At the Bengaluru airport lounge, a woman claimed she lost close to ₹1 lakh after she downloaded an app on her iPhone via an APK file on WhatsApp

On a similar note, India is trying hard to develop indigenous capacity (Make in India) for machineries and equipment required for, say, new steel capacity augmentation. Otherwise, the large scale of imports of capital goods in the form of machines and equipment for steel plants would have to continue by spending huge foreign exchange and make India import dependent.

The production is based on orders received from the customers and hence management is confident that sales despatches would pick up over the next 2-3 quarters, driving an uptick in sales and normalised inventories.

Europe’s utilities are re-evaluating their business models due to the energy transition. Members of POWER-GEN Europe’s Advisory Board consider how a reliance on fossil fuels is no longer politically desirable, forcing utilities to transform their portfolios to adapt to radical change.

In 2015, the United Nations Conference on Trade and Development (UNCTAD) estimated that foreign direct investment for the construction of greenfield projects in developing economies had jumped from US$22 billion in 2013, to US$42 billion in 2014 wit...

One of her goals is to make speaker panels and conferences more inclusive

Flight QF642 from Perth to Sydney took off about 9.30am on Thursday and was in the air for 58 minutes before having to make an emergency landing.

Buy a good Honda S2000 now for under £10,000 it should hold its value and reward you with many miles of high-revving fun, says Tony Middlehurst in our Cash Cars column.

Mr. Amit Kapur Ms. Poonam Verma Mr. Saunak Kumar Mr. Rajguru Mr. Sidhant Kaushik Ms. Aparajita Upadhyay Ms. Adhishree Chakraborty Ms. Sakshi Kapoor Counsel for the Respondent(s) : Ms. Abiha Zaidi for R-2 Order PER HON'BLE MR. S. D. DUBEY, TECHNICAL MEMBER IA No. 324 of 2020

Archives, Room Use Only - TK5261.I58 1901

Archives, Room Use Only - TK145.F57 1884

Archives, Room Use Only - TK5481.E27 1925

Archives, Room Use Only - TK145.M334 1919

Archives, Room Use Only - TK5262.R46 1924

Archives, Room Use Only - HE6935.B35 1939

Archives, Room Use Only - T223.Z1 K45 1924

Today, there is very little doubt that chemistry owes as much to crystallography as crystallography does to chemistry. This mutual synergy defines modern chemical crystallography.

Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with a membrane-bound ion channel and the complication that a heteromeric assembly is necessary to create a key, physiologically relevant binding site. Residues that form the orthosteric site in a highly stable ortholog, acetylcholine-binding protein, were selected for substitution. Recombinant proteins were prepared and characterized in stepwise fashion exploiting a range of biophysical techniques, including X-ray crystallography, married to the use of selected chemical probes. The decision making and development of the surrogate, which is termed a glycine-binding protein, are described, and comparisons are provided with wild-type and homomeric systems that establish features of molecular recognition in the binding site and the confidence that the system is suited for use in early-stage drug discovery targeting a heteromeric α/β glycine receptor.

Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methyl­ideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irreversible steroidal aromatase inhibitor, which is in clinical use to treat breast cancer. The present study deals with the synthesis of co-crystals of exemestane with thio­urea by liquid-assisted grinding. The purity and homogeneity of the exemestane–thio­urea (1:1) co-crystal were confirmed by single-crystal X-ray diffraction followed by thermal stability analysis on the basis of differential scanning calorimetry and thermogravimetric analysis. Detailed geometric analysis of the co-crystal demonstrated that a 1:1 co-crystal stoichiometry is sustained by N—H⋯O hydrogen bonding between the amine (NH2) groups of thio­urea and the carbonyl group of exemestane. The synthesized co-crystal exhibited potent urease inhibition activity in vitro (IC50 = 3.86 ± 0.31 µg ml−1) compared with the API (exemestane), which was found to be inactive, and the co-former (thio­urea) (IC50 = 21.0 ± 1.25 µg ml−1), which is also an established tested standard for urease inhibition assays in vitro. The promising results of the present study highlight the significance of co-crystallization as a crystal engineering tool to improve the efficacy of pharmaceutical ingredients. Furthermore, the role of various hydrogen bonds in the crystal stability is successfully analysed quantitatively using Hirshfeld surface analysis.

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (IgE-Fc), to understand the structural basis for its mechanism of action, surprisingly failed. Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were common to other Fab crystal structures. Mutations were therefore designed to disrupt two recurring packing interactions observed in the omalizumab Fab crystal structures without interfering with the ability of the omalizumab Fab to recognize IgE-Fc; this led to the successful crystallization and subsequent structure determination of the Fab/IgE-Fc complex. The mutagenesis strategy adopted to achieve this result is applicable to other intractable Fab/antigen complexes or systems in which Fabs are used as crystallization chaperones.

The Inka Empire is one of the greatest civilizations in the Western Hemisphere, spanning from the 13th century until the Spanish invasion in 1532. To […]

The post 5 Reasons the Inka Road is one of the Greatest Achievements in Engineering appeared first on Smithsonian Insider.

Engineers shouldn’t have to reinvent the wheel—or wings, or sonar systems—when mother nature has already done much of the heavy design work. In fact, finding […]

The post Next Engineering Revolution Is Hiding in Museum Collections appeared first on Smithsonian Insider.

The U.S. National Academy of Engineering (NAE) today announced the grand challenges for engineering in the 21st century. A diverse committee of experts from around the world, convened at the request of the U.S. National Science Foundation, revealed 14 challenges that, if met, would improve how we live.

The National Academy of Engineering (NAE) has elected 67 new members and 11 foreign associates, announced NAE President C.D. (Dan) Mote Jr. today. This brings the total U.S. membership to 2,250 and the number of foreign associates to 214.

While workers in the engineering technology (ET) field play an important role in supporting U.S. technical infrastructure and the country’s capacity for innovation, there is little awareness of ET as a field of study or category of employment in the U.S., says a new report from the National Academy of Engineering.

The National Academies Committee on Genetically Engineered Crops - Past Experiences and Future Prospects authored an almost 600-page landmark report, released in May 2016. It was perhaps the most comprehensive analysis of genetically engineered crops to date.

The U.S. National Academies of Sciences, Engineering, and Medicine are now serving as the host for the InterAcademy Partnership for Research (IAP-R) secretariat.

The National Academy of Engineering announced today that the 2018 Charles Stark Draper Prize for Engineering will be awarded to Bjarne Stroustrup.

Sexual harassment in science, engineering, and medicine diminishes the integrity of the U.S. research enterprise.

The National Academies of Sciences, Engineering, and Medicine are launching the “New Voices in Sciences, Engineering, and Medicine” initiative to identify outstanding early-career science, engineering, and medicine (SEM) leaders.

The National Academy of Engineering (NAE) 2019 nominating committee1 has recommended John L. Anderson, President Emeritus and distinguished professor of chemical engineering at the Illinois Institute of Technology (Illinois Tech), to stand as the sole candidate2 for the NAE presidency.

On Sunday, Sept. 30, during its 2018 annual meeting, the National Academy of Engineering (NAE) will present two awards for extraordinary impact on the engineering profession.

Centering science instruction around investigation and design can improve learning in middle and high schools and help students make sense of phenomena in the world around them.

Over the next several decades as the global population grows, society will be faced with pressing challenges such as providing reliable supplies of food and water, diminishing climate change and adapting to its impacts, and building healthy, resilient cities.

When John L. Anderson, president emeritus and distinguished professor of chemical engineering at the Illinois Institute of Technology, was first elected to the National Academy of Engineering almost 30 years ago, he remembers being deeply honored and excited about how the recognition would help his career.

International thought leaders will join the next generation of engineers in London from Sept. 16 to 18 for the Global Grand Challenges Summit 2019. The summit aims to help inspire and equip future engineering leaders to address the rapidly evolving challenges of an unpredictable world.

Engineering is emerging as an important topic in K-12 education in the U.S., and is being incorporated into education standards, instructional materials, and assessments.

Using 3D modeling and simulations to target tumors

New research investigating the effects of naturally occurring iron fertilisation in the sea suggests that large scale geoengineering projects designed to sequester carbon in the deep sea could have a dramatic impact on marine ecosystems. The study found that the organic matter arriving at the sea floor and the species that live there are very different, depending on whether waters are fertilised by iron leached from nearby islands or not.

Injecting light-reflecting particles into the atmosphere to counteract rising levels of greenhouse gas emissions cannot stabilise both temperatures and rainfall in all regions of the world at the same time, according to recent research. This raises serious questions about how such a process could be managed.

...

Professor Su Guaning, President Emeritus of Nanyang Technological University, Singapore (NTU Singapore), has been elected to the United States' National Academy of Engineering (NAE)....