Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 29th, 2024. We’ve got another big plate of new …

Continue reading "SwitchArcade Round-Up: ‘Emio: The Smiling Man’, ‘Gundam Breaker 4’, Plus Today’s Other Releases and Sales"

Among Us (Free) has done loads of crossovers and collaborations over the years, but one I didn’t expect at all …

Continue reading "‘Among Us’ Is Collaborating With ‘Ace Attorney Investigations’ for Its Newest Free Cosmetic DLC Out Next Week"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for September 5th, 2024. Thursday already, eh? Where does the time …

Continue reading "SwitchArcade Round-Up: Reviews Featuring ‘Emio – The Smiling Man’, Plus Today’s New Releases and Sales"

Israel's Defense Minister was fired last week by Prime Minster Benjamin Netanyahu who said that trust had "eroded" between them. The now former defense minister met with families of Israeli hostages held in Gaza and gave his thoughts on what Israel can still achieve in Gaza. We hear what was said.

I could be biased, but sex with transmasculine people is fantastic. A warning up front: this article is not safe for work, unless it’s your very first day at the ...

The post Your Guide To Enjoying Transmasculine Sex appeared first on Star Observer.

Researchers in Montreal are pointing to the benefits of bilingualism for the brain's health and efficiency — suggesting it could even help prevent diseases associated with aging, including Alzheimer's.

Outrage over the Washington Post’s presidential non-endorsement has renewed interest in a bad idea that would only tilt the media further to the left.

Democrats will come up with all sorts of explanations for Kamala Harris’s defeat just to avoid the obvious one.

Someone has to speak out against the pro-Hamas factions.

Baidu, which is often called China's answer to Google, has launched its own pair of AI-powered smart glasses at its annual World Conference event in Shanghai. The device will run on the company's ERNIE generative AI technology and was designed to "become a private assistant," according to the Financial Times. Users will reportedly be able to interact with the device using their voice and ask it questions about what it sees in their current environment. They can also tell it to play music and even track their calories consumption. And since the glasses are equipped with cameras, they can ask it to snap photos or take videos. 

When the glasses start shipping sometime next year, they could become the Chinese consumers' alternative to Meta's and Snap's devices. Meta teamed up with Ray Ban a few years ago to release a pair of smart sunglasses that can livestream and send photos hands-free. Its latest model comes built-in with Meta's generative AI assistant that users can talk to. However, the company's device isn't officially sold in China, because its servers are blocked in the country. Baidu has yet to announce how much its glasses would cost, but Meta is selling its device for $299. 

The Baidu World Conference had a huge focus on the company's AI efforts, as it takes steps to make sure ERNIE can keep up with its competitors' technologies. It also launched a new AI image generator called iRAG that apparently experiences fewer hallucinations than its predecessor, along with a tool that enables people to create software programs even if they don't have coding expertise. According to The Times, ByteDance's Doubao is now the leading AI chatbot in China based on monthly active users as observed by Sensor Tower. ByteDance is also growing its hardware offerings and recently launched a pair of earbuds with access to its AI assistant Doubao. 

Rode has announced the Wireless Micro, a two-mic kit with a smartphone receiver and charging case that costs just $149. The idea is to help TikTok and other creators capture much better-quality audio than their smartphone's microphone can offer. 

The receiver unit connects to the bottom of your smartphone via a USB-C or lightning port. Meanwhile, the microphones (aka transmitters) attach to the subject via integrated clips or magnetic attachments, then capture what Rode calls "pristine" quality sound. Specifically, they offer a 20-20 kHz frequency range and 73 dB signal-to-noise ratio, with a transmission range around 330 feet.

To use it, simply connect the receiver to your iOS or Android device and it will take over as the system microphone. From there, everything is automatic, as the transmitter mics are automatically paired to the receiver and sound will be captured to your camera app of choice. Levels are automatically controlled with the company's GainAssist technology. 

The omnidirectional transmitters weigh just 12 grams (0.42 ounces) and are tiny enough to be discreet when clipped onto your subject. The built-in microphones use what Rode calls "acoustic chambers" with a patent-pending design. That supposedly lets you capture clear and intelligible audio while reducing wind noise, though a pair of windmuffs is also included in the kit. 

The Wireless Micro also includes a charging case that delivers two full recharges for up to 18 hours of battery life, while giving you a secure place to store everything. 

There are a few things missing, though. You can't connect an external mic to the transmitters, unlike with other Rode wireless mics or the DJI Mic 2. There's no smartphone Bluetooth capability, and it doesn't offer a 3.5mm connection for cameras — a feature that will supposedly exist on the rumored DJI Mic Mini. Still, this looks like a great option for creators who primarily use smartphones. It's now available in a two mic kit with a receiver and charging case for $150. 

Apple is rumored to be working on a new smart home product. Mark Gurman at Bloomberg reported that the company is developing a wall-mounted display for controlling appliances, interacting with Siri and videoconferencing. The tablet is said to look "like a square iPad" with "a roughly 6-inch screen." It would have a camera at the top as well as internal speakers and a built-in rechargeable battery. His sources said this smart home display could be officially announced as soon as March following three years in development.

This description sounds a lot like the Google Home Hub, which came out in 2018, or the Echo Show, which is already up to its eighth iteration. If Apple wants to be a serious competitor in this smart home space, it'll have to prove to customers that it has something to offer that these more established brands and products don't.

Right now, the only distinguishing feature is likely Apple Intelligence, which finally began rolling out to users in late October, and the upcoming App Intents system for controlling software programs with AI. But Apple may be looking farther ahead toward something more extravagant than just a smart device control panel. Gurman reported that Apple is already working on a version with a robotic arm that could move the tablet around. It should be interesting to see exactly what Apple does formally launch and when.

New Delhi (AFP) Nov 5, 2024
The toxic smog season in India's capital has just begun, but those unable to escape cancer-causing poisonous fumes say the hazardous impact on health is already taking its toll. New Delhi regularly ranks among the world's most polluted capitals, with a melange of factory and vehicle emissions exacerbated by agricultural fires blanketing the city each winter, stretching from mid-October until

New Delhi (AFP) Nov 8, 2024
India's capital unveiled plans Friday to fly special drones to clear pollution from its smog-choked skies - a plan derided by experts as another "band-aid" solution to a public health crisis. New Delhi and the surrounding metropolitan area, home to more than 30 million people, consistently tops world rankings for air pollution in winter. The smog is blamed for thousands of premature de

Lahore, Pakistan (AFP) Nov 13, 2024
On the streets of Pakistan's second biggest city, smog stings eyes and burns throats. Inside homes, few people can afford air purifiers to limit the damage of toxic particles that seep through doors and windows. Lahore - a city of 14 million people stuffed with factories on the border with India - regularly ranks among the world's most polluted cities, but it has hit record levels this mon

Speaking with CBC News’s Eli Glasner, Cillian Murphy discusses ‘imploding emotionally’ in his role in Small Things Like These, his partnership with Matt Damon and Ben Affleck and how his experience on Oppenheimer influenced this film. CORRECTION: A previous version of this video interview includes reference to communities in Canada 'still finding bodies of Indigenous children in the ground' at 1:24. We have removed this portion of the interview. Searches at the sites of former residential schools using ground-penetrating radar have found evidence of possible unmarked graves.

If it seems like the Christmas shopping season starts earlier every year, you're not wrong. In response to growing customer demand, stores of all stripes brought out their festive collections weeks before the unofficial start of the holiday shopping season.

An internal report on workplace racism and harassment at the highest levels of the federal public service shows that not even the federal government’s top executives are immune from the problem.

A Canada Border Services Agency superintendent is speaking out after being targeted by the Indian government with allegations of murder and terrorism — allegations Canadian authorities say are not backed by any evidence.

Technology differences mean meters in northern England and Scotland may not work properly, energy firm body admits.

Whilst the timeline set for adhering to the revised Schedule M of the Drugs and Cosmetics Act ends on December 31 for pharmaceutical companies with a turnover of less than Rs. 250 crore, the union ministry's

The General Pharmaceutical Council has said it is “double, treble, quadruple-checking” for any “flexibility” that would allow all overseas candidates to sit the March 2021 registration assessment exam in their countries of residence.

The General Pharmaceutical Council has said most candidates living in countries with a two-hour or more time difference from the UK will be able to apply to sit the registration assessment at home.

By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but it was certainly

The post ESMO Reflections: Glimmers of Hope with the Next Wave of I-O Therapies? appeared first on LifeSciVC.

In the spirit of the Halloween season, IEEE Spectrum presents a pair of stories that—although grounded in scientific truth rather than the macabre—were no less harrowing for those who lived them. In today’s installment, Robert Langer had to push back against his field’s conventional wisdom to pioneer a drug-delivery mechanism vital to modern medicine.

Nicknamed the Edison of Medicine, Robert Langer is one of the world’s most-cited researchers, with over 1,600 published papers, 1,400 patents, and a top-dog role as one of MIT’s nine prestigious Institute Professors. Langer pioneered the now-ubiquitous drug delivery systems used in modern cancer treatments and vaccines, indirectly saving countless lives throughout his 50-year career.

But, much like Edison and other inventors, Langer’s big ideas were initially met with skepticism from the scientific establishment.

He came up in the 1970s as a chemical engineering postdoc working in the lab of Dr. Judah Folkman, a pediatric surgeon at the Boston Children’s Hospital. Langer was tasked with solving what many believed was an impossible problem—isolating angiogenesis inhibitors to halt cancer growth. Folkman’s vision of stopping tumors from forming their own self-sustaining blood vessels was compelling enough, but few believed it possible.

Langer encountered both practical and social challenges before his first breakthrough. One day, a lab technician accidentally spilled six months’ worth of samples onto the floor, forcing him to repeat the painstaking process of dialyzing extracts. Those months of additional work steered Langer’s development of novel microspheres that could deliver large molecules of medicine directly to tumors.

In the 1970s, Langer developed these tiny microspheres to release large molecules through solid materials, a groundbreaking proof-of-concept for drug delivery.Robert Langer

Langer then submitted the discovery to prestigious journals and was invited to speak at a conference in Michigan in 1976. He practiced the 20-minute presentation for weeks, hoping for positive feedback from respected materials scientists. But when he stepped off the podium, a group approached him and said bluntly, “We don’t believe anything you just said.” They insisted that macromolecules were simply too large to pass through solid materials, and his choice of organic solvents would destroy many inputs. Conventional wisdom said so.

Nature published Langer’s paper three months later, demonstrating for the first time that non-inflammatory polymers could enable the sustained release of proteins and other macromolecules. The same year, Science published his isolation mechanism to restrict tumor growth.

Langer and Folkman’s research paved the way for modern drug delivery.MIT and Boston Children’s Hospital

Even with impressive publications, Langer still struggled to secure funding for his work in controlling macromolecule delivery, isolating the first angiogenesis inhibitors, and testing their behavior. His first two grant proposals were rejected on the same day, a devastating blow for a young academic. The reviewers doubted his experience as “just an engineer” who knew nothing about cancer or biology. One colleague tried to cheer him up, saying, “It’s probably good those grants were rejected early in your career. Since you’re not supporting any graduate students, you don’t have to let anyone go.” Langer thought the colleague was probably right, but the rejections still stung.

His patent applications, filed alongside Folkman at the Boston Children’s Hospital, were rejected five years in a row. After all, it’s difficult to prove you’ve got something good if you’re the only one doing it. Langer remembers feeling disappointed but not crushed entirely. Eventually, other scientists cited his findings and expanded upon them, giving Langer and Folkman the validation needed for intellectual property development. As of this writing, the pair’s two studies from 1976 have been cited nearly 2,000 times.

As the head of MIT’s Langer Lab, he often shares these same stories of rejection with early-career students and researchers. He leads a team of over 100 undergrads, grad students, postdoctoral fellows, and visiting scientists, all finding new ways to deliver genetically engineered proteins, DNA, and RNA, among other research areas. Langer’s reputation is further bolstered by the many successful companies he co-founded or advised, like mRNA leader Moderna, which rose to prominence after developing its widely used COVID-19 vaccine.

Langer sometimes thinks back to those early days—the shattered samples, the cold rejections, and the criticism from senior scientists. He maintains that “Conventional wisdom isn’t always correct, and it’s important to never give up—(almost) regardless of what others say.”

Neurogene’s Rett syndrome gene therapy has preliminary data supporting safety and efficacy of the one-time treatment. But a late-breaking report of a serious complication in a patient who received the high dose sent shares of the biotech downward.

The post Neurogene Gene Therapy Shows Signs of Efficacy in Small Study, But an Adverse Event Spooks Investors appeared first on MedCity News.

TAIPEI — Taiwanese businessman Robert Tsao said on Nov 11 that he would sue in a Taiwan court senior Chinese officials over sanctions they had placed on him, saying he was seeking to counter China's intimidation of lawful activity. China, which claims Taiwan as its own territory, said in October it would punish and sanction Tsao, the retired founder of chipmaker United Microelectronics Corp (UMC), for alleged criminal and pro-Taiwan independence activities. China's Taiwan Affairs Office said the "Black Bear Academy" that Tsao has helped fund was seeking to incite separatism that would endanger cross-strait ties. Tsao, one of Taiwan's richest men who has pledged to provide millions to two civilian defence training programmes, told a press conference that China was threatening the lawful holding of political views in Taiwan and his personal safety. The lawsuit will be lodged in a Taipei court against Song Tao, head of China's Taiwan Affairs Office, and also the office's spokesman Chen Binhua. Taiwan courts have no jurisdiction in China and senior Chinese officials do not visit the island.

Sep 5, 2023

Stephen Walt critiques Vivek Ramaswamy's claim of being a foreign policy realist.

Embassy strongly recommends against providing a U.S. Government evaluation, saying it will inevitably expose performance gaps that would not meet American standards of training and equipment.

Though the Northwest Frontier Province (NWFP) and Federally Administered Tribal Areas (FATA) continue to grab headlines for terrorist violence, poor and underdeveloped regions in the rest of "settled" Pakistan are increasingly the recruiting and training ground for extremism and militancy.

Cutting off the flow of funds to terrorist organizations and achieving stability in Af/Pak are top U.S. priorities.

Mar 13, 2023

In honor of International Women's Day and U.S. Women's History Month, Erika Manouselis, Manager of the Future of Diplomacy Project, spoke with Desirée Cormier Smith, the U.S. State Department’s first ever Special Representative for Racial Equity and Justice.

Nov 26, 2020

• Elbe Group Discusses Strategic Stability, Hybrid Warfare and Terrorism.
• Mowatt-Larssen’s Book Details Lessons He Learned While Tracking Al-Qaida’s WMD Programs.
• Experts on New START Extension and Other Nuclear Priorities of Biden Presidency.
• Kazakhstan’s Last HEU Eliminated.
• William Potter Joins Russian Academy of Sciences.
• COVID, Nuclear Security On Agenda of IAEA’s 64th General Conference.
• Mayak Aims to Process Entire range of SNF.
• Atomguard Reports Foiling Unauthorized Access.
• Allison: US Vital Interest in Prevention of Nuclear Terrorism Will Continue to Guide Its North Korea Policy.
• Learning from COVID-19 to Prepare for Nuclear Attack.
• Hecker, Kassianova Encourage Young US and RF Professionals to Explore Lessons of Nuclear Accidents.
• Experts Weigh in on 75th Anniversary of Hiroshima Bombing.
• A New Look at IAEA’s Nuclear Security Recommendations.
• Azerbaijan Has Threatened to Strike Armenia’s NPP With Missiles.
• IAEA Notified of 189 Incidents Of Material Being Out Of Regulatory Control in 2019.
• Russia To Retrieve More Radioactive Debris from Bottom of Ocean.
• Researchers Propose Fast Way to Detect Weapons Grade Materials.
• Keeping Nuclear Power Plants Out of Reach of Terrorists During the Coronavirus Pandemic.
• Bunn, Tobey and Roth Testify on Prevention of Nuclear Theft, Call for Cooperation With Russia.
• Budapest Memorandum Parsed.
• IAEA Holds A Ministerial on Nuclear Security.
• Assessing Progress on Nuclear Security.
• 12^th GUMO Officer On Trial for Embezzlement.
• Lukashenko: Pompeo Alerted Me to Nuclear Materials at Border.
• US and Russia Reported HEU and Plutonium to IAEA.
• IAEA Bank Receives LEU.
• GICNT Hosted 8 Multilateral Activities in 2019.

Dec 10, 2021

• U.S.-Russia Elbe Group Maintains Focus on Threat of Nuclear Terrorism.
• Former Chernobyl Plant Manager Bryukhanov Dies.
• Matthew Bunn on Threat to Nuclear and Radiological Transports.
• On 9/11 Anniversary Russian Officials Call for Resumption of U.S.-Russian CT Cooperation.
• Experts Weigh in on 9/11 Anniversary.
• U.S. and Norway Agree to Eliminate All of Norway’s HEU.
• Two Soviet Nuclear Submarine Reactors Located.
• Russian Security Council: Terrorists Remain Interested in NBC.
• IAEA Adopts Resolutions on Nuclear Security, NS Center Planned.
• Allison on Risk of Mega-terrorist Attack After U.S. Withdrawal From Afghanistan.
• Arbatov Warns of Enduring Threat of Nuclear Terrorism to Russia in His New Volume.
• Russia’s New Security Strategy Drops References to CT Partnership With U.S.
• NNSA’s Non-Proliferation Budget to Decrease in ’22, Provides for US and Russian Visits.
• Should U.S.-Russian Interaction in Cyberspace Involve CT? 
• Russia’s NPP Operator Conducts Emergency Preparedness Exercise.
• Putin and Biden Discuss Terrorist Threat Emanating from Afghanistan, but No Deal.
• U.S. Experts on Ensuring Access to Neutrons While Reducing Nuclear Terrorism Risks.
• Beebe Weighs in on U.S.-Russian CT Interaction.
• Duo Detained for Alleged Attempt to Sell Americium-241.
• 12th GUMO Guard’s Sentence Upheld.
• NDAA-Mandated Group to Identify Nuclear Terrorism Risks.
• Belfer’s MTA Hosts Conference on Lessons of Fukushima and Chernobyl.
• Russia Withdraws from Uranium Hexafluoride Transportation Deal with U.S.
• Bell: U.S. Needs to Convince Russia on Contending With Nuclear Terrorism Threat.
• U.S. and Canada Complete Repatriation of HEU Material.
• Siegfried Hecker Outlines his Vision of Future for Nuclear Security Cooperation.
• Hackers Breach U.S. Nuclear Agency.
• Tobey on Assassinations of Nuclear Scientists and Terrorists.
• Rosatom Has Checked Nuclear Sites, Following a Tip on Terrorism from U.S.

Jun 21, 2022

Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy).  Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here.

Nov 8, 2023

Economic historian Emma Rothschild, the Jeremy and Jane Knowles Professor of History at Harvard, lauded the efforts of young scholars to discover local solutions to mitigate the impacts of global climate change in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Mar 14, 2024

The non-Soviet members of the Warsaw Pact contributed to the end of the Cold War along with the superpowers. These Eastern European states recognized that their relationship with the Soviet Union would impede their success in the post–Cold War world, so they ended the Pact.

Jun 10, 2024

Two and a half decades [after 9/11], Christopher Wray, the director of the FBI, is sounding similar alarms. His discussions within the Biden administration are private, but his testimony to Congress and other public statements could not be more explicit. Testifying in December to members of the Senate Intelligence Committee, Wray said, “When I sat here last year, I walked through how we were already in a heightened threat environment.” Yet after Hamas attacked Israel on October 7, “we’ve seen the threat from foreign terrorists rise to a whole nother level,” he added. In speaking about those threats, Wray has repeatedly drawn attention to security gaps at the United States’ southern border, where thousands of people each week enter the country undetected.

Jul 28, 2024

The Africa in Focus series is a forum for the intellectual and critical analysis of processes and policies from the continent and its engagement with the international community. Through thoughtful and dynamic programming, Africa in Focus brings greater African perspectives into broader policy conversations at HKS.

The �Design Smart, Live Beautifully� Home Tour coincides with the launch of the 2014 model of Blu�s award-winning�Breezehouse, which is�packed with luxurious features and an even more spacious floor plan

Herman Miller 'Living Beats Dying' video

Virtual tour of 350 Fifth, a new 20-story office building in one of the top-ranked U.S. cities for sustainable buildings. Pt. 1 Pittsburgh-Gateway to the World & 350 Fifth Urban Genius.

Edmunds.com�s roundup of new vehicles at the 2014 LA Auto Show

Ramco's SMS based Employee Self Service redefines 'Inclusive Computing'

This #AutismAwarenessMonth we encourage families with special needs to take steps now to plan for their loved ones� futures. Our Director of Advanced Planning, Ruthann Driscoll, discusses the importance of planning to secure long-term security and quality of life for your family. Learn more: http://u.nm.com/1AQBAsN

The Thumb Loop system is designed to meet the maximum wind energy potential of Michigan�s Thumb region as well as contribute to regional system reliability and facilitate wholesale market competition.