South Asia study of foreign direct investments impact in India, Pakistan, Bangladesh, Sri Lanka and Nepal on economic growth, domestic investment, and export; special emphasis on the role of infrastructure.

Regional disparities within and among Chinese provinces have declined, but are still a serious problem.

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.

SIGNIFICANCE STATEMENT

There has been significant progress in understanding cytokine-mediated drug interactions for CYP-sensitive substrates. This article provides an overview of the progress in this field, including a trend analysis of systemic exposures of CYP-sensitive substrates coadministered with anti-interleukin therapeutics. In addition, the review also provides a perspective of current methods used to assess these drug interactions during drug development and a focus on individualized medicine, particularly in acute care settings.

BackgroundCOVID-19 pandemic restrictions may have influenced behaviours related to weight.AimTo describe patterns of weight change among adults living in England with type 2 diabetes (T2D) and/or hypertension during the pandemic.Design and settingAn observational cohort study using the routinely collected health data of approximately 40% of adults living in England, accessed through the OpenSAFELY service inside TPP.MethodClinical and sociodemographic characteristics associated with rapid weight gain (>0.5 kg/m2/year) were investigated using multivariable logistic regression.ResultsData were extracted on adults with T2D (n = 1 231 455, 43.9% female, and 76.0% White British) or hypertension (n = 3 558 405, 49.7% female, and 84.3% White British). Adults with T2D lost weight overall (median δ = −0.1 kg/m2/year [interquartile range {IQR} −0.7–0.4]). However, rapid weight gain was common (20.7%) and associated with the following: sex (male versus female: adjusted odds ratio [aOR] 0.78 [95% confidence interval {CI} = 0.77 to 0.79]); age (older age reduced odds, for example, aged 60–69 years versus 18–29 years: aOR 0.66 [95% CI = 0.61 to 0.71]); deprivation (least deprived Index of Multiple Deprivation [IMD] quintile versus most deprived IMD quintile: aOR 0.87 [95% CI = 0.85 to 0.89]); White ethnicity (Black versus White: aOR 0.95 [95% CI = 0.92 to 0.98]); mental health conditions (for example, depression: aOR 1.13 [95% CI = 1.12 to 1.15]); and diabetes treatment (non-insulin treatment versus no pharmacological treatment: aOR 0.68 [95% CI = 0.67 to 0.69]). Adults with hypertension maintained stable weight overall (median δ = 0.0 kg/m2/year [IQR −0.6–0.5]); however, rapid weight gain was common (24.7%) and associated with similar characteristics as in T2D.ConclusionAmong adults living in England with T2D and/or hypertension, rapid pandemic weight gain was more common among females, younger adults, those living in more deprived areas, and those with mental health conditions.

If rumours are true and this one should be, I started it, we have a special edition of the Weekend show where we talk about the evolution of the role of the CIO with two incredible CIOs as the CIO Association of Canada turns 20. Don’t miss it.  MUSIC UP Can HP make you love […]

The post Hashtag Trending Mar.1- HP debacle; Humanoid robots closer to hitting our workplaces; Apple blew $10 billion on the electric car before pulling the plug first appeared on ITBusiness.ca.

In Canada, your IP address has the right to remain silent. Elon Musk is suing OpenAI for not being Open. Apple faces a class action not allowing competitive access to backup services and the World Server Throwing Competition in March 2024 is accused of being too violent towards servers.   All this and more on the […]

The post Hashtag Trending Mar.4- Canadian police need a search warrant to access IP address; Musk sues OpenAI; World Server Throwing Competition too violent? first appeared on ITBusiness.ca.

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

The post Hashtag Trending Mar.5- Apple Music fined for market dominance; LockBit back from the dead; OpenAI kills ChatGPT plugins first appeared on ITBusiness.ca.

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

The post Hashtag Trending Mar.6- Facebook goes down; Amazon nuclear-powered data centres; Public trust in AI sinking first appeared on ITBusiness.ca.

We’ve all been there. You’ve gone to the store or scrolled through countless online sites, desperately searching for a graduation gift that’s unique, funny, and something your friend won’t toss in a drawer and forget about. Well, it turns out there’s a new trend catching fire, and it’s a fake college diploma. Yes, you heard […]

The post Why Fake College Diplomas Are the Latest Comedy Trend in Graduation Gifts appeared first on Chart Attack.

AthletesCAN in partnership with CBC Sports presents the Most Trending Moment Award as part of the 47th Canadian Sport Awards.

James Hicks, healthcare application development and processing engineer at Syensqo explores the latest trends, challenges and solutions in sterilisation.

As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models.

During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact. Put simply: Buy low, sell high, collect early, and pay late.

But as I explain below, wholesalers continue to position themselves as essential intermediaries by expanding their industry position and strengthening their economic fundamentals.

Read on for five key pricing, pharmacy, provider, and manufacturer trends that are driving the U.S. drug wholesaling industry.

For even more, check out DCI's new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, the fifteenth edition of our deep dive into wholesale distribution channels.Click here to download a free report overview (including key industry trends, the table of contents, and a list of exhibits)
Read more »

Benchmarking the Accounting & Finance Function: 2014

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AARP's Travel Ambassador Samantha Brown Unveils the 2016 Top Travel Trends for Baby Boomers

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Browse 2024’s most popular gift ideas with Google Shopping’s Holiday 100.

Tax revenues fell across the OECD for the first time in a decade during 2019, but a much larger decrease is expected in 2020 as a result of the COVID-19 pandemic, according to the OECD's newly released annual Revenue Statistics report.

Tax revenues fell across the OECD for the first time in a decade during 2019, but a much larger decrease is expected in 2020 as a result of the COVID-19 pandemic, according to the OECD's newly released annual Revenue Statistics report.

Excessive smartphone use, lack of sleep, cyberbullying, and poor mental health are all interlinked issues affecting teens in today's digital era. Australian

Pre-exposure prophylaxis (PrEP) with antiretroviral medications is effective in preventing HIV infections. PrEP use has increased between 2013 and 2023.

According to recent Accor research, 2025 promises to be an exciting year for travel, with new trends shaping the ways in which Brits will explore the world. Following the rise of the “cool-cation,” destination dupes, and active tourism, a new Accor survey shows that 74% of Brits are planning to travel abroad in the coming year. But what adventures await them, and where are they headed? Using a blend of UK search data, survey insights, and keyword trends, we’ve compiled the top travel experiences and destinations expected to capture travelers’ imaginations in 2025. Get ready to discover the trends defining the future of British travel!

Data isn’t meaningful unless you do something with it. Let’s say your average RevPAR for June is $150. Alone, that doesn’t mean very much. But what if you compare that number to the average RevPAR, globally and within your region? If you measure whether you’re improving year-on-year, month-on-month? If you look beyond RevPAR to accompanying key metrics?

The landscape of travel, spa, and wellness is always transforming with technological advancements, changing consumer preferences, and shifting global paradigms.

Want to buy a brand that buzzes? Here's what to know.

Shiba Inu Coin’s recent surge, and subsequent fall in value, is part of a growing trend of meme coins that are rivaling some of the largest digital tokens in the world. WSJ retail investing reporter Caitlin McCabe explains why investors are pouring money into this meme based cryptocurrency. Photo: Amber Bragdon/Getty Images

Spending time with loved ones brings us joy, but sometimes we all need a break to enjoy our own company, right? While some might think it sounds boring or that's only for loners, everyone deserves a little self-love. You've probably heard

The double denim trend occasionally referred to as the "Canadian tuxedo," is back with new and intriguing ways to flaunt it. This style plays with textures, cuts, and eye-catching patterns to redefine denim as more than just jeans! Take your style

Saree blouses have long served as a creative canvas in the dynamic realm of ethnic fashion. The corset-saree combination, on the other hand, is the newest fashion to hit the red carpet and the holiday season. It's a striking, alluring twist

In the ever-evolving world of romance, new trends constantly reshape our understanding of love and connection. The latest trends have many reflecting on their own experiences years ago, especially those who grew up in a time when dating felt more

The ultra-smooth, shiny finish of "glass hair," which gives tresses a liquid-like lustre, has contributed to making become modern beauty mainstay. It takes beyond just a correct shampoo to achieve this look; it also calls for meticulous planning, the appropriate ingredients,

These are the television shows that will crackle and pop a lot longer than anything you'll get your paws on.

Popular YouTuber and social media influencer Elvish Yadav is making his presence felt inside the Bigg Boss OTT house.

Curating a home today goes beyond conventional decor. It is about telling a story through accents, blending nostalgia with contemporary aesthetics, and celebrating craftsmanship

You have to get creative when you lack a strong visual. This month's design trends roundup focuses on this concept.

Touchable texture, distinct grids, and two-column designs are some of the most trending website design elements of November 2024.

Hyderabadis’ love affair with apricot continues to delight with many modern variations

The sixth edition of the report, which was launched in Mumbai with a dinner highlighting millets, predicts more interest in hyper-regional cuisine, vegan diets and mindful snacking

Amidst rumours of shutting shop, the watches of HMT, which started over 60 years ago, are still ticking as collectors vie for their new Tiffany blue launch

Short-form videos, Chandrayaan-3 live telecast among Youtube’s top draws of 2023

Linguists Nicole Holliday and Ben Zimmer go through the history of some of the most popular slang words ever and talk about not only their origins, but why some of them have gone out of style while others have persevered.

Polarising though the fashion trend is, it continues to rule as it signifies authenticity and vulnerability

Sanjay Chugh writes on the renewed momentum in Chennai's residential market.

Bengaluru has seen the highest surge in real estate activity and the return on investment is high compared to other cities