Title: Spinal Fluid Test May Aid Early Detection of Parkinson's Disease
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM

Title: Deep Brain Stimulation Safe for Older Parkinson's Patients: Study
Category: Health News
Created: 8/26/2014 12:35:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: New Hope From Old Drugs in Fight Against Parkinson's
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: Health Tip: Parking Lot Safety
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Nourianz Approved to Treat 'Off' Episodes in Parkinson Disease
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: Is It Parkinson's? These 10 Signs Could Tell
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focusing on more recent knowledge. In particular, we review the genetic evidence linking AS to familial and sporadic PD, including a number of recently identified point mutations in the SNCA gene. We briefly go over the relevant neuropathological findings, stressing the evidence indicating a correlation between aberrant AS deposition and nervous system dysfunction. We analyze the structural characteristics of the protein, in relation to both its physiologic and pathological conformations, with particular emphasis on posttranslational modifications, aggregation properties, and secreted forms. We review the interrelationship of AS with various cellular compartments and functions, with particular focus on the synapse and protein degradation systems. We finally go over the recent exciting data indicating that AS can provide the basis for novel robust biomarkers in the field of synucleinopathies, while at the same time results from the first clinical trials specifically targeting AS are being reported.

I've spent quite a lot of today trying to figure out why, exactly, some of the monsters in the Monster Hunter Wilds beta looked like bundles of copulating pyramids slathered in crocodile gravy. Nic clued me in on this reddit thread earlier, which cites unnamed Chinese players who've allegedly data-mined the beta's monster models, and learned that they are extremely large, encompassing hundreds of thousands of polygons.

If every monster in Monster Hunter Wilds were that fancy all of the time, your computer would become a volcano. As such, the game resorts to loading-on-demand systems to ensure that you only see those gorgeous details when the monsters are close by and, as the case may be, angrily sitting on you. When they're further afield, the flourishes fall away to free up memory and processing power. The popular Redditor explanation for the presence of monsters that look like Henry Moore sculpture is basically that the LOD systems are being forgetful, and neglecting to load the additional polygons at proximity.

Read more

We'll have a review of Planet Coaster 2 soon, but I keep making Brendy do other tasks so he's not had enough time yet to ride the rails. That means it falls to me to at least let you know that Frontier's theme park builder is out now.

Read more

Two large grizzly bears followed 13 hikers down a trail in Banff National Park for 20 minutes — with one even making a few quick runs at the group.

People report greater life satisfaction six months after starting Parkrun events, which could partly be due to the supportive environment

Jessica Simpson sparked rumors this week with a cryptic post about making new music and having put up with "everything I did not deserve."

House Republicans are once again at odds with one another after conservatives threatened to protest Speaker Johnson's bid to lead the conference again.

A Kenora, Ont., resident says she wants to see more resources for people who encounter sick or injured animals after seeing a deer in her yard with a tomato cage stuck on its head. Here's how the community has responded to the incident, and what we know about the deer's status.

Directors Raj & DK bring texture and technique to this Indian spin-off of ‘Citadel’, with uneven results

The buzz surrounding his post even caused a temporary block on his Instagram account due to a surge in user engagement

Nintendo is set to show off the Donkey Kong Country expansion of its Super Nintendo World theme park today (Monday, November 11) at 5PM ET, the company revealed in a post on X. That means the new Universal Studios Japan area might finally open soon, after being delayed from the previously announced launch window of Spring 2024. 

The new park attraction featuring Mario's barrel-throwing nemesis was first revealed in 2021. The centerpiece is a ride called Mine Cart Madness, named after the best level in the 1994 SNES game Donkey Kong Country. After being blasted out of a barrel cannon, you'll take a mine cart ride through the jungle that includes a "leap across a collapsed track" as Nintendo showed in a render earlier this year.  

The direct livestream appears to be focused on Donkey Kong world alone, and Nintendo specifically pointed out that "no game information will be featured" — so don't expect any news on the next-gen Switch 2 console either. 

Donkey Kong Country will expand the park size by up to 70 percent, Nintendo said when it was announced. Current attractions at the Japan park are the Mario Kart: Kuppa's Challenge rollercoaster and Yoshi Adventure. Nintendo recently announced that it would open a Super Nintendo World attraction at Universal Studios Orlando on May 22nd, 2025 with the same attractions as the park in Osaka. 

La présence de lésions intestinales serait associée à une hausse importante du risque de développer la maladie de Parkinson.

Charco Neurotech, a medtech company based in the United Kingdom, has developed CUE1, a non-invasive wearable that is intended to assist those with Parkinson’s disease to manage their motor symptoms. The device is typically affixed to the sternum, and provides vibratory action in a focused region of the body. The technology is based on the […]

As a group of friends circled a hearse, chants were heard. Then, they stopped and bowed to the portrait displayed at the front of the vehicle. This was not a typical Buddhist funeral, but rather the unconventional birthday celebration of a funeral director, reported Shin Min Daily News. According to the Chinese evening daily, a video circulating online showed the friends chanting a birthday song. The hearse's interior had been decorated with balloons and a birthday banner, with the man even laying inside for photos. The clip garnered criticism from netizens, with some deeming it overboard and disrespectful to the funeral industry. In an interview with Shin Min, director of Xin An Funeral Services Chen Weisong (transliteration) explained that he had celebrated his birthday at the company's premises with his friends and family last week. Halfway through the performances by singers, his employees and business partners had surprised him with the birthday-themed hearse bearing his portrait. Chen told 8world he was not angry and did not think it was taboo. "I was too embarrassed to turn down their gesture," he said. 

The Asbury Park Waterfront

Carely�s founder Mike Eidsaune takes part in Brookdale�s Entrepreneur in Residence program during a short stay in Brookdale Kettering.

Learn more about the 2016 PetSafe� Bark for Your Park� grant-giving program in this video.

The Park Family�s Infertility Story

Watch these doctors enjoy a taste of their own medicine #FindYourPark

Trump has promised tariffs on all foreign goods. If he follows through, many smaller economies may be forced to respond in kind.

Triple gold medallist Chris Hoy helps unveil designs for London's 2012 Olympic cycling facilities.

The National Medical Commission (NMC) has recently stirred controversy by modifying its official logo, replacing the word "India" with "Bharat" and incorporating

Concerns about cross-contamination risks at airports due to the unsanitary practice of using the same trays for shoes and personal items during security

Accessory conduction pathways in the heart, associated with medlinkWolff-Parkinson-White syndrome/medlink, can lead to rhythm disturbances uncovered

The World Health Organization (WHO) issued a warning about the alarming surge in medlinkmeasles/medlink cases across Europe, emphasizing the imperative for vaccination.

A groundbreaking study has revealed hundreds of genetic variations that influence the development of critical brain structures. Researchers examined DNA

A video-processing technique developed, utilizing medlinkartificial intelligence/medlink, will assist neurologists in more accurately tracking the

Scientists have developed a low-cost, portable smartphone-based sensor system designed to assist in managing symptoms of medlinkParkinson's disease/medlink

A California-based company has received approval for trying out the world's first stem therapy on patients affected with mild to severe Parkinson's disease.

Galaxy Hotels Group today announced the opening of the company’s newly built Courtyard by Marriott Reno Sparks in northern Nevada. Offering 127 rooms/suites, the four-story Courtyard by Marriott Reno Sparks is conveniently located near the Tahoe Reno Industrial Center (TRI Center), home to some of the world’s most recognized tech companies. Frisco, Texas-based Galaxy Hotels Group, also known as Galaxy Management, is an approved Marriott International franchisee, hotel developer, and management company. Galaxy operates hotels across nine U.S. states, representing well-known brands. Galaxy Expands Presence in NevadaAccording to Jagmohan (Jag) Dhillon, chief executive officer, Galaxy Hotels Group, the Courtyard by Marriott Reno Sparks represents Galaxy’s sixth hotel in Nevada. Galaxy operates 900 hotel keys in "The Silver State." "Northern Nevada is experiencing impressive economic growth. To support the area’s growing demand, we’re excited to welcome guests to our brand new Courtyard by...

Here are the photos of Raashi Khanna who attended the Prati Roju Pandaage Trailer launch.

A grassfire was ignited next to a runway at Sydney Airport following a reported engine explosion on a Qantas flight upon takeoff

When GitHub Copilot launched and started autocompleting lines of code — and, later, entire code snippets — the question many people were asking was: How long until we can just describe an app in natural language and Copilot will build it for us? We’ve seen quite a few experiments in this arena in recent months, […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Demonstrators marched in Minneapolis over the weekend to protest the fatal police shooting of Amir Locke, a Black man who was killed last week when police executed a no-knock search warrant. Photo: Kerem Yucel/AFP/Getty Images

The Orioles have gone nearly the entire month of June allowing at least one home run in every game.

Warby Parker was one of the original direct-to-consumer brands, but now, the eyeglass-maker’s sales are split about evenly between its more than 140 brick-and-mortar locations and its online store. WSJ’s Charity Scott explains why this split is Warby Parker’s secret sauce. Photo: Adam Falk/The Wall Street Journal

The stump mic incident occurred in the penultimate over, where Pandya encouraged Arshdeep to "enjoy from the other end."

It's celebration time everywhere as Deepavali is just around the corner. Unfortunately, for many, the festival of lights can turn into darkness due to negligence or the mistakes of others. The fact is that festivals, no matter the faith, are meant

India faces a growing air pollution crisis, with emissions from factories and construction activities being significant contributors. Petrol and diesel vehicles also play a major role in this issue. To address this, both central and state governments are implementing measures to

Leeds : ARC Humanities Press, [2023]

Ithaca, NY : Cornell University Press, [2023]

New York, NY : Routledge, 2020