Edimakor provides an AI subtitle generator to support multiple languages and enables accurate subtitling with hardly any human involvement.

Event Begins: Thursday, November 14, 2024 10:00am
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Daniel Klionsky
Check the MCDB Weekly update for the password.

You can now use passkeys with LastPass, but is it worth the hassle?

Tracklist A1 Mein Weg Zur Schule 2:32 A2 Hallo Siehst Du Mich? 2:56 A3 Schulbus 3:26 A4 Alle Machen Fehler 3:18 A5 Rot Und Grün 2:30 A6 Es Ist Rot, Elfriede 3:14 A7 Was Zieh' Ich An? 3:00 A8 Aus Der Traum 2:54 B1 Ich Hab' Mich Verlaufen 4:12 B2 Mein Platz Im Auto Ist Hinten 2:16 B3 Zebrastreifen 3:....

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Managing payments in the hospitality industry has long presented challenges for many hoteliers, often involving manual processes and disconnected systems that contribute to operational inefficiencies.

The violence occurred at Bhatpara, the area adjoining Naihati Assembly where bypolls are being held on November 13, 2024

“Dit wordt echt het pretpark van oom Dagobert”: kritiek alom nu kerstparade in Disneyland Parijs plots (deels) betalend wordt  Het Laatste Nieuws

Ostrzegamy – nastąpił wyciek zaszyfrowanych haseł użytkowników menadżera LastPass. Podczas ataku zostały pobrane pliki z infrastruktury LastPass, zatem atakujący może mieć dostęp do: adresów email, nazwisk, zaszyfrowanych haseł czy niezaszyfrowanych pól.

SpotPaltalk recovers Paltalk instant messenger passwords, as well as passwords for AOL, Google, Facebook, MSN, Yahoo and ICQ saved in Paltalk messenger. The passwords are automatically recovered, if they are saved on the local system and you can login with Paltalk automatically without having to manually enter the password. Paltalk versions are supported including Basic, Paltalk Scene, Premium, SuperIMPlus, Extreme, Deluxe, PalPlus and Plus. Passwords from multiple profiles can be recovered as well as passwords from the Google, Facebook, MSN, Yahoo, ICQ and AIM messengers that are stored by Paltalk. All the mentioned features are provided with a user friendly graphical interface.

“Hello. My name is Gregory Daniels. I’m twelve years old. I live at 3251 Spring Lake Drive, and I’ve been kidnapped!” Not exactly what you’d expect to hear when loading up a lofi beats YouTube channel. Then again, MatPat’s newest alternate reality game LoreFi isn’t only focused on creating a playlist of over eight hours […]

The post Unpacking MatPat’s New LoreFi ARG first appeared on ARGNet: Alternate Reality Gaming Network.

(Telecompaper) Italy has become the cheapest country for postpaid mobile services in Western Europe, following the launch of Iliad there as the fourth operator, according to the latest research by Telecompaper. The market researcher's annual comparison of mobile prices across 16 European countries also shows that...

A Planning Inspectorate finds the path was "once a highway" so can therefore "always" be a highway.

If you ever had the app, odds are you were reading some barely coherent narrative about One Direction or Harry Potter

Solar electricity generation exceeded wind generation in May by 1.65 terawatt hours (TWh), and in June by 9.57 TWh

At the 13th October 2018, the Dirtpark Opening & 20Inch Trophy 2018 Contest will take place at the brand new Dirt Park in Innsbruck, which is next to the Baggersee/Rossau. You can participate in two challenges like for example a Fun race and a best trick Contest for BMX & MTB. Refreshments will be available, as well as live music and an after party, which will take place in the Dachsbau.

Arrival is possible on Friday

All the best, your kunstform BMX Shop Team!

Registration:
on-site

What:
Dirtpark Opening & 20Inch Trophy 2018

When:
13th of October 2018

Where:
Dirt Park Innsbruck
6020 Innsbruck


More infos on Facebook.

During this year's stock session, almost our entire BMX Team came to Stuttgart to celebrate 2019 and to have a good time in general. As there is BMX-only session from 6 p.m. on Thursdays in the Stuttpark Indoor Park, we did not miss the opportunity to ride together and stack clips until deep into the night. You can see the result above.

Have fun with the video, your kunstform BMX Shop Team!

Video: Felix Prangenberg

Related links:

• all products of kunstform
• Indoor Park Stuttpark

We are pleased to announce that we are now adding the Eastpak brand to our product range. Eastpak is a renowned manufacturer of high-quality backpacks, bags and luggage.

Eastpak is characterized by its modern design, durable workmanship and innovative functions, which is why the brand is very synonymous with quality and reliability.

The products are available online as well as in our BMX shops in Stuttgart and Berlin and we are happy to be able to offer them to you from now on.

Best regards
Your kunstform BMX shop team

Minneapolis — Recently released guidance from the state of Minnesota details steps employers in the meatpacking industry should take to reduce worker exposure to COVID-19.

Davis, CA — U.S. counties that are home to beef-, pork- and poultry-processing plants experienced accelerated COVID-19 infection rates during the pandemic, according to a recent study led by a researcher at the University at California, Davis.

Washington — Legislation recently introduced in the House and Senate is aimed at improving working conditions and whistleblower protections in the meat and poultry processing industry.

Washington — A new Government Accountability Office report recommends OSHA look at “available actions” – including developing a standard on infectious disease – to help protect workers in the meat and poultry processing industries.

Washington — Two days after OSHA and the Centers for Disease Control and Prevention issued voluntary interim guidance aimed at preventing the spread of COVID-19 among workers in the meatpacking and poultry-processing industries, President Donald Trump invoked the Defense Production Act of 1950 and declared the facilities “critical infrastructure” in an Executive Order intended to keep meatpacking facilities open.

Washington — OSHA has expanded and updated its inspection guidance for animal processing and slaughtering.

The post Life and Death of the American Worker: The Immigrants Taking on America’s Largest Meatpacking Company was curated by information for practice.

While many people believe that poor sleep during pregnancy is inevitable, new research has determined that cognitive behavioral therapy for insomnia (CBTi) while pregnant can not only improve sleep patterns but also address postpartum depression.

The post Sleeping for 2: Insomnia therapy reduces postpartum depression, study shows was curated by information for practice.

In today's digital age, safeguarding your mobile privacy is vital. Here are three easy steps, powered by Startpage, to keep your digital life secure.

The GTPase FlhF, a signal recognition particle (SRP)-type enzyme, is pivotal for spatial–numerical control and bacterial flagella assembly across diverse species, including pathogens. This study presents the X-ray structure of FlhF in its GDP-bound state at a resolution of 2.28 Å. The structure exhibits the classical N- and G-domain fold, consistent with related SRP GTPases such as Ffh and FtsY. Comparative analysis with GTP-loaded FlhF elucidates the conformational changes associated with GTP hydrolysis. These topological reconfigurations are similarly evident in Ffh and FtsY, and play a pivotal role in regulating the functions of these hydrolases.

Type VII secretion (T7S) systems, also referred to as ESAT-6 secretion (ESX) systems, are molecular machines that have gained great attention due to their implications in cell homeostasis and in host–pathogen interactions in mycobacteria. The latter include important human pathogens such as Mycobacterium tuberculosis (Mtb), the etiological cause of human tuberculosis, which constitutes a pandemic accounting for more than one million deaths every year. The ESX-5 system is exclusively found in slow-growing pathogenic mycobacteria, where it mediates the secretion of a large family of virulence factors: the PE and PPE proteins. The secretion driving force is provided by EccC5, a multidomain ATPase that operates using four globular cytosolic domains: an N-terminal domain of unknown function (EccC5DUF) and three FtsK/SpoIIIE ATPase domains. Recent structural and functional studies of ESX-3 and ESX-5 systems have revealed EccCDUF to be an ATPase-like fold domain with potential ATPase activity, the functionality of which is essential for secretion. Here, the crystal structure of the MtbEccC5DUF domain is reported at 2.05 Å resolution, which reveals a nucleotide-free structure with degenerated cis-acting and trans-acting elements involved in ATP binding and hydrolysis. This crystallographic study, together with a biophysical assessment of the interaction of MtbEccC5DUF with ATP/Mg2+, supports the absence of ATPase activity proposed for this domain. It is shown that this degeneration is also present in DUF domains from other ESX and ESX-like systems, which are likely to exhibit poor or null ATPase activity. Moreover, based on an in silico model of the N-terminal region of MtbEccC5DUF, it is hypothesized that MtbEccC5DUF is a degenerated ATPase domain that may have retained the ability to hexamerize. These observations draw attention to DUF domains as structural elements with potential implications in the opening and closure of the membrane pore during the secretion process via their involvement in inter-protomer interactions.

A study of a sophisticated Chinese browser injector that leaves more doors open!

ESET researchers discuss HotPage, a recently discovered adware armed with a highest-privilege, yet vulnerable, Microsoft-signed driver

Neighborhood health centers of 16,342 SF at Lee + White and 9,258 SF at Cascade Road to open in 2023 in metro Atlanta.

Utpal Bhalala is noted for his success in health care and health care administration

North York Aquatic Club is grateful to Toronto Pan Am Sports Centre for its focus on Athletic and Community Well-being and is looking forward to the additional reopening of pools across the Greater Toronto Area

Major Update! Your Ultimate Solution for Video Repair & Video Enhancement

Chicago’s Office of Inspector General said in its latest audit that contracting with a third-party administrator represented a “major improvement” in running the city’s work comp program compared to the…

In this program, Suzanne Honor-Vangerov discusses changes to payment methodology, changes to definitions, and changes to payment multipliers as well as updated tables. Workers' compensation professionals who work with the…

This year the wiki tool provided for delegates to try out is Wetpaint. Links to pages have been set up for all plenary talks, parallel sessions, discussion groups and the exhibition. You are also free to create any new areas of relevance. [2007-06-18]

Al Ruggie and Joshua Rudin give us their thoughts on how TPA’s affect the Restoration and Remediation Industry. 

With 484 companies already secured and more expected, the upstairs hall will feature displays of lightweight machinery and promotional materials.

The need to modernize technology, automate, and provide sustainable solutions – plus supply chain woes – influence the billions being poured into expansion.

HitPaw's latest Edimakor release offers additional customization and personalization.

Location: Electronic Resource- 

I was excited to see Microsoft bring the Windows Presentation Foundation (WPF) back from the dead this past year: At Build 2024 back in May, it announced that it would continue investing in this 20-year-old technology, starting with support for Windows 11 theming that would arrive as part of .NET 9. In fact, I was so excited about this that I brought my .NETpad project back from the dead as well, and I spent much of the summer modernizing my Notepad clone with the new features. I wrote 24 articles documenting this work, but I was stymied by the half-assed nature of the improvements.

Microsoft released exactly one WPF update during the several months of .NET 9 development, and it never added any of the features I discovered were missing. And so as we headed into today's release of .NET 9, my excitement was somewhat diminished. My assumption was that we wouldn't see those missing features implemented until .NET 10, if ever.

Well, Microsoft just released .NET 9. As part of that release, it published updated documentation for WPF (and all the other .NET technologies). And to my surprise, there are some updates to WPF that address at least one of those missing features.

So let's take a look.

To add support for Windows 11 theming to a WPF project, you need to add a reference to the new Fluent theme resource dictionary in its App.xml file. It looks like so:

<Application.Resources>
    <ResourceDictionary>
      <ResourceDictionary.MergedDictionaries>
        <ResourceDictionary Source="pack://application:,,,/PresentationFramework.Fluent;component/Themes/Fluent.xaml" />
      </ResourceDictionary.MergedDictionaries>
    </ResourceDictionary>
</Application.Resources>

But with the shipping version of .NET 9, there's a second, more elegant way to add Windows 11 theming support. Now, you can access a new Application.ThemeMode property of a new styling API to toggle the app's theme mode between Light, Dark, System, and None. And that's fantastic, because it addresses one of those missing features: To date, .NETpad has adapted itself to the system theme (Light or Dark), but there was no way to let the user pick a theme mode. (For example, if the system was set to Dark and the user wanted the app to use Light mode.) With this change, I can implement that feature.

Fortunately, .NETpad is ready for this change, too: If you followed along with my work this past summer, you may remember that I implemented the user interface for switching the app theme into its settings interface, but left the UI hidden because it didn't do anything. But I always felt that Microsoft would need to implement this features, so I left the code in there. Granted, I didn't think it would happen this quickly.

The shipping version of .NET 9 also adds explicit support for the Windows 11 accent color (as configured by the user in the Settings app in Personalization > Accent color). As it is, .NETpa...

The post Modernizing .NETpad: .NET 9 Arrives with a Few (More) Small Improvements for WPF (Premium) appeared first on Thurrott.com.

The bacterial enhancer-binding protein (bEBP) FlrC, controls motility and colonization of Vibrio cholerae by regulating the transcription of class-III flagellar genes in σ54-dependent manner. However, the mechanism by which FlrC regulates transcription is not fully elucidated. Although, most bEBPs require nucleotides to stimulate the oligomerization necessary for function, our previous study showed that the central domain of FlrC (FlrCC) forms heptamer in a nucleotide-independent manner. Furthermore, heptameric FlrCC binds ATP in “cis-mediated” style without any contribution from sensor I motif 285REDXXYR291 of the trans protomer. This atypical ATP binding raises the question of whether heptamerization of FlrC is solely required for transcription regulation, or if it is also critical for ATPase activity. ATPase assays and size exclusion chromatography of the trans-variants FlrCC-Y290A and FlrCC-R291A showed destabilization of heptameric assembly with concomitant abrogation of ATPase activity. Crystal structures showed that in the cis-variant FlrCC-R349A drastic shift of Walker A encroached ATP-binding site, whereas the site remained occupied by ADP in FlrCC-Y290A. We postulated that FlrCC heptamerizes through concentration-dependent cooperativity for maximal ATPase activity and upon heptamerization, packing of trans-acting Tyr290 against cis-acting Arg349 compels Arg349 to maintain proper conformation of Walker A. Finally, a Trp quenching study revealed binding of cyclic-di-GMP with FlrCC. Excess cyclic-di-GMP repressed ATPase activity of FlrCC through destabilization of heptameric assembly, especially at low concentration of protein. Systematic phylogenetic analysis allowed us to propose similar regulatory mechanisms for FlrCs of several Vibrio species and a set of monotrichous Gram-negative bacteria.

Yadong Yu
Dec 1, 2020; 19:1997-2014
Research