Flow chemistry process takes place on carbon nitride surface

At least eight people, including a child, died today morning after a toxic gas leaked from a chemical plant of a company in Visakhapatnam, Andhra Pradesh. Fire engines, police and ambulances have reached the area to control the situation and around

1. UFC 249: Reaction to Justin Gaethje’s TKO victory over Tony Ferguson  NEWS.com.au
2. UFC boss Dana White roundly praised as UFC 249 ushers in fan-free era of sport amid COVID-19  Wide World of Sports
3. Dana White reacts to epic Justin Gaethje vs. Tony Ferguson war | UFC 249 Post-Fight Press Conference  TheMacLife
4. UFC 249: Justin Gaethje, Tony Ferguson result, Henry Cejudo vs Dominik Cruz  NEWS.com.au
5. UFC 249 gets Mixed Martial Arts back underway behind closed doors in Florida  ABC News
6. View Full coverage on Google News

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Faith is strengthened when OMers learn how the Lord watches over them, not allowing harm to come to the people or the ministry.

Source: www.mmafighting.com - Friday, May 08, 2020
Check out video reaction to breaking news that UFC middleweight Ronaldo “Jacare” Souza has tested positive for coronavirus and is out of his UFC 249 fight against Uriah Hall .

The Ogun State Ministry of Health has reacted to a viral video circulating in the social media about a corpse claimed to be a victim of COVID-19 at its Primary Health Center (PHC), Oke-Ilewo, Abeokuta on Friday, May 9, 2020. The Hon. Commissioner for Health, Ogun State, Dr. Tomi Coker, in a statement said that the
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The post Ogun Ministry of Health reacts to viral video of corpse claimed to be COVID-19 victim at its PHC appeared first on Vanguard News.

President Muhammadu Buhari has commiserated with the government and people of Sokoto State over the death of Sheikh Haruna Waziri Usman. DAILY POST reported that the 96-year-old uncle of Sokoto State Governor, Aminu Tambuwa, passed away after a prolonged illness. Sheikh Tambuwal was the patriarch of the Waziri Tambuwal family. The President, in a statement […]

Buhari reacts to Sheikh Tambuwal’s death

A California Democrat seemed less than upset Saturday night at the news that entrepreneur Elon Musk planned to pull much of his company Tesla – along with an unspecified number of jobs -- out of the state over coronavirus shutdown rules that have stalled the automaker's operations.

Justin Gaethje put on a striking masterclass to score a surprise knockout victory over Tony Ferguson and win the interim lightweight title at UFC 249, which took place at the VyStar Veterans Memorial Arena in Jacksonville, Florida on Saturday.Ferguson, who came into the fight on a 12-win streak, suffered damage as Gaethje chopped at his legs and landed thunderous hooks before referee Herb Dean stepped in to end the fight late in the fifth round.

The Government's new "stay alert" slogan for the next stage of the UK's fight against coronavirus has divided opinion.The "stay at home, protect the NHS, save lives" message that has been drilled into the public for weeks is expected to be dropped for a call to "stay alert, control the virus, save lives".

The Government's new "stay alert" slogan for the next stage of the UK's fight against coronavirus has divided opinion.

Britons are now set to be asked to ‘Stay alert, control the virus, save lives’.

The NRL appears set to scrap the two referee system in favour of a single referee for the 2020 season, but the move has sparked heated debate in rugby league circles.

Read what the teams and drivers had to say after the Italian Grand Prix at Monza

Driver and team reaction after the action-packed Canadian Grand Prix

A round-up of the drivers' thoughts after the Australian Grand Prix in Melbourne

Driver and team reaction after the Japanese Grand Prix

Driver and team reaction after the first practice sessions for the Korean Grand Prix

All the driver's reaction after the Monaco Grand Prix

After a gruelling race in the heat of Sepang the competitors offer their thoughts

Layered with metaphors and allegories that give varied meanings to the narration, on the surface, the film is the adventure of a young boy named Jake (Asa Butterfield), who shuttles in time.

Much of the media coverage around PISA focused on the strong performance of Asia’s students, leaving many to wonder why other countries failed to score as high.

Registrations for Kaun Banega Crorepati begin tonight, Iulia Vangtur fields questions about rumours of marrying Salman Khan. More details in today's showbiz highlights.

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

Aditya Dhar's debut movie as director, Uri: The Surgical Strike (2019), was a great success among audiences and at the box office. Starring Vicky Kaushal in the lead, Uri was based on India's retaliation to the attack in Uri, a small

As the world struggles with the deadly coronavirus, there are some who are dealing with the pandemic in their own unique way.Here are 12 images that show how.

Two in situ `nanoreactors' for high-resolution imaging of catalysts have been designed and applied at the hard X-ray nanoprobe endstation at beamline P06 of the PETRA III synchrotron radiation source. The reactors house samples supported on commercial MEMS chips, and were applied for complementary hard X-ray ptychography (23 nm spatial resolution) and transmission electron microscopy, with additional X-ray fluorescence measurements. The reactors allow pressures of 100 kPa and temperatures of up to 1573 K, offering a wide range of conditions relevant for catalysis. Ptychographic tomography was demonstrated at limited tilting angles of at least ±35° within the reactors and ±65° on the naked sample holders. Two case studies were selected to demonstrate the functionality of the reactors: (i) annealing of hierarchical nanoporous gold up to 923 K under inert He environment and (ii) acquisition of a ptychographic projection series at ±35° of a hierarchically structured macroporous zeolite sample under ambient conditions. The reactors are shown to be a flexible and modular platform for in situ studies in catalysis and materials science which may be adapted for a range of sample and experiment types, opening new characterization pathways in correlative multimodal in situ analysis of functional materials at work. The cells will presently be made available for all interested users of beamline P06 at PETRA III.

The coordination of the ligands with respect to the central atom in the complex bromido­tricarbon­yl[diphen­yl(pyridin-2-yl)phosphane-κ2N,P]rhenium(I) chloro­form disolvate, [ReBr(C17H14NP)(CO)3]·2CHCl3 or [κ2-P,N-{(C6H5)2(C5H5N)P}Re(CO)3Br]·2CHCl3, (I·2CHCl3), is best described as a distorted octa­hedron with three carbonyls in a facial conformation, a bromide atom, and a biting P,N-di­phenyl­pyridyl­phosphine ligand. Hirshfeld surface analysis shows that C—Cl⋯H inter­actions contribute 26%, the distance of these inter­actions are between 2.895 and 3.213 Å. The reaction between I and piperidine (C5H11N) at 313 K in di­chloro­methane leads to the partial decoord­ination of the pyridyl­phosphine ligand, whose pyridyl group is replaced by a piperidine mol­ecule, and the complex bromido­tricarbon­yl[diphen­yl(pyridin-2-yl)phosphane-κP](piperidine-κN)rhenium(I), [ReBr(C5H11N)(C17H14NP)(CO)3] or [P-{(C6H5)2(C5H5N)P}(C5H11N)Re(CO)3Br] (II). The mol­ecule has an intra­molecular N—H⋯N hydrogen bond between the non-coordinated pyridyl nitro­gen atom and the amine hydrogen atom from piperidine with D⋯A = 2.992 (9) Å. Thermogravimetry shows that I·2CHCl3 losses 28% of its mass in a narrow range between 318 and 333 K, which is completely consistent with two solvating chloro­form mol­ecules very weakly bonded to I. The remaining I is stable at least to 573 K. In contrast, II seems to lose solvent and piperidine (12% of mass) between 427 and 463 K, while the additional 33% loss from this last temperature to 573 K corresponds to the release of 2-pyridyl­phosphine. The contribution to the scattering from highly disordered solvent mol­ecules in II was removed with the SQUEEZE routine [Spek (2015). Acta Cryst. C71, 9-18] in PLATON. The stated crystal data for Mr, μ etc. do not take this solvent into account.

The reactions of N-heterocyclic carbene CuI and AgI halides with potassium thio- or seleno­cyanate gave unexpected products. The attempted substitution reaction of bromido­(1,3-dibenzyl-4,5-di­phenyl­imidazol-2-yl­idene)silver (NHC*—Ag—Br) with KSCN yielded bis­[bis­(1,3-dibenzyl-4,5-di­phenyl­imidazol-2-yl­idene)silver(I)] tris­(thio­cyanato)­argentate(I) diethyl ether disolvate, [Ag(C29H24N2)2][Ag(NCS)3]·2C4H10O or [NHC*2Ag]2[Ag(SCN)3]·2Et2O, (1), while reaction with KSeCN led to bis­(μ-1,3-dibenzyl-4,5-diphenyl-2-seleno­imidazole-κ2Se:Se)bis­[bromido­(1,3-dibenzyl-4,5-diphenyl-2-seleno­imid­azole-κSe)silver(I)] di­chloro­methane hexa­solvate, [Ag2Br2(C29H24N2Se)4]·6CH2Cl2 or (NHC*Se)4Ag2Br2·6CH2Cl2, (2), via oxidation of the NHC* fragment to 2-seleno­imidazole. This oxidation was observed again in the reaction of NHC*—Cu—Br with KSeCN, yielding catena-poly[[[(1,3-dibenzyl-4,5-diphenyl-2-seleno­imidazole-κSe)copper(I)]-μ-cyanido-κ2C:N] aceto­nitrile monosolvate], {[Cu(CN)(C29H24N2Se)]·C2H3N}n or NHC*Se—CuCN·CH3CN, (3). Compound (1) represents an organic/inorganic salt with AgI in a linear coordination in each of the two cations and in a trigonal coordination in the anion, accompanied by diethyl ether solvent mol­ecules. The tri-blade boomerang-shaped complex anion [Ag(SCN)3]2− present in (1) is characterized by X-ray diffraction for the first time. Compound (2) comprises an isolated centrosymmetric mol­ecule with AgI in a distorted tetra­hedral BrSe3 coordination, together with di­chloro­methane solvent mol­ecules. Compound (3) exhibits a linear polymeric 1∞[Cu—C≡N—Cu—] chain structure with a seleno­imidazole moiety additionally coordinating to each CuI atom, and completed by aceto­nitrile solvent mol­ecules. Electron densities associated with an additional ether solvent mol­ecule in (1) and two additional di­chloro­methane solvent mol­ecules in (2) were removed with the SQUEEZE procedure [Spek (2015). Acta Cryst. C71, 9–18] in PLATON.

Ni-based intermetallics are promising materials for forming efficient contacts in GeSn-based Si photonic devices. However, the role that Sn might have during the Ni/GeSn solid-state reaction (SSR) is not fully understood. A comprehensive analysis focused on Sn segregation during the Ni/GeSn SSR was carried out. In situ X-ray diffraction and cross-section transmission electron microscopy measurements coupled with energy-dispersive X-ray spectrometry and electron energy-loss spectroscopy atomic mappings were performed to follow the phase sequence, Sn distribution and segregation. The results showed that, during the SSR, Sn was incorporated into the intermetallic phases. Sn segregation happened first around the grain boundaries (GBs) and then towards the surface. Sn accumulation around GBs hampered atom diffusion, delaying the growth of the Ni(GeSn) phase. Higher thermal budgets will thus be mandatory for formation of contacts in high-Sn-content photonic devices, which could be detrimental for thermal stability.

p-Hydroxymandelate oxidase (Hmo) is a flavin mononucleotide (FMN)-dependent enzyme that oxidizes mandelate to benzoylformate. How the FMN-dependent oxidation is executed by Hmo remains unclear at the molecular level. A continuum of snapshots from crystal structures of Hmo and its mutants in complex with physiological/nonphysiological substrates, products and inhibitors provides a rationale for its substrate enantioselectivity/promiscuity, its active-site geometry/reactivity and its direct hydride-transfer mechanism. A single mutant, Y128F, that extends the two-electron oxidation reaction to a four-electron oxidative decarboxylation reaction was unexpectedly observed. Biochemical and structural approaches, including biochemistry, kinetics, stable isotope labeling and X-ray crystallo­graphy, were exploited to reach these conclusions and provide additional insights.