dynamic SYSTEMS AND METHODS FOR ANALYZING ELECTRONIC COMMUNICATIONS TO DYNAMICALLY IMPROVE EFFICIENCY AND VISUALIZATION OF COLLABORATIVE WORK ENVIRONMENTS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Systems and methods for managing a collaborative environment are provided. A plurality of sheets is stored in a collaboration system. The collaboration system tracks user interactions with the plurality of sheets and generates a collaboration graph based on the interactions. The collaboration graph is analyzed to determine similarities between the sheets and/or the users. One or more visualizations are generated based on the collaboration graph and the determined similarities. In some embodiments, the collaboration system is able to provide project management information even for dynamic workflows that are not explicitly defined. Full Article
dynamic DYNAMICALLY DESIGNING WEB PAGES By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Various embodiments of systems, computer program products, and methods for dynamically designing webpages are described herein. In an aspect, a request for designing a webpage may be received. Based upon the request, a metadata related to the webpage may be identified. Based upon the identified metadata, one or more widgets for designing the webpage may be rendered. A selection of a widget from the one or more widgets may be received from a user. Multiple sections of the webpage and the widgets positioned in corresponding sections may be identified. The identified widgets of the webpage may be integrated with one or more security rules. Full Article
dynamic Apparatuses and methods for thermodynamic energy transfer, storage and retrieval By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems and methods for transferring and optionally storing and/or retrieving thermal energy are disclosed. The systems and methods generally include a heat engine and a heat pump, the heat engine including first isothermal and gradient heat exchange mechanisms, and the heat pump including second isothermal and gradient heat exchange mechanisms. The heat engine and the heat pump exchange heat with each other countercurrent across the first and second gradient heat exchange mechanisms, the first isothermal heat exchange mechanism transfers heat to an external heat sink, and the second isothermal heat exchange mechanism receives heat from an external heat source. Full Article
dynamic Electro-hydrodynamic cooling with enhanced heat transfer surfaces By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The electronic control has an electric control which incorporates circuitry which will generate heat in use. A cooling channel placed in contact with at least one surface on the electric control. The cooling channel has a portion which receives an enhanced heat transfer surface. At least one electrode pair is mounted on an inlet channel portion upstream of the portion of the channel that receives the enhanced heat transfer surface. A source of current is provided for the electrode. The electrode induces an electric field in the inlet channel, to drive a dielectric fluid across the enhanced heat transfer surfaces. Full Article
dynamic Dynamically limiting energy consumed by cooling apparatus By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Cooling apparatuses and methods are provided which include one or more coolant-cooled structures associated with an electronics rack, a coolant loop coupled in fluid communication with one or more passages of the coolant-cooled structure(s), one or more heat exchange units coupled to facilitate heat transfer from coolant within the coolant loop, and N controllable components associated with the coolant loop or the heat exchange unit(s), wherein N≧1. The N controllable components facilitate circulation of coolant through the coolant loop or transfer of heat from the coolant via the heat exchange unit(s). A controller is coupled to the N controllable components, and dynamically adjusts operation of the N controllable components, based on Z input parameters and one or more specified constraints, to provide a specified cooling to the coolant-cooled structure(s), while limiting energy consumed by the N controllable components, wherein Z≧1. Full Article
dynamic Spin or aerodynamically stabilized ammunition By www.freepatentsonline.com Published On :: Tue, 30 Sep 2014 08:00:00 EDT Disclosed is spin-stabilized ammunition for use in grooved or smooth bore handheld firearms with calibers up to 60 mm. The projectile of the ammunition features a body in the shape of a truncated cone at the top of a cylinder with proportions of the cone length to the cylinder length varying between from one-to-six to one-to-three depending on the expected initial speed of the projectile after the ammunition has been discharged. A central longitudinal barrel extends through the projectile with a proportion of the entrance diameter and exit diameter of 1.38-to-one for expected discharge speeds near sound velocity or of 1.22-to-one for expected discharge of hypersonic velocities. Finally, nozzles within the projectile create a spinning motion around the projectile's axis, the nozzles being located between cavities for propellant charges. Full Article
dynamic Fluid-dynamic circuit By www.freepatentsonline.com Published On :: Tue, 27 May 2014 08:00:00 EDT A fluid-dynamic circuit includes a source of a pressurized fluid; a distributor valve for distributing the pressurized fluid to transport lines; a feeding line for feeding the pressurized fluid, which is interposed between the source and the valve; a main user apparatus, which is reciprocatingly operated by an actuator that includes a slider sealably fitted in a sliding seat of a containing element divided thereby into a first chamber and a second chamber in opposite positions and having variable volumes; and second and third transport lines for the pressurized fluid, which are interposed between the distributor valve and the first and second chamber respectively, a first derived transport line being interposed between the valve and at least one of the second and third transport lines, and having a normally closed quick discharge device mounted thereto, whose opening is designed to be controlled by the actuator. Full Article
dynamic Arrangment for dynamic control of running trim and list of a boat By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An arrangement for dynamic control of running trim, list and/or yaw of a boat, having a housing member comprising a front plate a and rear plate, an interceptor member, an actuating means, a drive unit, and a guiding arrangement, arranged to guide said interceptor member between a first position and a second end position, said actuating means being arranged to displace said interceptor member in a movement between said first and second positions in relation to said housing member wherein said guiding arrangement has a first guiding member and a second guiding member arranged to interact with each other to provide a parallel movement of said interceptor member in relation to said housing member, said first guiding member being a torque transferring, rotatable element having a base body arranged to extend transverse to the direction of displacement of said interceptor member. Full Article
dynamic DYNAMIC STRETCHING, STRENGTHENING AND STABILIZATION DEVICE FOR POSTURAL CORRECTION AND RETRAINING By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A dynamic stretching, strengthening and stabilization device is provided for postural correction and retraining. The device has a pair of closed loop resistance tubes and a central harness member which positions the closed loop resistance tubes roughly in the form of a FIG. 8. Each loop of the resistance tube is sized to accommodate the arm and shoulder of the user. The device may be used in a stabilization mode or stretching/strengthening mode, and transitions easily between these modes to correct and retrain the user's posture. Full Article
dynamic Production of conductive nanodiamond by dynamic synthesis approaches By www.freepatentsonline.com Published On :: Tue, 20 May 2014 08:00:00 EDT In certain implementations, a method of manufacturing electrically conductive nanodiamond particles involves providing at least one type of carbon-containing explosive material and at least one type of non-explosive material; wherein the non-explosive material contains at least one or more than one element or species other than nitrogen that serve as a nanodiamond dopant; mixing the carbon containing explosive material with the non-explosive material; detonating the mixture under conditions of negative oxygen balance in the presence of a cooling medium; purifying the product of detonation from incombustible impurities; and carrying out additional processing for activation or enhancement of electrical conductance. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract. Full Article
dynamic Hybrid hydrodynamic and hydrostatic bearing bushing and lubrication system for rolling mill By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Rolling mill bearings incorporate bearing bushings with pluralities of hydrostatic pad recesses, that are preferably in conjunction hydrodynamic bearings also formed within the bushing. Each recess has an isolated lubricant passage that is adapted for coupling to a separate isolated source of pressurized lubricant. In some embodiments herein, the isolated pressurized lubricant source is supplied by a dedicated outlet of a pressure pump. In this manner each hydrostatic pad recess has a dedicated pressurized lubricant supply that is not interrupted by loss of lubricant pressure events in other bearing pads or elsewhere within the rolling mill lubrication system. Full Article
dynamic DYNAMIC POWER AND BRIGHTNESS CONTROL FOR A DISPLAY SCREEN By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An image is displayed on an electronic display device at a reduced power level. Power used by the display device is maintained below a predetermined maximum power level by uniformly scaling the initial optical intensity of an image to a lower optical intensity whenever displaying the image at the initial optical intensity would result in power consumption of the display device exceeding the predetermined maximum power level. Full Article
dynamic DYNAMICAL TIME DIVISION DUPLEX UPLINK AND DOWNLINK CONFIGURATION IN A COMMUNICATIONS NETWORK By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A technology is disclosed for an evolved Node B (eNB). The eNB can determine a set of configuration indication fields numbered 1 to N, included in a downlink control information (DCI) format Y carried on the PDCCH, where N=⌊LformatYM⌋, Lformat Y is equal to a payload size of the DCI format Y, and M is a number of bits of each indication field. The eNB can map the DCI format Y onto the PDCCH. The eNB can encode for transmission from to the UE the PDCCH with a cyclic redundancy check (CRC) scrambled by an enhanced interference mitigation and traffic adaptation (eIMTA) Radio-Network Temporary Identifier (RNTI) for the UE. Full Article
dynamic Using SQL extensibility for processing dynamically typed XML data in XQuery queries By www.freepatentsonline.com Published On :: Tue, 16 Nov 2010 08:00:00 EST XQuery queries that include functions that operate on dynamically typed XML data are rewritten into compilable SQL constructs. XML data that is dynamically typed is XML data for which a specific XML data type cannot be determined at compile time and in fact may vary. In general, XQuery queries are rewritten into SQL queries that use SQL constructs in lieu of XQuery constructs. The SQL constructs include an “SQL polymorphic function” that is defined or recognized by a database system as valid syntax for an SQL query. The rewritten query applies the XML data to the SQL polymorphic function, but the XML data has been typed as XMLType, a data type recognized by SQL standards. Full Article
dynamic FREQUENCY DYNAMIC ABSORBER FOR TORSIONAL VIBRATION DAMPER OF HYDROKINETIC TORQUE COUPLING DEVICE By www.freepatentsonline.com Published On :: Thu, 08 Jun 2017 08:00:00 EDT A torsional vibration damper assembly for a hydrokinetic torque coupling device, comprises a torsional vibration damper, and a dynamic absorber operatively connected to the torsional vibration damper. The torsional vibration damper comprises a driven member rotatable about a rotational axis, a first retainer plate rotatable relative to the driven member coaxially with the rotational axis, and a plurality of damper elastic members interposed between the first retainer plate and the driven member. The damper elastic members elastically couples the first retainer plate to the driven member. The dynamic absorber includes an inertial member. The inertial member is mounted to the torsional vibration damper rotatably relative to the driven member. The inertial member is rotationally guided and centered relative to the rotational axis by the driven member of the torsional vibration damper. Full Article
dynamic DEVICE AND METHOD FOR PRODUCING A DYNAMIC REFERENCE SIGNAL FOR A DRIVER CIRCUIT FOR A SEMICONDUCTOR POWER SWITCH By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A device (442) for producing a dynamic reference signal (UREF) for a control circuit for a power semiconductor switch comprises a reference signal generator (442) for providing a dynamic reference signal (UREF), which has a stationary signal level after elapse of a predefined time following a switching process of the power semiconductor switch, a passive charging circuit (450) which is configured to increase a signal level of the dynamic reference signal in reaction to a switching of a control signal of the power semiconductor switch from an OFF state to ON state for at least one part of the predefined time above the stationary signal level, in order to produce the dynamic reference signal and an output (A) for tapping the dynamic reference signal (UREF). Full Article
dynamic ELECTRODYNAMIC COMBUSTION CONTROL WITH CURRENT LIMITING ELECTRICAL ELEMENT By www.freepatentsonline.com Published On :: Thu, 04 May 2017 08:00:00 EDT An charge element disposed proximate to a combustion reaction is caused to carry a voltage while also being prevented from arc-discharging or arc-charging to or from the combustion reaction, by a current limiting element in electrical continuity with the charge element. Full Article
dynamic SYSTEM AND METHOD FOR DYNAMIC CONTROL OF A HEAT EXCHANGER By www.freepatentsonline.com Published On :: Thu, 15 Jun 2017 08:00:00 EDT The present application relates to a system for dynamic control of the operation of a heat exchanger, the system comprising a heat exchanger, a plurality of injector arrangements, a local sensor arrangement, and a controller, wherein the local sensor arrangement comprises a plurality of local temperature sensors being arranged to measure temperature values; and wherein the controller is arranged to determine a difference between the measured temperature values and is further arranged to communicate with the valves of the plurality of injector arrangements to adjust the local amount of first fluid supplied by at least one of the injector arrangements in order to even out the determined difference. The application also relates to a method for the dynamic control of the operation of a heat exchanger in such a system. Full Article
dynamic DYNAMIC LINKING OF CODESETS IN UNIVERSAL REMOTE CONTROL DEVICES By www.freepatentsonline.com Published On :: Thu, 25 May 2017 08:00:00 EDT A codeset having function-code combinations is provisioned on a controlling device to control functions of an intended target device. Input is provided to the controlling device which designates a function to be controlled on the intended target device. From a plurality of codes that are each associated with the designated function in a database stored in a memory of the controlling device a first code that is determined to be valid for use in controlling the designated function on the intended target device is selected. When the codeset is then provisioned on the controlling device, the provisioned codeset includes as a function-code combination thereof the designated function and the first code. Full Article
dynamic DYNAMIC DATA COMPRESSION SELECTION By www.freepatentsonline.com Published On :: Thu, 08 Jun 2017 08:00:00 EDT Aspects of dynamic data compression selection are presented. In an example method, as uncompressed data chunks of a data stream are compressed, at least one performance factor affecting selection of one of multiple compression algorithms for the uncompressed data chunks of the data stream may be determined. Each of the multiple compression algorithms may facilitate a different expected compression ratio. One of the multiple compression algorithms may be selected separately for each uncompressed data chunk of the data stream based on the at least one performance factor. Each uncompressed data chunk may be compressed using the selected one of the multiple compression algorithms for the uncompressed data chunk. Full Article
dynamic PROCESS FOR CONTROLLING, UNDER VOID, A JET OF PARTICLES WITH AN AERODYNAMIC LENS AND ASSOCIATED AERODYNAMIC LENS By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT The invention relates to a method for controlling the divergence of a jet of particles in vacuo with an aerodynamic lens, the aerodynamic lens including at least one chamber; a diaphragm, a so-called inlet diaphragm, intended to form an inlet of the aerodynamic lens for a jet of particles, the inlet diaphragm having a given diameter (d1); and another diaphragm, a so-called outlet diaphragm, intended to form an outlet of the aerodynamic lens for this jet of particles; the method including: a step for generating the jet of particles from the inlet to the outlet, in vacuo, of the aerodynamic lens; and a step for adjusting the diameter (ds) of the outlet diaphragm for controlling the divergence of the jet of particles. Full Article
dynamic FOOTWEAR UPPER WITH DYNAMIC AND LOCK-OUT REGIONS By www.freepatentsonline.com Published On :: Thu, 08 Jun 2017 08:00:00 EDT An article of apparel includes a base layer and an auxetic layer coupled to the base layer. The auxetic layer includes an auxetic structure defining a repeating pattern of shapes, with each of the shapes defined by perimeter walls and an interior recess. The auxetic layer includes a first region and a second region. Each interior recess in the first region provides a void exposing the base layer, and each interior recess in the second region is at least partially filled with a recess material. Full Article
dynamic Moog’s Mother-32 get dynamic new sequencer & clocking features with firmware v2.0 By rekkerd.org Published On :: Wed, 29 Apr 2020 12:34:22 +0000 Moog Music has announced a firmware update for the Mother-32 semi-modular analog synthesizer. Combining a flexible analog monophonic voice, robust step-sequencer, and 32-point 3.5mm patchbay for interconnectivity and expandability, Mother-32 is a dynamic standalone instrument that gives synthesists a way to incorporate classic Moog sound into the Eurorack modular world. The firmware version 2.0 update […] The post Moog’s Mother-32 get dynamic new sequencer & clocking features with firmware v2.0 appeared first on rekkerd.org. Full Article News hardware modular Moog sequencer synthesizer
dynamic Dynamic Controls 2 turns ROLI Lightpad Block into customizable MIDI control surface By rekkerd.org Published On :: Fri, 08 May 2020 06:42:30 +0000 The Dynamic Controls app for ROLI Dashboard turns a ROLI Lightpad Block into a highly customizable MIDI control surface, allowing you to design your own control layout using Buttons, Faders and XY Pads. Connect your Lightpad Block to the computer and launch ROLI Dashboard to load the Dynamic Controls app. Use Dashboard to edit the […] The post Dynamic Controls 2 turns ROLI Lightpad Block into customizable MIDI control surface appeared first on rekkerd.org. Full Article News controller freeware MIDI ROLI
dynamic Neural 58, Archivism (the dynamics of archiving) By neural.it Published On :: Thu, 22 Mar 2018 09:27:29 +0000 Issue #58, Autumn 2017 ISSN: 2037-108X The new Neural issue is hot from the press. Subscribe now! because only subscribers will get a free Cyanometer by Martin Bricelj Baraga. You can also subscribe to the magazine Digital Edition accessing all issues since #29.→ Full Article
dynamic Market dynamics are different for all channels; e-commerce ecosystem will stabilise: Tupperware MD Deepak Chhabra By retail.economictimes.indiatimes.com Published On :: 2020-02-07T15:46:40+05:30 Tupperware India's managing director Deepak Chhabra talks about how integrating the direct sales force with the retail franchisee model is working for the home and kitchen-ware maker. Full Article
dynamic Dynamic new Aboriginal art gallery opening in Tilba By www.abc.net.au Published On :: Thu, 27 Aug 2015 19:18:00 +1000 Merryn Apma is an Aboriginal artist who has been a major force in Aboriginal issues since the famous Long Walk led by former AFL footballer Michael Long from Melbourne to Canberra in 2004. She's made the move to Tilba to return to art practise and to open a gallery for Aboriginal and non-Aboriginal artists. She brings a powerful creativity and sense of spirit to a welcoming community. Full Article ABC Local southeastnsw Arts and Entertainment:All:All Arts and Entertainment:Visual Art:All Arts and Entertainment:Library Museum and Gallery:All Arts and Entertainment:Design:All Australia:NSW:Central Tilba 2546
dynamic Discover IBM Dynamic Infrastructure By www-200.ibm.com Published On :: 2009-04-02-14:00 Learn how IBM Business Partners can help their clients reduce costs, manage risks and improve service with Dynamic Infrastructure products, services and solutions. Full Article
dynamic Volkswagen's most aerodynamic car is a record-breaking prototype made in 1980 By news.yahoo.com Published On :: Sat, 09 May 2020 11:00:00 -0400 The most aerodynamic car ever to wear a Volkswagen emblem on its nose isn't the newest Golf GTI or an ID-badged electric model. It's a forward-thinking prototype named Aerodynamic Research Volkswagen (ARVW) developed and built in 1980 in response to the oil shortages that rocked the global economy in the 1970s. Volkswagen initiated the project because it wanted to learn more about aerodynamics and fuel efficiency. Full Article
dynamic M-1 Drilling Fluids UK Ltd. v. Dynamic Air Ltda. By feeds.findlaw.com Published On :: 2018-05-14T08:00:00+00:00 (United States Federal Circuit) - Reversing and remanding the suit alleging infringement of five US patents for lack of personal jurisdiction by a UK company with a Texas subsidiary suing a Brazilian company with a Minnesota subsidiary because Federal Rules of Civil Procedure supported the exercise of specific personal jurisdiction. Full Article Civil Procedure Intellectual Property Patent Corporation & Enterprise Law
dynamic Technical Appendix to Air Demand in a Dynamic Competitive Context with the Automobile By www.trb.org Published On :: Sun, 17 Nov 2019 18:20:12 GMT This technical appendix from the TRB Airport Cooperative Research Program, ACRP Web-Only Document 38: Technical Appendix to Air Demand in a Dynamic Competitive Context with the Automobile , supplements ACRP Research Report 204: Air Demand in a Dynamic Competitive Context with the Automobile with more detailed documentation of the research effort, including greater technical detail on the analytical models created for the research and their application. Full Article http://www.trb.org/Resource.ashx?sn=cover_acrp_wod_38
dynamic Safe Dynamic Memory Management in Ada and SPARK By lambda-the-ultimate.org Published On :: Thu, 26 Jul 2018 19:42:01 +0000 Safe Dynamic Memory Management in Ada and SPARK by Maroua Maalej, Tucker Taft, Yannick Moy: Handling memory in a correct and efficient way is a step toward safer, less complex, and higher performing software-intensive systems. However, languages used for critical software development such as Ada, which supports formal verification with its SPARK subset, face challenges regarding any use of pointers due to potential pointer aliasing. In this work, we introduce an extension to the Ada language, and to its SPARK subset, to provide pointer types (“access types” in Ada) that provide provably safe, automatic storage management without any asynchronous garbage collection, and without explicit deallocation by the user. Because the mechanism for these safe pointers relies on strict control of aliasing, it can be used in the SPARK subset for formal verification, including both information flow analysis and proof of safety and correctness properties. In this paper, we present this proposal (which has been submitted for inclusion in the next version of Ada), and explain how we are able to incorporate these pointers into formal analyses For the systems programmers among you, you might be interested in some new developments in Ada where they propose to add ownership types to Ada's pointer/access types, to improve the flexibility of the programs that can be written and whose safety can be automatically verified. The automated satisfiability of these safety properties is a key goal of the SPARK Ada subset. Full Article Implementation Type Theory
dynamic HOMETOWN HELPERS Like mother, like daughter: This dynamic duo helps feed homebound NYC seniors during COVID-19 crisis By www.nydailynews.com Published On :: Fri, 08 May 2020 20:47:47 +0000 “We’ve learned to assist each other, to help each other and listen,” said Magda Melendez, Citymeals warehouse distribution manager. “We leave aside the mother-daughter relationship and cooperate like best friends.” Full Article
dynamic HOMETOWN HELPERS Like mother, like daughter: This dynamic duo helps feed homebound NYC seniors during COVID-19 crisis By www.nydailynews.com Published On :: Fri, 08 May 2020 20:47:47 +0000 “We’ve learned to assist each other, to help each other and listen,” said Magda Melendez, Citymeals warehouse distribution manager. “We leave aside the mother-daughter relationship and cooperate like best friends.” Full Article
dynamic HOMETOWN HELPERS Like mother, like daughter: This dynamic duo helps feed homebound NYC seniors during COVID-19 crisis By www.nydailynews.com Published On :: Fri, 08 May 2020 20:47:47 +0000 “We’ve learned to assist each other, to help each other and listen,” said Magda Melendez, Citymeals warehouse distribution manager. “We leave aside the mother-daughter relationship and cooperate like best friends.” Full Article
dynamic Boston Dynamics’ ‘terrifying’ robotic dogs have been put to work by at least one police agency By www.washingtonpost.com Published On :: Tue, 26 Nov 2019 22:43:41 +0000 Boston Dynamics began began leasing their robotic dogs to the public this year. One of their first customers: The Massachusetts State Police. Full Article
dynamic Boston Dynamics' robot dog warns Singapore parkgoers not to get too close By feedproxy.google.com Published On :: Sat, 09 May 2020 16:45:05 +0000 In a startling turn for a robot that has long haunted your dreams, Boston Dynamics' Spot has been tasked to encourage healthy behavior. According to the Straits Times, the robot "dog" has been assigned to patrol the Bishan-Ang Mo Kio park in Singapore with the express purpose of encouraging social distancing. "Let's keep Singapore healthy," sounds a recording from the robot as it trots by two terrified people relaxing on a park bench in the above video. "For your own safety, and those around you, please stand at least one meter apart. Thank you." Notably, Spot's jaunt is part of a two-week trial that began Friday. The robot will supposedly not collect any personal information on the people it admonishes. Read more...More about Boston Dynamics, Coronavirus, Tech, and Other Full Article Boston Dynamics Coronavirus Tech Other
dynamic A comprehensive evaluation of a typical plant telomeric G-quadruplex (G4) DNA reveals the dynamics of G4 formation, rearrangement, and unfolding [Plant Biology] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth, development, and environmental adaptions, only few reports exist on plant telomeric G4 DNA (pTG4). Here, using bulk and single-molecule assays, including CD spectroscopy, and single-molecule FRET approaches, we comprehensively characterized the structure and dynamics of a typical plant telomeric sequence, d[GGG(TTTAGGG)3]. We found that this sequence can fold into mixed G4s in potassium, including parallel and antiparallel structures. We also directly detected intermediate dynamic transitions, including G-hairpin, parallel G-triplex, and antiparallel G-triplex structures. Moreover, we observed that pTG4 is unfolded by the AtRecQ2 helicase but not by AtRecQ3. The results of our work shed light on our understanding about the existence, topological structures, stability, intermediates, unwinding, and functions of pTG4. Full Article
dynamic POSTPONED: The Development of Libyan Armed Groups since 2014: Community Dynamics and Economic Interests By feedproxy.google.com Published On :: Wed, 04 Mar 2020 14:15:01 +0000 Invitation Only Research Event 18 March 2020 - 9:00am to 10:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Abdul Rahman Alageli, Associate Fellow, MENA Programme, Chatham HouseEmaddedin Badi, Non-Resident Scholar, Middle East InstituteTim Eaton, Senior Research Fellow, MENA Programme Chatham HouseValerie Stocker, Independent Researcher Since the overthrow of the regime of Muammar Gaddafi in 2011, Libya’s multitude of armed groups have followed a range of paths. While many of these have gradually demobilized, others have remained active, and others have expanded their influence. In the west and south of the country, armed groups have used their state affiliation to co-opt the state and professionals from the state security apparatus into their ranks.In the east, the Libyan Arab Armed Forces projects a nationalist narrative yet is ultimately subservient to its leader, Field Marshal Khalifa Haftar. Prevailing policy narratives presuppose that the interests of armed actors are distinct from those of the communities they claim to represent. Given the degree to which most armed groups are embedded in local society, however, successful engagement will need to address the fears, grievances and desires of the surrounding communities, even while the development of armed groups’ capacities dilutes their accountability to those communities.This roundtable will discuss the findings of a forthcoming Chatham House research paper, ‘The Development of Libyan Armed Groups Since 2014: Community Dynamics and Economic Interests’, which presents insights from over 200 interviews of armed actors and members of local communities and posits how international policymakers might seek to curtail the continued expansion of the conflict economy.PLEASE NOTE THIS EVENT IS POSTPONED UNTIL FURTHER NOTICE. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme, Countering Conflict Economies in MENA, Libya’s Conflict Economy Georgia Cooke Project Manager, Middle East and North Africa Programme +44 (0)20 7957 5740 Email Full Article
dynamic The Development of Libyan Armed Groups Since 2014: Community Dynamics and Economic Interests By feedproxy.google.com Published On :: Mon, 16 Mar 2020 17:25:16 +0000 17 March 2020 This paper explores armed group–community relations in Libya and the sources of revenue that have allowed armed groups to grow in power and influence. It draws out the implications for policy and identifies options for mitigating conflict dynamics. Read online Download PDF Tim Eaton Senior Research Fellow, Middle East and North Africa Programme @el_khawaga LinkedIn Abdul Rahman Alageli Associate Fellow, Middle East and North Africa Programme @abdulrahmanlyf Emadeddin Badi Policy Leader Fellow, School of Transnational Governance, European University Institute Mohamed Eljarh Co-founder and CEO, Libya Outlook Valerie Stocker Researcher Amru_24-2_13.jpg Fighters of the UN-backed Government of National Accord patrol in Ain Zara suburb in Tripoli, February 2020. Photo: Amru Salahuddien SummaryLibya’s multitude of armed groups have followed a range of paths since the emergence of a national governance split in 2014. Many have gradually demobilized, others have remained active, and others have expanded their influence. However, the evolution of the Libyan security sector in this period remains relatively understudied. Prior to 2011, Libya’s internal sovereignty – including the monopoly on force and sole agency in international relations – had been personally vested in the figure of Muammar Gaddafi. After his death, these elements of sovereignty reverted to local communities, which created armed organizations to fill that central gap. National military and intelligence institutions that were intended to protect the Libyan state have remained weak, with their coherence undermined further by the post-2014 governance crisis and ongoing conflict. As a result, the most effective armed groups have remained localized in nature; the exception is the Libyan Arab Armed Forces (LAAF), which has combined and amalgamated locally legitimate forces under a central command.In the west and south of the country, the result of these trends resembles a kind of inversion of security sector reform (SSR) and disarmament, demobilization and reintegration (DDR): the armed groups have used their state affiliation to co-opt the state and professionals from the state security apparatus into their ranks; and have continued to arm, mobilize and integrate themselves into the state’s security apparatus without becoming subservient to it. In the eastern region, the LAAF projects a nationalist narrative yet is ultimately subservient to its leader, Field Marshal Khalifa Haftar. The LAAF has co-opted social organizations to dominate political and economic decision-making.The LAAF has established a monopoly over the control of heavy weapons and the flow of arms in eastern Libya, and has built alliances with armed groups in the east. Armed groups in the south have been persuaded to join the LAAF’s newly established command structure. The LAAF’s offensive on the capital, which started in April 2019, represents a serious challenge to armed groups aligned with the Tripoli-based Government of National Accord (GNA). The fallout from the war will be a challenge to the GNA or any future government, as groups taking part in the war will expect to be rewarded. SSR is thus crucial in the short term: if the GNA offers financial and technical expertise and resources, plus legal cover, to armed groups under its leadership, it will increase the incentive for armed groups to be receptive to its plans for reform.Prevailing policy narratives presuppose that the interests of armed actors are distinct from those of the communities they claim to represent. Given the degree to which most armed groups are embedded in local society, however, successful engagement will necessarily rely on addressing the fears, grievances and desires of the surrounding communities. Yet the development of armed groups’ capacities, along with their increasing access to autonomous means of generating revenue, has steadily diluted their accountability to local communities. This process is likely to be accelerated by the ongoing violence around Tripoli.Communities’ relationship to armed groups varies across different areas of the country, reflecting the social, political, economic and security environment:Despite their clear preference for a more formal, state-controlled security sector, Tripoli’s residents broadly accept the need for the presence of armed groups to provide security. The known engagement of the capital’s four main armed groups in criminal activity is a trade-off that many residents seem able to tolerate, providing that overt violence remains low. Nonetheless, there is a widespread view that the greed of Tripoli’s armed groups has played a role in stoking the current conflict.In the east, many residents appear to accept (or even welcome) the LAAF’s expansion beyond the security realm, provided that it undertakes these roles effectively. That said, such is the extent of LAAF control that opposition to the alliance comes at a high price.In the south, armed groups draw heavily on social legitimacy, acting as guardians of tribal zones of influence and defenders of their respective communities against outside threats, while also at times stoking local conflicts. Social protections continue to hold sway, meaning that accountability within communities is also limited.To varying extents since 2014, Libya’s armed groups have developed networks that enmesh political and business stakeholders in revenue-generation models:Armed groups in Tripoli have compensated for reduced financial receipts from state budgets by cultivating unofficial and illicit sources of income. They have also focused on infiltrating state institutions to ensure access to state budgets and contracts dispersed in the capital.In the east of the country, the LAAF has developed a long-term strategy to dominate the security, political and economic spheres through the establishment of a quasi-legal basis for receiving funds from Libya’s rival state authorities. It has supplemented this with extensive intervention in the private sector. External patronage supports military operations, but also helps to keep this financial system, based on unsecured debt, afloat.In the south, limited access to funds from the central state has spurred armed groups to become actively involved in the economy. This has translated into the taxation of movement and the imposition of protection fees, particularly on informal (and often illicit) activity.Without real commitment from international policymakers to enforcing the arms embargo and protecting the economy from being weaponized, Libya will be consigned to sustained conflict, further fragmentation and potential economic collapse. Given the likely absence of a political settlement in the short term, international policymakers should seek to curtail the continued expansion of the conflict economy by reducing armed groups’ engagement in economic life.In order to reduce illicit activities, international policymakers should develop their capacity to identify and target chokepoints along illicit supply chains, with a focus on restraining activities and actors in closest proximity to violence. Targeted sanctions against rent maximizers (both armed and unarmed) is likely to be the most effective strategy. More effective investigation and restraint of conflict economy actors will require systemic efforts to improve transparency and enhance the institutional capacity of anti-corruption authorities. International policymakers should also support the development of tailored alternative livelihoods that render conflict economy activities less attractive. Department/project Middle East and North Africa Programme, Chaos States, Countering Conflict Economies in MENA, Libya’s Conflict Economy Full Article
dynamic Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules By feedproxy.google.com Published On :: 2005-09-01 Yi ZhangSep 1, 2005; 4:1240-1250Research Full Article
dynamic Understanding the dynamics of the Indo-Pacific: US–China strategic competition, regional actors, and beyond By feedproxy.google.com Published On :: Wed, 08 Jan 2020 21:20:01 +0000 6 November 2019 , Volume 96, Number 1 The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region. Read online Kai He and Mingjiang Li As a geographical concept, ‘Indo-Pacific’ has existed for decades. As a political and strategic concept, it has since 2010 gradually become established in the foreign policy lexicon of some countries, especially Australia, India, Japan and the United States. However, China seems to be reluctant to identify itself as part of the Indo-Pacific; Chinese leaders believe that the US-led Indo-Pacific strategy aims to contain China's rise. While the battle between the two geographical concepts ‘Indo-Pacific’ and ‘Asia–Pacific’ may be fairly easily settled in the future, US–China strategic competition has just begun. Will the Indo-Pacific become a battlefield for US–China rivalry? How will China cope with the US ‘free and open Indo-Pacific’ (FOIP) strategy? How will other regional actors respond to the US–China strategic competition in the Indo-Pacific? What are the strategic implications of the ‘Indo-Pacific’ concept for regional order transformation? How will the Indo-Pacific be institutionalized, economically, politically and strategically? This article introduces the January 2020 special issue of International Affairs, which aims to address those questions, using both country-specific and regional perspectives. Seven articles focus on the policy responses of major players (Australia, China, India, Indonesia, Japan and ASEAN) to the US FOIP strategy and related US–China rivalry in the region. A further three articles examine the profound implications of Indo-Pacific dynamics for regional institution-building and for geopolitical and geo-economic architecture. Full Article
dynamic The Morass of Central American Migration: Dynamics, Dilemmas and Policy Alternatives By feedproxy.google.com Published On :: Mon, 11 Nov 2019 16:10:01 +0000 Invitation Only Research Event 22 November 2019 - 8:15am to 9:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Anita Isaacs, Professor of Political Science, Haverford College; Co-Director, Migration Encounters ProjectJuan Ricardo Ortega, Principal Advisor for Central America, Inter-American Development BankChair: Amy Pope, Associate Fellow, Chatham House; US Deputy Homeland Security Adviser for the Obama Administration (2015-17) 2019 has seen a record number of people migrating from Central America’s Northern Triangle – an area that covers El Salvador, Guatemala and Honduras. Estimates from June 2019 have placed the number of migrants at nearly double of what they were in 2018 with the increase in numbers stemming from a lack of economic opportunity combined with a rise in crime and insecurity in the region. The impacts of migration can already be felt within the affected states as the exodus has played a significant role in weakening labour markets and contributing to a ‘brain drain’ in the region. It has also played an increasingly active role in the upcoming US presidential election with some calling for more security on the border to curb immigration while others argue that a more effective strategy is needed to address the sources of migration. What are the core causes of Central American migration and how have the US, Central American and now also Mexican governments facilitated and deterred migration from the region? Can institutions be strengthened to alleviate the causes of migration? And what possible policy alternatives and solutions are there that could alleviate the pressures individuals and communities feel to migrate? Anita Isaacs, professor of Political Science at Haverford College and co-director of the Migration Encounters Project, and Juan Ricard Ortega, principal advisor for Central America at the Inter-American Development Bank, will join us for a discussion on the core drivers of migration within and across Central America.Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project US and the Americas Programme US and Americas Programme Email Full Article
dynamic A comprehensive evaluation of a typical plant telomeric G-quadruplex (G4) DNA reveals the dynamics of G4 formation, rearrangement, and unfolding [Plant Biology] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth, development, and environmental adaptions, only few reports exist on plant telomeric G4 DNA (pTG4). Here, using bulk and single-molecule assays, including CD spectroscopy, and single-molecule FRET approaches, we comprehensively characterized the structure and dynamics of a typical plant telomeric sequence, d[GGG(TTTAGGG)3]. We found that this sequence can fold into mixed G4s in potassium, including parallel and antiparallel structures. We also directly detected intermediate dynamic transitions, including G-hairpin, parallel G-triplex, and antiparallel G-triplex structures. Moreover, we observed that pTG4 is unfolded by the AtRecQ2 helicase but not by AtRecQ3. The results of our work shed light on our understanding about the existence, topological structures, stability, intermediates, unwinding, and functions of pTG4. Full Article
dynamic Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase [Molecular Biophysics] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and liquids to visualize ring assembly, DNA binding, and unwinding activity of individual Twinkle hexamers at the single-molecule level. We observed that the Twinkle subunits self-assemble into hexamers and higher-order complexes that can switch between open and closed-ring configurations in the absence of DNA. Our analyses helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration. They also revealed that closed-ring conformers bind and unwind several hundred base pairs of duplex DNA at an average rate of ∼240 bp/min. We found that the addition of mitochondrial single-stranded (ss) DNA–binding protein both influences the ways Twinkle loads onto defined DNA substrates and stabilizes the unwound ssDNA product, resulting in a ∼5-fold stimulation of the apparent DNA-unwinding rate. Mitochondrial ssDNA-binding protein also increased the estimated translocation processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more than half of the mitochondrial genome could be unwound by Twinkle during a single DNA-binding event. The strategies used in this work provide a new platform to examine Twinkle disease variants and the core mtDNA replication machinery. They also offer an enhanced framework to investigate molecular mechanisms underlying deletion and depletion of the mitochondrial genome as observed in mitochondrial diseases. Full Article
dynamic Understanding the dynamics of the Indo-Pacific: US–China strategic competition, regional actors, and beyond By feedproxy.google.com Published On :: Wed, 08 Jan 2020 21:20:01 +0000 6 November 2019 , Volume 96, Number 1 The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region. Read online Kai He and Mingjiang Li As a geographical concept, ‘Indo-Pacific’ has existed for decades. As a political and strategic concept, it has since 2010 gradually become established in the foreign policy lexicon of some countries, especially Australia, India, Japan and the United States. However, China seems to be reluctant to identify itself as part of the Indo-Pacific; Chinese leaders believe that the US-led Indo-Pacific strategy aims to contain China's rise. While the battle between the two geographical concepts ‘Indo-Pacific’ and ‘Asia–Pacific’ may be fairly easily settled in the future, US–China strategic competition has just begun. Will the Indo-Pacific become a battlefield for US–China rivalry? How will China cope with the US ‘free and open Indo-Pacific’ (FOIP) strategy? How will other regional actors respond to the US–China strategic competition in the Indo-Pacific? What are the strategic implications of the ‘Indo-Pacific’ concept for regional order transformation? How will the Indo-Pacific be institutionalized, economically, politically and strategically? This article introduces the January 2020 special issue of International Affairs, which aims to address those questions, using both country-specific and regional perspectives. Seven articles focus on the policy responses of major players (Australia, China, India, Indonesia, Japan and ASEAN) to the US FOIP strategy and related US–China rivalry in the region. A further three articles examine the profound implications of Indo-Pacific dynamics for regional institution-building and for geopolitical and geo-economic architecture. Full Article
dynamic CBD News: "Sustainable Development: Which way next", Statement by Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Global Indian Diaspora Conference towards a Dynamic Indian Diaspora, Singapore, 9-11 October 2008. By www.cbd.int Published On :: Thu, 09 Oct 2008 00:00:00 GMT Full Article
dynamic New analytical tools for HDG in elasticity, with applications to elastodynamics By www.ams.org Published On :: Tue, 07 Apr 2020 14:09 EDT Shukai Du and Francisco-Javier Sayas Math. Comp. 89 (2019), 1745-1782. Abstract, references and article information Full Article
dynamic Dynamics: Topology and Numbers By www.ams.org Published On :: Wed, 12 Feb 2020 07:42 EST Pieter Moree, Anke Pohl, L’ubomír Snoha and Tom Ward, editors. American Mathematical Society, 2020, CONM, volume 744, approx. 358 pp. ISBN: 978-1-4704-5100-4 (print), 978-1-4704-5454-8 (online). This volume contains the proceedings of the conference Dynamics: Topology and Numbers, held from July 2–6, 2018, at the Max Planck Institute for... Full Article
dynamic Persistence and extinction in a stochastic nonautonomous logistic model of population dynamics By www.ams.org Published On :: Mon, 02 Mar 2020 06:58 EST O. D. Borysenko and D. O. Borysenko Theor. Probability and Math. Statist. 99 (2020), 67-75. Abstract, references and article information Full Article