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Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study

Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Methods:

We developed a VAT prediction score by regression equations averaged across 100 least absolute shrinkage and selection operator models in a cross-sectional study of 1,801 older adults in the Multiethnic Cohort (MEC). The score was then used as proxy for VAT in case–control studies of postmenopausal breast (950 case–control pairs) and colorectal (831 case–control pairs) cancer in an independent sample in MEC. Abdominal MRI–derived VAT; circulating biomarkers of metabolic, hormonal, and inflammation dysfunctions; and ORs for incident cancer adjusted for BMI and other risk factors were assessed.

Results:

The final score, composed of nine biomarkers, BMI, and height, explained 11% and 15% more of the variance in VAT than BMI alone in men and women, respectively. The area under the receiver operator curve for VAT >150 cm2 was 0.90 in men and 0.86 in women. The VAT score was associated with risk of breast cancer [OR (95% confidence interval [CI]) by increasing tertiles: 1.00, 1.09 (0.86–1.39), 1.48 (1.16–1.89); Ptrend = 0.002] but not with colorectal cancer (P = 0.84), although an association [1.00, 0.98 (0.68–1.39), 1.24 (0.88–1.76); Ptrend = 0.08] was suggested for this cancer after excluding cases that occurred within 7 years of blood draw (Pheterogeneity = 0.06).

Conclusions:

The VAT score predicted risks of postmenopausal breast cancer and can be used for risk assessment in diverse populations.

Impact:

These findings provide specific evidence for a role of VAT in breast cancer.




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Do the Magic Angle Effects or Susceptibility Effects Affect the Visualization of Nigrosome 1? [LETTERS]




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Bán gấp CH Vista Verde 3PN 130m2 view hồ bơi, giá chỉ 5.4 tỷ, 4PN tháp Lotus 212m2 view sông 9.8 tỷ

* Căn mới, duy nhất chỉ một căn, chủ nhà cần bán gấp. - Tháp T2, tầng trung, 3 phòng ngủ, 2WC, ban công rộng. - Diện tích: 130m2. - Decor full nội thất cao cấp phong cách Châu Âu, cực kỳ sang trọng. - Hướng cửa: Đông Nam. Ban công: Tây Bắc, View trọn vẹn hồ bơi nội khu đẹp lung l...




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Vista An Phu, over 100m2 - Discount price 4.6 billion

Vista An Phu, over 100m2 - Discount price 4.6 billion* 2BR, Tower 3, low floor, river view, 101.5m2 ______ Price 4.6 billion * 2BR, Tower 3, low floor, river view, 143m2________ Price 7.5 billion * 2BR Tower 3, low floor, pool view, 101.5m2 _______ Price 4.6 billion * 3BR Tower 1...




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Leadvisors Tower

Leadvisors Tower là tòa văn phòng hạng A gồm 3 tầng hầm và 25 tầng nổi. Lấy cảm hứng từ kiến trúc Nhật Bản, dự án với không gian độc đáo được ví như "Văn phòng Nhật Bản giữa lòng Hà Nội".




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US millionaire advises millennials should buy home, not rent

Self-made millionaire David Bach says not buying a home is the single biggest mistake millennials (who were born between 1980 and 2000) are making.




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Cập nhật " 5/2020" giỏ hàng 200 căn Vista Verde cần bán giá siêu tốt,có rất nhiều keys coi nhà ngay

Liên hệ ngay phòng kinh doanh tại dự án Vista Verde, văn phòng số 42 khu Failfolane. Điện thoại 070 576 9999 Đức Danh (Viber, Zalo, Whatsapp) hoặc 0906697090 cập nhật 09/05/2020 Chúng tôi luôn có sẵn chìa khoá cho khách hàng coi nhà 24/07. Kể cả chủ nhật. * Các căn 1 phòng n...




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Shounen-y punch 'em up Indivisible now has a DLC with 40 new challenges

If you didn’t feel challenged enough by Indivisible‘s main platforming and punching campaign, here’s some good news for ya. Lab Zero have released a new DLC for their turn-ish-based RPG today that promises the “forty specially crafted levels await to test your platforming and combat skills.” The Razmi’s Challenges DLC is available now, so you […]




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The Invisible Man – Movie Review

The Invisible Man – Movie Review Rating: A- (Great) Trailer/Thumbnail Courtesy Universal Pictures The horror genre doesn’t get nearly enough recognition for how it handles certain subject matter. Some can be gratuitous, while others are able to comment on society’s ills in a way that provokes a needed reaction from the audience. Director/writer Leigh Whannell […]

The post The Invisible Man – Movie Review appeared first on The Scene Magazine.




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Jarvis: The call to prayer, beautiful and haunting

The sun set Thursday, and a deep, melodious voice began from a loudspeaker at Windsor Mosque. “God is great,” Imam Mohamed Al-Jammali sang in Arabic. It was the athan, the Islamic call to prayer. The same words have summoned faithful Muslims around the world daily for centuries. It was beautiful and haunting. It was over […]




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The Invisible Man review: How science really can make things invisible

A new movie reimagines H.G. Wells's novel The Invisible Man. We still can't make people invisible, but it is possible to make tiny objects completely disappear




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Smart windows can let visible light through while blocking out heat

A 3D printed grate can be used to make a smart window that blocks heat from sunlight out in the summer while letting it through in the winter, conserving energy




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Help Rescuers Find Missing Persons With Drones and Computer Vision

A new contest aims to help first responders leverage computer vision algorithms and drone imagery during a search




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Dual personalities visualized for shape-shifting molecule

Researchers have made a breakthrough in understanding the structure of a key genetic molecule, called RNA, and revealing for the first time how these changes impact RNA's function. The research team developed a bioinformatics technique to resolve separate structures of RNA rather than viewing them as a 'blur' that averaged multiple structures. This underpinned their discovery that the structure of RNA can influence how cells function.




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China releases five prominent labour rights activists




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‘Of course I smoked marijuana!’ Elliott Gould on stardom, Streisand and Elvis Presley

The star of M*A*S*H, The Long Goodbye – and more recently, Friends – talks about drugs, his fiery marriage to Barbra Streisand and getting his best reviews from Groucho Marx and Muhammad Ali

The best review ever received by Elliott Gould – renowned actor and star of M*A*S*H and The Long Goodbye; not to mention, Ross and Monica’s dad on Friends – was from Groucho Marx. The two of them had become close in the comedian’s latter years – so close, Gould says, “he used to let me shave him”. One day Marx asked Gould to change a lightbulb in his bedroom. Gould took off his shoes, stood on the bed and replaced the broken bulb. Marx told him: “That was the best acting I’ve ever seen you do.”

Gould, now 81, has been telling the story for decades – but it is clear even in our pixelated video call that it still delights him. “Isn’t that great?” he says, his distinctive nasal, New York baritone now deepened with age. As we speak he is sitting at a computer at a friend’s house in Los Angeles, relaxed in a blue hoodie, with a seemingly bottomless mug of coffee before him. In isolation on either side of the Atlantic, neither of us has anywhere to be. And after more than half a century in Hollywood, in which he went from leading man to exile and, eventually, fixture – Gould could fill days, not just hours, with his stories. Even without his eight-year marriage to Barbra Streisand.

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'I Was A Feminist Activist In The '70s When The Pill Was Legalized For All Women'

It has been 60 years since the FDA first approved the birth control pill on May 9, 1960. It emerged as an essential pillar of women's ability to have good quality of life.




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Fortnite hosted a psychedelic Travis Scott concert and 12.3M people watched

The idea of an in-game Travis Scott concert might seem a little silly — particularly if, like me, you’re not really a Fortnite player. Yes, the popular multiplayer game has hosted other promotional events for movies and music. But even if all this COVID-19 imposed isolation has left you hungry for live performances, why not […]




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Pence spokeswoman, married to top Trump adviser, diagnosed with coronavirus

U.S. Vice President Mike Pence's press secretary, the wife of one of President Donald Trump's senior advisers, has tested positive for the coronavirus, raising alarm about the virus' potential spread within the White House's inner most circle.




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U.S. moves to drop case against Trump ex-adviser Flynn, who admitted lying to FBI

The U.S. Justice Department on Thursday abruptly asked a judge to drop criminal charges against Donald Trump's former national security adviser Michael Flynn following mounting pressure from the Republican president and his political allies on the right.




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UK science advisers expect coronavirus epidemic to peak within a month

The peak of the UK coronavirus epidemic now looks likely to arrive within the next month, according to analysis by the government’s science advisers




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Names of UK's coronavirus science advisers to be revealed

The membership of the UK's Scientific Advisory Group for Emergencies has so far been kept secret, but a list of names will soon be published, the UK's chief scientific adviser has said




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No gym, no problem: Italian gymnast improvises

With Italy's gym clubs and training facilities having fallen silent because of the coronavirus pandemic, 28-year-old Italian gymnast Marco Lodadio, silver medallist in the 2019 men's world artistic gymnastics championships, turned his garden into a fitness studio.

Without the sophisticated facilities that high-performance athletes normally count on, Lodadio modified a structure for a swing to train on rings.

Lodadio, whose parents had a gym where he began training when he was nine, has been stuck in lockdown for almost two months and this week has finally gotten back to his usual rigourous training regime as Italy begins gradually lifting its strict restrictions.





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U.S. dropping criminal case against ex-Trump adviser Flynn: AP

The U.S. Justice Department is dropping the criminal case against Michael Flynn, the former national security adviser to President Donald Trump, The Associated Press reported on Thursday, citing a court filing.




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Trump says his administration is talking to Republican senators about work visa issue

President Donald Trump said on Thursday his administration is talking to Republican senators about work visa issues, amid the coronavirus outbreak that has wreaked havoc on the U.S. economy.




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Revisiting AC Odyssey? Find Every Tomb and Ainigmata With This Map

This interactive map for Assassin's Creed Odyssey will help you find everything you need, like ainigmata ostraka and tombs.




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China releases five prominent labour rights activists

Five prominent labour activists have returned to their homes more than a year after they were arrested in coordinated raids in the southern Chinese city of Shenzhen, according to people close to them and a Hong Kong-based rights group.




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Tennis: Former Davis Cup rep boost for Bay

… advice from former New Zealand Davis Cup player Dan Willman, who has … challenges Taranaki for the Christie Cup, the symbol of Central … place at the World Junior Davis Cup tournament in the Czech … ; Willman added. The Christie Cup has been played for since ….




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Junior India squad for Davis Cup, Fed Cup named

… Junior Asia/ Oceania Davis Cup and Fed Cup final qualifying event. The … players selected for the Junior Davis Cup include Dev V. Javia, Sandeep … Gogoi (reserve). The Junior Fed Cup team includes Anisha Kashyap, Bhakti … Junior Asia/ Oceania Junior Davis Cup will begin in Kuching, Malaysia ….




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Spain’s Nadal Trains for 1st Time inside Davis Cup Venue

… Trains for 1st Time inside Davis Cup Venue VALENCIA, Spain – World No … the Spanish national team’s Davis Cup quarterfinals against Germany. Nadal, who ….




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Australia to face Germany on Davis Cup hard court

… the opening round of the Davis Cup World Group on hard court … . Kyrgios led Australia to the Davis Cup semi-finals this year, while Zverev ….




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Norrie Stuns Spain’s Bautista-Agut, Draws Great Britain Level in Davis Cup

… a big upset in his Davis Cup debut on Friday, defeating Spaniard ….




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Davis Cup: Fognini draws Italy level with France at 1-1

… level with France in the Davis Cup quarterfinals Friday. The 20th-ranked Fognini … all five of his previous Davis Cup matches and beat Fognini recently ….




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Activision Blizzard and EA report a strong first-quarter

Stay home, keep gaming




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Canned foods, seafood, supplements among revised alerts

The Food and Drug Administration uses import alerts to enforce U.S. food safety regulations for food from foreign countries. The agency updates and modifies the alerts as needed. Recent modifications to FDA’s import alerts, as posted by the agency, are listed below. Click on the links to view the full alerts. Import Alert Description URL... Continue Reading




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'The privilege to say goodbye': Hospitals move to allow family visits for people dying of coronavirus

After stories of people not being allowed to say goodbye to loved ones dying of coronavirus, hospitals around the world are moving to change the rules.




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TD Bank warns it’s expecting $1.1 billion in loan-loss provisions for U.S. unit

TD also said it will have about $600 million of set-asides tied to U.S. credit cards




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Berta Cáceres case: a warning for those who would kill activists

Trial is notable for highlighting land and nature defender murders that ordinarily go unpunished

The sentencing on Thursday of seven men accused of murdering the Honduran environmentalist Berta Cáceres is only partial justice, but it should inspire anyone committed to ending the slaughter of land and nature defenders around the globe.

A court in Tegucigalpa handed down guilty verdicts on all but one of the eight accused, including two employees of the hydro-electric dam company that the indigenous Lenca woman had been campaigning against before her assassination on 2 March 2016.

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Mexican activist shot dead before vote on power project he opposed

Environmental campaigners against electric plant and pipeline say Samir Flores Soberanes’s murder is a ‘political crime’

A Mexican environmental activist has been murdered before a referendum on a controversial thermal-electric plant and pipeline that he opposed.

Samir Flores Soberanes, an indigenous Náhuatl, was killed in his home during the early hours of Wednesday in the town of Amilcingo in Morelos state, 80 miles south of Mexico City. He was a human rights activist, producer for a community radio station and long-time opponent of the Proyecto Integral Morelos (the integral project for Morelos) – which includes the plant and pipeline.

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Keystone XL: police discussed stopping anti-pipeline activists 'by any means'

Revealed: records show law enforcement has called demonstrators possible ‘domestic terrorism’ threats

US law enforcement officials preparing for fresh Keystone XL pipeline protests have privately discussed tactics to stop activists “by any means” and have labeled demonstrators potential “domestic terrorism” threats, records reveal.

Internal government documents seen by the Guardian show that police and local authorities in Montana and the surrounding region have been preparing a coordinated response in the event of a new wave of protests opposing the controversial Keystone XL tar sands pipeline, which would carry crude oil from Canada to Montana, South Dakota and Nebraska.

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US national parks cause public health concern as visitors flood in

Parks have remained open amid the coronavirus and become a haven over the past week, prompting fears for staff and large crowds

Even as Broadway shows were shuttered and Disneyland was closed due to the Covid-19, most US national parks were open for business on Tuesday, confounding public health officials and worrying park staff who did not want to be exposed to the virus.

National parks have become a haven over the past week as the public seeks places to go during spring break. One park employee reported on Facebook that a visitor center at Big Bend national park was full on Monday with hundreds of people. Another shared a photo of shoulder to shoulder crowds at Zion national park waiting to board shuttle buses. (The park closed its shuttle bus system later in the day.)

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Computer vision helps scientists study lithium ion batteries

New machine learning methods bring insights into how lithium ion batteries degrade, and show it's more complicated than many thought.




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Google unifies messenger teams, plans “more coherent vision”

One person is now in charge of Google’s six messaging apps.




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Chile v Israel - Davis Cup scores

REUTERS - Davis Cup world group first round scores between Chile and Israel in Coquimbo on Monday (* denotes new result).




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Mexican broadcaster Televisa grapples with steamy soaps in social-distancing era

Some of the top creative minds at Mexican broadcaster Televisa are puzzling over an unexpected challenge: crafting their signature soap operas without a single love scene, or even a tender kiss.




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Coronavirus deaths to continue to rise 'for two weeks' even after intensive care admissions start to drop, top Government adviser says

Read our live coronavirus updates HERE Coronavirus: The symptoms




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UK park visits increased last weekend despite Covid-19 lockdown, Google data shows

Read our live updates on coronavirus HERE Coronavirus: The symptoms




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Climate activists referred to anti-terror programme by Home Office

Dozens of climate activists have been referred to the Home Office's anti-terror Prevent programme amid fears they may become radicalised, it has emerged.




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Royal hat-maker Philip Treacy joins 'visor army' to help make PPE for NHS workers in coronavirus fight

Read our live coronavirus updates HERE




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Time running out for Donald Trump in fight against an invisible enemy

As an election looms, the President has targeted state governors and even experts