The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is covalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative thereof. Preferably, the organometallic compounds are half-sandwich (“piano-stool”) compounds. The compounds of the present invention offer a high variability with respect to the bioactive compound and to the nature of the ligand bound to a central transition metal.

The present invention provides methods of making stereo-enriched ansa-metallocene compounds using an unchelated amine compound. Generally, these methods result in a rac:meso isomer selectivity of the stereo-enriched ansa-metallocene compound of greater than 4:1.

Nickel(II) compositions for use in manufacturing nickel metal (Ni(0)) compositions, and specifically to methods of making basic nickel carbonates used to produce nickel metal compositions are disclosed. By varying the molar ratios of carbonates and bicarbonates to nickel salts, the methods provide basic nickel carbonates that produce superior nickel metal-containing solids that are well-suited to forming nickel-ligand complexes with phosphorus-containing ligands. The phosphorus-containing ligands can be monodentate or bidentate phosphorus-containing ligands.

A method for forming a cobalt-containing thin film by a vapor deposition process is provided. The method comprises using at least one precursor corresponding in structure to Formula (I); wherein R1 and R2 are independently C2-C8-alkyl; x is zero, 1 or 2; and y is zero or 1; wherein both x and y can not be zero simultaneously.

The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparaion of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes.

A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention.

A platinum complex of a formula (I): whereR1 and R2 are each fluoroalkyl,X is C—H or nitrogen, andL1 is a bidentate, nitrogen-containing heteroaromatic ligand.

The present invention discloses metal (III) complex of a biuret-amide based macrocyclic ligand as green catalysts that exhibit both excellent reactivity for the activation of H2O2 and high stability at low pH and high ionic strength. The invention also provides macrocyclic biuret amide based ligand for designing of functional peroxidase mimics. Further, the present invention discloses synthesis of said metal (III) complex of a biuret-amide based macrocyclic ligand.

Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecu le, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.

A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).

Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.

Chelators of the formulae (I), (II) and (III) and tricarbonyl complexes of radioisotopes of Tc and Re bound to them, for use in myocardial imaging.

The rare-earth complex of the present invention has high luminous efficiency, since it has a structure represented by the following general formula (I):

The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor,2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof3) LINKER is a chemical group linking FOLATE and NOTA4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68.

Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since the GO-Gd-DTPA can stably exist in the body because it has high stability in water, it is expected that it can be effectively used as an MRI contrast agent.

Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

An OLED device comprises a cathode, an anode, and located therebetween a light-emitting layer containing a host material and a tris-C^N-cyclometallated complex of Ir or Rh wherein at least one of the ligands comprises a substituted quinazoline moiety. The device provides useful emission and stability attributes.

In one embodiment, a method includes obtaining a link to a video program; obtaining metadata that relates to the program and that defines, for a specified time point in the program, annotations to be invoked at the specified time point; wherein the annotations comprise: a graphic image; one or more filters, each of the filters comprising a key and one or more matching values; and optionally a reference to a video segment, an electronic document, program code statements, or a programmatic call; during playing the video, detecting that the video program is playing at the specified time point; in response to the detecting: for each particular annotation for the specified time point, retrieving a current value for the key, and causing to display the graphic image associated with that particular annotation only when the current value of the key matches one of the matching values of one of the filters.

The present invention relates to a method of identifying a natural substance that is capable of complexation with Ni2+, Cu2+ and/or Fe2+ ions, wherein an extract containing natural substances is led over a stationary phase loaded with Ni2+, Cu2+ and/or Fe2+ ions, which is suitable for immobilized metal affinity chromatography (IMAC).

A fullerene derivative, with a solubility in n-hexane of not lower that 0.1 mg/ml at 25° C., includes a fullerene skeleton and three or more organic groups attached to the fullerene skeleton, where each of the organic groups is represented by the general formula (III): —CH2—X (R2)(R3)(R4) (III) where X represents an element belonging to the group 14 in the periodic table; and R2, R3 and R4 may be the same or different and each represents a hydrogen atom, hydrocarbon group, alkoxy group or amino group.

An embodiment of this invention uses a massive parallel interconnect fabric (MPIF) at the flipped interface of a core die substrate (having the core logic blocks) and a context die (used for in circuit programming/context/customization of the core die substrate), to produce ASIC-like density and FPGA-like flexibility/programmability, while reducing the time and cost for development and going from prototyping to production, reducing cost per die, reducing or eliminating NRE, and increasing performance. Other embodiments of this invention enable debugging complex SoC through large contact points provided through the MPIF, provide for multi-platform functionality, and enable incorporating FGPA core in ASIC platform through the MPIF. Various examples are also given for different implementations.

There is provided a complex tuner module including a plurality of tuner chips through which users may simultaneously view and record a plurality of channels. The complex tuner module includes: a module substrate having a plurality of tuner chips mounted thereon; and a chassis part connected to the module substrate and having a plurality of blocking sidewalls disposed in spaces between the tuner chips to thereby block interference between the tuner chips.

Described is a process for preparing platinum-carbene complexes.

Methods and devices for milling a channel-shaped cavity by a five-axis computer numerical control (CNC) machine by selecting a workpiece to be machined, determining cutting tool flow along the channel-shaped cavity, determining cutting tool in-depth penetration, determining a trochoid path, and determining auxiliary movements.

A light-emitting element which emits light with high luminance and can be driven at low voltage. The light-emitting element includes n (n is a natural number of 2 or more) EL layers between an anode and a cathode, and includes a first layer, a second layer, and a third layer between an m-th (m is a natural number, 1≦m≦n−1) EL layer from the anode and an (m+1)th EL layer. The first layer functions as a charge-generation region, has hole-transport properties, and contains an acceptor substance. The third layer has electron-transport properties and contains an alkali metal or the like. The second layer formed of a metal complex having a metal-oxygen bond and an aromatic ligand is provided between the first and third layers, whereby an injection barrier at the time of injecting electrons generated in the first layer into the m-th EL layer through the third layer can be lowered.

A system and method for transmitting compressed video. A transmitter receives uncompressed video data from a video source, and compresses it using one or more reference frames. A receiver receives the compressed video data and decodes it, using the same reference frames, to form display data. The reference frames are stored in compressed form in both the transmitter and the receiver. Each frame of display data becomes a reference frame for the decoding of a subsequent frame.

A system and method is provided for reconstructing one or more collections of objects across platforms. More particularly, Java Annotations are used to assist a Web Services Description Language (WSDL) wizard in reconstructing a collection of objects. In implementation, the system and method parses the object types such that a wizard can recreate or reconstruct the collection of objects for use by a receiving service. The method includes reconstructing a collection using one or more annotations that document a base object of the collection.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

A process for producing granules containing one or more complexing agent salts of the general formula from an aqueous starting solution, containing the one or more complexing agent salts in a concentration of from 10 to 80% by weight, based on the total weight of the aqueous starting solution, in a jet apparatus.

Disclosed is a piezoelectric material including stereocomplex crystals of poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA), wherein poly(D-lactic acid) and poly(L-lactic acid) are crystallized into a stereocomplex, thus exhibiting superior heat resistance and piezoelectric properties. This piezoelectric material, which is obtained using poly(lactic acid), can be produced at very low cost compared to when using PVDF, and is configured to include stereocomplex crystals of PDLA and PLLA and can thus manifest high thermal stability and piezoelectric properties, compared to when using conventional PLLA alone. Such a piezoelectric material can be efficiently utilized in a variety of fields in which low production cost, high processing temperature in the manufacturing process, or high-temperature stability of piezoelectric material products is required.

Turf dancing has become ubiquitous on the trains, providing steady income, a creative platform, and a built-in audience. On a recent Friday, Yaameen Muhammad stood on the West Oakland BART platform, the afternoon sun reflecting off his neon-yellow high-tops.…

LEISURE bosses are today bracing themselves to make the next step towards the development of a huge, multi-million-pound, Las Vegas-style casino planned for Southampton.

THIS fine country farmhouse in the New Forest is on the market for £2.25 million

Disney Springs vice president Matt Simon posted Thursday on the official Disney Parks Blog that the area will reopen May 20 with enhanced safety measures to help prevent the spread of the coronavirus.

Dubspot's Rory PQ explores Generative Music and demonstrates an effective technique used to generate complex sequences of music using Live's native devices.

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The post Ableton Live Techniques: Creating Complex Sequences appeared first on Dubspot Blog.

Immigration is good for the economy — that's the big picture. It doesn't mean some Americans aren't hurt in their paychecks and opportunities.

As a historically seafaring town that’s also way ahead of its time, picturesque Port Townsend hopes to grow respectfully, responsibly and authentically offbeat.

The third part of this tutorial series goes deeper into joins and more complex queries. Learn how to get data from your Informix database and dump it in Spark so you can leverage it against other data sources and compile advanced analytics all that in Java. The targeted audience is Informix and non-Informix users seeking to bring RDBMS data into Spark.

Local government officials in Mount Barker say they are angered by the "senseless" burglary and vandalism at the town's swimming pool complex.

Scientist Richard Connor has discovered that Monkey Mia's dolphins have the most complex non-human society on the planet.

Police arrest a woman they had urged to come forward to authorities after a 23-year-old plunged to her death at a high-rise complex in Sydney's inner east.

A South Australian MP is calling for an increase in travel subsidies, coverage of services like Airbnb and Uber, and more flexibility for patients to see their own medical specialists under the state's Patient Assisted Transport Scheme (PATS).

A fortnightly welfare payment for farmers, considered to be the cornerstone of drought assistance, should be removed from social security legislation, an independent review recommends.

Our world is becoming increasingly intelligent, interconnected, and instrumented, resulting in massive amounts of data being collected. This data is a treasure trove of information that can be mined to improve service, increase sales, determine risk, or make operations more efficient.

Analysis of such large amounts of data, often called analytics, is increasingly desired by governments and businesses alike.

The groundbreaking celebration will have to wait, but construction is starting on the first of three buildings that will make up Colorado State University's complex at the National Western Center in Denver.

I'm getting so very tired of safety/accident researchers claiming that root cause analysis is an invalid, blame-focused practice that ignores systems and complexity. Most root cause investigators that I know are pretty well oriented towards process, organization, and system issues as the fundamental sources underlying problems and accidents... and even some of our simplest analysis […]

My previous post about root causes in complex systems, in retrospect, looks a little bit like a rant. That doesn't bother me too much, really... but I wish I had included the following info: it is one way to go about resolving the mess that complex systems can make of your root cause analysis. Basically, when […]

Less than half of global CEOs believe their enterprises are adequately prepared to handle a highly volatile, increasingly complex business environment, according to a major new survey by IBM of more than 1,500 Chief Executive Officers from 60 countries and 33 industries worldwide, including 22 respondents from New Zealand – the largest number of respondents in eight years of research.

No one is a stranger to financial challenges and problems. They tend to happen with people in different degrees and at separate points in time for that matter. We can unanimously agree that we need money to achieve many of our goals but also for financial independence at the same time.  When we refer to...

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