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Beware Russian and Chinese Positioning for After the Pandemic

9 April 2020

Keir Giles

Senior Consulting Fellow, Russia and Eurasia Programme
Authoritarian regimes can use the COVID-19 crisis to improve their international standing, taking advantage of others’ distraction. Their aims are different, but their methods have much in common.

2020-04-09-Russia-Aid-Serbia

An airlifter of the Russian Aerospace Forces prepares to fly to Serbia carrying equipment and professionals during the COVID-19 crisis. Photo by Russian Defence MinistryTASS via Getty Images.

Both Russia and China have mounted combined charm offensives and disinformation campaigns on the back of the pandemic. Shipments of ‘aid’ – reportedly of questionable utility and quality - have gone hand in hand with a concerted effort to deflect any blame from China for the early spread, and an ongoing drive by Russia to undermine states’ confidence and have sanctions lifted.

These concurrent operations have very different objectives, as Russia seeks to subvert international order while China is continuing its bid to demonstrate global leadership - but in both cases, they are seeking long-term gains by exploiting the inattention and distraction of their targets.

Both seek to present themselves as globally responsible stakeholders, but for divergent reasons – especially China which needs the rest of the world to recover and return to stability to ensure its own economic recovery. But despite this, the two campaigns appear superficially similar.

Fertile ground for disinformation

One reason lies in the unique nature of the current crisis. Unlike political issues that are local or regional in nature, COVID-19 affects everybody worldwide. The perceived lack of reliable information about the virus provides fertile ground for information and disinformation campaigns, especially feeding on fear, uncertainty and doubt. But Russia in particular would not be succeeding in its objectives without mis-steps and inattention by Western governments.

Confused reporting on Russia sending medical supplies to the United States showed Moscow taking advantage of a US administration in apparent disarray. Claims Russia was sending ’humanitarian aid’ were only belatedly countered by the US State Department pointing out it had been paid for. Meanwhile the earlier arrival of Russian military equipment in Italy also scored a propaganda victory for Russia, facilitated by curious passivity by the Italian government.

In both cases Russia also achieved secondary objectives. With the United States, Russia scored bonus points by shipping equipment produced by a subsidiary of a company under US sanctions. In the case of Italy, Russian state media made good use of misleading or heavily edited video clips to give the impression of widespread Italian acclaim for Russian aid, combined with disdain for the efforts of the EU.

Beijing’s external information campaigns have sought to deflect or defuse criticism of its early mishandling and misinformation on coronavirus and counter accusations of secrecy and falsifying data while also pursuing an opportunity to exercise soft power. For Moscow, current efforts boost a long-standing and intensive campaign to induce the lifting of sanctions, demonstrating if nothing else that sanctions are indeed an effective measure. Official and unofficial lobbying has intensified in numerous capital cities, and will inevitably find supporters.

But both the aid and the information campaigns are seriously flawed. While appropriate and useful aid for countries that are struggling should of course be welcomed, both Russian and Chinese equipment delivered to Europe has repeatedly been found to be inappropriate or defective

Russian photographs of cardboard boxes stacked loose and unsecured in a transport aircraft bound for the United States sparked alarm and disbelief among military and aviation experts - and there has still been no US statement on what exactly was purchased, and whether it was found to be fit for purpose when it arrived.

Reporting from Italy that the Russian equipment delivered there was ‘80% useless’ has not been contradicted by the Italian authorities. In fact, although the Italian sources criticizing Russia remain anonymous it is striking that - President Trump aside - no government has publicly endorsed materials and assistance received from Russia as actually being useful and helpful.

Even in Serbia, with its traditionally close ties with Russia, the only information forthcoming on the activities of the Russian Nuclear, Biological and Chemical Protection Troops and their equipment that arrived on April 3 was from Russian press releases.

Both countries’ strategic communications efforts are similarly fallible. China’s notoriously heavy-handed approach to its critics is of only limited use in the face of such a severe and immediate threat. One suggestion that the virus originated in the US – an early response to US criticism – has already been walked back by the Chinese diplomat who made it.

And Russia continues to be capable of spectacularly misjudging its targets. When investigative journalists looked more closely at the nature of the assistance to Italy, Russia’s official response was rage and personal threats, laying bare the real nature of the campaign and immediately alienating many of those whom Moscow had sought to win over.

Errors and deficiencies such as these provide opportunities to mitigate the worst side-effects of the campaigns. And actions by individuals can also mitigate much of the impact. The most effective disinformation plays on deeply emotional issues and triggers visceral rather than rational reactions.

Advocates of ’informational distancing’ as well as social distancing suggest a tactical pause to assess information calmly, instead of reacting or spreading it further unthinkingly. This approach would bolster not only calm dispassionate assessment of the real impact of Russian and Chinese actions, but also counter spreading of misinformation on the pandemic as a whole - especially when key sources of disinformation are national leaders seeking to politicize or profit from the crisis.

Limitations of Russian and Chinese altruism must be stated clearly and frankly to fill gaps in public understanding. Where help is genuine, it should of course be welcomed: but if it is the case that assistance received from Moscow or Beijing is not appropriate, not useful, or not fit for purpose, this should be acknowledged publicly.

Even without central direction or coordination with other Russian strategic communications efforts, the self-perpetuating Russian disinformation ecosystem continues to push narratives designed to undermine confidence in institutions and their ability to deal with the crisis. This too must continue to be monitored closely and countered where it matters.

In all cases, miscalculations by Russia or China that expose the true intent of their campaigns – no matter how different their objectives might be - should be watched for closely and highlighted where they occur.

Despite the enormity of the present emergency it is not a time for any government to relax its vigilance over longer-term threats. States must not lose sight of manoeuvres seeking to exploit weakness and distraction. If Russia and China emerge from the current crisis with enhanced authority and unjustifiably restored reputations, this will make it still harder to resist their respective challenges to the current rules-based international order in the future.




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Online Study Group: All Lukashenka’s Men: The Belarusian Ruling Elite and Why It Matters

Invitation Only Research Event

22 April 2020 - 2:30pm to 4:00pm

Event participants

Ryhor Astapenia, Robert Bosch Stiftung Academy Fellow, Russia and Eurasia Programme, Chatham House
Chair: James Nixey, Programme Director, Russia and Eurasia, Chatham House

Soon after assuming power in 1994, President Aliaksandr Lukashenka turned his back on democratic norms and overpowered the Belarusian political elite. However, the influence of the governing elite in Belarus is growing again. It seems likely that the current governing class could rule the country after Lukashenka leaves. It is thus important to study Belarusian elites not only to understand the current regime, but also to better forecast and navigate the political system that will one day replace it. 

This study group aims to disentangle how the Belarusian political system works, outline the types of individuals that make up the Belarusian ruling elite, assess the interaction of the elite and institutions with the West, and suggest changes that Western political actors might make to their approach to the Belarusian ruling class.

Event attributes

Chatham House Rule

Department/project

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Belarusians Left Facing COVID-19 Alone

16 April 2020

Ryhor Astapenia

Robert Bosch Stiftung Academy Fellow, Russia and Eurasia Programme

Anaïs Marin

Associate Fellow, Russia and Eurasia Programme
The way the epidemic is being mismanaged creates a risk of political destabilisation and leaves the country exposed to external influence.

2020-04-16-Belarus-COVID-Football

Playing accordion in front of dummy football fans in Brest, Belarus as the country's championship continues despite the COVID-19 outbreak. Photo by SERGEI GAPON/AFP via Getty Images.

Since the World Health Organisation (WHO) declared COVID-19 a pandemic, few countries have chosen to ignore social distancing recommendations. But, even among those states which have, the Belarusian official response to its epidemic remains unique.

President Aliaksandr Lukashenka’s statements that vodka, sauna and tractors are protecting Belarusians from coronavirus attracted amused attention in international media. Lukashenka also described other societies’ response to COVID-19 as ‘a massive psychosis’.

Although Lukashenka is notorious for his awkward style of public communication, the fact that Belarus is refusing to impose comprehensive confinement measures is of concern. Belarusians continue to work, play football and socialise.

Lukashenka, himself playing ice hockey in front of state cameras, claims it is the best way to stay healthy. Belarusian authorities clearly appear to be in denial – and this could have dire humanitarian consequences.

From denial to half measures

Belarus actually has one of the largest numbers of hospital beds in the world per 1,000 of the population. But in the absence of quarantine measures its health system, already crippled by corruption and embezzlement, is likely to be overwhelmed.

Patients being treated for pneumonia in hospitals have suggested medical staff are uninformed and inadequately equipped. It is claimed doctors are not reporting COVID-19 as the suspected cause of death, either through a lack of testing or for fear of reprisals.

Observers believe the real mortality rate is already well above official figures (40 deaths as of 16 April). Based on an Imperial College London model, between 15,000 and 32,000 people could die under the current mild confinement regime – and such a high death toll would hugely impact the country’s political stability. Citing personal data protection, the Ministry of Health has imposed a total news blackout; the only cluster officially acknowledged so far is the city of Vitsebsk.

Although specific Belarusian cities and some individuals started changing their approach – by extending school vacations or cancelling weddings – such measures remain half-hearted.

Clearly a major reason for such an apparently irresponsible reaction is that Belarus cannot afford a massive lockdown that would freeze its already underdeveloped economy and drive it deeper into recession. Unlike many other nations, Belarus lacks budgetary resources for a sizable stimulus package. But a delayed response might backfire on the economy.

Economic recession has been forecast to amount to at least 10% of GDP. For Lukashenka, who openly challenged conventional wisdom regarding the need for quarantine and isolation, such an economic downturn would harm his confidence rating in the eyes of Belarusian voters, mindful of the state’s mismanagement of the crisis. And it could create doubt within the ruling elite itself, with Lukashenka seeking re-election for a sixth mandate in late August.

Against this backdrop, a radicalization of the opposition-minded part of society is also to be expected, with greater reliance on social networks in the face of official secrecy and disinformation. The expected response of the regime is then likely to be pre-emptive repression. Evidence is emerging that law enforcement agencies have already stepped up judicial and paralegal harassment of dissenters, notably independent journalists and bloggers.

Russia’s initial reluctance to address the coronavirus crisis may also have influenced Belarus. Lukashenka and his administration often react to public health challenges by the Soviet rulebook, reminiscent of the Soviet authorities’ mismanagement of the Chernobyl disaster in 1986.

Russia has unilaterally closed its borders with Belarus and, as bilateral relations continue to deteriorate, this casts further doubt on the viability of the Union State of Belarus and Russia. Pro-Russian media forecast Moscow will be unwilling to alleviate the expected socio-economic crisis, as it continues to reject Minsk’s demands regarding subsidised oil deliveries. Yet the Kremlin might use the crisis as an opportunity to resume its integrationist pressure on Belarus.

China, with which Belarus engaged in a seemingly privileged strategic partnership in the 2010s, was actually the first country to dispatch humanitarian aid to beef up Belarusian capacity to fight the virus.

But Minsk should not expect Beijing to rescue its economy and, unless it commits to more internal reforms, Belarus is not likely to receive much from the EU either. The regime has already applied to the IMF for emergency financial support, but conditions are attached and, even if successful, the funds would amount to no more than $900m.

The government’s decision to take only half measures so far is rooted in the hope COVID-19 is not as bad as foreign experts fear. But, unless the leadership acknowledges the public health crisis and mitigates its economic impact, COVID-19 will accelerate Belarus’s slide back into international self-isolation. If combined with a humanitarian crisis, this will put the Belarusian regime under considerable stress.

This crisis does risk a new ‘Chernobyl moment’ for the authorities, but the population could react more vocally this time. As volunteers self-organise to fight the epidemic, it might become more difficult for the authorities to say that it is efficient in running the country. But the bottom line is Belarus desperately needs money. Whoever steps up to support Belarus financially will also be able to heavily influence its politics.




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Webinar: Russian Disinformation's Golden Moment: Challenges and Responses in the COVID-19 Era

Invitation Only Research Event

7 May 2020 - 3:00pm to 4:30pm

Event participants

Anneli Ahonen, Head, StratCom East Task Force, European External Action Service
Keir Giles, Senior Consulting Fellow, Russia and Eurasia Programme, Chatham House
Thomas Kent, Adjunct Associate Professor, Harriman Institute, Columbia University; Senior Fellow, the Jamestown Foundation
Chairs:
James Nixey, Programme Director, Russia and Eurasia, Chatham House
Glen Howard, President, The Jamestown Foundation
The COVID-19 pandemic provides the ideal environment for malign influence to thrive as it feeds on fear and a vacuum of authoritative information. What are the current challenges posed by Russian disinformation, and how should Western nations be responding?
 
In this discussion, jointly hosted by the Jamestown Foundation and the Chatham House Russia and Eurasia Programme, the speakers will consider what best practice looks like in safeguarding Western societies against the pernicious effects of disinformation. 
 
This event will be held on the record.

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Nuclear Tensions Must Not Be Sidelined During Coronavirus

1 May 2020

Ana Alecsandru

Research Assistant, International Security Programme
Although the pandemic means the Nuclear Non-Proliferation Treaty (NPT) Review Conference (RevCon) is postponed, the delay could be an opportunity to better the health of the NPT regime.

2020-05-01-Iran-Peace-Nuclear

Painted stairs in Tehran, Iran symbolizing hope. Photo by Fatemeh Bahrami/Anadolu Agency/Getty Images.

Despite face-to-face diplomatic meetings being increasingly rare during the current disruption, COVID-19 will ultimately force a redefinition of national security and defence spending priorities, and this could provide the possibility of an improved political climate at RevCon when it happens in 2021.

With US presidential elections due in November and a gradual engagement growing between the EU and Iran, there could be a new context for more cooperation between states by 2021. Two key areas of focus over the coming months will be the arms control talks between the United States and Russia, and Iran’s compliance with the 2015 Joint Comprehensive Plan of Action (JCPOA), also known as the Iran Nuclear Deal.

It is too early to discern the medium- and longer-term consequences of COVID-19 for defence ministries, but a greater focus on societal resilience and reinvigorating economic productivity will likely undercut the rationale for expensive nuclear modernization.

Therefore, extending the current New START (Strategic Arms Reduction Treaty) would be the best, most practical option to give both Russia and the United States time to explore more ambitious multilateral arms control measures, while allowing their current focus to remain on the pandemic and economic relief.

Continuing distrust

But with the current treaty — which limits nuclear warheads, missiles, bombers, and launchers — due to expire in February 2021, the continuing distrust between the United States and Russia makes this extension hard to achieve, and a follow-on treaty even less likely.

Prospects for future bilateral negotiations are hindered by President Donald Trump’s vision for a trilateral arms control initiative involving both China and Russia. But China opposes this on the grounds that its nuclear arsenal is far smaller than that of the two others.

While there appears to be agreement that the nuclear arsenals of China, France, and the UK (the NPT nuclear-weapons states) and those of the states outside the treaty (India, Pakistan, North Korea, and Israel) will all have to be taken into account going forward, a practical mechanism for doing so proves elusive.

If Joe Biden wins the US presidency he seems likely to pursue an extension of the New START treaty and could also prevent a withdrawal from the Open Skies treaty, the latest arms control agreement targeted by the Trump administration.

Under a Biden administration, the United States would also probably re-join the JCPOA, provided Tehran returned to strict compliance with the deal. Biden could even use the team that negotiated the Iran deal to advance the goal of denuclearization of the Korean peninsula.

For an NPT regime already confronted by a series of longstanding divergences, it is essential that Iran remains a signatory especially as tensions between Iran and the United States have escalated recently — due to the Qassim Suleimani assassination and the recent claim by Iran’s Revolutionary Guard Corps to have successfully placed the country’s first military satellite into orbit.

This announcement raised red flags among experts about whether Iran is developing intercontinental ballistic missiles due to the dual-use nature of space technology. The satellite launch — deeply troubling for Iran’s neighbours and the EU countries — may strengthen the US argument that it is a cover for the development of ballistic missiles capable of delivering nuclear weapons.

However, as with many other countries, Iran is struggling with a severe coronavirus crisis and will be pouring its scientific expertise and funds into that rather than other efforts — including the nuclear programme.

Those European countries supporting the trading mechanism INSTEX (Instrument in Support of Trade Exchanges) for sending humanitarian goods into Iran could use this crisis to encourage Iran to remain in compliance with the JCPOA and its NPT obligations.

France, Germany and the UK (the E3) have already successfully concluded the first transaction, which was to facilitate the export of medical goods from Europe to Iran. But the recent Iranian escalatory steps will most certainly place a strain on the preservation of this arrangement.

COVID-19 might have delayed Iran’s next breach of the 2015 nuclear agreement but Tehran will inevitably seek to strengthen its hand before any potential negotiations with the United States after the presidential elections.

As frosty US-Iranian relations — exacerbated by the coronavirus pandemic — prevent diplomatic negotiations, this constructive engagement between the E3 and Iran might prove instrumental in reviving the JCPOA and ensuring Iran stays committed to both nuclear non-proliferation and disarmament.

While countries focus their efforts on tackling the coronavirus pandemic, it is understandable resources may be limited for other global challenges, such as the increasing risk of nuclear weapons use across several regions.

But the potential ramifications of the COVID-19 crisis for the NPT regime are profound. Ongoing tensions between the nuclear-armed states must not be ignored while the world’s focus is elsewhere, and the nuclear community should continue to work together to progress nuclear non-proliferation and disarmament, building bridges of cooperation and trust that can long outlast the pandemic.




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Victory and Memory: WW2 Narratives in Modern Day Russia and Ukraine

Invitation Only Research Event

11 May 2020 - 4:00pm to 5:30pm
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Nina Tumarkin, Kathryn Wasserman Davis Professor of Slavic Studies; Professor of History; Director, Russian Area Studies Program, Wellesley College
Georgiy Kasianov, Head, Department of Contemporary History and Politics, Institute of History of Ukraine, National Academy of Sciences of Ukraine
Chair: Robert Brinkley, Chairman, Steering Committee, Ukraine Forum, Chatham House
In 2020 the world commemorates the 75th anniversary of the end of World War II. The Russian government has organized a wide range of activities to mark the USSR’s victory, aiming to raise the already prominent role of the USSR to a new level. Moscow also uses its narrative about the war as a propaganda tool. Ukraine, which suffered disproportionally huge human losses and material destruction during WWII, is departing from its Soviet legacy by focusing commemorative efforts on honouring the victims of WWII rather than on glorifying victory. 
 
This event will analyze the evolution of the WWII narratives in Russia and Ukraine in recent years. The panellists will discuss the role of those narratives in shaping national discourses and their implications for the countries' respective futures.
 
This event will be held on the record.

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274

Department/project




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Love the sinner, not the sin

I go to church and sit at the back while you tell me I’m going to hell I go to church and sit at the back while you announce the Dates for ‘Men’s Breakfast’ I go to church and sit at the back while you undress my sin, wanting to love me naked Stripped, beaten, […]




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On Loosing People

How I wish I had another chance at, Caroline, I would rub her stomach until, She fell asleep, And sit there some more, Catch her  when the nightmare , Threatened to be too real, I’d tell her stories about the past, about dragons and princesses and, Hero’s, I’d sit still beside her all night and, […]




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Hanging out with my father, and my brother and sister

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Pansies, Holly and Twinkly lights

The brown bee, Big as a bear, That visits my Polyandra, Flies meticulous patterns around morning blooms Dispersing pollen, As easily as the hummingbird next to it, Serenades hibiscus. We spend time collecting memories and ornaments like, Christmas bulbs have no lifetime, We miss Pansy’s and Holly’s and Twinkly lights, At Sundown, When closets shut, […]




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Loosing our minds

  I am right. You may say that I am not, but I have, Demanded love and, You, Are wrong. Black and blue and red hummingbird, I Know what I am saying, you Left the kids again, And we argue, Tall as bamboo we, Kill each other, Taking long hours to, Identify precisely who left […]




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Peptide Synthesis

Bio-Synthesis is USA based Custom Peptide Synthesis Company. In organic chemistry, peptide synthesis is the production of peptides. Peptides are chemically synthesized by the condensation reaction of the carboxyl group of amino acid.




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The UK's Vision for Tackling Climate Change

1 July 2012

Chatham House

This is a transcript of a speech made by Ed Davey MP, Secretary of State for Energy and Climate Change, on 11 July 2012 at Chatham House.

In his first keynote speech on the subject, the Secretary of State outlined his vision for ambitious action on climate change.

Event details.




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Climate Change: Raising Ambition, Delivering Results

Conference

3 November 2014 - 9:30am to 4 November 2014 - 1:15pm

Chatham House, London

Overview

Agenda

Speakers

Pricing

Media partners

Sponsors

Audience profile

Venue and accommodation

Press registration

Climate change is climbing the political agenda. Extreme weather has raised questions in public discourse about the role of anthropogenic warming and concerns about its future impacts; slowdowns in emerging economies and sluggish recoveries in the developed world mean debates about the impact of climate policies on energy bills and competitiveness have assumed particular significance. Against this background, governments are gearing up for a crucial series of agreements in 2015 with climate change at their core. The international community must agree new global sustainable development goals, a new framework on disaster risk reduction and, at the 21st UN Framework Convention on Climate Change (UNFCCC) meeting of the Conference of Parties (COP 21) in Paris, a new global deal on climate change. 

The 18th Annual Chatham House Conference on Climate Change will take stock of developments in 2014, including the latest science, the findings of high-level commissions, initiatives from the business community and the UN Secretary-General’s High Level Summit at the end of September. Looking forward to COP 20 in Lima and beyond, this conference will examine opportunities to raise ambition and convert this into results.

In particular, it will:

  • Review the latest science on climate risk and the implications for business, society and politics 
     
  • Examine the benefits of a low carbon economy, and assess the costs of climate action and where they fall 
     
  • Discuss concrete measures to decarbonize key sectors and the barriers to action
     
  • Identify the critical path to the UNFCCC’s Conference of the Parties (COP 21) in 2015, and look at whether, and how, support for ambitious action can be built among publics, business and politicians


The Chatham House Rule
To enable as open a debate as possible, this conference will be held under the Chatham House Rule.

Twitter
Suggested hashtag: #CHclimate

DAY ONE
Monday 3 November

Session One
Taking Stock and Mapping the Road Ahead
09:30-11:15

  • What was achieved at the UN Secretary General’s High Level Summit in September? 
  • What is the outlook for COP 20 in Lima, and how can ambition be increased?
  • How will success at COP 21 in Paris be defined?

Chair
Rob Bailey, Acting Research Director, Energy, Environment and Resources, Chatham House

Keynote Address
Manuel Pulgar-Vidal, Minister of State for the Environment, Peru; President, COP 20, UN Framework for the Convention on Climate Change (UNFCCC) (on the record)

Amber Rudd MP, Parliamentary Under Secretary of State, Department of Energy and Climate Change, United Kingdom (on the record)

Questions and Discussion

Chair
Jennifer Morgan, Director, Climate and Energy Programme, World Resources Institute (WRI) 

Speakers

Selwin Hart, Director, Secretary-General's Climate Change Support Team, United Nations

Dr Halldór Thorgeirsson, Director for Strategy, UN Framework for the Convention on Climate Change (UNFCCC)

Leena Srivastava, Executive Director, The Energy and Resource Institute (TERI) 

Paul Watkinson, Head of Climate Negotiation Team, Ministry of Ecology, Sustainable Development and Energy, France

Questions and Discussion

11:15-11:45 Refreshments

Session Two
Low Carbon Economy: Costs and Benefits
11:45-13:00 

  • What are the economic and social opportunities and benefits of a low carbon economy? Where do these occur? How much are they worth?
  • What are examples of leadership among governments and business? What is needed to accelerate the transition and translate ambition into results?
  • What has been the impact of climate policies on economic competitiveness? Which economies and sectors have been most affected? How has this influenced national and international climate politics?
Chair's Opening Remarks
Marianne Fay, Chief Economist, Climate Change Group, The World Bank
Keynote Panel Discussion

Jeremy Oppenheim, Programme Director, New Climate Economy, Global Commission on the Economy and Climate 

Jos Delbeke, Director General for Climate Action, European Commission 

Dr Qi Ye, Director, Brookings-Tsinghua Center for Public Policy; Professor of Environmental Policy and Management at Tsinghua University’s School of Public Policy and Management

Jeremy Bentham, Vice President, Global Business Environment, Shell

Questions and Discussion

13:00-14:00 Lunch

Session Three
Concrete Steps to Action: Finance and Achieving Net Zero 

There is growing interest in the concept of net zero carbon emissions, for businesses, sectors and even countries. This session will examine the feasibility of net zero for the power and transport sectors, and for buildings and cities.

Chair
Shane Tomlinson, Senior Research Fellow, Energy, Environment and Resources, Chatham House

Opening Discussion
Manfred Konukiewitz, Co-Chair, the Green Climate Fund 

Matthew Kotchen, Professor of Economics, Yale University 

Farhana Yamin, Associate Fellow, Chatham House

Power and Transport
14:45-15:45

  • What do decarbonization roadmaps for the power and transport sectors look like? Is net zero feasible? If so, by when and how? What are the challenges posed by increasing renewable penetration, and how can they be managed? What are the implications of vehicle electrification for the power sector?
  • What are the implications for infrastructure and investment?

Chair
Shane Tomlinson, Senior Research Fellow, Energy, Environment and Resources, Chatham House

Speakers
Abyd Karmali, Managing Director, Climate Finance, Bank of America Merrill Lynch

Dries Acke, Policy Manager, European Climate Foundation (Belgium) 

Olivier Paturet, General Manager,  Zero Emissions Strategy, Nissan Europe

Stefan Raubenheimer, Co-Founder and Director, South South North;  Co-Director, MAPS Programme 

Questions and Discussion

15:45-16:15 Refreshments

Buildings and Cities
16:15-17:15

  • What is the state of the art for low carbon building; how can this be rolled out at scale? 
  • How can decarbonization objectives be incorporated into urban planning and regulation?
  • How are the challenges and needs different for developed and developing countries? 

Chair
Farhana Yamin, Associate Fellow, Energy, Environment and Resources, Chatham House

Speakers
Ed Mazria, Founder and CEO, Architecture 2030

Tony Mallows, Director, Masdar City 

Questions and Discussion

17:15 Close of day and drinks reception

DAY TWO
Tuesday 4 November

Session Four 
Climate Impacts
9:30-11:15 

Chair
Sir David King, Foreign Secretary's Special Representative for Climate Change, United Kingdom

Keynote Addresses
HE Belete Tafere, Minister, Ministry of Environment Protection and Forestry, Ethiopia (on the record)

Professor Hans Joachim Schellnhuber, Founding Director, Potsdam Institute for Climate Impact Research (on the record)

  • What climate impacts are already being witnessed? Are these in line with expectations? What is the current state of attribution analysis?
  • What are the implications for climate politics?
  • What are the expected social, economic and environmental impacts under different climate scenarios? What is the most recent science since the deadline for Working Group II of the Intergovernmental Panel on Climate Change’s Fifth Assessment Report?  
  • Which countries and sectors are most vulnerable? What are governments and businesses doing to adapt?


Chair
Sir David King, Foreign Secretary's Special Representative for Climate Change, United Kingdom

Speakers
Chris Field, Founding Director, Department of Global Ecology, Carnegie Institution of Science, Co-Chair of Working Group II of the IPCC’s Fifth Assessment Report 

Professor Myles Allen, Leader of ECI Climate Research Programme and Professor of Geosystem Science, University of Oxford 

Nick Mabey, Director, E3G 

Oilver Bettis, Chair, Resource and Environment Board, Institute and Faculty of Actuaries

Questions and Discussion

11:15 - 11.45 Refreshments

Session Five
The Conditions for Action
11:45 - 13:00

  • What is the current state of public support for climate action? What shapes attitudes and beliefs? How does this vary by country? 
  • What can create political ambition, nationally and internationally?
  • What role can different stakeholders play in catalysing climate action?
  • What immediate obstacles need to be overcome and what lessons can be learned from recent success? 
Chair
Simon Maxwell, Executive Chair, Climate Development Knowledge Network
Keynote Address
Bill McKibben, President and Co-Founder, 350.org (on the record)

Panel Discussion
Antonio Hill, Executive Director, Global Campaign for Climate Action

Michael Jacobs, Senior Adviser on International Climate Policy, The Institute for Sustainable Development and International Relations  

Jennifer Morgan, Director, Climate and Energy Programme, World Resources Institute (WRI) 

Sergio Margulis, National Secretary of Sustainable Development, Secretariat of Strategic Affairs of the Presidency of Brazil 

Sir David King, Foreign Secretary's Special Representative for Climate Change, United Kingdom

Questions and Discussion

Closing remarks
Rob Bailey, Acting Research Director, Energy, Environment and Resources, Chatham House

1
3:10 End of conference and lunch

 © The Royal Institute of International Affairs 2014

Keynote Speakers

Speakers

Dries Acke

Policy Manager, European Climate Foundation (Belgium)

Myles Allen

Coordinating Lead Author, Intergovernmental Panel on Climate Change Special Report on Global Warming of 1.5 °C; Professor of Geosystem Science, University of Oxford

Oliver Bettis

Chair, Institute and Faculty of Actuaries' Resource and Environment Board

Marianne Fay

Chief Economist, Climate Change Group, The World Bank

Chris Field

Founding Director, Department of Global Ecology, Carnegie Institution of Science

Selwin Hart

Director, Secretary-General's Climate Change Support Team, United Nations

Antonio Hill

Executive Director, Global Campaign for Climate Action

Michael Hogan

Senior Adviser, Regulatory Assistance Project

Professor Michael Jacobs

Senior Adviser on International Climate Policy, The Institute for Sustainable Development and International Relations

Abyd Karmali

Managing Director, Climate Finance, Bank of America Merrill Lynch

Sir David King

Foreign Secretary’s Special Representative for Climate Change

Manfred Konukiewitz

Co-Chair, The Green Climate Fund

Matthew Kotchen

Professor of Economics, Yale University

Nick Mabey

Co-Founding Director and Chief Executive, E3G

Antony Mallows

Director, Masdar City

Sergio Margulis

National Secretary of Sustainable Development, Secretariat of Strategic Affairs of the Presidency, Brazil

Simon Maxwell

Executive Chairman, Climate and Development Knowledge Network

Edward Mazria

Founder and CEO, Architecture 2030

Jennifer Morgan

Executive Director, Greenpeace International

Olivier Paturet

General Manager, Zero Emissions Strategy, Nissan Europe

Stefan Raubenheimer

Co-Founder and Director, South South North; Co-Director, MAPS Programme

Jose-Manuel Sanoval

Coordinator, Colombian Low Carbon Development Strategy (CLCDS) and Mitigation Action Plans and Scenarios (MAPS)

Leena Srivastava

Hony. Executive Director (Operations), The Energy and Resources Institute (TERI)

Halldór Thorgeirsson

Director for Strategy, UN Framework for the Convention on Climate Change

Paul Watkinson

Head of Climate Negotiation Team, Ministry of Ecology, Sustainable Development and Energy, France

Farhana Yamin

Associate Fellow, Energy, Environment and Resources Programme

[node:event_chair]

Pricing

For any questions about rates, please call +44 (0)20 7314 2782.

                      FULL RATE
EXCL. VATINCL. VAT
Major corporate member rates
All organizations£595£714 
Corporate member rates
Commercial organizations£1,295£1,554
Government departments£775£930
NGOs and academics£495£594
Standard rates
Commercial organizations£1,445£1,734 
Government departments£845£1,014
NGOs and academics£550£660

This conference will offer a unique opportunity to network with senior officials from businesses, government, NGO's and academic institutions.

Our previous Climate Change conferences saw delegates from companies and institutions such as:

Accenture
AEA Energy & Environment
Agulhas
ArcelorMittal
Association of Asia Pacific Airlines (AAPA)
Atkins Ltd
Bank of America Merrill Lynch
BASF plc
Bayerngas Norge AS
Beetle Capital
BG Group plc
BHP Billiton
BIRA-IASB
BirdLife
Booz & Co
BP plc
British Council
BT Group plc
CAFOD
Cairn Energy plc
Cambridge Centre for Energy Studies
Cambridge Programme for Sustainable Leadership
Carbon Capture and Storage Association
Carbon Leapfrog
Carbon Trust
Caritas Internationalis
Catholic Fund for Overseas Development (CAFOD)
CH2M Hill
Chevron Ltd
Chubu Electric Power Co Inc
City of London
ClientEarth
Clifford Chance LLP
Climate & Development Knowledge Network (CDKN)
Climate Action Network (CAN)
Climate and Health Council
Climate Secure
Coalition for an International Court for the Environment (ICE Coalition)
Compassion in World Farming (CIWF)
Conocophillips (UK) Ltd
Control Risks
Co-operative Group
Cranfield University
Deloitte Consulting LLP
Department for Business, Innovation & Skills (BIS)
Department for International Development (DFID)
Department of Energy and Climate Change (DECC)
Ecofys UK Ltd
Ecologic Institute
EDF Energy
Energy Charter Secretariat
Energy Technologies Institute
Eni S.p.A
Environment Agency
Environmental Law Foundation (ELF)
Environmental Protection Agency (EPA)
Environmental Resources Management (ERM)
ENWORKS
Ernst & Young
Ethical Investment Research Services Ltd (EIRIS)
European Bank For Reconstruction & Development
European Commission (Directorate General for Enterprise and Industry)
European Parliament
ExxonMobil International Ltd
Fauna & Flora International
FIA Foundation for the Automobile and Society
Finnish Forest Association
Foreign and Commonwealth Office (FCO)
Forestry Commission
Friends of the Earth
Genesis Investment Management LLP
GLG Partners LP
Global CCS Institute
Global Humanitarian Forum
Global Sustainability Institute
Global Witness
Globeleq Ltd
Grantham Research Institute on Climate Change and the Environment, LSE
Greater Manchester Chamber of Commerce
Greenpeace International
Herbert Smith Freehills LLP
HM Treasury
Imperial College London
INPEX Corporation
Institute for Public Policy Research (IPPR)
Institutional Investors Group on Climate Change (IIGCC)
International Association of Oil & Gas Producers
International Council on Mining and Metals
International Finance Corporation (IFC)
International Institute for Environment and Development (IIED)
International Organization for Standardization (ISO)
Japan External Trade Organization (JETRO)
Joseph Rowntree Foundation
JPMorgan
King's College London
KPMG
Kuwait Petroleum Corporation
London Assembly
London Metropolitan University
London School of Economics and Political Science (LSE)
Maersk Group
Massey University
McKinsey & Company
Met Office
METREX
Ministere des Affaires Etrangeres, France
Ministry of Defence (Development, Concepts and Doctrine Centre)
Ministry of Foreign Affairs, Netherlands
Ministry of Foreign Affairs, Finland
Ministry of Foreign Affairs, Poland
Ministry of Infrastructure and the Environment
Mitsubishi Corporation
National Farmers' Union
National Round Table on the Environment and the Economy
Netherlands Development Finance Company (FMO)
NEXUS Singapore
Nordic Council
Office of National Assessments
Ogilvy
Open Society Foundation
Overseas Development Institute (ODI)
Oxford University
Plan UK
PricewaterhouseCoopers LLP
Privy Council Office
Progressio
Quaker Peace and Social Witness
Québec Government Office
Renewable Energy and Energy Efficiency Partnership (REEEP)
Renewable Energy Systems Ltd (RES)
Rolls-Royce International Ltd
RWE Power AG
Save the Children UK
SCA, Svenska Cellulosa Aktiebolaget
School of Oriental and African Studies (SOAS)
Shell
Standard Chartered Bank plc
Statoil (UK) Ltd
SustainAbility Ltd
Swedish Defence Research Agency (FOI)
Swiss Agency for Development and Cooperation SDC
Task Consult
Texas A&M University
The 40 Foundation
The Climate Group
The Gold Standard Foundation
The Norwegian Institute for Nature Research
The Open University
The Prince of Wales Corporate Leader Group
The Royal Society
The Saudi Fund For Development
Tokyo Electric Power Company
Total Holdings UK Ltd
UK Chamber of Shipping
UK Collaborative on Development Sciences (UKCDS)
United Nations Environment Programme (UNEP)
University College London (UCL)
University of Cambridge
University of East Anglia (School of Environmental Sciences)
University of Edinburgh
University of Oxford (Department of Politics and International Relations)
US Department of State
USAID
Warwick Business School
WaterAid
World Coal Association
World Coal Institute
World Economic Forum
World Society for the Protection of Animals (WSPA)
World Vision UK
WWF-UK
Xynteo Ltd
Yorkshire Forward

Venue

Chatham House
10 St James's Square
London
SW1Y 4LE
UK

conferences@chathamhouse.org

Telephone: +44 (0)20 7957 5729
Fax: +44 (0)20 7957 5710

If you wish to book the venue for your event please phone +44 (0)20 7314 2764


Directions

The nearest tube station is Piccadilly Circus which is on the Piccadilly and the Bakerloo Underground lines. From Piccadilly follow Regent Street southwards towards Pall Mall and take the first road on the right called Jermyn Street. Duke of York Street is the second road on the left and leads to St James's Square. Chatham House is immediately on your right.

Map

Accommodation

Although we cannot book accommodation for delegates, we have arranged a reduced rate at some nearby hotels, where you can book your own accommodation. Please inform the hotel that you will be attending a conference at Chatham House (The Royal Institute of International Affairs) to qualify for the Institute's reduced rate.

Please note all rates are subject to availability.

Flemings Mayfair
Half Moon Street
Mayfair
London W1J 7BH
Tel: + 44 (0)20 7499 2964
Fax: + 44 (0)20 7499 1817
Standard Single from £199 + VAT

The Cavendish London
81 Jermyn Street
London
SW1Y 6JF
Tel: + 44 (0)20 7930 2111
Fax: + 44 (0)20 7839 2125
Standard Single £205 + VAT

To book The Cavendish online

The Stafford London by Kempinski
St James's Place
London
SW1A 1NJ
Tel: 020 7518 1125
Fax: 020 7493 7121
Standard Single £230 +VAT

This conference will be held under the Chatham House Rule. Information for journalists
Press can request a press pass.


Chatham House Conferences

+44 (0)20 7957 5729




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Fossil Fuels Expert Roundtable: How Much Fossil Fuel Has to Stay in the Ground, and Where?

Invitation Only Research Event

17 March 2015 - 4:30pm to 6:00pm

Chatham House, London

Event participants

Christophe McGlade, Research Associate, UCL Institute for Sustainable Resources
Chair: Shane Tomlinson, Senior Research Fellow, Energy, Environment and Resources, Chatham House

 

It has long been argued that if we are to limit the effects of climate change, some fossil fuel reserves must stay in the ground. But how much of each fuel; and which locations must remain untapped? A new study, recently published in Nature finds that a third of oil reserves, half of gas reserves and over 80 per cent of current coal reserves globally should remain in the ground and not be used before 2050 if global warming is to stay below the 2°C threshold. The speaker will discuss the methods used to generate these estimates, the key findings of the paper, and the implications that they may have in this milestone year for addressing climate change. 

Attendance at this event is by invitation only.

Owen Grafham

Manager, Energy, Environment and Resources Programme
+44 (0)20 7957 5708




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A Good Deal? Assessing the Paris Climate Agreement

Invitation Only Research Event

16 December 2015 - 5:00pm to 6:30pm

Chatham House, London

Event participants

Shane Tomlinson, Senior Research Fellow, Energy, Environment and Resources Department, Chatham House

Following the conclusion of the Paris climate negotiations, this expert roundtable will examine the critical elements of the final agreement and what this means for the future of energy and climate policy in key countries.

The discussion will examine what the agreement means for keeping global average temperatures below two degrees Celsius and assess whether ambition will be ratcheted over time. It will also look at the primary implications of the outcome for key regions and countries such as the EU, United States, China and India. Finally, the session will also consider the next steps in terms of implementing the agreement. 

Attendance at this event is by invitation only. 

Owen Grafham

Manager, Energy, Environment and Resources Programme
+44 (0)20 7957 5708




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The UK's Decision to Leave the EU: What Next for UK Energy and Climate?

Invitation Only Research Event

12 July 2016 - 3:00pm to 6:30pm

Chatham House, London

In May 2016, Chatham House published a research paper that assessed the options for the UK’s climate and energy policy in the event of a British vote to leave the EU. It determined that:

  • The UK’s energy market is deeply integrated with that of its European neighbours and that it would be neither possible nor desirable to ‘unplug’ the UK from Europe’s energy networks. A degree of continued adherence to EU market regulations, energy efficiency standards of appliances, environmental and governance rules would be inevitable. 
  • The EU’s collective negotiation on international climate issues has given the UK greater political weight than any member state has alone.
  • The EU’s coordinated approach in engaging with major fossil fuel producers such as Russia and countries in the Middle East has helped support price stability and security of supply, including through infrastructure investment to make existing pipeline systems more efficient and improve storage and capacity.   

In light of the decision to leave, Chatham House is hosting a roundtable to reassess the options for a future UK-EU energy and climate change partnership. The meeting will bring together those experienced on UK and EU policy in both climate change and energy and explore the short and medium-term climate and energy policy considerations. 

Attendance at this event is by invitation only.

Owen Grafham

Manager, Energy, Environment and Resources Programme
+44 (0)20 7957 5708




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‘I Spy’ oversized denim and jumpers - Lila Ike opts to mute sex appeal in new video

Lila Iké’s latest single, ‘ I Spy’, is flirty and playful with a sultry tone. It’s the kind of song record labels in decades past would compulsorily conflate with bubblegum pop princess images of lollipops, pigtails, ribbons, and skirts with...




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Inner Circle gives thanks for Jacob Miller on his birthday - Singer would have caused ‘problem’ at King’s House, says ­former bandmate

Long before the existence of the Internet and going viral was a thing, reggae singer Jacob Miller, back in the ‘70s, coined a term that went viral – under heavy manners. Ian Lewis of Inner Circle band, the Bad Boys of Reggae, recalled that his...




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Jamaican musician finds fulfilment while stuck in Bali

LOCAL MUSICIAN Janine JKUHL’s two-month-long immersive creative residency programme in Bali, Indonesia, has been extended indefinitely, or at least until the world has the COVID-19 spread under control and international airports open up to...




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JaRIA considers threats, opportunities in the ‘new normal’

Industries across the world face uncertainty, as no one entity can absolutely declare when or if economies will revert to normal in the wake of COVID-19. The local entertainment industry suffers the same uncertainty – and to address it, the Jamaica...




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#WeAreInThisTogether against COVID-19 - Bay-C, ListenMiNews, Red Cross collaborate on anti-stigma music video

IN AN effort to alleviate misconceptions and misinterpretations of our current COVID-19 reality, and to create the idea that human beings deserve respect, especially when they are ill, ListenMi News has collaborated with the International...




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'My Boy Lollipop' singer Millie Small will be sorely missed

There has been an outpouring of grief following the death of legendary Jamaican singer Millicent Dolly May Small, popularly known as Millie Small. She died in the United Kingdom today at the age of 73 after suffering a stroke. The voice...




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Singer Owen Gray remembers ‘Sugar Plum’ Millie Small

BEFORE MILLIE Small became the ‘lollipop girl’, she was a ‘sugar plum’. Not only is it a term of endearment, it is also the title of her first song – a duet as it was called back in 1960 – with singer Owen Gray. This collab was born out of the time...




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Buju Banton calls new single with John Legend 'special'

LOS ANGELES (AP) — It’s been over a decade since reggae king Buju Banton and R&B star John Legend collaborated on a song, and the Grammy winners have reunited for a new track. Banton and Legend released the easygoing love song...




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Kingston meets MoBay for Mother’s Day concert - ‘Enchanting Evening of Music’ planned

Despite its best efforts, COVID-19 will not be allowed to steal the joy of Mother’s Day this year. An array of the island’s top singers and musicians have pledged to infuse the accustomed specialness into the day dedicated to mothers with a concert...




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Broadtail Designs hosts ‘Curvy in Quarantine’ Yoga Live on IG

COVID-19 has completely readjusted how we operate daily. With the proliferation of the ‘work from home’ concept, many persons have become even more stationary as they spend full days on their couches, tapping on their communication devices while...




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Pepsi-Cola responds to COVID-19

PEPSI-COLA JAMAICA, whose success has been built on the unwavering support of Jamaicans, is raising the bar in humanitarian leadership by aiding in the local COVID-19 fight through a donation valued at over $15 million The donation, made to the...




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An extremely fascinating website along with terrific posts!

This is one of the very most fascinating web sites I have ever before observed. This is quite exciting because of its distinct subject matter as well as remarkable write-ups.




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A very fascinating internet site along with great articles!

This is one of the very most exciting internet sites I have actually ever observed. It is very exciting considering that of its one-of-a-kind subject matter and also amazing short articles.




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Densil A. Williams | COVID-19 after-shocks: Is Jamaica ready?

As Jamaica signs off on Budget 2020-2021, we are still uncertain whether we will be able to withstand the economic onslaught that will accompany the crisis in the years to come. It is clear that this pandemic is like none other that we have seen...




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Donovan Stanberry | Revisiting food security amidst COVID-19 pandemic

Between December 2019 and February 2020, The Gleaner published a series of articles on my behalf, exploring the issue of food security in Jamaica based on an analysis of the country’s food-import bill for 2018. The current COVID-19 pandemic, which...




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Douglas Orane | Cultural attitudes to enhance productivity - Case Studies numbers five and six

In this article, I share my two final case studies, which examine changing our cultural attitudes to enhance productivity. Case study #5 – The role of punctuality An entrepreneur named Michael Fairbanks, who specialises in developing...




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Lacey-Ann Bartley: carving her name in business

From formalising her father’s business and taking it to higher and more profitable heights to sitting on the board of EXIM Bank and lecturing in the field of business development, Lacey-Ann Bartley has earned her stripes as the Distinguished Woman...




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Jamaica’s little helper – Dr Kazi-Ann Kasimbie

Empathetic, God-fearing, humanitarian, motivated, and optimistic – these are just a few words that come to mind when one thinks of Dr Kazi-Ann Kasimbie. Dr Kasimbie is the CEO and founder of Psychfactor Consulting Services, a psychological...




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Maintaining health with simple lifestyle changes

Let’s face it, ladies: boosting your health is not always your primary priority, but it needs to be. It doesn’t require a long, overbearing and spine-chilling regime. Simple lifestyle changes can get the job done! In the end you’ll be left with a...




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Flow pushes passion for action for team members

With passion, motivation and determination to go against what is deemed as conventional in today’s society, Flow hosted a staff summit ahead of the International Womens’ Day under the theme ‘Passion for Action’, which supports a collective will to...




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Danielia Mclean A powerhouse in business

M arketing guru and smashing entrepreneur Danielia McLean is known to the business and communication worlds as a powerhouse fiercely working to clutch success. Finding a novel business idea can be difficult; pursuing it, successfully, even more so...




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Ja’s women have combated and won in business

At age 13, Nadeen Matthews Blair, chief executive officer of the NCB Foundation, challenged the tide to prove to a guidance counsellor at her United States-based school, that black girls can overcome all odds to become powerful leaders. Matthews...




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Sir, it is not PMS - Endometriosis can cause depression in your partner

Women with endometriosis have significantly higher rates of depression than women in the general population. That’s according to psychiatrist Dr Kristen Robinson-Barrett. It’s the end of endometriosis month, so Flair spoke to the expert to explore...




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Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger {beta}-Cell Failure

Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we show that tacrolimus induces loss of human β-cell maturity and β-cell failure through activation of the BMP/SMAD signaling pathway when administered under mild metabolic stress conditions. Tacrolimus-induced phosphorylated SMAD1/5 acts in synergy with metabolic stress–activated FOXO1 through formation of a complex. This interaction is associated with reduced expression of the key β-cell transcription factor MAFA and abolished insulin secretion, both in vitro in primary human islets and in vivo in human islets transplanted into high-fat diet–fed mice. Pharmacological inhibition of BMP signaling protects human β-cells from tacrolimus-induced β-cell dysfunction in vitro. Furthermore, we confirm that BMP/SMAD signaling is activated in protocol pancreas allograft biopsies from recipients on tacrolimus. To conclude, we propose a novel mechanism underlying the diabetogenicity of tacrolimus in primary human β-cells. This insight could lead to new treatment strategies for new-onset diabetes and may have implications for other forms of diabetes.




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HB-EGF Signaling Is Required for Glucose-Induced Pancreatic {beta}-Cell Proliferation in Rats

The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on epidermal growth factor receptor (EGFR) signaling. The aim of this study was to determine the role of the EGFR ligand heparin-binding EGF-like growth factor (HB-EGF) in the β-cell proliferative response to glucose, a β-cell mitogen and key regulator of β-cell mass in response to increased insulin demand. We show that exposure of isolated rat and human islets to HB-EGF stimulates β-cell proliferation. In rat islets, inhibition of EGFR or HB-EGF blocks the proliferative response not only to HB-EGF but also to glucose. Furthermore, knockdown of HB-EGF in rat islets blocks β-cell proliferation in response to glucose ex vivo and in vivo in transplanted glucose-infused rats. Mechanistically, we demonstrate that HB-EGF mRNA levels are increased in β-cells in response to glucose in a carbohydrate-response element–binding protein (ChREBP)–dependent manner. In addition, chromatin immunoprecipitation studies identified ChREBP binding sites in proximity to the HB-EGF gene. Finally, inhibition of Src family kinases, known to be involved in HB-EGF processing, abrogated glucose-induced β-cell proliferation. Our findings identify a novel glucose/HB-EGF/EGFR axis implicated in β-cell compensation to increased metabolic demand.




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Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through {beta}-Cell Adaptation

Aging-dependent changes in tissue function are associated with the development of metabolic diseases. However, the molecular connections linking aging, obesity, and diabetes remain unclear. Lamin A, lamin C, and progerin, products of the Lmna gene, have antagonistic functions on energy metabolism and life span. Lamin C, albeit promoting obesity, increases life span, suggesting that this isoform is crucial for maintaining healthy conditions under metabolic stresses. Because β-cell loss during obesity or aging leads to diabetes, we investigated the contribution of lamin C to β-cell function in physiopathological conditions. We demonstrate that aged lamin C only–expressing mice (LmnaLCS/LCS) become obese but remain glucose tolerant due to adaptive mechanisms including increased β-cell mass and insulin secretion. Triggering diabetes in young mice revealed that LmnaLCS/LCS animals normalize their fasting glycemia by both increasing insulin secretion and regenerating β-cells. Genome-wide analyses combined to functional analyses revealed an increase of mitochondrial biogenesis and global translational rate in LmnaLCS/LCS islets, two major processes involved in insulin secretion. Altogether, our results demonstrate for the first time that the sole expression of lamin C protects from glucose intolerance through a β-cell–adaptive transcriptional program during metabolic stresses, highlighting Lmna gene processing as a new therapeutic target for diabetes treatment.




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30 low-key acquisitions who could pay off big

Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with.




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Inciarte's key to success in 2019? Consistency

It could be argued that Ender Inciarte stands as the X-factor in regard to the Braves' bid to defend last year's National League East crown and experience a successful postseason.




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30 low-key acquisitions who could pay off big

Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with.




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Orioles considering using 'opener' strategy

Since the Rays debuted "the opener" last May, no fewer than eight teams have helped transform the concept from a fad into a mini-movement. Consider the Orioles a candidate to dive in next.




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Around the horn: Will Sisco be the starting C?

As we inch closer and closer to Opening Day, we'll continue to take a position-by-position look at the Orioles roster options and remaining questions. Now that pitchers and catchers have officially reported to Spring Training, now feels like a good time to take a look behind the plate, where the Orioles have a ton of options but no clear answer.




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O's Harvey feeling good after BP session

Orioles right-hander Hunter Harvey had hopped off a backfield mound at the club's Spring Training complex and exhaled. He was one of 14 pitchers scheduled to face hitters as part of the club's first full-squad workout on Monday, and now that he had, Harvey was asked to recall when was the last time he threw competitive pitches.




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Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue

The whitening and loss of brown adipose tissue (BAT) during obesity and aging promote metabolic disorders and related diseases. The imbalance of Ca2+ homeostasis accounts for the dysfunction and clearance of mitochondria during BAT whitening. Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear. In this study, we determined that the inhibitory effects of capsaicin on HFD-induced obesity and BAT whitening were dependent on the participation of SIRT3, a critical mitochondrial deacetylase. SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD. Mechanistically, SIRT3 inhibits mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium overload by reducing the H3K27ac level on the MCU promoter in an AMPK-dependent manner. In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin. Capsaicin intervention also inhibited aging-induced BAT whitening through this mechanism. In conclusion, this study emphasizes a critical role of the AMPK/SIRT3 pathway in the maintenance of BAT morphology and function and suggests that intervention in this pathway may be an effective target for preventing obesity- or age-related metabolic diseases.