Unique low-profile keyboard crafted by Ben Fryc...

Dozens of competitive eaters polish off their webcams in preparation for the yearly biscuit showdown.

Plus: Heidi Klum’s Earth Day and Howard Stern’s animal instincts.

Easy connector enables less assembly and less wiring(A3US)

A retention knob for use with a tool holder that is less prone to distorting a tapered tool holder surface, especially if it is over-tightened. The retention knob includes a knob head, a flange engageable with an end of a tool holder shank, a pilot segment receivable by the counter bore defined by said tool holder shank and a threaded segment spaced from said flange by an undercut segment. The threaded segment is configured so that it has a length that is substantially the minimum length required to achieve maximum thread holding strength. The undercut segment is configured to space the threaded segment from its head so that a distal end of the threaded segment is substantially near the bottom of the tapered bore forming part of the tool holder.

Provided is a button structure of a shift knob for use with a shift lever in which a rod is provided. The shift knob comprises: a button capable of being pushed to allow the rod to be moved downwardly from a lock position to a lock release position; a pinion gear provided in coaxial relation to a pivot shaft of the button; and a rack meshed with the pinion gear. The button structure moves the rod to a shift-lock release position, interlockingly with a downward movement of the rack caused by a swinging movement of the pinion gear in a forward direction, according to a pushing operation of the button, and moves the rod to a shift-lock position, interlockingly with an upward movement of the rack caused by a swinging movement of the pinion gear in a reverse direction, according to a push-mode releasing operation of the button.

Audified has released its new audio effect VocalMint Saturator, an easy-to-use single knob vocal saturator with powerful processing hidden under the hood. Most one-knobs do one thing and one thing only: they linearly mix in a certain effect to your track. However, VocalMint runs the track through its virtual signal chain and tunes multiple parameters […]

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W.A. Production has released its new audio plugin Punchy Worm, a one-knob punch and saturation effect with a dancing worm. At W.A. Production they’re serious about music and over the last few years, they’ve created many top-quality plugins with finely tuned controls and pro studio features. But sometimes they just like to go a bit […]

The post Punchy Worm one-knob punch & saturation plugin by W.A. Production appeared first on rekkerd.org.

It works like a very fine "molecular knob" able to modulate the electrical activity of the neurons of our cerebral cortex, crucial to the functioning of our brain.

ABSTRACT

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of infected red blood cells (RBCs) via membranous organelles, known as the Maurer’s clefts. We developed a method for efficient enrichment of Maurer’s clefts and profiled the protein composition of this trafficking organelle. We identified 13 previously uncharacterized or poorly characterized Maurer’s cleft proteins. We generated transfectants expressing green fluorescent protein (GFP) fusions of 7 proteins and confirmed their Maurer’s cleft location. Using co-immunoprecipitation and mass spectrometry, we generated an interaction map of proteins at the Maurer’s clefts. We identified two key clusters that may function in the loading and unloading of PfEMP1 into and out of the Maurer’s clefts. We focus on a putative PfEMP1 loading complex that includes the protein GEXP07/CX3CL1-binding protein 2 (CBP2). Disruption of GEXP07 causes Maurer’s cleft fragmentation, aberrant knobs, ablation of PfEMP1 surface expression, and loss of the PfEMP1-mediated adhesion. GEXP07 parasites have a growth advantage compared to wild-type parasites, and the infected RBCs are more deformable and more osmotically fragile.

IMPORTANCE The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. We characterize a protein needed for virulence protein trafficking and provide new insights into the mechanisms for host cell remodeling, parasite survival within the host, and virulence.

Its name is Foxg1, it is a gene, and its unprecedented role is the protagonist of the discovery just published on the journal Cerebral Cortex. Foxg1 was already known for being a "master gene" able to coordinate the action of hundreds of other genes. As this new study reports, the "excitability" of neurons, namely their ability to respond to stimuli, communicating between each other and carrying out all their tasks, also depends on this gene.

Look for something elegant and distinctive but not overbearing

New York, NY : Oxford University Press, 2020.