James Acaster explores his love/hate relationship with standup by relinquishing control of his set and accepting a healthy dose of audience interference - aka heckling.

REVIEW – It’s a punch-to-the-gut, sinking, black hole feeling to reach into a pocket, pack, or purse and find your missing wallet. Adding a SwitchBot Wallet Finder is a remedy to a common problem that fits the pocketbook – pun intended!  ???? What is it? The SwitchBot Wallet Finder card is a Bluetooth device that […]

Kaiserstraße is a new residential building currently under construction in Blumenau, Brazil. The project is designed by Alencar Arquitetura and aims to harness connections between residents and the natural world.[...]

This is the second round of Princeton Alliance for Collaborative Research (PACRI) projects partnering HBCU and Princeton researchers.

The absolute number of Black men enrolled at Historically Black Colleges and Universities is the lowest it's been since 1976.

The number of Black men enrolled at Historically Black Colleges and Universities is the lowest it’s been since 1976.

Ethiopia is not a very free country. It ranks low on measures of economic and political freedom. It also is fairly poor: Incomes in Ethiopia are 86% lower than the world average. But it is a good neighbor. It has approved a $738 million loan to its more backward neighbor, South Sudan, to build a […]

The post Ethiopia helps neighboring countries with electricity and roads appeared first on Liberty Unyielding.

His comments came ahead of an assisted dying bill being introduced to Parliament.

Smart-Home Tech Can Achieve ‘Toothbrush-Ready’ Status

Justin Welby has stepped down over a church abuse scandal.

The leader of the world's Anglican communion, Archbishop of Canterbury Justin Welby, announced Tuesday he was resigning following a damning report that concluded the Church of England covered up a serial abuse case.

Shortly after President-elect Donald Trump appointed Tom Homan as “border czar,” the immigration hardliner’s hilarious 2019 smackdown of Democratic Rep. Alexandria Ocasio-Cortez of New York went viral on social media. […]

The post Flashback: Video of Tom Homan Taking Down AOC Resurfaces, Showing Why Trump Picked Him appeared first on The Western Journal.

Expert

Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and transport of LPL by GPIHBP1, thereby disrupting the lipolytic processing of triglyceride-rich lipoproteins. Here, we review the "GPIHBP1 autoantibody syndrome" and summarize clinical and laboratory findings in 22 patients. All patients had GPIHBP1 autoantibodies and chylomicronemia, but we did not find a correlation between triglyceride levels and autoantibody levels. Many of the patients had a history of pancreatitis, and most had clinical and/or serological evidence of autoimmune disease. IgA autoantibodies were present in all patients, and IgG4 autoantibodies were present in 19 of 22 patients. Patients with GPIHBP1 autoantibodies had low plasma LPL levels, consistent with impaired delivery of LPL into capillaries. Plasma levels of GPIHBP1, measured with a monoclonal antibody–based ELISA, were very low in 17 patients, reflecting the inability of the ELISA to detect GPIHBP1 in the presence of autoantibodies (immunoassay interference). However, GPIHBP1 levels were very high in five patients, indicating little capacity of their autoantibodies to interfere with the ELISA. Recently, several GPIHBP1 autoantibody syndrome patients were treated successfully with rituximab, resulting in the disappearance of GPIHBP1 autoantibodies and normalization of both plasma triglyceride and LPL levels. The GPIHBP1 autoantibody syndrome should be considered in any patient with newly acquired and unexplained chylomicronemia.

A new HBO Max teaser offers a glimpse of the upcoming shows viewers can look forward to in the next year.

Archbishop of Canterbury Justin Welby has opted to quit as head of the Church of England after a critical report over his handling of an abuse scandal, it was announced.

Joel Bervell was one of the only Black students in his medical school program. After noticing how misconceptions about race were embedded in health care, he turned to social media to raise awareness about the harmful impact of biases in medicine. He unpacks the long history of race-based health care disparities — and shows what the medical field can do to better serve all patients.

TED Fellow and composer Sahba Aminikia brings the healing power of dance, storytelling, music and performance to some of the most dangerous places on Earth. By celebrating children and their communities with beauty and joy, he shows how to cultivate hope, connection and love — even in conflict zones. "The ultimate power is in unity," Aminikia says.

Impaired inhibitory synapse development is suggested to drive neuronal hyperactivity in autism spectrum disorders (ASD) and epilepsy. We propose a novel mechanism by which astrocytes control the development of parvalbumin (PV)-specific inhibitory synapses in the hippocampus, implicating ephrin-B/EphB signaling. Here, we utilize genetic approaches to assess functional and structural connectivity between PV and pyramidal cells (PCs) through whole-cell patch–clamp electrophysiology, optogenetics, immunohistochemical analysis, and behaviors in male and female mice. While inhibitory synapse development is adversely affected by PV-specific expression of EphB2, a strong candidate ASD risk gene, astrocytic ephrin-B1 facilitates PV->PC connectivity through a mechanism involving EphB signaling in PV boutons. In contrast, the loss of astrocytic ephrin-B1 reduces PV->PC connectivity and inhibition, resulting in increased seizure susceptibility and an ASD-like phenotype. Our findings underscore the crucial role of astrocytes in regulating inhibitory circuit development and discover a new role of EphB2 receptors in PV-specific inhibitory synapse development.

Sometimes, in fact, nature is stranger than fiction

Take in the sights and sounds of the European influences of Argentina's capital city (Produced by: Brendan McCabe). Read more at: https://www.smithsonianmag.com/travel/daniel-politi-on-hola-buenos-aires-138874294/

In WW2, the British made destroying German dams a key strategic target in order to kneecap the German industrial effort. To accomplish this, they needed a special plane to deliver the payload: the Lancaster Bomber.

Orbiting Barnard's star, the nearest solo star to Earth, the world is too hot to be habitable—a scorching 257 degrees Fahrenheit

Loved ones, friends, and people from across the city have all come together to support each other at Pastel Rita, the café Jocelyn Després helped so many call home.

A group of volunteers have been providing emergency services to West Dawson residents during the periods of freeze up and break up, when there is no reliable access across the Yukon River to town.

Mar del Plata, Argentinen :: Schiffsmitarbeiter besuchen ein christliches Suchtrehabilitationszentrum und erinnern die Frauen dort daran, dass sie in Gottes Augen wertvoll sind

A retired lawyer from Sault Ste. Marie has written a book that celebrates the working-class neighbourhood in which he grew up. The West End: A Magical Place Created by Giants is by Frank Sarlo, whose grandfather emigrated to Chicago from Italy, but ended up in Sault Ste. Marie with the promise of work on the railroad.

A Mississauga couple is in the midst of a war of words with their townhouse complex's board of directors — which a handful of residents say is imposing unnecessarily strict new rules on the complex's roughly 140 homeowners.

An OM worker in Israel has an opportunity to share the gospel with his neighbours.

The team in Pakistan responds with compassionate care for earthquake survivors.

OM Hong Kong hosts a Christmas party on 23 December 2011 for Pakistani women and children.

Teams all over Australia connect with their Muslim neighbours and share God’s love.

The Berks LaunchBox in partnership with Penn State Berks will host its free 3D Modeling and Printing Workshop for Manufacturing Companies from 3 to 5 p.m. on Tuesday, Nov. 12, in Reading, Pennsylvania.

The Berks LaunchBox recently announced seven recipients of the second round of the “IMAGINE Your Business” grants.

Penn State Brandywine’s and Penn State Berks’ LaunchBoxes, powered by Penn State, collaborated with Penn State Great Valley to hold the fall 2024 Idea TestLab Pitch Competition on Nov. 4. Six startup entrepreneurs participated in the competition, which was held at Great Valley.

The North Central Pennsylvania (NCPA) LaunchBox powered by Penn State DuBois marked a year of significant achievements in 2023-24 by fostering regional industry growth and workforce development. A key highlight of the year was the LaunchBox’s pivotal role in the North Central Pressed Materials Strategy Development Consortium, an initiative aimed at advancing the pressed material industry in central Pennsylvania.

DOVER – Six projects statewide will receive $2.8 million from Delaware’s Strong Neighborhoods Housing Fund to address vacant, abandoned or foreclosed properties, Governor John Carney and Delaware State Housing Authority (DSHA) Director Anas Ben Addi announced today. The Strong Neighborhoods Housing Fund is used to support community development, address crime and transform neighborhoods that are […]

DOVER, DE (Nov. 9, 2022) – The Delaware Division of Public Health (DPH) is announcing the launch of the My Healthy Community (MHC) influenza (flu) dashboard, which shares weekly as well as seasonal data on positive cases, hospitalizations, deaths, and for the first time, vaccinations in the state. The dashboard is intended to provide an accurate […]

The Delaware Division of Public Health (DPH), in collaboration with the Delaware Division of Professional Regulation (DPR), announces important updates to the Mental Health and Substance Use Disorder section of the My Healthy Community (MHC) Dashboard.  These updates are located within this section’s Prescription Monitoring Program (PMP) tab and present trends in prescription drug dispensing in Delaware. The […]

NEW CASTLE (February 12, 2024) – The Delaware Department of Health and Social Services and the Delaware Health Care Commission have launched the Benchmark Trend Report Dashboard to further support the State’s efforts to improve health care quality for all residents, while simultaneously working to monitor and reduce the economic burden of health care spending. […]

A fund created to help strengthen neighborhoods throughout Delaware hit hardest by the 2008 financial crisis is now up and running.

The rapid rise in size and sophistication of AI/ML training models requires increasingly powerful hardware deployed in the data center and at the network edge. This growth in complexity and data stresses the existing infrastructure, driving the need for new and innovative processor architectures and associated memory subsystems. For example, even GPT-3 at 175 billion parameters is stressing the bandwidth, capacity, training time, and power of the most advanced GPUs on the market.

To this end, Cadence has shown our HBM3E memory subsystem running at 12.4Gbps at nominal voltages, demonstrating the PHY’s robustness and performance margin. The production version of our latest HBM3E PHY supports DRAM speeds of up to 10.4Gbps or 1.33TB/s per DRAM device. This speed represents a >1.6X bandwidth increase over the previous generation, making it ideal for LLM training.

Cadence has been the HBM performance leader since 2021, when we announced our first 8.4Gbps HBM3E PHY supporting >1TB/s of memory bandwidth per HBM DRAM. Customers building advanced AI processors have used this speed while building margin into their systems. Recall that HBM3E is a 3D stacked DRAM with 1024-bit wide data (16 64-bit channels). While this wide data bus enables high data transfer, routing these signals requires interposer technology (2.5D) capable of routing close to 2000 signals (data and control), including silicon, RDL, and silicon bridges.

The interposer design is critical for the system to operate at these data rates. Cadence provides 2.5D reference designs, including the interposer and package, as part of our standard IP package. As demonstrated in our test silicon, these designs give customers confidence they will meet their memory bandwidth requirements. The reference design is also a good starting point, helping to reduce development time and risk. Our expert SI/PI and system engineers work closely with customers to analyze their channels to ensure the best system performance.

Even as HBM3E delivers the highest memory bandwidth today, the industry keeps pushing forward. JEDEC recently announced that HBM4, the next version of the HBM DRAM standard, is nearing completion. JEDEC calls HBM4 an “evolutionary step beyond the currently published HBM3 standard.” They also claim HBM4 “enhancements are vital for applications that require efficient handling of large datasets and complex calculations.” HBM4 will support AI training applications, high-performance computing (HPC), and high-end graphics cards.

Cadence will continue to push the HBM performance boundaries to ensure designers of these data-intensive systems can take advantage of the highest memory bandwidth available.

Learn more about Cadence HBM PHY IP products.

Hello,

I have been running this `uvm_reg_hw_reset_seq` sequence for the AHB protocol. My UVM Adapter looks like:

Issue: When I use basic reg.write, my write access are working well, as that is managed by the driver i.e. once adapter gives the packet to the driver, the driver supplies the address and the control signals to the DUT on the first clock cycle and then the write data on the next clock cycle. But when I am performing the read operation, somehow the UVM adapter is reading the data at the same clock cycle where read address + Controls are supplied and this is triggering read failure messages from the `uvm_reg_hw_reset_seq` sequence. What should I modify in the driver/sequencer/adapter so that the UVM adapter can read the data on the next cycle instead of the same clock cycle.

Just FYI: The waveforms of the read operation are correct, it is just the Adapter and the `uvm_reg_hw_reset_seq`. The AHB Driver + AHB Monitor is fully proven and verified to be working correctly.