Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention of estrogen receptor (ER)-negative mammary tumors at three different temporal exposure windows using a spontaneous breast cancer mouse model. Our findings indicate that maternal BSp treatment exhibited profound inhibitory and preventive effects on mammary cancer formation in the nontreated mouse offspring. The BSp diet administered to adult mice also showed suppressive effects on mammary cancer but was not as profound as the maternal BSp preventive effects. Moreover, such protective effects were linked with differentially expressed tumor- and epigenetic-related genes, as well as altered global histone acetylation, DNA methylation, and DNA hydroxymethylation levels. We also found that the expression changes of tumor-related genes were associated with the levels of histone methylation of H3K4 and H3K9 in the gene promoter regions. In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNA methyltransferases, and histone deacetylases in ERα-negative breast cancer cell lines. Collectively, these results suggest that maternal exposure to key phytochemicals may contribute to ER-negative mammary tumor prevention in their offspring through epigenetic regulations.

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

BACKGROUND AND PURPOSE:

Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

Condo is currently the top trend among single-family home buyers as it is a good way to own a home without breaking budget, in addition to various utilities a condo could bring to its owner. For a first-time home buyer, here are 8 things to consider before purchasing a condo if you don't want to regret it later.

For those who have a limited budget, a bank loan is the perfect financial solution to buy a home. To choose the right bank, here are 5 things you should consider.

Buying a new home is not always easy, especially when you have kids to consider. Here are 5 tips to choose the most suitable home for your kids.

Buy-to-let is enjoying a bit of renaissance: more mortgages available, higher rental yields and high demand. But have you considered the investment risks?

“Dear Designer” is a blog series on orienting novice practitioners to the discipline of instructional design and learning experience design.

The post Dear Designer: 3 Considerations for Length When Shifting to VILT appeared first on e-Learning Feeds.

It’s time to start planning our return to the workplace. Adjustments made during the pandemic will extend into and impact our return to the office. […]

The post 5 L&D considerations for returning to the workplace appeared first on e-Learning Feeds.

The question of how the brain gives rise to subjective experience is the hardest of all. Mathematicians think they can help, but their first attempts have thrown up some eye-popping conclusions

Human movements can teach robots the skills they need to dig holes and—maybe someday—build the first colonies on Mars

The Lovecraftian inspired adventure game will launch on Xbox Series X, Xbox One and PC in late 2020 and will be available on Xbox Game Pass

Codemasters next racing game, DIRT 5 has been announced.

SCOTLAND’S Economy Secretary has penned a letter to the UK Government venting her frustration at being given “insufficient time” to consider workplace safety proposals.

First Minister Nicola Sturgeon has said the Scottish Government is looking into expanding the current guidance about exercise during the lockdown.

For weeks after Ahmaud Arbery was killed while running down a road in coastal southern Georgia, there were few public developments in the case of a 25-year-old unarmed black man who was shot while being pursued by two white men with weapons in February.Then a graphic video of the shooting surfaced online, spurring widespread outrage.Within days, the Georgia Bureau of Investigation had taken over the case. The video was criticized by celebrities and politicians alike, including President Donald Trump, who called the footage "very, very disturbing," and former Vice President Joe Biden, the presumptive Democratic presidential nominee, who said Arbery had essentially been "lynched before our very eyes."And in a major turn, the authorities announced Thursday night that they had arrested two suspects in the case and charged them with murder and aggravated assault.The video -- which by Friday officials had described as "a very important piece" of evidence in moving forward with criminal charges -- was first posted by WGIG, a radio station in Brunswick, Georgia, which said it had obtained the footage from an anonymous source.But in a twist emblematic of the small-town politics that have defined the case, that source turned out to be a criminal defense lawyer in town who had informally consulted with the suspects.The lawyer, Alan Tucker, said in an interview Friday that the video had come from the cellphone of a man who had filmed the episode and that he later gave the footage to the radio station. Tucker's role was confirmed by Scott Ryfun, who oversees the station's programming.Asked why he had leaked the video, Tucker said he had wanted to dispel rumors that he said had fueled tension in the community. "It wasn't two men with a Confederate flag in the back of a truck going down the road and shooting a jogger in the back," Tucker said."It got the truth out there as to what you could see," he added. "My purpose was not to exonerate them or convict them."The video, taken from inside a vehicle, shows Arbery running when he comes upon a white truck, with one man standing next to its open driver's-side door and another in the bed of the pickup. Arbery runs around the truck and disappears briefly from view. Then the man standing outside the truck tussles with him, and three gunshots are heard.The authorities identified Travis McMichael, 34, as the person who shot Arbery. His father, Gregory McMichael, 64, a retired investigator at the local district attorney's office, was also charged.Before the charges were filed this week, two prosecutors had recused themselves from handling the case, citing professional ties to Gregory McMichael. Tucker, too, said he had been an acquaintance of McMichael's from their work in legal circles.Reports suggest Tucker had consulted with the McMichael family in some capacity during the investigation, although it is not clear to what extent. Reached by The Washington Post before his arrest Thursday, Gregory McMichael referred questions to Tucker.Tucker declined to comment on his conversations with the McMichaels on Friday, citing attorney-client privilege."I'm not going to tell you what I told them or what they told me," he said, using profanity to say that any conversations -- had they occurred, he said -- were none of the public's business.At times during the interview, a woman could be heard in the background whispering suggested answers to Tucker.By Friday afternoon, Tucker said that it had been decided that he would not be retained as the lawyer for either of the McMichaels, and it was unclear who was representing them.Tucker said he would not be representing anyone else involved in the case, as the authorities announced Friday that they were pursuing a number of leads, including investigating the man who took the video.The man, Roddie Bryan, lives in the neighborhood. He had shared the video with the police before sharing it with Tucker and was cooperating with the authorities, his lawyer, Kevin Gough, said in an interview Friday evening."Mr. Bryan has never tried to hide anything from anybody," Gough said. "If anybody wanted a copy of the video, he would give it to them."But he said the added attention, including the scrutiny from the authorities, had come as a shock to his client, a mechanic who had since lost his job and received threats. "The atmosphere down here is very volatile," Gough said. "People are in fear. That's all a result of the last few days."The latest developments in the case on Friday fell on Arbery's birthday, when he would have turned 26. Thousands of people commemorated the occasion by running 2.23 miles, a nod to Feb. 23, the date he was killed.This article originally appeared in The New York Times.(C) 2020 The New York Times Company

2020 and 2021 will be one of the periodic transitional eras in gaming as Sony and Microsoft debut their shiny new consoles, the PlayStation 5 and Xbox Series X. To ease the process (and spur adoption of the next generation), EA may make its upcoming titles free to “upgrade” to your chosen console. On an […]

The new coronavirus is upending our lives, but simple actions can slow its spread, help our neighbours, foster a sense of togetherness and rejuvenate our immune systems

"If we don't have all the information in front of us to help us make decisions, then how do we flatten the curve and stop the spread?"

There are benefits to getting a collateral charge for long-term estate and financial planning. As an adviser to high-net-worth clients, I have always recommended setting up a collateral charge for every client regardless of their debt or savings situation. A collateral charge is a financial planning tool secured against your primary residence for 100 per […]

U.S. President Donald Trump said on Wednesday he did not wear a mask during a tour on Tuesday of a Honeywell International Inc factory in Arizona after consulting the company's chief executive, despite requirements at the plant that workers wear them.

President Donald Trump said on Thursday his administration was considering further economic measures, possibly via executive orders, to provide help against the economic fallout from the novel coronavirus pandemic.

The White House has halted talks with Congress over any further coronavirus stimulus package as it waits for more information about how U.S. state reopenings affect the economy, White House top economic adviser Larry Kudlow told reporters on Friday.

Relationships that suffer as a result of unreconcilable politics may force you to make a decision. To make that less distressing, choose consciously.

Planet of the Humans film has had 5m views on YouTube and has enraged renewable energy experts who are demanding an apology

Planet of the Humans is an environmental documentary that has enraged renewable energy experts and environmentalists, with some calling for its high-profile executive producer, Michael Moore, to apologise.

It was released for free less than two weeks ago, and at the time of writing had had close to 5m views on YouTube.

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Read our live coronavirus updates HERE Coronavirus: The symptoms

Read our live coronavirus updates HERE Coronavirus: The symptoms

Follow our live Covid-19 updates HERE

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Former Home Office Permanent Secretary Sir Philip Rutnam has formally begun legal action against Home Secretary Priti Patel, claiming "constructive dismissal".

An emergency consultant, who worked at the Royal Derby Hospital, has died after contracting Covid-19.

A UK police force has upped patrols around 5G masts in a bid to stop further attacks linked to coronavirus conspiracy theories.

The head of the World Health Organisation has brushed off calls for his resignation as he told the US to reconsider freezing its funding.

A consultant who died after contracting Covid-19 has been described as a "very special human being" and "a real NHS hero".

At least 38 people have died after a devastating fire broke out at a construction site near South Korea's capital, Seoul.

EXCLUSIVE

Chancellor Rishi Sunak is considering options to taper off the Government's furlough scheme which is supporting workers staying at home during the coronavirus outbreak.

YouTube, Facebook crack down on two viral videos for spreading medical misinformation.

Swarm Technologies has struck an agreement with California-based Momentus for the launch of a dozen telecommunication satellites, each the size of a slice of bread, aboard a SpaceX Falcon 9 rocket in December. The December rideshare mission is the first of a series that Momentum plans to execute for Swarm, continuing into 2021 and 2022. Swarm plans to have 150 satellites launched over the next couple of years for a communication network in low Earth orbit. The first 12 SpaceBee satellites covered by the agreement announced today will be deployed into orbit from the Falcon 9. The inch-thick satellites fit… Read More

With false information linking the coronavirus to 5G telecoms or Chinese labs being widely shared on social media, Ian Sample speaks to social psychologist Dr Daniel Jolley about why the pandemic is such fertile ground for conspiracy theories

Users will receive a prompt from the UK government with a link to accurate information

Uplay+ service, with access to + 100 games is is 50% off for the 1st month!  Members can get unlimited access to + 100 games for $6.99
https://store.ubi.com/us/uplayplus/
 
Free shipping and +50% off on all physical games until April 19th. There's merch on sale as well.
https://store.ubi.com/us/free-shipping-sale/

https://www.ebay.com/itm/Microsoft-Xbox-One-X-1TB-Black-Console-as-is-for-repair-or-parts-only/264227168298

YMMV obviously--I ordered two of these a month ago and they have been running fine for me.  All I had to do was reinstall the newest system update and they have both been fine with no issues.  One system's issue noted was "freezes" and the other was "no video". 

It says he has only 2 in stock, but I bought two a while back and the listing has remained active for the entire time with stock available, so he probably leaves the number low to keep demand going. This is probably a bulk buyer who doesn't extensively troubleshoot the systems.  I am not affiliated with the seller.  Cosmetically, the systems are nice enough to trade in without taking a refurb fee when stores re-open for business.

In this article, we want to evaluate the pros and cons of starting a farming business. Farming is a go-to line of business which is always strategic no matter the time and place. People will always want to eat so starting a farming business is clearly a perfect fit for aspiring entrepreneurs. However, there are […]

The post The Pros And Cons Of Starting A Farming Business in 2020 appeared first on Chart Attack.

Police have no suspects in connection with the fires.