When I first discovered that you could get into Yahoo’s RSS Feed directory so quickly, I started making a lot of observations about their site. The first thing I noticed is that they made some subtle changes to their search page. That same day, I noticed that certain sites have more information in their listings than others.

Micro-factories are closer to the market, require less capital investment, and are faster to set up

Samsung Knox Vault Security that was available in S series models, now features in A series smartphones

Damodaran emphasises the importance of accountability, suggesting that the SEBI chairperson report to Parliament biannually

Added surface glycine residues cause partial unfolding that adapts enyzyme to low temperatures

Enhance Search Engines with Google Search Suggestions

New research shows that the drug makes cells in the retina more sensitive to light

25 years ago, pharmacologist M. E. West of the University of the West Indies in Kingston, Jamaica, noted that local fisherman who smoke cannabis or drink rum made with the leaves and stems of the plant had “an uncanny ability to see in the dark,” which enabled them to navigate their boats through coral reefs. “It was impossible to believe that anyone could navigate a boat without compass and without light in such treacherous surroundings,” he wrote after accompanying the crew of a fishing boat one dark night, “[but] I was then convinced that the man who had taken the rum extract of cannabis had far better night vision than I had, and that a subjective effect was not responsible.”

Some of these crew members told West that Moroccan fishermen and mountain dwellers experience a similar improvement after smoking hashish, and in 2002, another research team travelled to the Rif mountains in Morocco to investigate further. They gave a synthetic cannabinoid to one volunteer, and hashish to three more, then used a newly developed piece of kit to measure the sensitivity of their night vision before and after. Confirming West’s earlier report, they found that cannabis improved night vision in all three of their test subjects.

Related: How marijuana impairs memory

Related: A brief history of psychedelic psychiatry | Mo Costandi

The Datsun Go and Go+ CVT claimed mileage is better/almost same as the manual versions and this along with the enhanced features should make them tick.

Spot Release 2.0, launching today, includes improvements to navigation, autonomy, stair climbing, and more

This week, we bring you a fun and interesting chat with Floyd Kane, the creator and writer of the CBC series Diggstown. Floyd and Mike chat about the use of music as a storytelling and emotional device in TV, how and when music comes into the TV writing process, how songs are chosen for the show, and some of the great independent Canadian artists whose music is featured in Diggstown.

http://canadianmusician.com

This episode is sponsored by Bandzoogle. Try it free for 30 days and use the promo code “CMPOD” to get 15% off your first year of any subscription. https://bandzoogle.com/?pc=cmpod

Scientists have shown that the manner in which food and drink is served contributes hugely to the perception of taste.

You may not have even been acquainted to the thought of social media management in recent past, however in today’s world you will hear it spoken of from presumably every one. A number of us use this expression as we have a...

Since its independence from the Soviet Union, Kyrgyzstan has rather been known as an emigration country, however around 4% of the population was born outside the current national territory and the country keeps attracting new immigrants.

Launch of the review process of Regulatory Inspections and Enforcement in the OEFA.

Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methyl­ideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irreversible steroidal aromatase inhibitor, which is in clinical use to treat breast cancer. The present study deals with the synthesis of co-crystals of exemestane with thio­urea by liquid-assisted grinding. The purity and homogeneity of the exemestane–thio­urea (1:1) co-crystal were confirmed by single-crystal X-ray diffraction followed by thermal stability analysis on the basis of differential scanning calorimetry and thermogravimetric analysis. Detailed geometric analysis of the co-crystal demonstrated that a 1:1 co-crystal stoichiometry is sustained by N—H⋯O hydrogen bonding between the amine (NH2) groups of thio­urea and the carbonyl group of exemestane. The synthesized co-crystal exhibited potent urease inhibition activity in vitro (IC50 = 3.86 ± 0.31 µg ml−1) compared with the API (exemestane), which was found to be inactive, and the co-former (thio­urea) (IC50 = 21.0 ± 1.25 µg ml−1), which is also an established tested standard for urease inhibition assays in vitro. The promising results of the present study highlight the significance of co-crystallization as a crystal engineering tool to improve the efficacy of pharmaceutical ingredients. Furthermore, the role of various hydrogen bonds in the crystal stability is successfully analysed quantitatively using Hirshfeld surface analysis.

Phase-contrast enhanced micro-computed tomography reveals huge discontinuities at the interfaces between dental fillings and the tooth substrate. Despite the complex micromorphology, gaps in bonding could be visualized and quantified in 3D.

Yinlong Song, Yikan Zhang, Ying Pan, Jianfeng He, Yan Wang, Wei Chen, Jing Guo, Haiteng Deng, Yi Xue, Xianyang Fang, and Xin Liang

Microtubules dynamics is regulated by the plus end-tracking proteins (+TIPs) in cells. End binding protein 1 (EB1) acts as a master regulator in +TIPs networks by targeting microtubule growing ends and recruiting other factors. However, the molecular mechanism of how EB1 binds to microtubule ends with a high affinity remains to be an open question. Using single-molecule imaging, we show that the end-binding kinetics of EB1 changes along with the polymerizing and hydrolysis rate of tubulin dimers, confirming the binding of EB1 to GTP/GDP-Pi tubulin at microtubule growing ends. The affinity of wild-type EB1 to these sites is higher than monomeric EB1 mutants, suggesting that two CH domains in the dimer contribute to the end-binding. Introducing phosphomimicking mutations into the linker domain of EB1 weakens the end-binding affinity and confers a more curved conformation to EB1 dimer without compromising dimerization, suggesting that the overall architecture of EB1 is important for the end-binding affinity. Taken together, our results provide insights into understanding how the high-affinity end-binding of EB1 can be achieved and how this activity may be regulated in cells.

Assistive products and technologies – such as wheelchairs, upper-limb prostheses, and hearing and speech devices – hold promise for partially or fully mitigating the effects of impairments and enabling people with disabilities to work, but in some cases environmental and personal factors create additional barriers to employment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced grant awards for seven new projects totaling $5.3 million.

A new report from the National Academies of Sciences, Engineering, and Medicine says that enhancements to the geodetic infrastructure are needed to answer important questions about sea level rise, water resources, geological hazards, and more over the next decade.

Researchers have demonstrated that hatching in polar cod can begin as early as January in Arctic seas that receive large freshwater input, compared to April-July in seas with little freshwater input. Since early hatching leads to higher survival rates, the effects of climate change may enhance polar cod’s survival by favouring conditions that allow winter hatching to occur.

Adding nanoparticles to water in solar collectors, which are used to capture the sun’s energy, can considerably improve their performance, a recent study on nanofluids has found. The energy efficiency of the collector can be increased by up to 76.6% when using water containing 0.1% by volume of titanium dioxide nanoparticles, compared with water alone.