Tata Group has joined hands with General Electric Ventures, Microsoft Ventures and others to set up a new technology incubator in Israel.

Anil Ambani promoted Reliance Group on Tuesday announced a strategic partnership with Cisco Jasper for the launch of its new venture 'UNLIMIT' to provide Internet of Things (IoT) services to enterprise customers across India.

The OECD and the ESRC Genomics Policy & Research Forum jointly organised a one-day Forum on 12 November 2012 in Paris. The event was both retrospective and forward-looking. The forum concluded that the promise of biotechnology is not set but evolves with fresh scientific knowledge, novel laws and regulations. The future of biotechnology needs to also integrate social and cultural dimensions.

This book discusses scientific and technological tools at the centre of a renewed interest in marine biotechnology that is contributing to a new bioeconomy sector in many countries and offering potential new solutions to global challenges.

This newsletter provides up-to-date information on activities related to biotechnology at the Organisation for Economic Co-operation and Development (OECD). It is mainly intended for delegates to OECD meetings who are already familiar with certain aspects of OECD‟s work. We hope that it is also informative for the wider biotech community.

OECD major events and activities relating to biotechnologies: latest developments are updated biannually in this Newsletter

A major fruit crop of temperate regions, APPLE is consumed worldwide as fresh fruit, juice and other food products. This consensus document provides science-based key insights for the regulatory assessment of the environmental safety of genetically-engineered products: taxonomy, reproductive biology, genetics, hybridisation and introgression, and ecology.

In Berlin, hundreds of protesters swarmed Alexanderplatz yesterday, clashing with riot police officers and shouting 'We are the people!' and 'Freedom!'.

Drivers were caught driving at 'extreme speeds' on quiet roads over the Easter weekend, including a man who was clocked at 151mph on the M1 near London as he led police on a high-speed chase.

The French international only joined Juventus on a free transfer from Paris Saint-Germain last summer but has failed to nail down a regular starting place in Maurizio Sarri's side this season.

In Berlin, hundreds of protesters swarmed Alexanderplatz yesterday, clashing with riot police officers and shouting 'We are the people!' and 'Freedom!'.

There's been plenty of head-scratching over at Omega Diagnostics, one of the biotech minnows whose share price has shot up on the back of its efforts to tackle the pandemic.

The French international only joined Juventus on a free transfer from Paris Saint-Germain last summer but has failed to nail down a regular starting place in Maurizio Sarri's side this season.

Although much amended and bent, the Constitution of India is still a charter for a democratic republic of men and women. But a recent experience made me realise that we are in danger of ceding highly resonant words to the men on our right, writes Ramachandra Guha.

Both India and Pakistan played well in the Twenty20 tournament, and played in a positive frame of mind. Why then should a mainstream media channel insist on harping on the rivalry between two countries that are making tentative attempts at peace, asks Kalpana Sharma.

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

Archives, Room Use Only - TK9946.H68 1914

Archives, Room Use Only - TK5283.I58 1927

Archives, Room Use Only - TK6545.A1 G86 1992

Archives, Room Use Only - TK455.J34 1897

Archives, Room Use Only - UG611.5.F8 F73 1918

Archives, Room Use Only - TK5743.G74 1915

Chance found me, three years ago, at the end of a brilliant summer day in Leeds, seated at dinner next to a distinguished gentleman, vice-chair of a venerable UK bank.

Former Patriots executive Mike Lombardi still won't rule out New England signing Cam Newton at some point despite Bill Belichick indicating he plans to roll with the current QB group he has now.

Former Patriots linebacker Rob Ninkovich explained why veteran quarterback Brian Hoyer will be very important to New England's offense in 2020.

If Patriots fans want to separately watch the Patriots and Bill Belichick and the Buccaneers and Tom Brady (and Rob Gronkowski) this year, they can do so at least 14 times. As noted by Mike Reiss of ESPN.com, the two teams don't play at the same time until late in the 2020 season. It happens [more]

The Congress requested the President to remind the central government of its 'raj dharma', Singh said.

Security personnel have been conducting flag marches and holding regular consultations with locals to assuage their fears. They are also urging residents to not pay attention to rumours on social media and report them to the police.

No untoward incident has been reported from the district over the past three days.

The Congress and other opposition parties have accused the police of bias and inaction in the Delhi violence.

Interacting with locals, he observed that the situation is gradually improving day by day, and urged them not to pay attention to rumours and avoid circulating unconfirmed messages.

There was also no fresh incident of violence and there is a heavy deployment of security personnel

Many of those who fled during the violence are still fearful about returning.

Speaking with reporters, Gandhi said, "This (school) is India's future. Hate and violence has destroyed it. Nobody has benefited from this. Violence and hate are enemies of development."

As the government came under attack from the Opposition during the debate on the recent communal riots in the national capital that have claimed over 50 lives, the BJP members alleged that the violence was a pre-planned conspiracy and the home minister and authorities took pro-active steps to control the situation.

From making 'COVIDIOTS' (a term coined for those flouting restrictions) squat on the road and do sit-ups, to making them pose with pamphlets admitting their fault, police officials have pulled out all the stops from their kitty of creativity to drive home the message.

The vaccine will be developed using the virus strain isolated at the ICMR's National Institute of Virology (NIV), Pune, a statement said.

Virus strain from NIV Pune transferred.

Björn Eismann, Teresa G. Krieger, Jürgen Beneke, Ruben Bulkescher, Lukas Adam, Holger Erfle, Carl Herrmann, Roland Eils, and Christian Conrad

3D cell cultures enable the in vitro study of dynamic biological processes such as the cell cycle, but their use in high-throughput screens remains impractical with conventional fluorescent microscopy. Here, we present a screening workflow for the automated evaluation of mitotic phenotypes in 3D cell cultures by light-sheet microscopy. After sample preparation by a liquid handling robot, cell spheroids are imaged for 24 hours in toto with a dual-view inverted selective plane illumination microscope (diSPIM) with a much improved signal-to-noise ratio, higher imaging speed, isotropic resolution and reduced light exposure compared to a spinning disc confocal microscope. A dedicated high-content image processing pipeline implements convolutional neural network based phenotype classification. We illustrate the potential of our approach by siRNA knock-down and epigenetic modification of 28 mitotic target genes for assessing their phenotypic role in mitosis. By rendering light-sheet microscopy operational for high-throughput screening applications, this workflow enables target gene characterization or drug candidate evaluation in tissue-like 3D cell culture models.

Tara L. Mastro, Vishnu P. Tripathi, and Susan L. Forsburg

Translesion synthesis polymerases (TLSPs) are non-essential error-prone enzymes that ensure cell survival by facilitating DNA replication in the presence of DNA damage. In addition to their role in bypassing lesions, TLSPs have been implicated in meiotic double strand break repair in several systems. Here we examine the joint contribution of four TLS polymerases to meiotic progression in the fission yeast S. pombe. We observed the dramatic loss of spore viability in fission yeast lacking all four TLSPs which is accompanied by disruptions in chromosome segregation during meiosis I and II. Rec8 cohesin dynamics are altered in the absence of the TLSPs. These data suggest that the TLSPs contribute to multiple aspects of meiotic chromosome dynamics.

Ana Loncar, Sergio A. Rincon, Manuel Lera Ramirez, Anne Paoletti, and Phong T. Tran

To segregate the chromosomes faithfully during cell division, cells assemble a spindle that captures the kinetochores and pulls them towards opposite poles. Proper spindle function requires correct interplay between microtubule motors and non-motor proteins. Defects in spindle assembly or changes in spindle dynamics are associated with diseases like cancer or developmental disorders. Here we compared mitotic and meiotic spindles in fission yeast. We show that even though mitotic and meiotic spindles undergo the typical three phases of spindle elongation, they have distinct features. We found that the relative concentration of kinesin-14 Pkl1 is decreased in meiosis I compared to mitosis, while the concentration of kinesin-5 Cut7 remains constant. We identified the second kinesin-14 Klp2 and microtubule dynamics as factors necessary for proper meiotic spindle assembly. This work defines differences between mitotic and meiotic spindles in fission yeast, and provides prospect for future comparative studies.

Mei Wang, Luping Yu, Shu Wang, Fan Yang, Min Wang, Lufan Li, and Xin Wu

RNA-binding protein LIN28A is required for maintaining tissue homeostasis, including the reproductive system, but the underlying mechanisms on how LIN28A regulates germline progenitors remain unclear. Here, we dissected LIN28A-binding targets using high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) in the mouse testes. LIN28A preferentially binds to CDS or 3'UTR regions through these sites with GGAG(A) sequences enriched within mRNAs. Further investigation of Lin28a null mouse testes indicated that meiosis-associated mRNAs mediated by LIN28A were differentially expressed. Next, ribosome profiling revealed that the mRNA levels of these targets were significantly reduced in polysome fractions, and their protein expression levels decreased in the Lin28a null mouse testes, even when meiotic arrest in null mouse testes was not apparent. Collectively, these findings provide a set of binding targets that are regulated by LIN28A, which may potentially be the mechanism for the prominent role of LIN28A in regulating mammalian undifferentiated spermatogonia fates and male fertility.