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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
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559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS

Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server?




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Could Maini be India's next F1 driver?

India could finally have a driver on the F1 grid after 13 long years.




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A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




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As India’s installed solar capacity crosses 90GW, a look at the journey 

Sun-sational growth: In September, India’s installed solar power capacity reached 90,762 MW. Given the current rate of monthly capacity additions, there is little doubt that installed capacity will exceed 100 GW in 2024-25.




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Diamonds are a UV photodetector’s best friend

How lab-grown rocks from Surat are set to power the development of high-performance electronics



  • Science and Technology

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Catalysing Indian IP creation 

How policy support and monetisation can rev up India’s innovation ecosystem



  • Science and Technology

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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey




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How Jio is powering Reliance’s media, entertainment biz

Despite a late entry into telecom, digital services, and media, Reliance has raced to the top




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India seeks $70 million from Climate Investment Funds

India looks to accelerate proposed ‘renewable energy integration programme’




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Toxic air chokes urban India 

Residents grapple with respiratory, cardiac, and other ailments as the air thickens




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Why more NRIs are buying health insurance in India

The number of NRIs buying health insurance from India has increased steadily over the past three years




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Corporates look to tread the India Way  

Business leaders are realising that longevity may be a better marker for growth than shareholder value maximisation




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Nvidia: The lynchpin of the AI revolution

The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation




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India's climate policies expected to reduce CO2 emissions by around 4 billion tonnes by 2030: Report

The study by Delhi-based independent think tank Council on Energy, Environment and Water (CEEW) said policies for India's power, residential and transport sectors have already saved 440 million tonnes of carbon dioxide (MtCO2) between 2015 and 2020.




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Security upped outside Canadian High Commission due to protest against temple attack

The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area




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Can India arrest income inequality?

Thomas Piketty’s prescriptions are too radical. Dattopant Thengadi’s vision is more useful for us




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A theory of fiscal dominance in India

Former RBI Deputy Governor Viral Acharya offers solutions on how the central bank can ensure financial stability in the country




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Thirukkural and Indian diplomacy

India’s unique ethos will help it navigate the choppy waters of global diplomacy, writes Jaishankar




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Dialectics of government deficits

The book, espousing modern monetary theory, busts a few conservative myths on government spending




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Towards a fossil-free India

The data-rich book chalks out the challenges and opportunities in India’s renewables push




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Make in India — for the world

The inspiring story of a lifesaving product developed in the fight against Covid-19




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How Star shone bright in India

A first-hand and in-depth account of the channel’s rise and the media business in India




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Exploring India’s diversity

A corporate honcho’s reflections on business and beyond




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‘India has carved out its own path in foreign policy’

In his new book, former diplomat Vijay Keshav Gokhale throws fresh light on India-China relations since Independence




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Indian influence in US polity, culture

From Kamal Harris to Mindy Kaling — this book charts the Indian story in America




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Booming Digital Stars: 11 Inspiring Journeys from India’s Creator Economy 

Lessons from the exciting success stories of social media influencers




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Need for climate-smart agriculture in India

Climate-smart agriculture has the potential to assure food security, empower farmers, and protect our delicate ecosystems




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India asks U.S. to permit domestic labs for fruit irradiation to cut trade cost

The issue was raised during the 14th India-U.S. Trade Policy Forum meeting here on January 12.




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From beauty parlours to farming, prisoners in India’s jails are channeling their time into creative new outlets

Some trivia from prisons across the country




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Space data fuels India's farming innovation drive

Satellite data has gives an Indian farmer optimal sowing times, weather warnings, and better use of irrigation and pesticides




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India’s agri transformation a lesson for others: Modi

India has become the second-largest producer of food grains, fruits, vegetables, cotton, sugar, and tea, says PM Modi at the inauguration of the 32nd International Conference of Agricultural Economists




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The road to 2047 for Indian agriculture

There are several challenges but also opportunities




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Climate change impact harsher on poorer farmers in India: FAO report

FAO recommends enhanced social security net for all, Niti Aayog member says India doing its best to deal with climate change.




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Virat Kohli remains India's most-valuable celebrity

Kohli remains the most valued celebrity for the fourth consecutive year with a steady brand value of $237.7 million in 2020 despite the pandemic





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Richa Ghosh only Indian in ICC's 'Most Valuable Team'

Richa Ghosh's exploits during the side's run to the semis of the Women's T20 World Cup in South Africa earned her a place




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Women in India earn 19% less than men: report




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Aditya Birla Fashion to acquire Forever 21 India




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Volkswagen India enters compact sedan segment




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India home to 56 of the world’s largest public firms: Forbes

Reliance Industries maintains its top position of leading the largest public companies in India




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Indians score high on well-being at work




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Quality of farm loans by Indian banks won’t weaken: Moody’s




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S. Korea woos startups in India with ‘grand challenge’

Wants them to look at Korea as a testing bed for their ventures




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India will outperform global equity markets: Morgan Stanley




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India among top five innovation destinations: report