There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples. Analyses for these applications assume that mutagenic mechanisms have a distinct relationship with neighboring bases that allows them to be distinguished. Direct support for this assumption is limited to a small number of simple cases, e.g., CpG hypermutability. We have evaluated whether the mechanistic origin of a point mutation can be resolved using only sequence context for a more complicated case. We contrasted single nucleotide variants originating from the multitude of mutagenic processes that normally operate in the mouse germline with those induced by the potent mutagen N-ethyl-N-nitrosourea (ENU). The considerable overlap in the mutation spectra of these two samples make this a challenging problem. Employing a new, robust log-linear modeling method, we demonstrate that neighboring bases contain information regarding point mutation direction that differs between the ENU-induced and spontaneous mutation variant classes. A logistic regression classifier exhibited strong performance at discriminating between the different mutation classes. Concordance between the feature set of the best classifier and information content analyses suggest our results can be generalized to other mutation classification problems. We conclude that machine learning can be used to build a practical classification tool to identify the mutation mechanism for individual genetic variants. Software implementing our approach is freely available under an open-source license.

Background:

Relatives of patients with bladder cancer have been shown to be at increased risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related behaviors that may concentrate in some families. We demonstrate a novel approach to simultaneously assess risks for multiple cancers to identify distinct multicancer configurations (multiple different cancer types that cluster in relatives) surrounding patients with familial bladder cancer.

On May 7th, we announced a change to our brand from the eLearning Guild to the Learning Guild. As a member of our community, you […]

The post The eLearning Guild is now The Learning Guild. Here’s Why. appeared first on e-Learning Feeds.

Let’s talk collabs — no, not your Nikes (but yeah, they’re probably pretty fresh). What we are drawing on here is the collabing that makes […]

The post Collaborative Learning in the Workplace appeared first on e-Learning Feeds.

John Deere, the nearly 200-year-old tractor manufacturer, now considers itself a software company

As the pachyderms increasingly clash with farmers and villagers over disappearing land, scientists study the way the animals' minds work

Learning a language is good for brain-training so get out your smartphone and start downloading

The Duchess of Cambridge revealed that her eldest children, Prince George and Princess...

British multinational GlaxoSmithKline have hired computational drug design expert Dr Kim Branson as the company’s new Senior Vice President, Global Head of Artificial Intelligence and Machine Learning.

In his new role, the biotech veteran will oversee projects which use AI to identify novel targets for potential medicines.

Dr Branson brings to the role more than 15 years’ worth of experience in biotech and academia having held positions at a number of Silicon Valley firms including Gliimpse, Lumia and Hessian Informatics.

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The Justice Department announced today that it reached a settlement agreement with the Metropolitan School District of Decatur Township, Ind., to prevent and respond to peer on peer harassment in schools.

Nenko, Yuliia and Кybalna, Nelia and Snisarenko, Yana The COVID-19 Distance Learning: Insight from Ukrainian students. Revista Brasileira de Educação do Campo, 2020, vol. 5, pp. 1-19. [Journal article (Paginated)]

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

There is one golden rule for flying with an infant or toddler: Do whatever it takes to get through the flight peacefully with no harm done. Every parent knows this means relaxing their standards. Planting your kid in front of an iPad screen or giving them not so healthy treats might not win you a…

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

Feb 3, 2020

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.

In 2010, the Australian Commonwealth Government, in partnership with the Australian states and territories, created an online tool called My School. The objective of My School was to enable the collation and publication of data about the nearly 10,000 schools across the country. Effectively offering a report card for each Australian school,[1] My School was…

For perhaps the first time in recent memory, parents and teachers may be actively encouraging their children to spend more time on their electronic devices. Online learning has moved to the front stage as 90 percent of high-income countries are using it as the primary means of educational continuity amid the COVID-19 pandemic. If March will forever…

For perhaps the first time in recent memory, parents and teachers may be actively encouraging their children to spend more time on their electronic devices. Online learning has moved to the front stage as 90 percent of high-income countries are using it as the primary means of educational continuity amid the COVID-19 pandemic. If March will forever…

For perhaps the first time in recent memory, parents and teachers may be actively encouraging their children to spend more time on their electronic devices. Online learning has moved to the front stage as 90 percent of high-income countries are using it as the primary means of educational continuity amid the COVID-19 pandemic. If March will forever…

Residents of the driest inhabited continent, Australia, have evidently been cottoning onto the fact that water means life and we need to be more thoughtful in our use of this rather precious resource. Since the year 2000, Australians have managed to

The Malawi Schools Permaculture Clubs, a recipient of the 2018 Lush Spring Prize, provides basic gardening kits and lesson packs to teachers in order to teach valuable agricultural skills.

Bayer MSMS “Say TkU” Campaign

Most companies are not giving earnings guidance, leaving investors and analysts in the dark, yet the market is still rewarding better-than-expected results.

In the United States, the typical pre-trial process proceeds from arrest to preliminary arraignment to a mandatory court appearance, when appropriate.

What really works when it comes to an online learning module/program? Do all online learning solutions offer and ensure an effective and efficient learning experience for the person on the other side of the screen? "Online", "Remote", "Virtual". The...

Distance learning solutions and online educational tools are rapidly growing in popularity and effectiveness with teachers, colleges and university-level programs worldwide. One recent survey estimated that...

Many latest developments are made in educational system of not only India but also of the world. In last few years students prefer to select distance education while doing part time job. Besides this, married...

The internet has, for better or worse, become the default platform for people seeking information, and today one of the companies leveraging that to deliver educational content has raised some funding to fuel its next stage of growth. Udemy, which provides a marketplace offering some 150,000 different online learning courses from business analytics to ukulele […]

A source told People magazine that Prince George, six, and Princess Charlotte, four, are learning to 'lean on each other' as they grow up, because they're so close in age.

MERSEY BEAT — DOMINIC KING: Can you play football by numbers? This is an era when statistics have become king and a player’s importance is measured by the digits they produce.

Have you ever wondered how forensic scientists help bring poachers to trial? Or how it feels to walk in forest land for three hours amidst torrential rain? From theory to practice, the exhilarating experience of wildlife conservation comes alive in a course for enthusiasts. Deepa Mohan recounts her experience.

The course is available in 17 different languages on the Google News Initiative Training Centre.