The post Searching for Resources, Documents, and Information on Compensation Strategies in Head Start/Early Head Start (Due by Nov 21) was curated by information for practice.

202 E 6th Street
Ongoing through Saturday, December 28, 2024

Senior cords, decorated corduroy pants and skirts popular with high school and college seniors, are a unique piece of Hoosier heritage. This exciting exhibit guest-curated by Kelly Richardson (Director of IU Sage Collection) follows their history from their Purdue University origins through their high school heyday in the 50s and 60s and up to their contemporary revival in bespoke fashion brands like BODE.
Exhibit is currently open and closes Dec. 28th

On view at the Monroe County History Center
202 E. 6th St
Bloomington, IN 47408
Visit monroehistory.org for hours, pricing, and parking information.

Presenter: www.monroehistory.org
Contact: Sarah Rosenkrans
Age Range: All Ages
Cost: $2 adults, $1 kids, free for members and ages under 5
Communities: Bloomington
More info: www.monroehistory.org

Global pandemic treaty negotiators are hashing out cooperation plans this week and considering rushing the process out of fear that the Trump administration would pull the U.S. out of negotiations.

January 25, 2013

President Obama officially began his second term of office on January 20th. In his inaugural address to the nation the following day, his focus was on the strengths and promises of America. In this Basic Black conversation, we explore the challenges, the goals, and the demands for the second Obama administration.

Our panel this week:
- Callie Crossley, host and moderator, Boston Public Radio, WGBH
- Kim McLarin, assistant professor of writing, literature and publishing, Emerson College
- Phillip Martin, senior reporter, 89.7 WGBH Radio
- Peniel Joseph, professor of history, Tufts University
- Robert Fortes, Republican strategist and political consultant




Photo: Supreme Court Chief Justice John Roberts administers the oath of office to President Barack Obama during the inaugural swearing-in ceremony at the U.S. Capitol in Washington, D.C., Jan. 21, 2013. (Official White House Photo by Sonya N. Hebert)

President-elect Donald Trump won the election by flipping Georgia, Pennsylvania and Wisconsin after President Biden won them in 2020. Looking at how Democratic counties voted explains how he did it.

Donald Trump is naming longtime adviser Stephen Miller, an immigration hard-liner, to be the deputy chief of policy in his new administration. The announcement was first reported by CNN on Monday.

The current Sinophobia in the 2nd Cold War between the U. S. and China has contributed to the 2nd strategic mistake that the U. S. is making by allying with India against China (without examining thoroughly its long-term consequences) -- just as the U. S. made the 1st strategic mistake by aligning with China against the U. S. S.R. in the 1st Cold War (also without examining thoroughly its long-term consequences). In global geopolitics, a friend of today can become an enemy of tomorrow. Therefore, is it too late for the U. S. to correct this 2nd strategic mistake by handling India with great care, due to the latter's hegemonic ambition as a new world power, which will then lead to the coming of what I call "Indophobia” in the next decade(s)? 1. Introduction: Historical Background In my 1999 book titled "The Future of Human Civilization” (published in 1999), I had already untimely predicted the emergence of China as the dominant global power on Earth in the following decades, as it was based on the untimely prediction made in my 1995 doctoral dissertation at the Massachusetts Institute of Technology (M.I.T.). In my 2007 book titled "Beyond the World of Titans, and the Remaking of World Order” (published in 2007), I had already untimely predicted the emergence of China and India as the two "hyper-empires” in the top (1st) tier of global politics, with the U. S. and the EU falling to the 2nd tier (as the two "meso-empires”).

TalkTalk and CityFibre have agreed a strategic partnership to accelerate their B2B Ethernet offering to the wholesale community.

As AI regulations in the US have evolved to be more supportive of commercial use, retailers and malls are increasingly adopting technologies that were once the domain of law enforcement and federal agencies. This shift is driven by the need for enhanced security and operational efficiency, with many turning to advanced video analytics and facial intelligence.

Quorum Cyber - with offices in Edinburgh, UK, and Tampa, Florida – has acquired Difenda, a Canadian-based, full-stack Microsoft Security Managed Services company. The announcement underscores Quorum Cyber's global momentum and strengthens its position as a leader of Microsoft Security services. 

By Luke Alexander, freelance writer.

In today's digital landscape, social media has become a pivotal tool for eCommerce businesses looking to thrive in a competitive market. With 5.17 billion active users, social media is essential for businesses aiming to grow and sustain their presence.

How do famous film directors and athletes become baits for pyramid schemes? How are such prominent figures as Anatoly Karpov, Nikita Mikhalkov and other renowned personalities in Russia involved with the scammers from Anchor-Invest? Scarcely ever it is possible to catch and put into jail big-time operators of financial pyramids how it happened with Mavrodi, the famous "financier of Russia". Apart from Mavrodi, a variety of pyramids existed and continue to operate in Russia that have the same backbone; to take your money.

Rising global commodity prices and falling economic growth around the world are the result of the decision by Biden and his European "acolytes" to declare economic war on Russia. The U. S. and the European Union announced tougher sanctions against Russia because of the "Bucha incident" without an international investigation. Nevertheless, as Pravda previously wrote, the "atrocities in Bucha" were most likely staged by the Zelensky regime. The economic war of Western civilization against Russia has in any case been declared and its goal is clear: the complete destruction of Russia, the seizure of its territories and natural resources. Most likely, the total energy blockade of Russia will only intensify, throwing the world financial markets into chaos.

SUZOHAPP – a global market leader of software and hardware payment management solutions – will be exhibiting at EuroShop, the world’s largest retail trade fair from February 16-20 in Dusseldorf, Germany.On display at booth #6A75 will be the market leading CashComplete™ line of payment management solutions.

By Adrian Stokes, freelance writer.

In the fast-paced world of retail, simply offering quality products is no longer enough to stay competitive. To thrive, retailers must adopt a strategic approach to pricing. Price optimisation is not just a tool for boosting profits; it's a matter of survival and growth. Here are three reasons why retailers need to embrace price optimisation and the benefits of automating pricing operations.

Today, Russia produces almost 8 times more Kh-101 (aka X-101) missiles than before the special military operation, Western media report. In 2021, Russia manufactured 56 Kh-101 missiles and increased their production to 420 pieces in 2023.  Noteworthy, the Kh-101 missile may contain more than fifty different foreign-made parts, despite numerous anti-Russian sanctions. For example, two components of the Russian missile are labeled as "products of Swiss company STMicroelectronics", whereas other parts of the Russian missile including chips from Analog Devices, Texas Instruments and Intel are made in the US.

Ivalua, a global leader in spend management solutions provider, has been named a Market Leader in the Ardent Partners "2024 Strategic Sourcing Technology Advisor." The report evaluated the 8 vendors Ardent identified as solution and market leaders in the strategic sourcing space, placing Ivalua in the Market Leaders Quadrant based on its solution and provider strength.

AI-Media - the global provider of audiovisual encoding technology and AI-driven transcription and translation solutions, and Speechmatics - the provider of speech recognition technology, have announced a strategic expansion of their multi-year partnership to deliver new and better AI-driven products to market.

University of Georgia School of Law Assistant Professor of Law & Faculty Co-Director of the Dean Rusk International Law Center Desiree LeClercq, who specializes in international labor law and worked in the Office of the U.S. Trade Representative during the previous Trump administration, as well as in the International Labor Organization and at the National Labor Relations Board, is available for further commentary at desireelc@uga.edu.

[Inter-Korea] :
North Korea has reportedly ratified a treaty to establish a strategic partnership with Russia that includes a defense provision. The North’s state-run Korean Central News Agency(KCNA) said Tuesday that the treaty was ratified as a decree of the president of the state affairs of North Korea, which refers ...

[more...]

[Culture] :
To strengthen the global competitiveness of K-contents, eleven organizations will pool their resources to create a strategic fund worth approximately 600 billion won, or over 454 million U.S. dollars. The Ministry of Culture, Sports and Tourism and the Ministry of Science and ICT announced Wednesday that ...

[more...]

BGS maps out priorities with five-year strategy  British Geological Survey

BGS to update geological maps of Strathmore  British Geological Survey

1,2-Bis(3,5-di­methyl-2-thienyl)perfluoro­cyclo­pentene formed its own spherulites by sublimation onto the hydro­philic surfaces of the (0001) planes of α-quartz and sapphire substrates. The formation of different morphologies of these spherulites was attributed to the surface properties of each substrate. Depending on the morphology of the spherulites, hollow rod crystals with cross sections of different sizes and shapes and branching structures were generated on the surfaces of the spherulites.

The rotating substrate method of crystallite deposition is modeled, allowing computation of effective material coefficients of the layers resulting from the averaging. A worked numerical example particularized to 6mm ZnO is provided.

Sublimation methods utilizing the surface properties of substrates can address the challenge of controlling hollow morphologies in rod crystals. Spherulites were formed on the hydrophilic surface of the (0001) planes of α-quartz and sapphire substrates by sublimation of 1,2-bis(3,5-dimethyl-2-thienyl)perfluorocyclopentene (1a). Various types of hollow morphologies, distinguished by the size and shape of their cross sections and by the presence or absence of branching structures, were formed separately on α-quartz and sapphire substrates. Such precise control of the hollow morphologies was attributed to the wettability of each substrate, leading to the formation of spherulites of 1a. In addition, it was indicated that the formation process of the surface morphologies of spherulites was associated with the hollow morphologies of rod crystals of 1a.

The structural and chemical evolution of battery electrodes at the nanoscale plays an important role in affecting the cell performance. Nano-resolution X-ray microscopy has been demonstrated as a powerful technique for characterizing the evolution of battery electrodes under operating conditions with sensitivity to their morphology, compositional distribution and redox heterogeneity. In real-world batteries, the electrode could deform upon battery operation, causing challenges for the image registration which is necessary for several experimental modalities, e.g. XANES imaging. To address this challenge, this work develops a deep-learning-based method for automatic particle identification and tracking. This approach was not only able to facilitate image registration with good robustness but also allowed quantification of the degree of sample deformation. The effectiveness of the method was first demonstrated using synthetic datasets with known ground truth. The method was then applied to an experimental dataset collected on an operating lithium battery cell, revealing a high degree of intra- and interparticle chemical complexity in operating batteries.

Deflectometric profilometers are used to precisely measure the form of beam shaping optics of synchrotrons and X-ray free-electron lasers. They often utilize autocollimators which measure slope by evaluating the displacement of a reticle image on a detector. Based on our privileged access to the raw image data of an autocollimator, novel strategies to reduce the systematic measurement errors by using a set of overlapping images of the reticle obtained at different positions on the detector are discussed. It is demonstrated that imaging properties such as, for example, geometrical distortions and vignetting, can be extracted from this redundant set of images without recourse to external calibration facilities. This approach is based on the fact that the properties of the reticle itself do not change – all changes in the reticle image are due to the imaging process. Firstly, by combining interpolation and correlation, it is possible to determine the shift of a reticle image relative to a reference image with minimal error propagation. Secondly, the intensity of the reticle image is analysed as a function of its position on the CCD and a vignetting correction is calculated. Thirdly, the size of the reticle image is analysed as a function of its position and an imaging distortion correction is derived. It is demonstrated that, for different measurement ranges and aperture diameters of the autocollimator, reductions in the systematic errors of up to a factor of four to five can be achieved without recourse to external measurements.

The paper considers the possibility of using the diamond-silicon carbide composite Skeleton® with a technological coating of polycrystalline silicon as a substrate for X-ray mirrors used with powerful synchrotron radiation sources (third+ and fourth generation). Samples were studied after polishing to provide the following surface parameters: root-mean-square flatness ≃ 50 nm, micro-roughness on the frame 2 µm × 2 µm σ ≃ 0.15 nm. The heat capacity, thermal conductivity and coefficient of linear thermal expansion were investigated. For comparison, a monocrystalline silicon sample was studied under the same conditions using the same methods. The value of the coefficient of linear thermal expansion turned out to be higher than that of monocrystalline silicon and amounted to 4.3 × 10−6 K−1, and the values of thermal conductivity (5.0 W cm−1 K−1) and heat capacity (1.2 J K−1 g−1) also exceeded the values for Si. Thermally induced deformations of both Skeleton® and monocrystalline silicon samples under irradiation with a CO2 laser beam have also been experimentally studied. Taking into account the obtained thermophysical constants, the calculation of thermally induced deformation under irradiation with hard (20 keV) X-rays showed almost three times less deformation of the Skeleton® sample than of the monocrystalline silicon sample.

The ability to freely control the polarization of X-rays enables measurement techniques relying on circular or linear dichroism, which have become indispensable tools for characterizing the properties of chiral molecules or magnetic structures. Therefore, the demand for polarization control in X-ray free-electron lasers is increasing to enable polarization-sensitive dynamical studies on ultrafast time scales. The soft X-ray branch Athos of SwissFEL was designed with the aim of providing freely adjustable and arbitrary polarization by building its undulator solely from modules of the novel Apple X type. In this paper, the magnetic model of the linear inclined and circular Apple X polarization schemes are studied. The polarization is characterized by measuring the angular electron emission distributions of helium for various polarizations using cold target recoil ion momentum spectroscopy. The generation of fully linear polarized light of arbitrary angle, as well as elliptical polarizations of varying degree, are demonstrated.

For cryo-electron tomography (cryo-ET) of beam-sensitive biological specimens, a planar sample geometry is typically used. As the sample is tilted, the effective thickness of the sample along the direction of the electron beam increases and the signal-to-noise ratio concomitantly decreases, limiting the transfer of information at high tilt angles. In addition, the tilt range where data can be collected is limited by a combination of various sample-environment constraints, including the limited space in the objective lens pole piece and the possible use of fixed conductive braids to cool the specimen. Consequently, most tilt series are limited to a maximum of ±70°, leading to the presence of a missing wedge in Fourier space. The acquisition of cryo-ET data without a missing wedge, for example using a cylindrical sample geometry, is hence attractive for volumetric analysis of low-symmetry structures such as organelles or vesicles, lysis events, pore formation or filaments for which the missing information cannot be compensated by averaging techniques. Irrespective of the geometry, electron-beam damage to the specimen is an issue and the first images acquired will transfer more high-resolution information than those acquired last. There is also an inherent trade-off between higher sampling in Fourier space and avoiding beam damage to the sample. Finally, the necessity of using a sufficient electron fluence to align the tilt images means that this fluence needs to be fractionated across a small number of images; therefore, the order of data acquisition is also a factor to consider. Here, an n-helix tilt scheme is described and simulated which uses overlapping and interleaved tilt series to maximize the use of a pillar geometry, allowing the entire pillar volume to be reconstructed as a single unit. Three related tilt schemes are also evaluated that extend the continuous and classic dose-symmetric tilt schemes for cryo-ET to pillar samples to enable the collection of isotropic information across all spatial frequencies. A fourfold dose-symmetric scheme is proposed which provides a practical compromise between uniform information transfer and complexity of data acquisition.

The Mycobacterium tuberculosis trifunctional enzyme (MtTFE) is an α2β2 tetrameric enzyme in which the α-chain harbors the 2E-enoyl-CoA hydratase (ECH) and 3S-hydroxyacyl-CoA dehydrogenase (HAD) active sites, and the β-chain provides the 3-ketoacyl-CoA thiolase (KAT) active site. Linear, medium-chain and long-chain 2E-enoyl-CoA molecules are the preferred substrates of MtTFE. Previous crystallographic binding and modeling studies identified binding sites for the acyl-CoA substrates at the three active sites, as well as the NAD binding pocket at the HAD active site. These studies also identified three additional CoA binding sites on the surface of MtTFE that are different from the active sites. It has been proposed that one of these additional sites could be of functional relevance for the substrate channeling (by surface crawling) of reaction intermediates between the three active sites. Here, 226 fragments were screened in a crystallographic fragment-binding study of MtTFE crystals, resulting in the structures of 16 MtTFE–fragment complexes. Analysis of the 121 fragment-binding events shows that the ECH active site is the `binding hotspot' for the tested fragments, with 41 binding events. The mode of binding of the fragments bound at the active sites provides additional insight into how the long-chain acyl moiety of the substrates can be accommodated at their proposed binding pockets. In addition, the 20 fragment-binding events between the active sites identify potential transient binding sites of reaction intermediates relevant to the possible channeling of substrates between these active sites. These results provide a basis for further studies to understand the functional relevance of the latter binding sites and to identify substrates for which channeling is crucial.

A key prerequisite for the successful application of protein crystallography in drug discovery is to establish a robust crystallization system for a new drug-target protein fast enough to deliver crystal structures when the first inhibitors have been identified in the hit-finding campaign or, at the latest, in the subsequent hit-to-lead process. The first crucial step towards generating well folded proteins with a high likelihood of crystallizing is the identification of suitable truncation variants of the target protein. In some cases an optimal length variant alone is not sufficient to support crystallization and additional surface mutations need to be introduced to obtain suitable crystals. In this contribution, four case studies are presented in which rationally designed surface modifications were key to establishing crystallization conditions for the target proteins (the protein kinases Aurora-C, IRAK4 and BUB1, and the KRAS–SOS1 complex). The design process which led to well diffracting crystals is described and the crystal packing is analysed to understand retrospectively how the specific surface mutations promoted successful crystallization. The presented design approaches are routinely used in our team to support the establishment of robust crystallization systems which enable structure-guided inhibitor optimization for hit-to-lead and lead-optimization projects in pharmaceutical research.

During the automatic processing of crystallographic diffraction experiments, beamstop shadows are often unaccounted for or only partially masked. As a result of this, outlier reflection intensities are integrated, which is a known issue. Traditional statistical diagnostics have only limited effectiveness in identifying these outliers, here termed Not-Excluded-unMasked-Outliers (NEMOs). The diagnostic tool AUSPEX allows visual inspection of NEMOs, where they form a typical pattern: clusters at the low-resolution end of the AUSPEX plots of intensities or amplitudes versus resolution. To automate NEMO detection, a new algorithm was developed by combining data statistics with a density-based clustering method. This approach demonstrates a promising performance in detecting NEMOs in merged data sets without disrupting existing data-reduction pipelines. Re-refinement results indicate that excluding the identified NEMOs can effectively enhance the quality of subsequent structure-determination steps. This method offers a prospective automated means to assess the efficacy of a beamstop mask, as well as highlighting the potential of modern pattern-recognition techniques for automating outlier exclusion during data processing, facilitating future adaptation to evolving experimental strategies.

A significant part of the present and future of optoelectronic devices lies on thin multilayer heterostructures. Their optical properties depend strongly on strain, being essential to the knowledge of the stress level to optimize the growth process. Here the structural and microstructural characteristics of sub-micron a-ZnO epilayers (12 to 770 nm) grown on r-sapphire by metal–organic chemical vapour deposition are studied. Morphological and structural studies have been made using scanning electron microscopy and high-resolution X-ray diffraction. Plastic unit-cell distortion and corresponding strain have been determined as a function of film thickness. A critical thickness has been observed as separating the non-elastic/elastic states with an experimental value of 150–200 nm. This behaviour has been confirmed from ultraviolet photoelectron spectroscopy, X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy measurements. An equation that gives the balance of strains is proposed as an interesting method to experimentally determine this critical thickness. It is concluded that in the thinnest films an elongation of the Zn—O bond takes place and that the plastic strained ZnO films relax through nucleation of misfit dislocations, which is a consequence of three-dimensional surface morphology.

Neutron diffraction beamlines have traditionally relied on deploying large detector arrays of 3He tubes or neutron-sensitive scintillators coupled with photomultipliers to efficiently probe crystallographic and microstructure information of a given material. Given the large upfront cost of custom-made data acquisition systems and the recent scarcity of 3He, new diffraction beamlines or upgrades to existing ones demand innovative approaches. This paper introduces a novel Timepix3-based event-mode imaging neutron diffraction detector system as well as first results of a silicon powder diffraction measurement made at the HIPPO neutron powder diffractometer at the Los Alamos Neutron Science Center. Notably, these initial measurements were conducted simultaneously with the 3He array on HIPPO, enabling direct comparison. Data reduction for this type of data was implemented in the MAUD code, enabling Rietveld analysis. Results from the Timepix3-based setup and HIPPO were benchmarked against McStas simulations, showing good agreement for peak resolution. With further development, systems such as the one presented here may substantially reduce the cost of detector systems for new neutron instrumentation as well as for upgrades of existing beamlines.

Source: Streetwise Reports 10/22/2024

Canter Resources Corp. (CRC:CSE; CNRCF:OTC; 601:FRA) has completed its acquisition of the Railroad Valley lithium-boron claims (RV project). The RV project claim block shares a common border with land controlled by 3 Proton Lithium (3PL), a private critical mineral explorer in Railroad Valley. Canter intends to complete follow-up sampling at the project in the fourth quarter of 2024, 164 kilometers from their exploration base in Tonopah, Nevada.

In the company news release, Joness Lang, CEO of Canter Resources, commented on the acquisition, stating, "We are excited to have expanded our lithium-boron exploration footprint in Nevada with this strategic acquisition in a highly prospective, yet underexplored area. While our primary focus remains on advancing our flagship Columbus project, we see value in adding low-cost, high-potential projects that strengthen our portfolio and align with our long-term growth strategy."

Lithium-Boron Market Trends and Opportunities

Visual Capitalist reported on September 29 that cobalt, a critical mineral used in battery production, had "gained significant attention in recent years due to its wide range of commercial, industrial, and military applications." The growing demand for cobalt in the electric vehicle (EV) sector was highlighted, with "the EV sector accounting for 40% of the global cobalt market," reinforcing its importance in the global transition to electrification. Additionally, 87% of China's cobalt consumption was "dedicated to the lithium-ion battery industry."

On October 1, Ahead of the Herd emphasized a favorable environment for risk assets, noting, "The combination of interest-rate cuts from the Federal Reserve, resilient economic growth, and the un-inversion of the yield curve" as contributing factors. The S&P/TSX Global Mining Index gained 14% since September 6, marking its biggest jump of the year, with central banks cutting interest rates and the U.S. signaling more battery metal funding. Ahead of the Herd also stated that "majors, mid-tiers, and juniors all looked ripe for a rebound" in this risk-tolerant environment.

On October 8, Forbes reported that "a 50% rise in the price of a downtrodden lithium producer has boosted investor hopes that a revival in the battery metal is possible" after two difficult years of oversupply and low prices. Lithium was "once the hottest metal in the commodity sector" and had begun showing "signs of recovery as investor interest picks up again." Despite the downturn, the long-term outlook for lithium remained strong, with Forbes emphasizing its essential role "for the future of electric vehicles and battery technology."

According to Barry Dawes of Martin Place Securities that same day, "the lithium market is showing strong signs of upturn," with the possibility of "lithium shortages post-2027," highlighting the sector's future growth potential.

Canter's Catalysts Driving Growth

As outlined in their investor presentation, Canter Resources' Railroad Valley acquisition aligns with the company's strategy of expanding its critical minerals portfolio at a low cost while leveraging geological similarities to proven lithium-producing regions. The Railroad Valley project holds promise due to its favorable geological features, such as volcanic calderas and closed-basin characteristics, which are known to enhance lithium and boron concentration.

According to the company's investor presentation, this acquisition bolsters Canter's portfolio as it continues to focus on the Columbus project. The upcoming follow-up sampling and the planned Q4 2024 exploration at the Railroad Valley site further demonstrate the company's commitment to expanding its exploration activities. Canter's continued exploration efforts are expected to provide the data necessary to identify lithium-boron deposits across its portfolio, enhancing long-term growth potential.

Analysts On Canter

*According to Technical Analyst Clive Maund, who issued an opinion on October 16, Canter Resources Corp. was viewed as an "Immediate Strong Buy." Maund pointed out that the company's stock was priced at "some 8% of its price at its late 2023 peak," making it a highly favorable entry point. He emphasized that despite the severe bear market in lithium, Canter had made "considerable progress" on its projects, which positioned the company to benefit as lithium prices stabilized. Maund highlighted that Canter's Columbus Basin Project, located in a region with favorable geology, "looks set to provide a 'kicker' for the stock," especially following positive Phase II drilling results.

On October 15, Jeff Clark from The Gold Advisor also shared a positive assessment of Canter Resources. Clark noted that the company had reported "significant findings from its Phase II Geoprobe drilling program" at the Columbus Project, including the highest boron concentration to date and consistent lithium values. He highlighted Canter's potential to make a major discovery at Columbus, particularly due to the structural similarities between this project and other successful lithium-boron operations in the region. Clark added that Canter's "low-cost shallow drilling" had laid the foundation for a deeper and more extensive exploration phase. He affirmed that Canter's market cap of CA$3.85M represented an "incredible bargain" considering the company's potential.

In What is Chen Buying? What is Chen Selling?, published on October 16, analyst Chen Lin provided a positive outlook on Canter Resources' drilling results. He highlighted that Phase II drilling at the Columbus Lithium-Boron Project returned "the highest dissolved boron concentration to date," which further underscored the project's potential. Lin emphasized the promising geochemical similarities between Canter's Columbus Basin and other major lithium-boron-producing regions, stating that these results "bolster the company’s hypothesis" and position Canter as a key player in the critical minerals market. [OWNERSHIP_CHART-10988]

Ownership and Share Structure

According to the company, managers and insiders own about 9.6% of Canter Resources, and strategic investors (including the founding group and Michael Gentile & Advisors) own about 12%.

The investors with the largest stake are all insiders. They are CEO and Director Joness Lang with 3.38%, Director and Strategic Adviser Warwick Smith with 2.14%, Director and Technical Adviser Kenneth Cunningham with 1.95%, Chief Financial Officer Alnesh Mohan with 0.97%, and Director and Technical Adviser Eric Saderholm with 0.58%, and Gentile, who owns about 4% personally.

Four institutions or funds, including Euro Pacific Asset Management, collectively hold 3%. Retail investors own the remaining.

The Canadian explorer has 51.29 million outstanding shares, 46.41 million free float traded shares with a CA$4.11 million market cap.

Over the past 52 weeks, Canter has traded between CA$0.07 and CA$0.99 per share.

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Important Disclosures:

1. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Canter Resources Corp.
2. James Guttman wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.
3. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

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* Disclosure for the quote from the Clive Maund article published on October 16, 2024

1. For the quoted article (published on October 16, 2024), the Company has paid Street Smart, an affiliate of Streetwise Reports, US$2,500.
2. Author Certification and Compensation: [Clive Maund of clivemaund.com] is being compensated as an independent contractor by Street Smart, an affiliate of Streetwise Reports, for writing the article quoted. Maund received his UK Technical Analysts’ Diploma in 1989. The recommendations and opinions expressed in the article accurately reflect the personal, independent, and objective views of the author regarding any and all of the designated securities discussed. No part of the compensation received by the author was, is, or will be directly or indirectly related to the specific recommendations or views expressed

Clivemaund.com Disclosures

The quoted article represents the opinion and analysis of Mr. Maund, based on data available to him, at the time of writing. Mr. Maund's opinions are his own, and are not a recommendation or an offer to buy or sell securities. As trading and investing in any financial markets may involve serious risk of loss, Mr. Maund recommends that you consult with a qualified investment advisor, one licensed by appropriate regulatory agencies in your legal jurisdiction and do your own due diligence and research when making any kind of a transaction with financial ramifications. Although a qualified and experienced stock market analyst, Clive Maund is not a Registered Securities Advisor. Therefore Mr. Maund's opinions on the market and stocks cannot be only be construed as a recommendation or solicitation to buy and sell securities.

( Companies Mentioned: CRC:CSE; CNRCF:OTC; 601:FRA, )

Source: Streetwise Reports 11/08/2024

Vertex Pharmaceuticals Inc. (VRTX:NASDAQ) has reported a robust financial performance for the third quarter of 2024. The report has demonstrated the company's continued revenue growth and the strengthening of its innovative pipeline. For Q3 2024, Vertex's product revenue reached US$2.77 billion, a 12% increase from the previous year. This was primarily driven by strong demand for its TRIKAFTA®/KAFTRIO® therapies. Based on this momentum, Vertex raised its full-year product revenue guidance to a range of US$10.8 billion to US$10.9 billion, citing a solid trajectory in its cystic fibrosis (CF) portfolio and expected future launches.

In Q3, the company made notable advancements in its pipeline. Three programs have begun moving into Phase 3 clinical development: suzetrigine in diabetic peripheral neuropathy (DPN), povetacicept in IgA nephropathy (IgAN), and VX-880 in type 1 diabetes (T1D). Vertex is also preparing for the launch of two potential treatments in early 2025, with PDUFA dates set for January 2 for the vanzacaftor triple therapy for CF and January 30 for suzetrigine, the latter being a pain medication in a new therapeutic class aimed at reducing reliance on opioids.

GAAP and Non-GAAP net income both reached US$1.0 billion, largely driven by increased product revenue, which offset rising R&D and SG&A expense. This was s due to investments in global commercialization and late-stage clinical development. For Q3, Vertex's combined R&D and SG&A expenses were US$1.2 billion and US$1.1 billion, respectively, an increase from last year attributed to new global program advancements and upcoming launch support.

Vertex's cash position remained strong, with US$11.2 billion in cash, cash equivalents, and marketable securities as of September 30. The decline from US$13.7 billion at the end of 2023 primarily reflects the acquisition of Alpine Immune Sciences and share repurchases under the company's buyback program.

A Look At Biotechnology and Pharma

The U.S. Pharmaceuticals Report for 2024 by Nova One Advisor detailed the size and growth trajectory of the U.S. pharmaceutical market. Valued at US$602.19 billion in 2023, the sector is projected to exceed US$1 trillion by 2033. The report pointed to a "high healthcare expenditure provided by government bodies" as a primary growth driver, further bolstered by the aging population's demand for advanced treatments.

In an October 24 article, The Investing News Network reported on a dynamic landscape within the biotechnology sector. The report highlighted advancements in AI-powered drug discovery. Despite a cautious investment climate, interest remained strong in AI's potential to reshape healthcare, with venture capital investment reaching US$6.59 billion. At the HealthTech Ignite conference, Susie Roberts from Relay Therapeutics expressed confidence, noting, "We will definitely see AI design drugs in the next 10 years."

On November 4, Yahoo! Finance shared insights from MIT professors Andrew Lo and Dennis Whyte. They emphasized that biotechnology's rapid advancement over the past five decades offers valuable lessons for future innovation. In their research paper, Lo and Whyte proposed initiatives to accelerate biotechnology's growth, underscoring the importance of "reducing risk and uncertainty" to foster a robust investment ecosystem that supports groundbreaking discoveries.

Catalysts Driving Vertex Pharma

According to Vertex's November 2024 investor presentation, the company sees multiple growth catalysts over the next few years. Vertex aims to meet its goal of achieving "five launches in five years," focusing on expanding the treatable patient base in CF with vanzacaftor triple, addressing critical needs in sickle cell disease (SCD) and beta thalassemia (TDT) with CASGEVY, and launching suzetrigine for acute pain management.

Additionally, Vertex expects its expansive R&D pipeline to support long-term growth. This includes pivotal clinical trials for VX-880 in T1D, povetacicept in IgAN, and NaV1.8 pain inhibitors like suzetrigine, indicating a commitment to treating a range of chronic and life-threatening conditions with limited therapeutic options.

By driving advancements in CF therapies, diversifying its portfolio with novel pain treatments, and pursuing accelerated approvals for renal and blood-related disorders, Vertex is strategically positioning itself to sustain growth and achieve several near-term milestones.

What Are Experts Saying About Vertex?

In a November 5, 2024, H.C. Wainwright & Co. update, the analysts highlighted promising data from Vertex's recent Phase 2 trial for suzetrigine, which showed encouraging reductions in pain intensity. [OWNERSHIP_CHART-4085]

The analysts noted that suzetrigine's peripheral nervous system-specific mechanism could potentially address "a significant, unmet medical need worldwide" in non-opioid pain management. They set a price target of US$600.00, projecting Vertex's continued growth from its strong cystic fibrosis franchise and pipeline expansion.

From the November 7 Kingswood Capital Partners report, analysts noted Vertex Pharmaceuticals' "sustained execution" in advancing product development programs and achieving robust operating margins, enabling "continued, significant investments" in both its pipeline and commercial capabilities. The firm maintained a "Buy" rating with a 12-month target price of US$550.00, attributing this outlook to Vertex's deep cash resources and historical successes in clinical trials.

Ownership and Share Structure

According to Refinitiv, 95.44% of Vertex Pharmaceuticals is held by Institutions. The top among them are Capital World Investors at 10.37%, The Vanguard Group at 8.88%, BlackRock Institutional Trust with 5.49%, State Street Global Advisors (US) with 4.55%, and Fidelity Management and Research with 4.11%. Strategic Investors hold .12%. The rest is retail.

The company's market cap is US$129,395.59 million with 257.07 million free float shares. The 52 week range is US$341.90–$510.64.

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1) James Guttman wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.

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The Biden administration plans to open the California coast to offshore wind development, ending a long-running stalemate with the Department of Defense that has been the biggest barrier to building wind power along the Pacific Coast.

The move adds momentum to the administration's goal of reaching 100% carbon-free electricity by 2035, coming just weeks after the country's first large-scale offshore wind farm was approved off the coast of New England. Today, the country has just a handful of offshore wind turbines in the Atlantic Ocean, with around a dozen wind farms being developed in federal waters off the East Coast.

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In 2018, the federal Bureau of Ocean Energy Management solicited interest from wind developers. But negotiations with the Department of Defense have been slow going ever since, effectively blocking wind development off California.

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"It's our view that the world faces a grave and growing climate crisis," says Dr. Colin Kahl, undersecretary of defense for policy. "Climate change is both a threat to the Department of Defense's operations around the world and an existential challenge to our ability to maintain resilience here at home."

Another key site, just offshore from the Diablo Canyon nuclear power plant, was not included in Tuesday's deal. California's last-remaining nuclear plant is scheduled to completely close by 2025, freeing up more potential transmission lines for offshore wind.

The Biden administration has set a goal of jump-starting the country's offshore wind sector with 30 gigawatts of projects by 2030. Those wind farms will foster tens of thousands of jobs, according to the White House, between renewable energy installers, manufacturers and steelworkers.

"This is a major breakthrough — a major advancement that will allow California to start planning for its carbon-free electricity goals with offshore wind firmly in the picture," says Nancy Rader of the California Wind Energy Association, who also pointed to the challenges. "Offshore wind development off the coast at Morro Bay and Humboldt will require a major port facility in each area to construct the floating platforms and assemble the turbines that will require continued proactive planning by the state and federal governments."

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A potential lease auction for the offshore wind sites could be held in mid-2022. But the projects will still have to negotiate concerns about the potential impacts on California's fishing industry and shipping channels, as well as any environmental concerns about sensitive ecosystems.

"Far too many questions remain unanswered regarding potential impacts to marine life which is dependent on a healthy ecosystem," says Mike Conroy of the Pacific Coast Federation of Fishermen's Associations. "The fishing industry has been told these areas work best for offshore wind developers; but no one has asked us what areas would work best for us."

This content is from Southern California Public Radio. View the original story at SCPR.org.

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