The latest edition of the ISMG Security Report analyzes the many challenges involved in developing and implementing contact-tracing apps to help in the battle against COVID-19. Also featured: A discussion of emerging privacy issues and a report on why account takeover fraud losses are growing.

Australia, India and UK Pursuing Centralized Approach Many Privacy Experts Warn Against
Technology is no panacea, including for combating COVID-19. While that might sound obvious, it's worth repeating because some governments continue to hype contact-tracing apps. Such apps won't magically identify every potential exposure. But they could make manual contact-tracing programs more effective.

We Need These Apps, But Some Nations' Security and Privacy Follies Don't Bode Well
Despite the need to battle COVID-19, several nations' in-development digital contact-tracing apps are already dogged by security and privacy concerns. Whether enough users will ever trust these apps to make them effective remains a major question. Is it too late to get more projects back on track?

The latest edition of the ISMG Security Report analyzes the many challenges involved in developing and implementing contact-tracing apps to help in the battle against COVID-19. Also featured: A discussion of emerging privacy issues and a report on why account takeover fraud losses are growing.

Australia, India and UK Pursuing Centralized Approach Many Privacy Experts Warn Against
Technology is no panacea, including for combating COVID-19. While that might sound obvious, it's worth repeating because some governments continue to hype contact-tracing apps. Such apps won't magically identify every potential exposure. But they could make manual contact-tracing programs more effective.

We Need These Apps, But Some Nations' Security and Privacy Follies Don't Bode Well
Despite the need to battle COVID-19, several nations' in-development digital contact-tracing apps are already dogged by security and privacy concerns. Whether enough users will ever trust these apps to make them effective remains a major question. Is it too late to get more projects back on track?

The latest edition of the ISMG Security Report analyzes the many challenges involved in developing and implementing contact-tracing apps to help in the battle against COVID-19. Also featured: A discussion of emerging privacy issues and a report on why account takeover fraud losses are growing.

Australia, India and UK Pursuing Centralized Approach Many Privacy Experts Warn Against
Technology is no panacea, including for combating COVID-19. While that might sound obvious, it's worth repeating because some governments continue to hype contact-tracing apps. Such apps won't magically identify every potential exposure. But they could make manual contact-tracing programs more effective.

We Need These Apps, But Some Nations' Security and Privacy Follies Don't Bode Well
Despite the need to battle COVID-19, several nations' in-development digital contact-tracing apps are already dogged by security and privacy concerns. Whether enough users will ever trust these apps to make them effective remains a major question. Is it too late to get more projects back on track?

The latest edition of the ISMG Security Report analyzes the many challenges involved in developing and implementing contact-tracing apps to help in the battle against COVID-19. Also featured: A discussion of emerging privacy issues and a report on why account takeover fraud losses are growing.

The commissioner for the digital portfolio, Margrethe Vestager, warned that "without the technology, it will be very difficult to open [society] to the degree that we all want" - since new outbreaks might surge back until there is a vaccine.

The app would need to be paired with more than 100,000 daily tests in order to have effect. And far more than 60 percent of the population will need to use the app in order for it to be effective.

The all-female W Series is launching an esports league for female drivers, with actual racing still suspended due to the COVID-19 pandemic.With its second season ...

A Utah-based start-up says it has exclusive business rights to the use of smartphones and other electronic devices for tracing people who have come into contact with a person with Covid-19, setting up a potential patent-infringement battle with some of the biggest technology companies.Blyncsy, which describes itself as a “movement and data intelligence” company headquartered in Salt Lake City, holds the business method patent for “tracking proximity relationships and uses thereof” by…

US government requests from China for early coronavirus samples make sense as part of efforts to bring the pandemic under control and avoid future ones, but the “political drama” around the efforts is undermining progress, two public health experts warned.RNA viruses like Sars-CoV-2, the coronavirus that causes Covid-19, mutate about once a month, making them “essentially a clock that enables one to extrapolate when the virus actually evolved”, said Dr Barry Bloom, an infectious disease…

BEIJING: China said on Thursday it supports the World Health Organization in trying to pinpoint the origins of the COVID-19 pandemic and accused U.S. Secretary of State Mike Pompeo of telling one...

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As India enters an extended coronavirus lockdown, the government is actively pursuing contact tracing to help control infections.

The World Health Organization (WHO) plans to launch an app this month to enable people in under-resourced countries to assess whether they may have the novel coronavirus, and is considering a Bluetooth-based contact tracing feature too, an official told Reuters Friday.

A European coalition is forming around an approach to using smartphone technology to trace coronavirus infections which, it's hoped, will enable borders to reopen. Joe Davies reports.

A European coalition is forming around an approach to using smartphone technology to trace coronavirus infections which, it's hoped, will enable borders to reopen. Joe Davies reports.

The UK government will begin trials of its coronavirus contact-tracing app this week, but what impact it will have on slowing the spread of covid-19 is unclear

Dr Aaron Holley warns against following 'false prophets' as we confront treatment decisions for patients with COVID-19.

ABSTRACT

Candida auris has emerged globally as a multidrug-resistant yeast that can spread via nosocomial transmission. An initial phylogenetic study of isolates from Japan, India, Pakistan, South Africa, and Venezuela revealed four populations (clades I, II, III, and IV) corresponding to these geographic regions. Since this description, C. auris has been reported in more than 30 additional countries. To trace this global emergence, we compared the genomes of 304 C. auris isolates from 19 countries on six continents. We found that four predominant clades persist across wide geographic locations. We observed phylogeographic mixing in most clades; clade IV, with isolates mainly from South America, demonstrated the strongest phylogeographic substructure. C. auris isolates from two clades with opposite mating types were detected contemporaneously in a single health care facility in Kenya. We estimated a Bayesian molecular clock phylogeny and dated the origin of each clade within the last 360 years; outbreak-causing clusters from clades I, III, and IV originated 36 to 38 years ago. We observed high rates of antifungal resistance in clade I, including four isolates resistant to all three major classes of antifungals. Mutations that contribute to resistance varied between the clades, with Y132F in ERG11 as the most widespread mutation associated with azole resistance and S639P in FKS1 for echinocandin resistance. Copy number variants in ERG11 predominantly appeared in clade III and were associated with fluconazole resistance. These results provide a global context for the phylogeography, population structure, and mechanisms associated with antifungal resistance in C. auris.

IMPORTANCE In less than a decade, C. auris has emerged in health care settings worldwide; this species is capable of colonizing skin and causing outbreaks of invasive candidiasis. In contrast to other Candida species, C. auris is unique in its ability to spread via nosocomial transmission and its high rates of drug resistance. As part of the public health response, whole-genome sequencing has played a major role in characterizing transmission dynamics and detecting new C. auris introductions. Through a global collaboration, we assessed genome evolution of isolates of C. auris from 19 countries. Here, we described estimated timing of the expansion of each C. auris clade and of fluconazole resistance, characterized discrete phylogeographic population structure of each clade, and compared genome data to sensitivity measurements to describe how antifungal resistance mechanisms vary across the population. These efforts are critical for a sustained, robust public health response that effectively utilizes molecular epidemiology.

Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to many controversies in the scientific community. In the past decade, to enhance the specificity and precision of genetic targeting, researchers have used two or more orthogonal recombinases simultaneously for labeling cell lineages. Here, we review the history of cell-tracing strategies and then elaborate on the working principle and application of a recently developed dual genetic lineage-tracing approach for cell fate studies. We place an emphasis on discussing the technical strengths and caveats of different methods, with the goal to develop more specific and efficient tracing technologies for cell fate mapping. Our review also provides several examples for how to use different types of DNA recombinase–mediated lineage-tracing strategies to improve the resolution of the cell fate mapping in order to probe and explore cell fate–related biological phenomena in the life sciences.

Retrospective lineage tracing harnesses naturally occurring mutations in cells to elucidate single cell development. Common single-cell phylogenetic fate mapping methods have utilized highly mutable microsatellite loci found within the human genome. Such methods were limited by the introduction of in vitro noise through polymerase slippage inherent in DNA amplification, which we characterized to be approximately 10–100x higher than the in vivo replication mutation rate. Here, we present RETrace, a method for simultaneously capturing both microsatellites and methylation-informative cytosines to characterize both lineage and cell type, respectively, from the same single cell. An important unique feature of RETrace was the introduction of linear amplification of microsatellites in order to reduce in vitro amplification noise. We further coupled microsatellite capture with single-cell reduced representation bisulfite sequencing (scRRBS), to measure the CpG methylation status on the same cell for cell type inference. When compared to existing retrospective lineage tracing methods, RETrace achieved higher accuracy (88% triplet accuracy from an ex vivo HCT116 tree) at a higher cell division resolution (lowering the required number of cell division difference between single cells by approximately 100 divisions). Simultaneously, RETrace demonstrated the ability to capture on average 150,000 unique CpGs per single cell in order to accurately determine cell type. We further formulated additional developments that would allow high-resolution mapping on microsatellite-stable cells or tissues with RETrace. Overall, we present RETrace as a foundation for multi-omics lineage mapping and cell typing of single cells.

Many countries are hoping to use contact-tracing apps to leave lockdown and suppress further coronavirus outbreaks, but the use of such technology has many issues

The UK government will begin trials of its coronavirus contact-tracing app this week, but what impact it will have on slowing the spread of covid-19 is unclear

• France Galop lobbied Emmanuel Macron for go-ahead
• Longchamp one of three meetings to take place on Monday

France Galop, the ruling body of French racing, confirmed on Saturday it will resume with meetings at Longchamp, Toulouse and Compiegne on Monday, but only after what is believed to have been urgent behind-the-scenes lobbying by Edouard de Rothschild, FG’s president, late on Friday night that persuaded Emmanuel Macron, the French president, to finally give his approval to the resumption.

De Rothschild thanked Macron and Édouard Philippe, France’s prime minister, for their efforts in a tweet in the early hours of Saturday morning that confirmed racing had seen off last-minute objections to its return.

The World Health Organization (WHO) plans to launch an app this month to enable people in under-resourced countries to assess whether they may have the novel coronavirus, and is considering a Bluetooth-based contact tracing feature too, an official told Reuters on Friday.

Read our live coronavirus updates HERE

A major study has deemed increasing testing and contact tracing in the community the "most promising approach" to lifting coronavirus lockdown measures in the short term.

All essential workers are to be able to get coronavirus tests if they need them due to increased screening capacity, health secretary Matt Hancock announced today.

Britain and France are working together to develop contact-tracing apps to fight coronavirus.

The NHS coronavirus contact tracing app will be trialled in the Isle of Wight this week before being rolled out more widely later this month, the Transport Secretary said.

Matt Hancock has urged people living on the Isle of Wight to download the coronavirus contact tracing app to "save lives" during the pandemic.

The UK public's right to privacy could become "another casualty" of the coronavirus crisis through the use of a contact-tracing app, Amnesty International UK has warned.

Trials are beginning on a new coronavirus contact-tracing app which ministers have said will save lives and help lift Britain out of lockdown.

The number of new Covid-19 cases "needs to come down further", an expert has warned, as the UK death toll recorded its lowest daily rise since the end of March.

Researchers say evidence from China 'may demonstrate the huge scale of testing and contact tracing that's needed to reduce the virus spreading'

Both companies said privacy and preventing governments from using the system to compile data on citizens was a primary goal.

Alberta is currently the only Canadian jurisdiction to have a contact-tracing app available to download, but several other provinces, including Ontario, B.C. and New Brunswick, have said they are investigating this technology.

Federal privacy commissioner Daniel Therrien says the health crisis calls for some flexibility when it comes to the application of privacy laws.

The app will ask people about their symptoms and offer guidance on whether they may have COVID-19, the potentially lethal illness caused by the coronavirus, said Bernardo Mariano, chief information officer for the WHO.

The tech giants shared details Monday about the tools they’ve been developing to help governments and public health authorities trace the spread of the coronavirus.

A European coalition is forming around an approach to using smartphone technology to trace coronavirus infections that, its backers hope, could help to reopen borders without unleashing a second wave of the pandemic.

Alberta's use of a smartphone app to help slow the spread of the coronavirus may provide other provinces with insight on what to do — and what to avoid — as Canada begins easing restrictions, heightening the need for effective contact tracing.

Health experts agree contact tracing is a key measure to contain a pandemic. But is the answer a contact tracing app?

As New Brunswick and other provincial governments contemplate launching COVID-19 contact-tracing apps, privacy watchdogs from across the country have issued joint guidelines on what they are describing as an "extraordinary" measure, urging transparency and accountability.

The app will ask for your name (or pseudonym), age range, postcode and phone number. Scott Morrison says the Australian government’s covid safe tracking app won’t be mandatory to download and install, but its uptake numbers could play a part in easing Covid-19 restrictions

• Authorities admit app is not working properly on iPhones
  
• How Australia’s Covidsafe compares to other countries’ contact tracing technology
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The Australian government has launched Covidsafe, an app that traces every person running the app who has been in contact with someone else using the app who has tested positive for coronavirus in the previous few weeks, in a bid to automate coronavirus contact tracing, and allow the easing of restrictions.

Here’s what we know about the app so far.

Expert advice on the NHS contact tracing app