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Synergetic effect of mild hypothermia and antioxidant treatment on ROS-mediated neuron injury under oxygen-glucose deprivation investigated by scanning electrochemical microscopy

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05977H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Zhang, Yulin Liu, Yuxiang Zhao, Siyu Zhang, Feng Xu, Fei Li
Ischemic stroke and reperfusion injury result in neuronal damage and dysfunction associated with oxidative stress, leading to overproduction of cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). In...
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Pronounced Electronic Modulation of Geometrically-Regulated Metalloenediyne Cyclization

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05396F, Edge Article
Open Access
Sarah E. Lindahl, Erin M. Metzger, Chun-Hsing Chen, Maren Pink, Jeff Zaleski
Using a diverse array of thermally robust phosphine enediyne ligands (dxpeb, X = Ph, Ph-pOCH3, Ph-pCF3, Ph-m2CH3, Ph-m2CF3, iPr, Cy, and tBu) a novel suite of cisplatin-like Pt(II) metalloenediynes (3,...
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Rediscovering repositories of heritage

Often considered dull and uninviting, Indian museums are storehouses of history and culture, and deserve repeat visits saysShailaja Tripathi




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Dabbling in different mediums

Beyond sharing her experience of working with the powerhouse combination of Alia Bhatt, Shah Rukh Khan and Gauri Shinde in the upcomingDear Zindagi, Ira Dubey talks about her undying love for theatre and more




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Share Market Highlights 18 April 2024: Sensex falls 330 pts, Nifty at 22,000; media, metal stocks shine, FMCG, healthcare drag

Sensex, Nifty updates on 18th April 2024: Equity benchmarks BSE Sensex and NSE Nifty extended losses on Thursday. As per provisional figures, BSE Sensex fell 332.23 pts or 0.46 per cent to trade at 72,611.45 as of 3.35 pm and Nifty 50 declined 103.70 pts or 0.47 per cent to trade at 22,044.20., Bharti Airtel, Power Grid Corp, M&M, BPCL, and Tata Steel were the top gainers, while Nestle, Apollo Hospitals, Axis Bank, HCL Technologies, and ONGC were the major laggards. The stocks that hit a 52-week high on the NSE include AAA Tech (19.33 per cent), Just Dial (12.95 per cent), Indo Tech (10 per cent) and Hi-Tech Gear (10 per cent).




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Should you invest in ICICI Prudential Credit Risk Fund?

Credit risk funds, which invest at least 65 per cent of their portfolio in corporate bonds rated AA or below, offer a shot at high accrual returns




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In debt funds, the focus is on high-quality credit strategies: Rahul Goswami, CIO-India Fixed Income, Franklin Templeton Mutual Fund

Rahul Goswami, CIO &MD - India Fixed Income, Franklin Templeton Asset Management, on what investors can expect on the debt side from the AMC and on his rate cut expectations





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Laugh in life: Kochi-based comedians Abhishek and Akshay on their latest show, their inspirations and more

The duo has been performing stand-up comedy for around three years now.




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Media rights cannot be restricted: Kerala High Court

Expression by the media of any definitive opinion regarding the guilt or innocence of a party in an ongoing criminal investigation will not get protection under Article 19(1)(a), observes an HC bench




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About 10 lakh tonnes of legacy waste awaiting scientific remediation




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HC allows medical termination of pregnancy of minor rape survivor

Division Bench passed the order while allowing an appeal filed against a single judge’s order declining permission. Medical board said that termination of pregnancy was most appropriate




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Sweet Legacy, Young Heart, Lebua and Dedicate impress




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Lt Gen Upendra Dwivedi appointed as next Chief of Army Staff

Lt. Gen Dwivedi brings extensive experience in military operations, technology integration, and strategic leadership, having served in various command and staff appointments throughout his illustrious 39-year career




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QR code diktat to be widened for more medicines, says DCGI Raghuvanshi 

already Top 300 drug brands are already under mandatory QR code net 




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Aviation Minister proposes over 50 helicopter emergency medical units along highways

This initiative aims to enhance rapid medical assistance, particularly in remote areas, and align with global healthcare standards




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MG 100-Year Limited Editions launched 

The prices of special editions start from ₹9.40 lakh for the Comet EV, ₹14.81 lakh for the Astor, ₹21.20 lakh for the Hector, and ₹24.18 lakh for the ZS EV




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BMW 2 Series Shadow Edition now available 

The car is available in two colours, namely Alpine White and Skyscraper Grey




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TN: Leopard kills dog at home stay in Valparai, locals demand immediate capture




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Heavy rains predicted in coastal TN districts till Nov 8




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Heavy rains predicted across Tamil Nadu for next five days




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Bengal govt to bring exams in medical colleges under CCTV surveillance, live-streaming




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Ceiling prices of 8 common drugs raised by 50%, these medicines treat asthma, tuberculosis, others...

The National Pharmaceutical Pricing Authority (NPPA) has sanctioned the ceiling price hike for 11 formulations by 50 per cent in response to representations from drug makers.




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Inherited genetic factors may predict the pattern of X chromosome loss in older women

An NCI study explores the causes and effects of a phenomenon known as mosaic loss of chromosome X, or mLOX, which may lead to several health conditions, including cancer.




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NIH clinical trial will test precision medicine treatments for myeloid cancers

NCI has launched myeloMATCH, a precision medicine treatment trial that will test treatment combinations targeting specific genetic changes in people with acute myeloid leukemia and myelodysplastic syndromes.




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All set for the first moves in the second edition of Global Chess League




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Qatar halts its mediation efforts on Gaza, says the Hamas office ‘no longer serves its purpose’

In Washington, a U.S. official said the Biden administration informed Qatar two weeks ago that the Hamas office's continued operation in Doha was no longer useful and the Hamas delegation should be expelled




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Canadian Foreign Ministry denies blocking Indian-diaspora media outlet Australia Today

The news site and video of media comments by both India’s Foreign Minister Jaishankar and Australia’s Foreign Minister Wong can be easily and freely viewed in Canada, the Ministry said




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India to push for accountability, fair financing, green credit at COP29: Delegates

The 29th session of the climate change conference of parties (COP29) is being held from November 11-22 in Baku, the capital of Azerbaijan Baku




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Israeli strikes set off explosions in Beirut suburbs and kill 14 Palestinians in Gaza, medics say

The strike came hours after the Israeli military announced an expansion of the zone, where it has told Palestinians evacuating from other parts of Gaza to take refuge




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Eluru Government Medical College named after biochemist Yellapragada SubbaRow

SubbaRow, born in 1895 in Bhimavaram, is credited with discovering drugs for Filariasis and the role of ATP in muscular activity




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Lakshmi Parvathi flays coalition government for arrest of social media activists




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Magali Koenig : courir apres la pluie / direction editoriale, Geraldine Lay, Pierre Starobinski. [Accompagne de], Les yeux dans le samovar / Blaise Hofmann

[Arles] : Actes Sud, [2022]




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State, Society and Mobilization in Europe during the First World War [electronic resource] / edited by John Horne.

Cambridge : Cambridge University Press , 1997.




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Sodium alginate hydrogelation mediated paper-based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of L-lactate

Anal. Methods, 2024, 16,2077-2084
DOI: 10.1039/D4AY00041B, Paper
Wenjuan Wang, Danrong Chen, Yujiao Cai, Zijing Liu, Hongfen Yang, Hongbin Xie, Jinquan Liu, Shengyuan Yang
Here, we show a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric dual-signal analysis to determine the concentration of L-lactate in yogurt samples.
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Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

Anal. Methods, 2024, 16,2002-2008
DOI: 10.1039/D4AY00276H, Communication
Yajie Huang, Yajun Zheng, Qianqian Zuo, Zhiming Zhang, Lixuan Zhu, Yun Li, Zhiping Zhang
A novel surface charge induced electrospray ionization is proposed due to its features of no contact between sample solution and metal electrode, fast analytical process (less than 40 s), and high analytical sensitivity.
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Correction: An impedimetric sensor based on molecularly imprinted nanoparticles for the determination of trypsin in artificial matrices – towards point-of-care diagnostics

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sabrina Di Masi, Marco Costa, Francesco Canfarotta, Antonio Guerreiro, Alicia Hartley, Sergey A. Piletsky, Cosimino Malitesta
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Dual-mode detection of 2,6-pyridinedicarboxylic acid based on the enhanced peroxidase-like activity and fluorescence property of novel Eu-MOFs

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00331D, Paper
Jintao Yi, Xianqin Han, Jiahao Jian, Yayan Lai, Jun Lu, Lei Peng, Zhongkai Liu, Jun Xue, Hui Zhou, Xun Li
The dual-mode fluorescence and colorimetric detection of 2,6-pyridinedicarboxylic acid (DPA) based on the enhanced peroxidase-like activity and fluorescence property of a novel MOF.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A complementary method with PFBBr-derivatization based on a GC-EI-MS platform for the simultaneous quantitation of short-, medium- and long-chain fatty acids in murine plasma and feces samples

Anal. Methods, 2024, 16,2330-2339
DOI: 10.1039/D3AY02271D, Paper
Hong-Xu Zhou, Qing Jiang, Xin He, Xian Fu, Jun-Yan Liu
Fatty acids (FAs) are essential molecules in all organisms and are involved in various physiological and pathophysiological processes.
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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​Judge and prejudice: On conduct in judicial proceedings

Judicial officers must be mindful of language that reveal bias




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​Regulation role: On the 2024 Medicine Nobel

The discovery of microRNA changed the understanding of gene regulation




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
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Introduction to the themed collection on ‘AI in Medicinal Chemistry’

RSC Med. Chem., 2024, 15,3284-3285
DOI: 10.1039/D4MD90035A, Editorial
Jian Zhang, Ola Engkvist, Gerhard Hessler
Jian Zhang, Ola Engkvist and Gerhard Hessler introduce the RSC Medicinal Chemistry themed collection on ‘AI in Medicinal Chemistry’.
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
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