From foundry-inspired knobs to playful wall hooks, Viefe's new hardware makes it easy to add the finishing touches to a space.

When Joe Hill launched his career as a writer, he didn't want anyone to know about his famous writer parents, Stephen and Tabitha King. Rather than ride their coattails, he wanted to find success on his own—thus the pen name, Joe Hill.

Collins vowed to not write a goodbye post. We're not sure if's staying true to that, so here comes old friend Tom Weber "to sing a little on behalf of a friend who’s made immeasurable contributions to MPR and Minnesota."

Many middle-income families are frustrated by the cost of higher education, feeling they earn too much for financial aid, but not enough to pay for it themselves.

Muslim vigilante groups are working with federal authorities to lure young people into sharing blasphemous content on social media in order to put them behind bars, according to an investigation by Pakistan’s National Commission for Human Rights

The Currier Museum of Art 's latest exhibition features the work of Philadelphia-based potter Roberto Lugo. Lugo finds inspiration for his work in his upbringing and his cultural heritage. His new collection, Te traigo mi le lo lai -- I bring you my joy , will be on display at the Currier Museum through September. Lugo will also be in Manchester this summer for a residency with the museum, where he'll be teaching pottery classes. Below are some excerpts from Robert Lugo's conversation with NHPR's Rick Ganley. On Lugo’s inspiration: “ I've always found that it's important for me as a person to not forget where I'm from. I'm from Philadelphia in a really impoverished neighborhood, mostly made up of Black and Latinx people. And so I identify and associate that as a culture and as almost its own society. And so in the tradition that people have represented their cultures in pottery, I do that.” On his new exhibition, Te traigo mi le lo lai -- I bring you my joy : “ One of the reasons why I

Suzannah Clark (Harvard University) Title and description TBA A reception will follow.

Pheaross Graham (Stanford) Title and description TBA A reception will follow.

Jennifer Iverson (University of Chicago) Title and description TBA A reception will follow.

Gavin Steingo (Princeton University) Title and description TBA A reception will follow.

Pasolini, World Music, and the Demise of the Film ComposerWhile somewhat neglected in the English-language literature on film music, Pasolini’s daring use of pre-existing music in his early films—most notably Bach’s sacred music and Vivaldi—marked a watershed in the history of the subject. It also places him alongside such figures as Godard and Kubrick (among others) in an ideal pantheon of mavericks who broke away with the traditional division of labor that underpinned the creation of film soundtracks. Pasolini’s decision to hire Morricone for the music for The Hawks and the Sparrows(1966) could have signaled a change in direction. In fact, following that first collaboration, the relationship between Pasolini and Morricone soon turned into something of an embarrassment for the composer. By the early 1970s, Morricone’s role was to merely arrange already-existing repertoires “scavenged” on various recordings by the omnivorous and ever up-to-date poet/director. Pasolini’s gleeful embrace of reproduced music calls to mind André Malraux’s “museum without walls” and his celebration of the library as both a cabinet of curiosities and workshop. Focusing on Medea(1969) and the so-called “Trilogy of Life,” this talk examines Morricone’s work as mediated and indeed guided by Pasolini the consumer, curator and ultimately producer—for Arabian Nights(1974)—of recordings.Short BioGiorgio BiancorossoGiorgio Biancorosso’s work investigates the boundaries of music and sound in the theater, cinema and digital media. He is the author of Situated Listening: The Sound of Absorption in Classical Cinema(Oxford University Press, 2016) and Remixing Wong Kar Wai: Music, Bricolage, and the Aesthetics of Oblivion(Duke University Press, 2024). Biancorosso is the co-founder and editor of the journal SSS (Sound-Stage-Screen) and the co-editor of Scoring Italian Cinema: Patterns of Collaboration(Routledge, forthcoming).Biancorosso is Professor of Music and inaugural director of the Society of Fellows at The University of Hong Kong. He is currently 2024-25 Luce East Asia Fellow in Musicology at the National Humanities Center, N.C.

dj sniff (Takuro Mizuta Lippit) Composition Colloquium (CNMAT) – Nov. 22Title of your talkParallel Traces - Records that stoped the war, trained the ear, and gave birth to turntablismshort abstractFor this occasion, I will talk about how my practice in turntablism and free improvisation led to the creation of my latest works that deal with historical narratives manifested through vinyl records and their playback devices. Namely, I will talk about Parallel Traces of the Jewel Voice (2022) and The Inverted Listening of Explosive Enemy Aircraft Sounds (2023) which both examine the critical roles that phonograph records played during WWⅡ Japan and its colonized territories, and Transformer (2023) - a sound installation that is constructed by reinterpreting stories about Grandmaster Flash’s early experiments with sound technology.short biodj sniff (Takuro Mizuta Lippit) is a musician and curator in the field of experimental electronic arts and improvised music. His work builds upon a distinct practice that combines DJing, instrument design, and free improvisation. Over the years, he has collaborated with artists such as: Evan Parker, Otomo Yoshihide, Tarek Atoui, Senyawa and many others. He holds a B.A. from Keio University Department of Aesthetics and Science of Arts, M.P.S. from NYU Interactive Telecommunications Program, and Ph.D. from De Montfort University Faculty of Computing, Engineering and Media. Alongside his artistic work, he has held positions at various institutions such as Artistic Director of STEIM – Studio for Electro-Instrumental Music Amsterdam (2007-2012), Visiting Assistant Professor at City University of Hong Kong School of Creative Media (2012-17), and Associate Professor at Kyoto Seika University (2020 - 2022). Currently based in Los Angeles, he is the Co-Director of Asian Meeting Festival (AMF) - an international music festival that brings together experimental musicians from Asia since 2005, instructor at Shared Campus Summer Schools led by Zurich University of the Arts, and a part-time lecturer at Kyoto Seika and Tokyo University of the Arts Graduate School of Global Arts.

‘Un Matisse Qui Chante’: Image, Sound, and Story in The Umbrellas of CherbourgWalter Frisch (Columbia University)The year 2024 marks the sixtieth anniversary of the release of Les Parapluies de Cherbourg(The Umbrellas of Cherbourg, 1964), which has since become a beloved classic in France and around the world. Diverging in many respects from the aesthetics of the contemporary Nouvelle Vague, Umbrellaswas a bold experiment by writer-director Jacques Demy and composer Michel Legrand that also departed markedly from traditional film musicals. Umbrellaswas sung from beginning to end, without any spoken dialogue. The creators aimed for a “transposed realism” that also bore little resemblance to opera. Legrand’s score, composed in close collaboration with Demy, was recorded before any filming began. The painterly costumes and sets were also coordinated with the music and screenplay. Umbrellashas been recognized as reflecting important cultural, political, and social issues of the France of its day, including modernization and commodification in the decades after World War II, the pervasive impact of Algerian War of 1954–1962, and changing family values during an early wave of feminism in France. More recently, Umbrellashas been interpreted within the framework of queer cinema. This talk will explore the genesis and unique qualities of Umbrellas, as well as some of these important contexts.Note: Frisch recommends watching Les Parapluies de Cherbourgin advance, if possible. It is available with subtitles on several streaming platforms. A reception will follow.

Karola Obermueller Composition Colloquium (Morrison 250) – Nov. 15time, timbre, and transformation  abstractMy creative research revolves around a collection of themes which I return to again and again in my composing. I will discuss these areas of inquiry, how they connect to each other, and in which ways they form / govern / appear in my compositions. short bioKarola Obermüller’s composing, described by the NYT as “hyperkinetic music”, is constantly in search of the unknown. Her unique voice began forming in collages of sound made with tape recorders and evolved later with composition degrees obtained in Nuremberg, Saarbrücken, and at the Mozarteum Salzburg. Her sense of rhythm and form was forever changed by studying Carnatic and Hindustani classical music in India. Since receiving a doctorate from Harvard, Obermüller taught composition and co-directed the composition area at the University of New Mexico before joining the Department of Music at UC San Diego in 2023. Her music can be heard on CD (WERGO, New Focus Recordings, Brilliant Classics) and at karolaobermueller.net.

Since 1478, Russia has taken part in 138 wars and suffered defeat in 18 of them. Three of those wars led to most severe territorial and human losses for Russia.  Livonian War (1558 - 1583) The conflict sparked after the Livonian Confederation refused to pay tribute that Russia had imposed  since the previous war in 1481. The Livonians actively obstructed the development of Russian trade in the Baltic Sea and concluded an offensive-defensive treaty with Poland and Lithuania. Having realised that the war with the Baltic would be inevitable, Ivan the Terrible organised a crusade to Livonia. At first, Russia was winning, and both Livonia and Lithuania were completely defeated. However, the European countries joined their forces in the face of the threat from the Russian army. 

A football player was killed when a flash of lightning struck him during a match between Juventud Bellavista and Familia Chocca in Peru. The incident occurred when the players were leaving the field due to bad weather. Thirty-nine-year-old defender Hugo de la Cruz Mesa died on the spot. Four other players were hospitalized, one of them remains in serious condition, Peruvian agency Andina said.

Admiral Vyacheslav Popov, the former commander of the Northern Fleet of the Russian Navy, said that the Kursk submarine (nuclear submarine K-141 Kursk) sank in 2000 as a result of the collision with a NATO submarine. The name of the Western submarine is known almost for sure, Popov said in an interview with RIA Novosti. The ex-commander-in-chief of the Northern Fleet suggested that the submarine that collided with the Kursk was tracking the sub. The Western submarine could not ensure the required level of safety under the conditions of the sea and other circumstances, so it came too close to the Kursk. According to the admiral, the sub was later found off the coast of Norway. Popov added that the manoeuvre of the Russian nuclear submarine could also lead to the "loss of contact." According to the admiral, he can reveal the name of the NATO submarine with almost 100 percent certainty, but said that he would not do it for a number of reasons.

Cleveron, a click-and-collect automation solutions innovator, is proud to launch a modular outdoor parcel locker, Cleveron 355. The newest solution is specially engineered for DIY and home furnishing retailers, enabling the automated handover of extra-large items.

The Ukrainian army will be able to hold out until the beginning of autumn at most. Most likely, though, everything will collapse in June-July, observers believe. France Presse wrote that Zelensky's office repeatedly used Western weapons to strike the Russian Federation. For the last time, Kyiv struck targets in the Krasnodar Territory (Southern Russia). The US has gauthorised Kyiv to use US-made weapons to strike deep into Russia too. Is further escalation with the West coming? "The real strategy of the West is logical and consistent. They understand it in the West very well that they will have to switch to strategic defense, because there are not enough troops and losses have been growing catastrophically. The Ukrainian army lacks weapons and military equipment. Therefore, they want the Armed Forces of Ukraine to hold out, and this is only possible by switching to strategic defense. In other words, they want Ukrainian to maintain relative stability at least for several months,” Director of the Center for Military-Political Studies of MGIMO Alexey Podberezkin told Ukraina.ru publication.

British Business-to-Business (B2B) companies take on average 32 days to collect, collate and enrich all the necessary data for a new product launch, significantly impacting UK productivity and go-to-market times, according to research conducted by Akeneo, the Product Experience (PX) Company and leading provider of Product Information Management (PIM) solutions.

The University of Pennsylvania Graduate School of Education (Penn GSE) has been awarded $3.5 million, part of a larger $8 million grant from Education Initiatives, to partner with the School District of Philadelphia (SDP) to launch The Academy at Penn, an innovative five-year, cohort-based college- and career-readiness model for high school students. Foundations, Inc. and the Consortium for Policy Research in Education (CPRE) were also awarded through the grant as part of the larger partnership. The close collaboration involves working together to design, implement, and evaluate the project.

[Domestic] :
The nation’s annual college entrance exam will be distributed across the nation from Monday to Wednesday ahead of Thursday’s College Scholastic Ability Test(CSAT).  The education ministry said the CSAT question and answer sheets will be transported to all 85 test zones across the nation starting ...

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[Domestic] :
The Seoul Metropolitan Government will enforce comprehensive measures to control traffic when the annual college entrance exam takes place on Thursday. According to city officials on Monday, work hours at public offices in the city will start an hour late at 10 a.m. Thursday to prevent exam-takers from ...

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[Domestic] :
The transport ministry will restrict the takeoff and landing of all aircraft for about half an hour on Thursday to prevent distractions during the English listening portion of the annual College Scholastic Ability Test. The ministry said Tuesday that the restrictions will be in place from 1:05 p.m. to 1:40 ...

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[Domestic] :
Students taking this year’s College Scholastic Ability Test(CSAT) on Thursday are set to meet for venue checks on Wednesday. Test takers are required to visit their test sites Wednesday to check the locations and receive their admission tickets.  They need to check their admission tickets to be sure ...

[more...]

[Domestic] :
The country is taking steps to make sure the College Scholastic Ability Test(CSAT) proceeds smoothly on Thursday, with local governments and companies adjusting their schedules to reduce traffic congestion. Banks will open later than usual, operating from 10 a.m. to 5 p.m. The government has also ...

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BGS collaborates with Icelandic colleagues to assess windfarm suitability  British Geological Survey

New geological collaboration for Ordnance Survey  Ordnance Survey

BGS announces collaboration with Ordnance Survey  British Geological Survey

Fixed targets (`chips') offer efficient, high-throughput microcrystal delivery for serial crystallography at synchrotrons and X-ray free-electron lasers (XFELs). Within this family, sheet-on-sheet (SOS) chips offer noteworthy advantages in cost, adaptability, universality and ease of crystal loading. We describe our latest generation of SOS devices, which are now in active use at both synchrotrons and XFELs.

Here we describe TOMOMAN (TOMOgram MANager), an extensible open-sourced software package for handling cryo-electron tomography data preprocessing. TOMOMAN streamlines interoperability between a wide range of external packages and provides tools for project sharing and archival.

Serial crystallography (SX) efficiently distributes over many crystals the radiation dose absorbed during diffraction data acquisition, enabling structure determination of samples at ambient temperature. SX relies on the rapid and reliable replacement of X-ray-exposed crystals with fresh crystals at a rate commensurate with the data acquisition rate. `Solid supports', also known as `fixed targets' or `chips', offer one approach. These are microscopically thin solid panes into or onto which crystals are deposited to be individually interrogated by an X-ray beam. Solid supports are generally patterned using photolithography methods to produce a regular array of features that trap single crystals. A simpler and less expensive alternative is to merely sandwich the microcrystals between two unpatterned X-ray-transparent polymer sheets. Known as sheet-on-sheet (SOS) chips, these offer significantly more versatility. SOS chips place no constraint on the size or size distribution of the microcrystals or their growth conditions. Crystals ranging from true nanocrystals up to microcrystals can be investigated, as can crystals grown in media ranging from low viscosity (aqueous solution) up to high viscosity (such as lipidic cubic phase). Here, we describe our two SOS devices. The first is a compact and lightweight version designed specifically for synchrotron use. It incorporates a standard SPINE-type magnetic base for mounting on a conventional macromolecular crystallography goniometer. The second and larger chip is intended for both X-ray free-electron laser and synchrotron use and is fully compatible with the fast-scanning XY-raster stages developed for data collection with patterned chips.

An integrated computer software system for macromolecular crystallography (MX) data collection at the BL02U1 and BL10U2 beamlines of the Shanghai Synchrotron Radiation Facility is described. The system, Finback, implements a set of features designed for the automated MX beamlines, and is marked with a user-friendly web-based graphical user interface (GUI) for interactive data collection. The Finback client GUI can run on modern browsers and has been developed using several modern web technologies including WebSocket, WebGL, WebWorker and WebAssembly. Finback supports multiple concurrent sessions, so on-site and remote users can access the beamline simultaneously. Finback also cooperates with the deployed experimental data and information management system, the relevant experimental parameters and results are automatically deposited to a database.

Deflectometric profilometers are used to precisely measure the form of beam shaping optics of synchrotrons and X-ray free-electron lasers. They often utilize autocollimators which measure slope by evaluating the displacement of a reticle image on a detector. Based on our privileged access to the raw image data of an autocollimator, novel strategies to reduce the systematic measurement errors by using a set of overlapping images of the reticle obtained at different positions on the detector are discussed. It is demonstrated that imaging properties such as, for example, geometrical distortions and vignetting, can be extracted from this redundant set of images without recourse to external calibration facilities. This approach is based on the fact that the properties of the reticle itself do not change – all changes in the reticle image are due to the imaging process. Firstly, by combining interpolation and correlation, it is possible to determine the shift of a reticle image relative to a reference image with minimal error propagation. Secondly, the intensity of the reticle image is analysed as a function of its position on the CCD and a vignetting correction is calculated. Thirdly, the size of the reticle image is analysed as a function of its position and an imaging distortion correction is derived. It is demonstrated that, for different measurement ranges and aperture diameters of the autocollimator, reductions in the systematic errors of up to a factor of four to five can be achieved without recourse to external measurements.

The Keck-PAD (pixel array detector) was developed at Cornell as a burst-rate imager capable of recording images from successive electron bunches (153 ns period) from the Advanced Photon Source (APS). Both Si and hole-collecting Schottky CdTe have been successfully bonded to this ASIC (application-specific integrated circuit) and used with this frame rate. The facility upgrades at the APS will lower the bunch period to 77 ns, which will require modifications to the Keck-PAD electronics to image properly at this reduced period. In addition, operation at high X-ray energies will require a different sensor material having a shorter charge collection time. For the target energy of 40 keV for this project, simulations have shown that electron-collecting CdTe should allow >90% charge collection within 35 ns. This collection time will be sufficient to sample the signal from one frame and prepare for the next. 750 µm-thick electron-collecting Schottky CdTe has been obtained from Acrorad and bonded to two different charge-integrating ASICs developed at Cornell, the Keck-PAD and the CU-APS-PAD. Carrier mobility has been investigated using the detector response to single X-ray bunches at the Cornell High Energy Synchrotron Source and to a pulsed optical laser. The tests indicate that the collection time will meet the requirements for 77 ns imaging.

The Circular Electron–Positron Collider (CEPC) in China can also work as an excellent powerful synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field as it has a broad spectrum, with energies ranging from visible light to X-rays used in conventional radiotherapy, up to several megaelectronvolts. FLASH radiotherapy is one of the most advanced radiotherapy modalities. It is a radiotherapy method that uses ultra-high dose rate irradiation to achieve the treatment dose in an instant; the ultra-high dose rate used is generally greater than 40 Gy s−1, and this type of radiotherapy can protect normal tissues well. In this paper, the treatment effect of CEPC synchrotron radiation for FLASH radiotherapy was evaluated by simulation. First, a Geant4 simulation was used to build a synchrotron radiation radiotherapy beamline station, and then the dose rate that the CEPC can produce was calculated. A physicochemical model of radiotherapy response kinetics was then established, and a large number of radiotherapy experimental data were comprehensively used to fit and determine the functional relationship between the treatment effect, dose rate and dose. Finally, the macroscopic treatment effect of FLASH radiotherapy was predicted using CEPC synchrotron radiation through the dose rate and the above-mentioned functional relationship. The results show that the synchrotron radiation beam from the CEPC is one of the best beams for FLASH radiotherapy.

A considerable bottleneck in serial crystallography at XFEL and synchrotron sources is the efficient production of large quantities of homogenous, well diffracting microcrystals. Efficient high-throughput screening of batch-grown microcrystals and the determination of ground-state structures from different conditions is thus of considerable value in the early stages of a project. Here, a highly sample-efficient methodology to measure serial crystallography data from microcrystals by raster scanning within standard in situ 96-well crystallization plates is described. Structures were determined from very small quantities of microcrystal suspension and the results were compared with those from other sample-delivery methods. The analysis of a two-dimensional batch crystallization screen using this method is also described as a useful guide for further optimization and the selection of appropriate conditions for scaling up microcrystallization.

The expansive scientific software ecosystem, characterized by millions of titles across various platforms and formats, poses significant challenges in maintaining reproducibility and provenance in scientific research. The diversity of independently developed applications, evolving versions and heterogeneous components highlights the need for rigorous methodologies to navigate these complexities. In response to these challenges, the SBGrid team builds, installs and configures over 530 specialized software applications for use in the on-premises and cloud-based computing environments of SBGrid Consortium members. To address the intricacies of supporting this diverse application collection, the team has developed the Capsule Software Execution Environment, generally referred to as Capsules. Capsules rely on a collection of programmatically generated bash scripts that work together to isolate the runtime environment of one application from all other applications, thereby providing a transparent cross-platform solution without requiring specialized tools or elevated account privileges for researchers. Capsules facilitate modular, secure software distribution while maintaining a centralized, conflict-free environment. The SBGrid platform, which combines Capsules with the SBGrid collection of structural biology applications, aligns with FAIR goals by enhancing the findability, accessibility, interoperability and reusability of scientific software, ensuring seamless functionality across diverse computing environments. Its adaptability enables application beyond structural biology into other scientific fields.

We report the synthesis and structures of two transition-metal complexes involving 2-(2-hy­droxy­phen­yl)benzimidazole (2hpbi – a ligand of inter­est for its photoluminescent applications), with cobalt, namely, bis­[μ-2-(1H-1,3-benzo­diazol-2-yl)phenolato]bis­[ethanol(thio­cyanato)­cobalt(II)], [Co2(C13H9N2O)2(NCS)2(C2H6O)2], (1), and manganese, namely, bis­[μ-2-(1H-1,3-benzo­diazol-2-yl)phenolato]bis­{[2-(1H-1,3-benzo­diazol-2-yl)phenolato](thio­cyanato)­mang­an­ese(III)} dihydrate, [Mn2(C13H9N2O)4(NCS)2]·2H2O, (2). These structures are two recent examples of a fruitful collaboration between researchers at the Laboratoire de Chimie de Coordination Organique/Organic Coordination Chemistry Laboratory (LCCO), University of Dakar, Senegal and the National Crystallography Service (NCS), School of Chemistry, University Southampton, UK. This productive partnership was forged through meeting at Pan-African Conferences on Crystallography and quickly grew as the plans for the AfCA (African Crystallographic Association) developed. This article therefore also showcases this productive partnership, in celebration of the IUCr's 75 year anniversary and the recent inclusion of AfCA as a Regional Associate of the IUCr.

JUAMI, the joint undertaking for an African materials institute, is a project to build collaborations and materials research capabilities between PhD researchers in Africa, the United States, and the world. Focusing on research-active universities in the East African countries of Kenya, Ethiopia, Tanzania and Uganda, the effort has run a series of schools focused on materials for sustainable energy and materials for sustainable development. These bring together early-career researchers from Africa, the US, and beyond, for two weeks in a close-knit environment. The program includes lectures on cutting-edge research from internationally renowned speakers, highly interactive tutorial lectures on the science behind the research, also from internationally known researchers, and hands-on practicals and team-building exercises that culminate in group proposals from self-formed student teams. The schools have benefited more than 300 early-career students and led to proposals that have received funding and have led to research collaborations and educational non-profits. JUAMI continues and has an ongoing community of alumni who share resources and expertise, and is open to like-minded people who want to join and develop contacts and collaborations internationally.

President Biden plans to visit the Champlain Towers condo collapse later this week.; Credit: Lynne Sladky/AP

The White House says President Biden and first lady Jill Biden will travel to Florida Thursday to view first hand the partial collapse of the Champlain Towers condominium.

Asked by reporters if he planned to visit Surfside, Biden said, "Yes I hope so, as soon as we can. Maybe as early as Thursday." The White House issued a formal announcement of the trip shortly afterward.

The official death toll in the collapse has risen to 11, with some 150 people unaccounted for.

The Biden administration has responded to the disaster, dispatching FEMA administrator Deanne Criswell to the scene earlier this week.

"[The agency] has deployed an Incident Management Assistance Team, as well as building science experts, structural engineers and geotechnical experts to support search-and-rescue operations, and a mobile command center," White House press secretary Jen Psaki said Monday.

Psaki said the U.S. Army Corps of Engineers is also providing technical assistance for debris removal. Two FEMA-supported search-and-rescue teams are also involved in the response to the collapse.

Florida Gov. Ron DeSantis has praised FEMA and the Biden administration for "stepping up to the plate" in providing assistance in the search and recovery effort. Miami-Dade Mayor Daniella Levine Cava said Biden's upcoming trip would be "an important reminder that our county, our state and our nation are giving everything we have to search for the victims of this tragedy and support the families in this incredibly devastating time."

Here's what we know about what led to the collapse. Follow more coverage on the aftermath here.

Florida Division of Emergency Management is urging people with information about loved ones who are either unaccounted for or known to be safe to call 305-614-1819.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Full Text:

On August 17, 2017, scientists made history with the first direct observation of a merger between two neutron stars. It was the first cosmic event detected in both gravitational waves and the entire spectrum of light, from gamma rays to radio emissions. The impact also created a kilonova -- a turbocharged explosion that instantly forged several hundred planets’ worth of gold and platinum. The observations provided the first compelling evidence that kilonovae produce large quantities of heavy metals, a finding long predicted by theory. Astronomers suspect that all of the gold and platinum on Earth formed as a result of ancient kilonovae created during neutron star collisions. Based on data from the 2017 event, first spotted by the Laser Interferometer Gravitational-wave Observatory (LIGO), astronomers began to adjust their assumptions of how a kilonova should appear to Earth-bound observers. A team of scientists reexamined data from a gamma-ray burst spotted in August 2016 and found new evidence for a kilonova that went unnoticed during the initial observations.

Image credit: NASA/ESA/E. Troja

Source: Dr. Robert Driscoll 10/28/2024

Wedbush analysts Dr. Robert Driscoll, Dr. Ritika Das, and Sam Ravina, in a research report published on October 28, 2024, maintained their Outperform rating on Monte Rosa Therapeutics Inc. (GLUE:NASDAQ) while raising their price target to US$15.00 from US$11.00. The report follows Monte Rosa's announcement of a collaborative agreement with Novartis for the development of MRT-6160, its VAV1-degrader program.

The analysts highlighted the significant financial terms of the agreement, stating, "GLUE will receive an upfront payment of US$150M as well as total milestone payments of up to US$2.1B that will include US$1.5B in potential development and regulatory milestones that begin upon Ph 2 studies."

Regarding the partnership structure, the analysts noted, "Upon start of Ph 3 studies, 30% US P&L would be shared with Ph 3 development co-fund and ex-US tiered royalties. Importantly, NVS will cover the complete costs of Ph 2 studies and will obtain worldwide rights to develop, commercialize and manufacture MRT-6160 as well as other VAV MGDs."

The analysts viewed this collaboration positively, stating, "We view this favorable collaboration agreement as an additional robust validation of GLUE's QuEEN MGD platform (noting Novartis' significant efforts in the degrader space), as well as an acknowledgment of the significant potential opportunities around targeting VAV1 with a first in class degrader."

They also emphasized the strategic benefits, noting, "Furthermore, we note the likely accelerated timelines for the MRT-6160 development program overall, and significant extension of GLUE's operational cash runway, which we expect to allow advancement of its deep pipeline."

The report highlighted the ongoing Phase 1 SAD/MAD healthy subject study for MRT-6160 in autoimmune diseases, with initial data expected in 1Q:25.

Wedbush's valuation methodology is based on sales multiples. The analysts explained, "Our PT is derived from applying a 6x multiple to estimated US sales and a 15x multiple to EU royalties of MRT-2359 in 2031, discounted by 30% annually."

The analysts also outlined several risk factors, including potential clinical and regulatory failure of MRT-2359, challenges in achieving sales estimates, and possible commercial competition from current and future therapies.

In conclusion, Wedbush's increased price target to US$15 reflects growing confidence in Monte Rosa Therapeutics following the Novartis collaboration agreement. The share price at the time of the report of US$8.05 represents a potential return of approximately 86% to the analysts' target price, highlighting the significant upside potential as the company advances its development programs with its new partner.

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Disclosures for Wedbush, Monte Rosa Therapeutics Inc., October 28, 2024

Analyst Certification We, Robert Driscoll, Ritika Das and Sam Ravina, certify that the views expressed in this report accurately reflect our personal opinions and that we have not and will not, directly or indirectly, receive compensation or other payments in connection with our specific recommendations or views contained in this report.

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As search and rescue efforts at the site of the Surfside, Fla., condo collapse stretch into day nine, officials have said that the number of confirmed fatalities has risen to 20, while the number of people unaccounted for has dropped from 145 to 128.

Miami-Dade County Mayor Daniella Levine Cava told reporters Friday that one of the two fatalities recovered overnight was the 7-year-old daughter of a firefighter for the city of Miami.

"It goes without saying that every night since this last Wednesday has been immensely difficult for everybody, particularly the families that have been impacted," Levine Cava said. "But last night was truly different and more difficult for our first responders. These men and women are paying an enormous human toll each every day, and I ask that all of you please keep all of them in your thoughts and prayers."

"They truly represent the very best in all of us, and we need to be there for them as they are here for us," she said.

The number of people who have been accounted for has grown to 188, officials also confirmed Friday. In many cases, detectives followed leads regarding individuals who were unaccounted for but then reached them and discovered they were safe.

They even discovered additional family members who were safe and who could have been in the building, and added them to the tally of accounted for individuals.

Officials have not yet released the names of all of the dead and missing people, and asked Friday that the privacy of the families be respected.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Three applied research centers at the Charlotte Research Institute will install instrumentation and conduct experiments at the Eco-Complex, an expansion of innovative waste reduction and waste processing technology already underway at the Complex.

Do you have any unwanted household products, such as paints, cleansers, solvents, antifreeze, batteries or used motor oils; or electronics like computer equipment, old radios, mobile phones, TVs, VCRs, calculators or copiers? Dispose of them properly, free of charge, on May 7th from 9 a.m. to 3 p.m.

Lori A. Mathes was appointed by the Catawba County Board of Commissioners as the County�s new Tax Collector, based upon staff�s recommendation, at the Board�s meeting on February 18, 2013. Mathes served as Chief Financial Officer for Mental Health Partners of Hickory for eight years, responsible for overseeing the agency�s expenditures and revenues, its accounting policies and procedures.

A new State law will soon shift collection of motor vehicle taxes from counties to the North Carolina Division of Motor Vehicles.