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The Moth Radio Hour: When the World Shifts

In this hour, stories of seismic changes and subtle shifts—and the aftershocks left in their path. New perspectives on faith, family, and one's self. This episode is hosted by Brandon Grant, Director of Marketing at The Moth. The Moth Radio Hour is produced by The Moth and Jay Allison of Atlantic Public Media.

Hosted by: Brandon Grant

Marlon James discovers his talent as a junior exorcist.

Hannah Brennan learns there is wisdom in her body.

While going through a divorce, Tricia Rose Burt finds comfort in her art.

Kim Sykes recalls growing up in New Orleans with a complicated father.




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25 Years of Stories: When The Podcast Started

This week, we learn about how this podcast got started, and play one of our favorite stories from our early days. This episode is hosted by Dan Kennedy.

Host: Dan Kennedy.

Storytellers: Dan Kennedy.




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The Moth Radio Hour: Knowing When And How To Fight

In this hour, five stories of picking our battles. The internal and external pressures that guide how we speak up, speak out, or stay silent. Hosted by The Moth's Artistic Director Catherine Burns. The Moth Radio Hour is produced by The Moth and Jay Allison of Atlantic Public Media.

Hosted by: Catherine Burns

Storytellers:

Hillary Boone and her mother scheme to save Vermont from hate.

Maria Hodermarska fights for services for her son.

Ed Mabaya finds himself in danger while visiting his girlfriend.

Brad Lawrence and his sister work their mom's last nerve with their brawling.

Angela Lush struggles to speak up.




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The Moth Radio Hour: When We Were Young

In this hour, stories of childhood, growing up, and growing pains. From hearing your first Bruce Springsteen song, to experiencing a cultural divide to having your heart broken wide open. This episode is hosted by Moth Senior Director Meg Bowles. The Moth Radio Hour is produced by The Moth and Jay Allison of Atlantic Public Media. 

Storytellers:

Sarfraz Manzoor discovers life lessons in the lyrics of Bruce Springsteen.

Oanh Ngo Usadi and her family arrive in Texas from Vietnam with high hopes and an American Dream.

Max García Conover finds faith in an unexpected place.

Podcast: 642




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When Does Dr. Fauci Think "Normal" Will Happen?

Dr. Anthony Fauci, the top infectious disease expert in the U.S., returns to HBR Now to discuss the latest coronavirus surge, his expectations for a more effective vaccination roll-out, and when we can expect to restart our normal lives.




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How To Thrive When Everything Feels Terrible

Research shows that negativity causes us to shut down, stop communicating, and cease being helpful to others. But thriving—the mental state in which people feel a sense of vitality and learning — blunts negativity’s toxic effects.




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How to Give Feedback—Especially When You’re Dreading it

Giving feedback can be tricky and awkward, especially if you’re conflict averse. How do you give feedback that’s empathetic yet effective?




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A Neurodivergent Leadership Guide: How to Run a Business When You Have ADHD

Business leaders with ADHD do best when they surround themselves with teammates who offset their executive functioning weaknesses.




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When Will Remote Workers Feel Safe Heading Back to the Office?

With states starting to lift lockdown restrictions amid fluctuating infection and hospitalization rates — and some localities even forced to pause reopenings in progress — the safety of heading back to the workplace is still very much in question. What will it take for the typical worker whose routine has shifted as a result of the pandemic to ...




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How to Build a Side Hustle When You Have No Idea Where to Start

There's a good chance you know someone who works a day job and also spends part of their free time working on a side hustle. In fact, according to a survey commissioned by Vistaprint, 27 percent of Americans have already turned their hobbies into side businesses, and 55 percent of us would like to make the same move. Side hustles are a great way to make extra cash, but getting one ...




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The Quality Show Preview: When Quality & Sustainability Meet

Tariq Masud sat down with Quality to explain why this topic is so important. He will be presenting at The Quality Show on Tuesday, October 24.




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Reverse Engineering Software: Who? What? When? Where? Why?

Reverse engineering as a term is adopted by many industry subsets. From genetics, computer code, complex PCBs (printed circuit boards), and even military espionage. In this article, we are specifically relating to a metrology-driven process steered by high-precision 3D data acquisition tools. 




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Key Considerations When Selecting a Machine Vision Lens

In this article we survey key considerations when making a lens selection. Of course, your lensing professional will be happy to advise – but they’ll ask you some of these questions anyway, so it’s helpful to make notes relative to your planned application.




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How Did You Know? More Important Than When?

One of the major challenges in the manufacturing industry is the skills gap and the need to attract more individuals, especially young people, to pursue careers in this field. Organizations like IMTS and ASQ emphasize the importance of showcasing the opportunities that a career in manufacturing offers.





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Nine Reasons to Hire Outside Expertise When Putting a New Measurement Tool In Place

3D measurement tools offer incredibly precise and accurate measurements. However, using them correctly requires specialized knowledge, and integrating them into current processes can be quite complex.




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When I See An Elephant Fly

When I See An Elephant Fly by Bruce Lau is a(n) Limited Edition. The Edition is Limited to Limited Edition to 750 pcs




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Perseverance and collaboration: How a new clinical trial aims to determine whether sex matters when matching blood products to patients

Perseverance and collaboration: How a new clinical trial aims to determine whether sex matters when matching blood products to patients


Thursday, October 31, 2024 Abby Wolfe

As the Principal Investigator for the SexMatters trial described in this blog, Dr. Mickey Zeller is an Associate Professor in the Department of Medicine at McMaster University. She is also a Medical Officer at Canadian Blood Services. 

Around 2018, Dr. Mickey Zeller's grandmother asked her a question that she couldn’t fully answer at the time. It’s a question that Dr. Zeller continues to keep top-of-mind in her roles as an Associate Professor at McMaster University and a Medical Officer at Canadian Blood Services. Having sustained a pelvic fracture at the age of 94, she asked her granddaughter, “If I need a blood transfusion, could it come from a man... and if it does, would that be safe?”. As Dr. Zeller describes, “I looked at her and, in that moment, I said, ‘Grandma, no one knows! But it’s on my list to find out!’.” 

In fact, questions about whether selecting products based on the sex of donor and recipient could improve outcomes following blood transfusions have been around for years. However, there is not yet been enough evidence to definitively answer whether this strategy would help optimize hospital and blood operator practices.

After much perseverance, collaboration with researchers across Canadian Blood Services’ extended research network, and a successful bid for CIHR funding, a research team led by Dr. Zeller is embarking on a new research journey they hope will finally provide the evidence to answer questions about whether sex matters in red blood cell transfusion.

What will the study focus on and why is it needed?

When a patient requires a transfusion of red blood cells (RBCs), the matching of product to patient is based on compatibility testing that looks at whether the blood is group A, B, AB or O, whether it is Rh positive or negative, and what other antibodies are present. Canadian Blood Services’ Rare Blood Program also helps ensure patients with specific combinations of antigens – proteins that appear on the surface of red blood cells – can be matched with appropriate blood components. Laboratory studies on donor factors such as age and sex have looked at their impact on characteristics of RBCs in terms of hematocrit, cell volume, hemoglobin content, and deformability – that is, the flexibility or “squeeze-ability” of the cells. However, currently available evidence has not demonstrated a need for red blood cells for transfusion to be matched based on the sex of either donor or recipient. 

The principal research question being posed by this study is: In adults admitted to the ICU who require RBC transfusions, do donor-recipient sex-matched RBC transfusions result in improved 30-day mortality compared with sex-mismatched RBC transfusions? Answering this question has a large potential for impact because of the substantial number of blood transfusions that occur throughout Canada every year.  

“If there was a risk identified [from the sex of the donor and recipient], even moving the needle a little bit to improve the matching of blood product to recipient could add another layer of safety to current practices,” Dr. Zeller explains.  

What had to happen to make this study possible?

While it seems like a basic question to remain unanswered, Dr. Zeller acknowledges the investments of energy, expertise, and funding to get the study to this point.  

“Sometimes these basic questions remain for a long time because it is challenging to get the funding and infrastructure in place to be able to answer them in a scientifically rigorous way; even if they’re basic-level questions, it’s only by investing that you are able to gather the evidence to answer the question.” Dr. Zeller says.

That’s part of the reason why Canadian Blood Services’ investments in networks like CTTG are important. The Canadian Transfusion Trials Group (CTTG) is funded by Canadian Blood Services with the aim of supporting and accelerating clinical trials that can inform best practices in transfusion medicine in Canada. CTTG reviewed and endorsed this SexMatters study and provided support through its development, making it the second RCT since CTTG’s inception to earn CIHR funding following participation in their review process.

"I had the opportunity to present to CTTG twice and receive feedback that improved this study design and my application to CIHR for its funding. Having it reviewed by people like Dr. Donald Arnold, Dr. Jeannie Callum, Dr. Nadine Shehata – people with world-recognized expertise in this area – really led to the success of this application,” Dr. Zeller says. “We were able to have really rich discussions on tough questions about study design and impact, including details like how we would account for patients that are pre-transfused entering the study.”

Dr. Mickey Zeller, Principal Investigator for the SexMatters clinical trial, and Dr. Donald Arnold, Co-Director of the CTTG network, discuss aspects of the newly funded clinical trial. 

Says Dr. Zeller, “Each time the application went through reviews, I could present to these colleagues to essentially say, 'Here are the criticisms it has received and here’s how I’ve handled them.' And they would provide me advice and encouragement to resubmit. It is really valuable having people across the country who are cheering for you, and who are hand-in-hand with you to celebrate your success!”

“It’s an absolute privilege to do high quality research because you have to be surrounded by an incredible group of humans. Academic curiosity and commitment by those that have mentored me have enabled me to do this work. It’s out of a generosity of spirit that people have shared their expertise with me for this work, and it takes a lot of time and effort.”

Dr. Mickey Zeller, Principal Investigator for the SexMatters trial

What other research has informed this study? 

Before this study received CIHR support, the research team undertook an exploratory analysis, a systematic review and meta-analysis, and a pilot trial which took place in 2022 across five Ontario-based hospitals to establish feasibility of the randomized controlled trial. Findings of retrospective observational studies indicated potential association between sex-mismatched transfusions and mortality, but some aspects remained unclear due to low certainty of evidence, inconsistencies or contradictory subgroup analyses in the available literature.  

Much previous research involving Canadian Blood Services researchers has also supported the need for this randomized controlled trial. This includes: 

Read the Research Unit summarizing some of MCTR’s research on blood.ca (2019)Sex-mismatched red blood cell transfusions and mortality | Canadian Blood Services

Earlier publications involving these and other researchers have also investigated the impact that blood donor age and sex have on outcomes for transfusion recipients, summarized evidence related to sex-matched versus mismatched transfusions and mortality, and the biological mechanisms implicated in adverse outcomes of sex-mismatched transfusions. There is still room for more investigation to build on this previously completed research, and that aligns with Canadian Blood Services' emphasis on the importance of research that spans the continuum from bench-to-bedside to continuously improve our processes, products and services. As Dr. Zeller describes: “There are biological studies and retrospective data, but we only have one existing RCT. There’s a real importance to pursue a prospective, RCT so we can look forward as opposed to looking back.”

“As every blood donor is unique, the challenge we have is to understand which donor-specific factors can be better matched to improve patient outcomes.  Differences in the biology of blood cells from male and female blood donors are well defined, but what we do not understand is if these differences affect health outcomes in transfused patients.  This is very important question that the SexMatters clinical trial is proposing to address.”

Dr. Jason Acker, Co-Investigator in the SexMatters trial

How will the study work and why the focus on transfusions in the ICU?  

Focusing on transfusions in the ICU is a significant distinguishing feature of this study. The iTADS trial was completed as a multicentre, double-blind trial, but it looked at mortality rates across the whole hospital. This new trial will look at transfusions received by patients in the intensive care unit (ICU) specifically. 

“In the hospital, we know that mortality rate is much higher in a transfused ICU patient compared to a patient in another part of the hospital,” Dr. Zeller says. “We’ve chosen to focus this study on the sickest population of patients – those in the ICU – with the idea that any impact will be seen most prominently in this group. The analysis will include consideration to dosage so we can adjust for the specific number of units transfused to each patient.” 

The study is also designed so that participants will not know whether a blood transfusion is matched or mismatched based on the sex of donor or recipient – a method used to prevent potential bias in the trial. 

“At the hospital, you always get a list with each shipment of blood product that says what units you have received from the blood operator”, Dr. Zeller explains. “As part of this study’s protocol, participating hospitals will see an additional colour-coding noted on this inventory, and this is what will be used when it comes time for us to do our analysis.”  

Who could benefit from this knowledge and what are the next steps?  

Dr. Zeller is glad to have Canadian Blood Services involved in this research, acknowledging that changing policy related to matching of blood products would be a significant change for hospitals and blood suppliers, requiring strong evidence from RCTs like this one.  

“This study will help to inform health-care professionals who prescribe and administer blood products, along with patients, donors, and the blood operator, too. One of the important questions if it does turn out to have a significant difference is ‘Then what?’ We already divide our inventory by group (ABO) and by Rh status (+/-). Would the need to be matching by sex further impact inventory? We don’t know yet, but that’s why it’s important to have the blood supplier involved,” Dr. Zeller says. 

The study will require a total sample size of approximately 11,000 patients across an expected nine hospital sites in Ontario.  

“We’ve designed this study to be very efficient; it’s got components of what would be considered a pragmatic study design,” Dr. Zeller says. “In terms of the products, Canadian Blood Services does not have to provide anything different than they already do for this study (other than the colour-coded markers) and we will use electronic capture to pull data, so we don’t need to collect study information at bedside. These were processes leveraged from the earlier iTADS study as the iTADS research team was very supportive of us learning from what they did.”  

“Whether transfusions should be matched for donor sex is a question that has been percolating in people’s minds for many years. Dr. Zeller has had the courage and perseverance to tackle this important question, which could have important policy implications.  I’m excited for Dr. Zeller to embark on this journey and advance knowledge on best transfusion practices.”  

Dr. Donald Arnold, Co-Director of CTTG and Co-Investigator in the SexMatters trial 


Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.   

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.  

Related blog posts


Monday, December 23, 2019
Tricia Abe

When doctors select compatible red blood cell units for transfusion into a patient, they don’t consider the sex of the patient and whether the donor is the same (sex-matched) or opposite sex (sex-mismatched). But a study led by Dr. Michelle Zeller, Canadian Blood Services medical officer and assistant professor in the department of medicine at McMaster University, suggests that the role of donor sex in red blood cell compatibility may be worth a closer look.


Wednesday, October 04, 2017
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In this six-part series, Dr. Jeannie Callum, a hospital-based transfusion specialist, shares her real-life experience witnessing the impact of blood donation on patient lives. She provides some fascinating insight into blood transfusion, past and present, and emphasizes the need for male donors and why some donors may be safer for patients. Read the complete series here.


Tuesday, September 26, 2023
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Recent research involving Canadian Blood Services researchers highlights the relationship between donor age and the quality of blood products like red blood cells, while considering the complex interplay between storage conditions, oxidative stress, and genetic factors. Though the clinical implications remain uncertain, these findings underscore the importance of ongoing research in optimizing blood storage practices and continuing to improve the efficacy of blood transfusions for patients in need.




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Neurons Grow Faster When Muscles Exercise, MIT Study Reveals




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When You Should Look Beyond the HVAC System

Some comfort and indoor air quality issues we encounter bleed over from areas that we might be unfamiliar with. The most common are the influences of building construction, like leakage and insulation.




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Key Considerations When Transitioning to Eco-Friendly Electric Boilers

Consulting with an expert can streamline the conversion to electric boilers while reducing total project cost and maximizing system reliability.




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When to Repair or Replace an Evaporator Coil

When faced with a leaky coil on a reach-in cooler, a decision needs to be made whether to repair or replace it. The final decision may come down to where the leak is located.




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Take Care When Inspecting Compressor Terminals

When electrically inspecting or troubleshooting a compressor, you should always protect yourself against the possibility of terminal venting.




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When is the Best Time to Sell Your HVAC Business?

When you’ve decided to sell your HVAC business, the time of year to close is an important detail.




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An HVACR Distributor's Guide to ERPs: When, Why, and How

Today, HVACR distributors rely on enterprise resource planning (ERP) software to handle nearly every level of their operations. Vendor data, turns, dead stock, cycle counts, sales margins, and much more can be accessed directly from a computer or, in some cases, a mobile device.




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When Will HVAC Contractors Own a Fleet of Electric Autonomous Vehicles?

It’s been said that technology takes longer to arrive than expected, but once it does, adoption occurs more quickly than expected as well.




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Training Is Huge When It Comes to Troubleshooting Mini-Split Systems

Once only found in mild climates, the technology now stretches across the U.S., thanks to advances in inverter technology and zone controls. On the other hand, the level of sophistication in these systems sometimes makes them difficult to troubleshoot when something goes wrong.




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When Troubleshooting a Refrigeration System, Don’t Make Assumptions

Troubleshooting refrigeration systems can be complex and frustrating, so put aside any assumptions and inspect the system thoroughly before making any diagnosis.




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When Consumers Opt to Repair v. Replace

Homeowners likely won’t choose to replace unless it’s cheaper than the repair.




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Why Protest Works—Even When It’s Unpopular

High-profile, disruptive protests can lead to increased polarization—but often still yield increased public support for the protest’s goals, even if the tactics are criticized.






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Twelve ultimate mistakes when selecting circuit protection for low-voltage equipment

To be honest, a circuit breaker is fairly simple device. However, the process of specifying circuit protection is often complicated and unclear, leading many engineers to either include insufficient or excessive protection in their equipment designs. Insufficiently protected circuits expose... Read more

The post Twelve ultimate mistakes when selecting circuit protection for low-voltage equipment appeared first on EEP - Electrical Engineering Portal.




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Parallel switching phenomenon when MV/HV circuit breakers interrupt a shared fault current

Parallel switching occurs when two or more circuit-breakers are tripped to interrupt a shared fault current. This is typically the case for such bus arrangements as a double breaker, breaker-and-a-half, breaker-and-a-third, and ring buses. Ideally, all of the circuit-breakers should... Read more

The post Parallel switching phenomenon when MV/HV circuit breakers interrupt a shared fault current appeared first on EEP - Electrical Engineering Portal.




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11 factors that significantly influence the transformer price (Be careful when specifying)

The majority of utilities are normally extremely well aware of the economic aspects and savings that can be obtained at all stages of the transformer’s life cycle. This is because the purchase of a transformer involves a very high capital... Read more

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Secondary equipment you should always consider when retrofitting existing HV substation

This approach assumes retrofitting and upgrading old substation secondary equipment such as intelligent electronic devices (IEDs), monitoring sensors, power apparatus, communication protocol and operating standards to improve the overall performance or reduce cost without disrupting the continuity of service. For... Read more

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8 tips to avoid ground loops when dealing with signal level circuits

General recommendation is to properly design and implement the facility’s grounding system to avoid unwanted involvement of ground loops with the operation of the equipment. This kind of approach can also eliminate the need to consider equipment modifications and to... Read more

The post 8 tips to avoid ground loops when dealing with signal level circuits appeared first on EEP - Electrical Engineering Portal.




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Tomorrow When The War Began website

Online resource suitable for English, Media and PSHEE at KS3 and KS4 encouraging personal and critical reflection on characters, relationships and ideas.




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Common Pitfalls to Avoid When Selecting PPE for Restoration & Remediation Work

Discover crucial tips that help you avoid common PPE pitfalls and ensure your team is protected against hazardous chemicals and atmospheric dangers.




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Contents Restoration Training: When-How-What

This edition of Ask Annissa addresses when, how and what to train for at your restoration business.




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When adoption agencies can turn away gay prospective parents, what happens to the kids?

Religious News Service reporter Bobby Ross, Jr. recently asked this question, “When adoption agencies can turn away gay prospective parents, what happens to the kids?” With conflicts between religious based adoption and foster care agencies and government non-discrimination regulations playing out across the country including the Archdiocese of Philadelphia, this is an important question. In March, the City of Philadelphia issued an urgent call for 300 new foster parents to provide loving homes for some of the over 6,000 kids in Philadelphia foster care. That same month, the City abruptly barred Catholic Social Services, one of the city’s top-rated foster agencies, from placing children with foster families. This decision makes it exponentially harder for hundreds of children in need of foster care to find homes. Foster homes are sitting empty, even as the city begs for more families to help in its foster care crisis. Catholic Social Services and the Archdiocese of Philadelphia have been serving children throughout Philadelphia for over a century. Their Catholic mission drives them to find loving homes for all children in their care, regardless of the child’s race, color, sex, religion, sexual orientation or gender identity. Catholic Social Services currently serves over 100 children in foster homes. No family or individual has ever complained that the agency’s Catholic mission prevented them from fostering or adopting a child. Sharonell Fulton from Overbrook Farms has been a foster parent for over 25 years. She has opened her home to over 40 children, including two children currently in her care. She strives to provide a loving, stable home and treat each child as if they were her own. To do that, Fulton relies on Catholic Social Services’ help, including around-the-clock support and access to information and resources. “What justice is there in taking stable, loving homes away from children?” Fulton said in a statement to CatholicPhilly.com. “If the city cuts off Catholic Social Services from foster care, foster moms like me won’t have the help and support they need to care for the special-needs kids.” By freezing and threatening to cancel its foster care contract with the CSS, the city is “taking away this help and causing harm and heartache to countless families like mine,” Fulton said. The children will suffer if parents like Fulton do not have the support they need. In May, The Becket Fund for Religious Liberty filed the lawsuit in the United States District Court in Philadelphia on behalf of archdiocesan Catholic Social Services (CSS), Sharonell Fulton and two other women caregivers associated with the archdiocesan agency. They asked the court to halt the city’s harmful policy. A hearing is expected later this year.




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Appearances shouldn’t be misleading when it comes to sustainable packaging

Businesses are seeking innovative ways to reduce their environmental impact and invest in sustainability. A Gartner survey found that 87% of business leaders plan to increase their sustainability investment in the next two years. There is pressure from investors, supply chains, and consumers to make more sustainable decisions.




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Several Key Developments Have Taken Place When it Comes to Palletizing

As suppliers are looking to be more efficient in their end-to-end solutions, a key area of focus has been finding innovative ways to improve the palletizing process.




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Motivating Children – What Works When Talking to Parents About Practicing Music?

We know from talking to hundreds of music teachers over the years that students' practicing habits are always a point of discussion. We've seen parents fall into a whole range of attitudes. Here are a few that we've seen.




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When Do US Elections Polls Close?

Hundreds of millions of Americans head to the ballots today to vote for who they believe should be their next President: Kamala Harris or Donald Trump. Although more than 81 million ballots have been cast early this year, most of the electorate will do so today, ultimately determining who will reside in the White House and control the Senate.

Later this evening, we will have the first results rolling in, although given the time differences across the 50 States and the District of Columbia, this will not be simultaneous.

Knowing the closing times of polling stations is crucial for traders and investors, particularly for the seven key battleground States (highlighted in bold below – often called ‘toss-up States’). These States account for 93 of the 538 Electoral College votes, of which a candidate needs 270 to win the election.

It is important to acknowledge that results will not be reported immediately at poll closing times as the counting process will still be ongoing. You can expect most of the seven swing States’ results to be reported between 11:00 pm and midnight ET (4:00-5.00 am GMT Wednesday).

*Times are Eastern Time (ET) and Greenwich Mean Time (GMT)

  • 7 pm ET (midnight GMT Wednesday)

South Carolina (9), Indiana (11), and Kentucky (8) – Republican-leaning States (28 electoral votes)

Vermont (3) and Virginia (13) – Democratic-leaning States (16 electoral votes)

Georgia (16) – toss-up Votes (16 electoral votes)

  • 7:30 pm ET (12:30 am GMT Wednesday)

West Virginia (4) and Ohio (17) – Republican-leaning States (21 electoral votes)

North Carolina (16) – toss-up Votes (16 electoral votes)

  • 8:00 pm ET (1:00 am GMT Wednesday)

Missouri (10), Tennessee (11), Mississippi (6), Oklahoma (7), Alabama (9), Florida (30), and Maine District 2 (1) – Republican-leaning States (74 electoral votes)

New Hampshire (4), Maine (1), Massachusetts (11), Illinois (19), New Jersey (14), Connecticut (7), Rhode Island (4), Washington DC (12), Maryland (10), Delaware (3) – Democratic-leaning States (85 electoral votes)

Pennsylvania (19) – toss-up Votes (19 electoral votes)

  • 9:00 pm ET (2:00 am GMT Wednesday)

North Dakota (3), South Dakota (3), Wyoming (3), Kansas (6), Louisiana (8), Texas (40), Nebraska (4), Lowa (6) – Republican-leaning States (73 electoral votes)

Colorado (10), Minnesota (10), New York (28), New Mexico (5), Nebraska District 2 (1) – Democratic-leaning States (54 electoral votes)

Michigan (15), Arizona (11), Wisconsin (10) – toss-up Votes (36 electoral votes)

  • 10:00 pm ET (3:00 am GMT Wednesday)

Montana (4) and Utah (6) – Republican-leaning States (10 electoral votes)

Nevada (6) – toss-up Votes (19 electoral votes)

  • 11:00 pm ET (4:00 am GMT Wednesday)

Idaho (4) – Republican-leaning States (4 electoral votes)

Oregon (8), Washington (12), California (54) – Democratic-leaning States (74 electoral votes)

This article was written by FL Contributors at www.forexlive.com.




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#362: Database Golden Rules: When (and Why) to Break Them

American inventor Thomas Edison, once said, “Hell, there are no rules here. We're trying to accomplish something.” What we hope to accomplish with this episode of the Groundbreaker Podcast is an exploration of the idea that the evolution in today’s architectures makes it advantageous, perhaps even necessary, to challenge some long-established concepts that have achieved “golden rule” status as they apply to the use of databases.

View the complete show notes.




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#383: Cloud Native or Low Code: What, When, Why?

If you listened to our previous episode -- and of course you did! -- you heard a panel discussion of the ins and outs of low code development. In this episode we expand on that initial conversation to bring you a discussion that compares and contrasts low code with cloud native development. 

Returning for this discussion is Joel Kallman, who heads the Oracle development team behind Oracle APEX. Joel is in Columbus, Ohio. Also returning is Oracle ACE Director and Groundbreaker Ambassador Martin Giffy D’Souza. Martin is Director of Innovation at Insum Solutions, and lives in Alberta, Canada. Joining the panel is Oracle ACE Director and Groundbreaker Ambassador Roel Hartman. Roel lives in the Netherlands, where he is Director & Senior APEX Developer at APEX Consulting. Also on the panel is Oracle ACE Director Niels de Bruijn. Niels is Business Unit Manager at MT AG in Cologne, Germany. 

See the complete program show notes.

 




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Key Considerations and Challenges When Adding Solar Power to Existing Buildings




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When to Heave To: Windward

When do you heave to when sailing to windward? Lin and Larry Pardey give you the answer and show you how. From Storm Tactics: Cape Horn Tested (84-Minutes).

VIDEO DOWNLOAD
TheSailingChannel.TV offers Storm Tactics as a HIGH QUALITY VIDEO DOWNLOAD available in both Windows Media (WMV) and QuickTime (MOV) versions suitable for full screen viewing. PRICE: JUST $12.99. DVD also available.


Just pay with Paypal or your Credit Card, download and watch full screen on your PC or MAC.
This 84 minute video delivers the skills you need to weather storms with confidence. If you like the preview, buy the DVD. It's the next best thing to having Lin and Larry Pardey onboard, coaching you on storm tactics as the seas build and the rigging howls.
Closing in on 200,000 miles of blue water voyaging, Lin and Larry Pardey are recognized as the sailing world's most experienced and knowledgeable cruising couple. In Storm Tactics, they provide a detailed look at the techniques and gear that have kept them safe at sea. "... I wanted to show how the sailor's safety valve--heaving-to-works, and the slick it creates. It's hard for people to imagine the almost magic effect of a slick as it saps the power of breaking waves...." - Larry Pardey.
"One of the reasons I wanted to sail east-to-west around Cape Horn was to take video shots proving that small vessels can safely weather storms if they are well outfitted and efficiently handled," Larry Pardey stated after his record-breaking voyage. Lin and Larry completed their against-the-wind rounding of the Great Southern Capes on board their engineless 29-foot Taleisin, weathering nine days of storm-force winds to reach Puerto Montt in Chile. There they interviewed several high-latitude voyagers, prepared the narrative, and shot further detailed footage to complete the Storm Tactics video, a project Lin and Larry conceived almost ten years ago. Read more about Storm tactics at http://www.thesailingchannel.tv/pardey/storm_tactics/

Brought to you by TheSailingChannel.TV

     




when

When to Heave To: Windward

When do you heave to when sailing to windward? Lin and Larry Pardey give you the answer and show you how. From Storm Tactics: Cape Horn Tested (84-Minutes).

VIDEO DOWNLOAD
TheSailingChannel.TV offers Storm Tactics as a HIGH QUALITY VIDEO DOWNLOAD available in both Windows Media (WMV) and QuickTime (MOV) versions suitable for full screen viewing. PRICE: JUST $12.99. DVD also available.


Just pay with Paypal or your Credit Card, download and watch full screen on your PC or MAC.
This 84 minute video delivers the skills you need to weather storms with confidence. If you like the preview, buy the DVD. It's the next best thing to having Lin and Larry Pardey onboard, coaching you on storm tactics as the seas build and the rigging howls.
Closing in on 200,000 miles of blue water voyaging, Lin and Larry Pardey are recognized as the sailing world's most experienced and knowledgeable cruising couple. In Storm Tactics, they provide a detailed look at the techniques and gear that have kept them safe at sea. "... I wanted to show how the sailor's safety valve--heaving-to-works, and the slick it creates. It's hard for people to imagine the almost magic effect of a slick as it saps the power of breaking waves...." - Larry Pardey.
"One of the reasons I wanted to sail east-to-west around Cape Horn was to take video shots proving that small vessels can safely weather storms if they are well outfitted and efficiently handled," Larry Pardey stated after his record-breaking voyage. Lin and Larry completed their against-the-wind rounding of the Great Southern Capes on board their engineless 29-foot Taleisin, weathering nine days of storm-force winds to reach Puerto Montt in Chile. There they interviewed several high-latitude voyagers, prepared the narrative, and shot further detailed footage to complete the Storm Tactics video, a project Lin and Larry conceived almost ten years ago. Read more about Storm tactics at http://www.thesailingchannel.tv/pardey/storm_tactics/

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