Next-Gen Analyzer Transforms CIO2 Monitoring with Precision and Sustainability

Kemtrak's advanced photometer features dual-wavelength technology, enhancing product quality and facilitating regulatory compliance

WILMINGTON – The Delaware Child Psychiatry Access Program has expanded and updated its service offerings for participating pediatric primary care providers. Over the summer, the Delaware Child Psychiatry Access Program, known as DCPAP, added three new child psychiatrists to offer consultations to pediatric serving primary care providers. Saurabh Gupta, M.D., Narpinder Malhi, M.D., and Markian […]

NDCP 2018 is made-to-order for resolution of the challenges seen today in the environment. However, this superb policy—almost entirely—is awaiting implementation since more than a year. 

Talking Heads leader David Byrne’s new project, “Theater of Mind,” will miss its scheduled world premiere in Denver later this year, the Denver Center for the Performing Arts said today.

Douglas Langworthy, director of new play development at the Denver Center for the Performing Arts, died Monday at the age of 61, the DCPA said.

Plays and musicals are being canceled through early summer.

DCPA isn't giving up on Hamilton yet.

Two days after announcing it, the Denver Center for the Performing Arts is postponing public sales of tickets for the touring Broadway musical “Hamilton.”

Talking Heads leader David Byrne’s new project, “Theater of Mind,” will miss its scheduled world premiere in Denver later this year, the Denver Center for the Performing Arts said today.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

strataconf: A roundup of healthcare tools used in the field from #hdpalooza http://t.co/0d2x3OlaeC including @MedCPU @SVBiosystems @CHRankings & more

You know as well as anyone that the challenges we face are daunting. You’ve shown us that, as we seek to address the problem of substance abuse, it makes sense to focus on the most dangerous types of drugs. And right now, few substances are more lethal than prescription opioids and heroin.

A new helpline has been launched by the Delhi Commission for Protection of Child Rights (DCPCR) to provide counseling support to children and parents