a downward lip to transfer axial forces to the cutter body. The insert can be square or triangular, wherein the serrations are in the form of a plurality of sets of parallel serrations disposed adjacent respective cutting edges.

A cutting insert with a substantially triangular or square basic form is particularly suited for face milling at high feed rates. It has convex cutting edges, which are each made up of a circular arc and at least one straight portion. Each cutting edge has, adjoining a cutting corner, a straight face cutting edge that merges with a main cutting edge, having 1 to 3 straight portions, a circular portion with a radius of at most 80% of the radius Ri of the inscribed circle. The cutting edges have an all-round cutting edge chamfer with a chamfer angle α. This chamfer angle α has along the cutting corners a value in the range from −10° to −20° and changes continuously along sub-portions of the face cutting edge and main cutting edge and along the circular portion to a constant value in the range from 0° to −10°.

A cutting insert includes an upper surface; a lower surface; a side surface which is connected to each of the upper surface and the lower surface and includes a first side surface, a second side surface and a third side surface being adjacent to each other in order; an upper cutting edge including an upper major cutting edge located at an intersection of the upper surface and the first side surface, and an upper flat cutting edge located closer to the upper major cutting edge in an intersection of the upper surface and the second side surface; and a lower cutting edge including a lower major cutting edge located at an intersection of the lower surface and the third side surface, and a lower flat cutting edge located closer to the lower major cutting edge in an intersection of the lower surface and the second side surface. The second side surface comprises an upper flank surface connected to the upper flat cutting edge, and a lower flank surface connected to the lower flat cutting edge. As going from the upper surface to the lower surface, the upper flank surface is closer to a central axis extending between the upper surface and the lower surface and the lower flank surface is separated from the central axis in a side sectional view. A cutting tool including the cutting insert, and a method of manufacturing a machined product by using the cutting tool are also provided.

A cutting insert having excellent chip discharge performance is provided. The cutting insert (1) according to an embodiment of the present invention includes an upper surface (2), a lower surface (3), a side surface (4) connected to the upper surface (2) and the lower surface (3), and a cutting edge (5) which is located at an intersection of the upper surface (2) and the side surface (4), and includes a major cutting edge (51) and a flat cutting edge (52). The major cutting edge (51) includes a major cutting section (512) which has a concave shape and is inclined downward as a straight line connecting both ends thereof is away from the flat cutting edge (52) in a side view. A cutting tool (11) according to an embodiment of the present invention includes the cutting insert (1) and a holder (10) configured to attach the cutting insert (1) thereto.

An upper surface of a cutting insert includes a first rake face and a second seating surface. A lower surface of the cutting insert includes a second rake face and a first seating surface. The cutting edge includes a first cutting edge portion formed at a crossing edge line portion between the first rake face and a flank face and a second cutting edge portion formed at a crossing edge line portion between the second rake face and the flank face. The first cutting edge portion and the crossing edge line portion between the first seating surface and the flank face are positioned opposite each other. The second cutting edge portion and the crossing edge line portion between the second seating surface and the flank face are positioned opposite each other.

A cutting insert according to an embodiment of the present invention includes an upper surface; a lower surface; a side surface located between the upper surface and the lower surface; at least one concave part extending in a thickness direction in the side surface, and having one end thereof located at the upper surface; and a cutting edge which is located at an intersection region of the upper surface and the side surface, and is divided into a plurality of divided cutting edges with the at least one concave part interposed therebetween. The upper surface includes a first raised part located inwardly of the at least one concave part, and a plurality of second raised parts respectively located inwardly of the plurality of divided cutting edges. The plurality of the second raised parts are located inward compared to one end of the first raised part close to the cutting edge in a top view. A cutting tool including the cutting insert, and a method of manufacturing a machined product using the cutting tool are also provided.

A cutting insert according to an embodiment of the invention includes: an upper surface; a lower surface; a side surface which is connected to each of the upper surface and the lower surface, and includes a first side surface and a second side surface adjacent to each other; and a cutting edge including a major cutting edge located at an intersection of the upper surface and the first side surface, and a minor cutting edge located at an intersection of the upper surface and the second side surface. The upper surface includes a rake surface which is located along the major cutting edge, and is inclined downward as the upper surface separates from the major cutting edge. The second side surface includes a second upper constraining surface and a second lower constraining surface in order as the second side surface goes from the upper surface to the lower surface. The second upper constraining surface is inclined inward at an inclination angle α1 with reference to a central axis extending between the upper surface and the lower surface. The second lower constraining surface is continuous with the second upper constraining surface, and is inclined outward at an inclination angle α2 with reference to the central axis. A cutting tool with the cutting inserts, and a method of manufacturing a machined product by using the cutting tool are also provided.

A milling cutter for chip removing machining, including a basic body rotatable in a predetermined direction around a center axis and having a front end surface and an envelope surface that extends axially backward from the front end surface and is concentric with the center axis. A number of indexable milling inserts are mounted in respective peripherally spaced-apart seats having a mutually fixed pitch, each milling insert including an upper side, an under side and at least one clearance surface, the clearance surface together with the upper side delimiting at least two alternately active cutting edges that are uniform in their extension between first and second end points. The cutting edges of each milling insert are situated on different levels in relation to the under side of the milling insert to alter the effective pitch between the active cutting edges of the milling inserts by indexing of at least one of the milling inserts.

A double-sided cutting insert may generally comprise a top surface, a bottom surface, at least one side surface interconnecting the top surface and the bottom surface and forming at least one cutting edge, a through hole extending between the top surface and bottom surface, wherein each of the top surface and bottom surface comprise at least one anti-rotation element. The cutting insert may comprise a single anti-rotation element on the top surface and a single anti-rotation element on the bottom surface. The anti-rotation element may be proximate to the through hole. A cutting tool using the cutting inserts, as well as methods of making and using the same are also described.

A cutting insert is provided with a plurality of cutting portions formed at the intersection portion of each end surface and a peripheral surface. Each cutting portion includes first and second cutting edges. First corners and second corners which differ in their internal angles are alternately formed in each end surface. An internal angle of the first corner is smaller than an internal angle of the second corner. Each first cutting edge has a portion extending to approach the median plane as a distance from a corresponding first corner increases. A first side surface portion extending on the peripheral surface from each first cutting edge forms an insert internal obtuse angle, and a second side surface portion extending on the peripheral surface from each second cutting edge forms an insert internal acute angle.

Provided is a surface-coated cemented carbide insert obtained by containing at least WC powder and Co powder as raw materials, including a WC-based cemented carbide obtained by forming and sintering mixed raw materials containing at least any of (a) Zr compound powder, Nb compound powder, and Ta compound powder, (b) complex compound powder of Nb and Ta, and Zr compound powder, (c) complex compound powder of Nb, Ta, and Zr, (d) complex compound powder of Nb, Zr, and Ta compound powder, and (e) complex compound powder of Ta and Zr, and Nb compound powder, as essential powder components, as a substrate, and forming a hard coating layer on the substrate by vapor deposition, in which a Co enrichment surface region is formed in a substrate surface, Co content in the Co enrichment surface region satisfies to be between 1.30 and 2.10 (mass ratio) of Co content in cemented carbide.

A roughing end mill comprises an end mill body and plural inserts which are placed on an outer circumference of the end mill body with a predetermined distance apart from each other in the axial direction of the end mill body, wherein the plural inserts form plural insert rows which are provided in a circumferential direction of the end mill body, where the inserts are offset in the axial direction from each other between the different insert rows which are adjacent in the circumferential direction. The inserts have waveform cutting edges which face towards an outer circumferential side of the end mill body. One insert of one insert row and an insert of another insert row are positioned such that the waveform cutting edges of each of these inserts make up a waveform cutting edge row whose phase is continuous on a rotation trajectory around the axis.

A cutting insert (14) is formed with an insert aperture (32) opening out to insert top and bottom surfaces (14A, 14B) of the cutting insert (14). In a plan view of the insert top surface (14A), the cutting insert (14) and the insert aperture (32) both have oblong shapes which are elongated along a common insert longitudinal axis (AIL). The aperture (32) includes first and second side surfaces (32A1, 32A2) which each extend along the insert longitudinal axis (AIL), and aperture first and second end surfaces (32B1, 32B2) which each extend transverse relative to the insert longitudinal axis (AIL). At least one of the aperture first and second end surfaces (32B1, 32B2) is formed with a clamping lip (32C1, 32C2).

A cutting tool used for grooving and turning operations where a cutting insert is resiliently securable in a holder blade. The cutting insert includes an insert central lower surface located between, and recessed with respect to, two insert lower component surfaces, each having an insert lower abutment surface. At least one of the two insert lower component surfaces includes an insert inner curved ramp extending from its insert lower abutment surface to the adjacent insert lower intermediate surface and at least the other of the two insert lower component surfaces includes an insert outer curved ramp extending from its insert lower abutment surface to an adjacent end surface.

A cutting insert includes a first surface having a first rake surface, a second surface having a second rake surface, a central axis of the insert extending between the first and second surfaces, four side surfaces extending between the first surface and the second surface, and four cutting edges. Each cutting edge has a first cutting edge component and a second cutting edge component and being associated with a respective one of the first and second surfaces and with two respective ones of the side surfaces. The first rake surface is identical to the second rake surface and the first rake surface and the second rake surface are oriented at a 90° angle to each other about the central axis of the insert.

The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.

A MEMS sensor includes at least one closed nodal anchor along a predetermined closed nodal path on at least one surface of a resonant mass. The resonant mass may be configured to resonate substantially in an in-plane contour mode. Drive and/or sense electrodes may be disposed within a cavity formed at least in part by the resonant mass, the closed nodal anchor, and a substrate.

A biosensor is provided. The biosensor is used to sense a biological sample and has a code representing features of the biosensor. The biosensor includes a substrate and a conductive layer. The conductive layer is disposed on a first side of the substrate and includes a first conductive loop and a second conductive loop. The first conductive loop is formed between a first node and a second node and has a first impedance. The second conductive loop is formed between the second node and a third node and has a second impedance. The code is determined according to a comparison result between the second impedance and the first impedance.

A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

Bioprinting station (1) comprising:—a Bioprinting device (4) adapted to deposit a pattern of biological material (2) onto an area of interest (3a) of a substrate (3),—an imaging system (15) adapted to acquire an image of the substrate (3) and to reveal on the acquired image the area of interest (3a) with respect to a remaining part (3b) of the substrate (3), the acquired image of the substrate (3) being processed so as to detect the revealed area of interest (3a) on the acquired image and to determine the pattern corresponding to the area of interest (3a) detected on the acquired image.

Devices and methods are described herein that are configured for use in laboratory testing, such as, for example, during a procedure including the monitoring and detection of chemical reactions. For example, the systems and devices described herein can be used during a procedure to monitor and detect polymerase chain reactions (PCR). In some embodiments, a sample container includes a container body that defines an interior volume and has an open end in fluid communication with the interior volume. A cap is sealingly engageable with the open end of the container body. The cap defines a receptacle that is configured to extend within a portion of the interior volume of the container body when the cap is sealingly engaged thereto. The receptacle can receive therein a sensor, such as, a temperature sensor that can monitor the temperature of a sample material disposed within the container body.

An apparatus for sampling and storing biological fluids from a human or animal subject is provided. In one embodiment of the present disclosure, the apparatus includes a main body, lancet carrier or hub, lancet, lancet trigger, capillary tube, and sample compartments for collecting and storing dried blood and other bodily fluids. The lancet hub supports a lancet and provides for moving the lancet longitudinally between a first retracted position and a second extended position. The device includes a capillary tube having an internal diameter sized to draw and retain fluid from a contacted source using capillary action. The main body of the apparatus further includes a sample compartment for holding sampling and storage materials. In at least one embodiment of the present disclosure, the sample compartment can be accessed by lifting sample compartment lid. Also included is a new “fan” or “daisy” shaped collection material format for use in collecting and preserving samples.

A sensing device including an inlet port for receiving a fluid, a measurement chamber for sensing the fluid, a fluid channel coupling the inlet port and the measurement chamber for transporting the fluid from the inlet port to the measurement chamber, and a fluid stop unit for stopping and controllably releasing the flow of fluid between the inlet port and the measurement chamber.

The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.