Laissez les beaux-pères au chalet et vos candidats libres de vous étonner. S’ils en sont capables, ils le feront.

Florence et Marianne seront finalement au concert de leur idole, vendredi, à Toronto, mais elles ont eu toute une frousse.

Donald Trump va nommer la représentante Elise Stefanik, républicaine du nord de l’État de New York, ambassadrice des États-Unis à l’ONU.

La majorité des billets encore offerts en ligne pour aller voir Taylor Swift à Toronto sont des arnaques, constate un expert en cybersécurité.

They can cost hundreds of pounds, but are these products actually worth the money?

La découverte d’un circuit cérébral impliqué dans l’effet antidouleur des placebos pourrait permettre le développement de traitements analgésiques.

Maybe those pesky sites are good for something after all. 

It's been six years since Pfizer boldly announced the launch of its "clinical trial in a box". The REMOTE trial was designed to be entirely online, and involved no research sites: study information and consent was delivered via the web, and medications and diaries were shipped directly to patients' homes.

Despite the initial fanfare, within a month REMOTE's registration on ClinicalTrials.gov was quietly reduced from 600 to 283. The smaller trial ended not with a bang but a whimper, having randomized only 18 patients in over a year of recruiting.

Still, the allure of direct to patient clinical trials remains strong, due to a confluence of two factors. First, a frenzy of interest in running "patient centric clinical trials". Sponsors are scrambling to show they are doing something – anything – to show they have shifted to a patient-centered mindset. We cannot seem to agree what this means (as a great illustration of this, a recent article in Forbes on "How Patients Are Changing Clinical Trials" contained no specific examples of actual trials that had been changed by patients), but running a trial that directly engages patients wherever they are seems like it could work.

The less-openly-discussed other factor leading to interest in these DIY trials is sponsors' continuing willingness to heap almost all of the blame for slow-moving studies onto their research sites. If it’s all the sites’ fault – the reasoning goes – then cutting them out of the process should result in trials that are both faster and cheaper. (There are reasons to be skeptical about this, as I have discussed in the past, but the desire to drop all those pesky sites is palpable.)

However, while a few proof-of-concept studies have been done, there really doesn't seem to have been another trial to attempt a full-blown direct-to-patient clinical trial. Other pilots have been more successful, but had fairly lightweight protocols. For all its problems, REMOTE was a seriously ambitious project that attempted to package a full-blown interventional clinical trial, not an observational study.

In this context, it's great to see published results of the TAPIR Trial in vasculitis, which as far as I can tell is the first real attempt to run a DIY trial of a similar magnitude to REMOTE.

TAPIR was actually two parallel trials, identical in every respect except for their sites: one trial used a traditional group of 8 sites, while the other was virtual and recruited patients from anywhere in the country. So this was a real-time, head-to-head assessment of site performance.

And the results after a full two years of active enrollment?

• Traditional sites: 49 enrolled
• Patient centric: 10 enrolled

D�couvrez la tour EQHO en vid�o

Philippe Jourdan: Partner - Promise Consulting

Star Wars & VELUX Galactic Night Collection Copyright: VELUX Group

Magic Denim - Camille Seydoux for Roger Vivier

Опубликован выпуск инструментария Lima 1.0, изначально развивавшего похожую на WSL2 (Windows Subsystem for Linux) прослойку для запуска Linux-приложений в macOS (LInux-on-MAc), но затем переросший в универсальный инструментарий для запуска виртуальных машин с Linux в различных операционных системах. В настоящее время Lima может использоваться в macOS, Linux, Windows и BSD-системах. Ключевой целью проекта является предоставление простого способа запуска произвольных Linux-дистрибутивов в изолированных контейнерах или виртуальных окружениях, обеспечивая при этом автоматическое перенаправление сетевых портов и совместный доступ к файлам. Код проекта написан на языке Go и распространяется под лицензией Apache 2.0.

Компания Microsoft опубликовала обновление дистрибутива Azure Linux 3.0.20241101, продолжающее развитие сформированной в августе стабильной ветки 3.0. Дистрибутив развивается в качестве универсальной базовой платформы для Linux-окружений, используемых в облачной инфраструктуре, edge-системах и различных сервисах Microsoft. Собственные наработки проекта распространяются под лицензией MIT. Сборки пакетов формируются для архитектур aarch64 и x86_64. Размер установочного образа 751 МБ.

As voters across the United States head to the polls, we speak with New York Times writer Jim Rutenberg about how Donald Trump may try to preemptively declare victory and challenge election results. The former president has ramped up claims Democrats are “a bunch of cheats” and preemptively cast doubt on a win by Vice President Kamala Harris, following a similar playbook as 2020 when he baselessly claimed the election was stolen. Rutenberg spoke to pro-Trump election officials in battleground states of Arizona, Georgia, Nevada and Pennsylvania who say they are ready to refuse to certify local election results as part of a wide-ranging effort to throw the system into disarray. Rutenberg says after the failed insurrection of January 6, 2021, many in Trump’s orbit had a clear goal for 2024: “We have to go local.” He also discusses the Electoral Count Reform Act of 2022 that makes it harder to stop the final certification of results.

In the dying stages of innovation, companies at the top of the heap use their market power to maintain their high profits.

The post Suckage begins here: why search engines now prioritize advertising over good UX appeared first on Zeldman on Web and Interaction Design.

The Russian Government has disclosed that both Luxembourg and Malta have agreed to change their double tax agreement with Russia to increase withholding tax rates on cross-border dividends and interest income.

At its December 22 plenum, Russia's lower house of parliament approved revisions to the country's double tax agreements with Cyprus and Luxembourg.

Luxembourg's Direct Tax Administration has issued guidance covering various aspects of the European Union sixth Directive on Administrative Cooperation, under which intermediaries are required to report cross-border tax planning arrangements.

Luxembourg and Belgium will extend the duration of an agreement that clarifies the tax rules for cross-border workers affected by COVID-19 restrictions.

On November 17, 2020, Luxembourg's tax authority published Circular LG – Conv. DI no. 66, outlining the changes made by the BEPS multilateral instrument (BEPS MLI) to the double tax agreement in place with Switzerland.

The Russian Government has disclosed that both Luxembourg and Malta have agreed to change their double tax agreement with Russia to increase withholding tax rates on cross-border dividends and interest income.

Luxembourg and France have agreed to extend an agreement that eases tax residency rules for cross-border workers affected by COVID-19 restrictions.

At its December 22 plenum, Russia's lower house of parliament approved revisions to the country's double tax agreements with Cyprus and Luxembourg.

On November 17, 2020, Luxembourg's tax authority published Circular LG – Conv. DI no. 66, outlining the changes made by the BEPS multilateral instrument (BEPS MLI) to the double tax agreement in place with Switzerland.

Luxembourg and Belgium will extend the duration of an agreement that clarifies the tax rules for cross-border workers affected by COVID-19 restrictions.

Vesicoureteral reflux (VUR) is a congenital condition most common in infants and young children. The urine flows backward from the bladder to one or both ureters and sometimes to the kidneys.

greet, Accor’s beacon of sustainable hospitality, proudly announces the opening of greet Brussels Airport Zaventem, the brand’s first hotel in the Benelux region. Located less than a five-minute drive from Brussels Airport, this 68-room property offers the perfect location for travellers and visitors to the city. Launched in 2019, greet is on a mission to redefine the eco-hospitality segment, establishing itself as the most sustainable hotel brand in the industry. With affordability and convenience at its core, greet hotels are designed for individuals who care deeply about their environmental impact. Every aspect of the guest experience, from check-in to check-out, revolves around the principles of reducing, reusing, and recycling. The brand is a testament to circular hospitality, where sustainability and creativity merge to offer affordable and meaningful stays. The brand has grown to include more than 35 properties across Europe, with hotels in locations such as Paris, Berlin, Vien...

Accor and the Arora Group are proud to announce the groundbreaking of the highly anticipated Sofitel Dublin Airport, a new luxury hotel set to redefine the hospitality experience at Ireland’s main international gateway. The hotel will feature 412 elegantly designed rooms and suites, an all-day dining restaurant, a tea salon, and a sky bar located on the 11th floor, offering stunning views of the airport and beyond. This franchised development project features a new-build Sofitel hotel located at Dublin Airport, set to open by late 2026 as a full-service luxury hotel comprising approximately 412 guest rooms. The hotel will be directly linked to the airport’s Terminal 2, providing seamless connectivity for travellers. The developer for this project is the Arora Group, a significant franchise partner of Accor in the UK and the owner of both the Sofitel London Heathrow Airport and the Sofitel London Gatwick Airport. In 2018, Arora was awarded the opportunity to develop this over €100 mill...

Belmond proudly unveils the Britannic Explorer, A Belmond Train, the first luxury sleeper train in England and Wales, debuting in July 2025.

The 21st century has already seen immense changes in how people travel and their demands for hotel services and amenities. In focus here is the growth, evolution and diversification of the luxury segment, wherein we recently sat down with the team behind the rebranding of EAST Hotels, a hotel brand that’s emblematic of this modern dynamic and the aspirational nature of travel for the 2020s and beyond. EAST Hotels has launched three hotels in Beijing, Hong Kong and Miami, with several more in the pipeline on multiple continents.

Threat type: Backdoor

Aliases:

Platforms: Unix

Overall Risk Rating: Low

Damage Potential: High

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Low

Overview:

This new Mirai variant exploits CVE-2020-10173, a vulnerability in Comtrend VR-3033 routers. Similar to earlier variants, this Mirai variant uses telnet and SSH brute-forcing techniques to attack vulnerable devices.

This Backdoor arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.

The retail sector needs inventory planning to maintain margins and meet demand. This is getting harder because there are now many distribution channels, more complex supply chains, and shorter sales cycles. Mid-market retailers and premium brands have less firepower than the retail giants and tend to rely on legacy software. Founded in 2020, Autone aims […]

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If you always wanted to replicate the plush-looking living room look featured in home decor magazines and simply brushed off the idea thinking it will cost the earth, then it's time you change this decor perspective for good. For a start,

Discover the 2026 Cadillac VISTIQ, a luxury electric SUV offering performance, spaciousness, and cutting-edge technology for an elevated driving experience.

Berlin ; Boston : De Gruyter, [2023]

San Francisco, California : No Starch Press, 2019.

Abingdon, Oxon ; New York, NY : Routledge, 2016.

'Normally we would do this privately, but given that the gossip industry cannot resist an opportunity to speculate and invent, we wanted to convey the truth directly.'

The high-end home and living store opens in a century-old building in Kolkata

Mumbai-based Nahar Group has ventured into the Chennai market with an uber luxury project. Manju Yagnik, vice-chairperson talks about the new project.

The new team is set to participate in various international racing series, starting with the competitive 24H European series in the Porche 992 GT3 cup category

This year, Chennai has seen two staunchly-local five-star hotels spring up. ELIZABETH MATHEW meets the men behind the ambitious projects

Abu Dhabi is rising as a culinary destination with an emphasis on luxury dining offering cuisine from across the globe

Set on 37 acres of farmland, the restaurant seats just 18 guests, serving multi-course menus starring ethically sourced seafood and meat, as well as freshly harvested vegetables and foraged wild greens

25,00 €

25,90 €