hd Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux [Research Articles] By www.jlr.org Published On :: 2020-11-17T08:30:36-08:00 Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Carriers of these mutations do not exhibit increased cardiovascular disease risk despite displaying reduced levels of ApoA-I/ HDL-cholesterol. To explain this paradox, we show that the HDL particle profile of patients carrying either L75P or L174S ApoA-I amyloidogenic variants a higher relative abundance of the 8.4 nm vs 9.6 nm particles, and that serum from patients, as well as reconstituted 8.4 and 9.6 nm HDL particles (rHDL), possess increased capacity to catalyze cholesterol efflux from macrophages. Synchrotron radiation circular dichroism and hydrogen-deuterium exchange revealed that the variants in 8.4 nm rHDL have altered secondary structure composition and display a more flexible binding to lipids compared to their native counterpart. The reduced HDL-cholesterol levels of patients carrying ApoA-I amyloidogenic variants are thus balanced by higher proportion of small, dense HDL particles and better cholesterol efflux due to altered, region-specific protein structure dynamics. Full Article
hd rHDL modelling and the anchoring mechanism of LCAT activation [Research Articles] By www.jlr.org Published On :: 2020-12-02T13:30:37-08:00 Lecithin:cholesterol-acyl-transferase (LCAT) plays a major role in cholesterol metabolism as it is the only extracellular enzyme able to esterify cholesterol. LCAT activity is required for lipoprotein remodelling and, most specifically, for the growth and maturation of HDLs. In fact, genetic alterations affecting LCAT func- tionality may cause a severe reduction in plasma levels of HDL-cholesterol with important clinical consequences. Although several hypotheses were formulated, the exact molecular recognition mechanism between LCAT and HDLs is still unknown. We employed a combination of structural bioinformatics procedures to deepen the insights into the HDL-LCAT interplay that promotes LCAT activation and cholesterol esterification. We have generated a data-driven model of reconstituted HDL (rHDL) and studied the dynamics of an assembled rHDL::LCAT supramolecular complex, pinpointing the conformational changes originating from the interaction between LCAT and apolipoprotein A-I (apoA-I) that are necessary for LCAT activation. Specifically, we propose a mechanism in which the anchoring of LCAT lid to apoA-I helices allows the formation of a hydrophobic hood that expands LCAT active site and shields it from the solvent, allowing the enzyme to process large hydrophobic substrates. Full Article
hd Site-specific deacylation by ABHD17a controls BK channel splice variant activity [Signal Transduction] By www.jbc.org Published On :: 2020-12-04T00:06:05-08:00 S-Acylation, the reversible post-translational lipid modification of proteins, is an important mechanism to control the properties and function of ion channels and other polytopic transmembrane proteins. However, although increasing evidence reveals the role of diverse acyl protein transferases (zDHHC) in controlling ion channel S-acylation, the acyl protein thioesterases that control ion channel deacylation are very poorly defined. Here we show that ABHD17a (α/β-hydrolase domain-containing protein 17a) deacylates the stress-regulated exon domain of large conductance voltage- and calcium-activated potassium (BK) channels inhibiting channel activity independently of effects on channel surface expression. Importantly, ABHD17a deacylates BK channels in a site-specific manner because it has no effect on the S-acylated S0–S1 domain conserved in all BK channels that controls membrane trafficking and is deacylated by the acyl protein thioesterase Lypla1. Thus, distinct S-acylated domains in the same polytopic transmembrane protein can be regulated by different acyl protein thioesterases revealing mechanisms for generating both specificity and diversity for these important enzymes to control the properties and functions of ion channels. Full Article
hd WITHDRAWN: Extraordinary apolipoprotein oxidation in chronic hepatitis C and liver cirrhosis [13. Other] By www.mcponline.org Published On :: 2007-09-05T09:37:40-07:00 Withdrawn by Author. Full Article
hd WITHDRAWN: Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma [Research] By www.mcponline.org Published On :: 2017-04-28T07:30:39-07:00 This article has been withdrawn by the authors. We discovered an error after this manuscript was published as a Paper in Press. Specifically, we learned that the structures of glycans presented for the PD-L1 peptide were drawn and labeled incorrectly. We wish to withdraw this article and submit a corrected version for review. Full Article
hd WITHDRAWN: Heralds of parallel MS: Data-independent acquisition surpassing sequential identification of data dependent acquisition in proteomics [Research] By www.mcponline.org Published On :: 2017-05-26T10:39:04-07:00 This article has been withdrawn by the authors. This article did not comply with the editorial guidelines of MCP. Specifically, single peptide based protein identifications of 9-19% were included in the analysis and discussed in the results and conclusions. We wish to withdraw this article and resubmit a clarified, corrected manuscript for review. Full Article
hd Boy who survived life support withdrawal confirms “medicine is a science of uncertainty,” says judge By www.bmj.com Published On :: Thursday, September 26, 2024 - 09:06 Full Article
hd Famous birthdays for Nov. 11: Leonardo DiCaprio, Calista Flockhart By www.upi.com Published On :: Mon, 11 Nov 2024 03:00:07 -0500 Actor Leonardo DiCaprio turns 50 and actor Calista Flockhart turns 60, among the famous birthdays for Nov. 11. Full Article
hd Famous birthdays for Nov. 12: Anne Hathaway, Raffey Cassidy By www.upi.com Published On :: Tue, 12 Nov 2024 03:00:07 -0500 Actor Anne Hathaway turns 42 and actor Raffey Cassidy turns 23, among the famous birthdays for Nov. 12. Full Article
hd Famous birthdays for Nov. 13: Whoopi Goldberg, Julia Michaels By www.upi.com Published On :: Wed, 13 Nov 2024 03:00:06 -0500 Actor/TV personality Whoopi Goldberg turns 69 and singer Julia Michaels turns 30, among the famous birthdays for Nov. 13. Full Article
hd 1 in 4 Adults Believe They Have ADHD — Are You Missing The Signs? (M) By www.spring.org.uk Published On :: Fri, 25 Oct 2024 17:00:03 +0000 The most common ADHD symptoms in adults are often different to those in children. Full Article ADHD subscribers-only
hd How To Cope With the Psychological Symptoms of Suboxone Withdrawal By www.whatispsychology.biz Published On :: Wed, 24 Jul 2024 12:46:10 +0000 Suboxone is a medicine prescribed to treat opioid use disorder. But in recent times, it has gained a poor reputation for contributing to severe side effects, such as dental damage and decay. Many patients have had to undergo costly dental repair surgery to treat the gum and tooth issues they faced. But the side effects […] The post How To Cope With the Psychological Symptoms of Suboxone Withdrawal first appeared on What is Psychology?. Full Article Abnormal Psychology Definitions Psychology News manage suboxone withdrawal newsnow suboxone side effects suboxone withdrawal symptoms
hd Utah Inflated Its High School Graduation Rate, Federal Watchdog Finds By blogs.edweek.org Published On :: Thu, 29 Nov 2018 00:00:00 +0000 Federal watchdogs find that Utah inflated its high school graduation rate in the last of a series of reports warning states not to make end runs around the rules for calculating graduation rates. Full Article Utah
hd No ordinary World Food Day for FAO's 75th Birthday By www.fao.org Published On :: Thu, 29 Oct 2020 00:00:00 GMT Celebrated in over 150 countries around the world, this year’s edition of World Food Day marked the 75th anniversary of the foundation of FAO. With the theme “Grow, nourish, sustain. Together. Our [...] Full Article
hd Rare Apollo 11 Footage, Remixed and in HD By www.smithsonianmag.com Published On :: Mon, 07 Oct 2024 00:00:00 -0000 In 1969, three men traveled to the moon cameras documented their every move Full Article
hd Canada launches AI watchdog to oversee the technology’s safe development and use By www.cbc.ca Published On :: Tue, 12 Nov 2024 19:17:56 EST Amid rapid global advances and deployment of artificial intelligence technologies, the federal government has invested millions to combine the minds of three existing institutes into one that can keep an eye on potential dangers ahead. Full Article
hd Sask. watchdog investigating Moose Jaw police's role in fatal crash By www.cbc.ca Published On :: Tue, 12 Nov 2024 13:13:42 EST Saskatchewan's Serious Incident Response Team (SIRT) is investigating the role the Moose Jaw Police Service played in a crash that killed a 31-year-old man. Full Article News/Canada/Saskatchewan
hd Police watchdog investigating Hamilton shooting involving officer that left man dead By www.cbc.ca Published On :: Sun, 10 Nov 2024 10:04:16 EST A 43-year-old man is dead after being shot by police at a west-end Hamilton apartment building Saturday, in an incident which also sent an officer to hospital, Ontario's police watchdog says. Full Article News/Canada/Hamilton
hd Vanessa James, Eric Radford still eligible for Olympic team despite withdrawal at nationals By www.cbc.ca Published On :: Sat, 08 Jan 2022 15:05:12 EST Vanessa James and Eric Radford withdrew from the pairs competition at the Canadian figure skating championships before Saturday's free program in Ottawa. Full Article Sports/Olympics/Winter Sports/Figure Skating
hd N.C. watchdog agency critiques teacher diversity efforts By www.edweek.org Published On :: Tue, 10 Nov 2020 00:00:00 +0000 Full Article Diversity
hd News24 Business | GEPF two-pot frustrations: After two months, some withdrawals still not processed By www.news24.com Published On :: Tuesday Nov 05 2024 20:07:19 Delays in the payment of withdrawals from the two-pot retirement system have led members of the Government Employees Pension Fund to voice their concerns on social media. Full Article
hd HDFS program at Penn State DuBois hosts future opportunities panels for students By www.psu.edu Published On :: Mon, 30 Sep 2024 10:47:33 -0400 The Human Development and Family Studies program at Penn State DuBois recently held two panel events aimed at preparing students for life after graduation. The first event, the annual grad school panel, took place on Sept. 12, while the second event, the internship panel, was hosted on Sept. 19. Full Article
hd News24 Business | Deepfake drama's latest twist: Watchdog probes claims that agents have been lying about licence By www.news24.com Published On :: Tuesday Nov 12 2024 17:43:20 SA's financial regulator is investigating allegations that agents of online brokerage Banxso, whose licence has been suspended, contacted clients claiming it has been "cleared". Full Article
hd Blog from Bolivia: Moving ministries and the best birthday By www.om.org Published On :: Mon, 27 May 2019 08:05:10 +0000 Santa Cruz, Bolivia :: God surprises a Logos Hope crewmember with birthday treats and new perspectives as she serves with a team on shore. Full Article
hd Gigabyte 27-Inch Gaming Monitor With QHD Resolution, 180Hz Refresh Rate Launched in India By www.gadgets360.com Published On :: Tue, 12 Nov 2024 16:09:42 +0530 Gigabyte M27QA ICE monitor has been launched in India. It joins the Taiwanese manufacturer’s extensive lineup of gaming monitors and boasts features such as a 27-inch panel with QHD resolution, a refresh rate of 180Hz, and AMD FreeSync technology for improved visuals. Gigabyte says its monitor carries support for OSD Sidekick software which enables users to tweak various display settings and allows for further customisation through the keyboard and mouse. Full Article
hd Parineeti Chopra's Birthday Post For Husband Raghav Chadha: "They Don't Make Gentlemen Like You Anymore" By www.ndtv.com Published On :: Mon, 11 Nov 2024 12:50:03 +0530 "I'm glad God gave me the best one of them all," Parineeti Chopra wrote in her caption Full Article
hd Demi Moore’s Pet Chihuahua Pilaf “Says Thank You” For Birthday Wishes By www.ndtv.com Published On :: Mon, 11 Nov 2024 13:12:53 +0530 Demi Moore will next be seen in Landman Full Article
hd Love And War: Ranbir Kapoor Celebrates Team Member's Birthday On The Set Of Sanjay Leela Bhansali Film By www.ndtv.com Published On :: Mon, 11 Nov 2024 13:30:39 +0530 Directed by Sanjay Leela Bhansali, Love And War will hit the big screens on March 20, 2026 Full Article
hd Steven Spielberg, Robert De Niro, Brad Pitt And Others Attend Leonardo DiCaprio's Star-Studded Birthday Bash By www.ndtv.com Published On :: Tue, 12 Nov 2024 10:39:34 +0530 Paris Hilton, Katy Perry and Orlando Bloom, Robin Thicke and Marvel star Mark Ruffalo were also present. Full Article
hd Juhi Chawla Birthday: A Look At Her Career-Best Performances By www.ndtv.com Published On :: Wed, 13 Nov 2024 10:34:26 +0530 Juhi Chawla was last seen in the web series Hush Hush Full Article
hd Navya Nanda And Suhana Khan Share Throwback Pics To Wish Birthday Boy Aryan Khan By www.ndtv.com Published On :: Wed, 13 Nov 2024 11:56:34 +0530 Aryan Khan celebrated his 27th birthday on November 12 Full Article
hd "If Bowlers Are Medium Pace...": Arshdeep Opens Up On Improving Batting By sports.ndtv.com Published On :: Tue, 12 Nov 2024 23:04:45 +0530 Arshdeep Singh has batted at No. 8 for India in the T20I series against South Africa. Full Article
hd Masaba Gupta Is Still Eating This Special Cake Three Days After Her Birthday By food.ndtv.com Published On :: Tue, 05 Nov 2024 17:56:19 +0530 Masaba Gupta shared an Instagram story describing her delicious birthday cake crafted by chef and baker, Pooja Dhingra. Full Article
hd Tara Sutaria Relished These Delicious Delights On Her Parsi Roj Birthday - See Pics By food.ndtv.com Published On :: Mon, 11 Nov 2024 19:02:47 +0530 Tara Sutaria celebrated her Parsi Roj birthday at home with her close friends. Full Article
hd Boney Kapoor's Birthday Celebration Featured Cheesecake, Gulab Jamun And More By food.ndtv.com Published On :: Tue, 12 Nov 2024 15:31:38 +0530 Anshula shared a heartwarming video from the intimate gathering on Instagram, where Boney Kapoor can be seen feeding cake to everyone. Full Article
hd Delaware joins $10 million settlement with ACI Worldwide over attempted unauthorized withdrawals By news.delaware.gov Published On :: Tue, 17 Oct 2023 16:50:20 +0000 Attorney General Jennings joined a multistate coalition of attorneys general announcing a $10 million settlement with payment processor ACI Worldwide over a 2021 testing error that led to the attempted unauthorized withdrawal of $2.3 billion from the accounts of mortgage-holders. This case was investigated and negotiated with the state financial regulators. The state regulators have entered […] Full Article Department of Justice Press Releases Fraud
hd Delaware Children Wish Smokey Bear Happy 80th Birthday at Dover Public Library By news.delaware.gov Published On :: Fri, 09 Aug 2024 21:18:42 +0000 More than 100 Delawareans, from newborns to seniors, attended story time at the Dover Public Library to wish Smokey Bear a happy 80th birthday on August 9, which marks Smokey’s official birthday. Full Article Delaware Libraries Department of Agriculture Forest Service News birthday Delaware Forest Service Delaware Secretary of Agriculture Michael T. Scuse Dover Public Library Smokey Bear State Librarian Dr. Annie Norman
hd Karnataka Minister's Racist Comment Against HD Kumaraswamy Sparks Row By www.ndtv.com Published On :: Mon, 11 Nov 2024 16:03:37 +0530 A political controversy has broken out over an alleged racist remark by Karnataka Minister BZ Zameer Ahmed Khan against Union Minister and JD(S) leader HD Kumaraswamy. Full Article
hd Karnataka Minister Apologises For Racist Comment Against HD Kumaraswamy By www.ndtv.com Published On :: Tue, 12 Nov 2024 14:37:29 +0530 Karnataka Minister BZ Zameer Ahmed Khan tendered an apology on Tuesday for referring to Union Minister and JD(S) leader HD Kumaraswamy as "Kaalia", which the NDA had slammed as a "racist" slur. Full Article
hd Sony A9G 55 inch 4K UHD Smart TV Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Sony A9G 55 inch 4K UHD Smart TV TV. Know detailed info about Sony A9G 55 inch 4K UHD Smart TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd CloudWalker 55 Inches 4K Ultra HD Smart LED Screen (55SUA7) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of CloudWalker 55 Inches 4K Ultra HD Smart LED Screen (55SUA7) TV. Know detailed info about CloudWalker 55 Inches 4K Ultra HD Smart LED Screen (55SUA7) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Onida 43 Inches Full HD Smart IPS LED TV(Fire TV Edition) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Onida 43 Inches Full HD Smart IPS LED TV(Fire TV Edition) TV. Know detailed info about Onida 43 Inches Full HD Smart IPS LED TV(Fire TV Edition) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd OnePlus U1 55-inch 4K HDR TV Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of OnePlus U1 55-inch 4K HDR TV TV. Know detailed info about OnePlus U1 55-inch 4K HDR TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Realme 43 inch Full HD LED Smart Android TV (TV 43) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Realme 43 inch Full HD LED Smart Android TV (TV 43) TV. Know detailed info about Realme 43 inch Full HD LED Smart Android TV (TV 43) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Hisense 55 inches Ultra HD 4K Smart LED TV(55A71F) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Hisense 55 inches Ultra HD 4K Smart LED TV(55A71F) TV. Know detailed info about Hisense 55 inches Ultra HD 4K Smart LED TV(55A71F) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Akai 43-inch Full-HD Fire TV Edition (AKLT43S-DFS6T) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Akai 43-inch Full-HD Fire TV Edition (AKLT43S-DFS6T) TV. Know detailed info about Akai 43-inch Full-HD Fire TV Edition (AKLT43S-DFS6T) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Philips 50 inches 4K UHD LED Android TV (50PUT8215/94) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Philips 50 inches 4K UHD LED Android TV (50PUT8215/94) TV. Know detailed info about Philips 50 inches 4K UHD LED Android TV (50PUT8215/94) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd AmazonBasics 55 inches 4K Ultra HD Smart LED TV (AB55U20PS) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of AmazonBasics 55 inches 4K Ultra HD Smart LED TV (AB55U20PS) TV. Know detailed info about AmazonBasics 55 inches 4K Ultra HD Smart LED TV (AB55U20PS) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Realme Smart 32-inch Full HD LED TV Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Realme Smart 32-inch Full HD LED TV TV. Know detailed info about Realme Smart 32-inch Full HD LED TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
hd Sony 65 inch 4K Ultra HD Smart TV (KD-65X80J) Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Sony 65 inch 4K Ultra HD Smart TV (KD-65X80J) TV. Know detailed info about Sony 65 inch 4K Ultra HD Smart TV (KD-65X80J) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article TV
