Shout out to my 20 million brothers and sisters-  The one in seven U.S. taxpayers who waited until the last minute to file. 

This year, the IRS even gave us 'til April 18th-  So the 18th is when I filed- For my extension!  See you in October!

In my defense, it was not due to lack of effort.  It feels like I spent 200 hours on my taxes this year, because they were unusually complicated. 

Back when I was in my twenties?  Much effort was put into stacking red milk crates for bookshelves and trying to fold up a futon without mangling my fingers-30 years later, I'm trying to do really smart grown-up things.

To wit, my life partner and I have been business partners for almost 20 years.  We used to be young-  Now we're-ahem-"less young"-  Picture the Boomers you see in those ads, silver-haired, in wet suits, running towards the ocean with surfboards, very at peace with nature and our fully-funded 401-K plans - Except that we don't surf and, regarding those 401-K plans?

Well, what I have written on the notepad I stole from Charles Schwab is-  And I quote:
"Retirement and write it off, and something about medical." 

When I look at this enigmatic scribble, an image comes to me: A friendly thirty-something man dressed in charcoal gray business casual- And a desk, and a plant-  And that man is saying:

"Sandra, by all means, you need to form a C corp!  NOT an S corp!"

But wait, is that what he said? Maybe it was:
"Sandra, by all means, you need to form an S Corp!  NOT a C corp!"

It was like being in school and confronting a page of long division- Or sitting in a deadly after-lunch class like "US Government"-  There's this mix of incomprehension, coupled with boredom, that makes it all sound like white noise.

S corp, C corp-  These things involve a part of my brain that refuses to fire.  All I know is there was one kind that was right, it's not the one I did, at some moderate expense, and now I'm going to jail. 

Where at least I won't have to fold a futon.  I think.

Next week: Separate Bathrooms, Separate Quicken Accounts

This content is from Southern California Public Radio. View the original story at SCPR.org.

Dave Ramsey—  The financial radio talk show host—  Says every couple has two people.  One is the nerd with the calculator.   The other is the spendy free spirit. 

In my couple, I am the nerd.  I am calmed by a seven-by-seven Ken Ken and a mechanical pencil.  No surprise that I have used Quicken now for several decades.  But it seems in the last five or 10 years—  What with the Russian hackers stealing our info to get porn—  The cheapo, Windows-based laptops Quicken favors have gotten very buggy. 

So buggy, I bought a sacrificial Dell laptop just for Quicken.   But even that lasted barely six months without crashing.  So Charlie, the free spirit, took over paying the bills!  Writing checks by hand!  Notating them in a large, impressive leatherette binder!  The checks are pretty—tan and sort of antique-looking.  There's a stagecoach on them.

This was all charming until I realized it was tax time. To get all my financial info into the computer, I was going to have to hand-enter each check.  With a quill pen and a butter churn.

While in the joyous process of hand-inputting each check that went out in calendar year 2016— I learned some interesting things!

That beautiful 8-lane highway we drove on that time we visited friends in Orange County? That was a toll road that we apparently didn't pay for. 250 dollar fine! Plus--We're subscribers to something called Cook's Country Magazine, even though I am NOT into "homestyle cooking." And -- we've been paying hundreds of dollars a month for gym memberships that I didn't know we have!

Argh!

Losing it, I throw in the towel and buy myself my own personal version of Quicken—for Mac—  There's a help line to call—  And unbelievably, an operator immediately answers.  He's a courteous gentleman with a lilting, slightly British accent.  He answers my "sign in" question, and asks: "Do you want me to stay on the line while you try it?" "Sure!" I say, surprised.

We click pleasantly through a few more windows—  He's marvelously patient, and attentive—  Wanting to be entertaining, I actually start reciting my passwords aloud as I type them.  

"Let's see—2, 3, 4—asterisk, star, Sparky Sparky, that was my first pet— "Now I'm actually going to have to go downstairs to get my purse," I say, "and maybe go to the ladies' on the way 'cause I've had a lot of coffee— "
"It's fine!" he says—
"Well you can continue playing Solitaire or whatever you're doing!" I say.  And he chuckles!
Doing your taxes?  It takes a village.  And a butter churn.

This content is from Southern California Public Radio. View the original story at SCPR.org.

“This year’s PLP Throne Speech promised taxi owners a payroll tax relief, but legislation still has to be tabled and passed before the relief can be meted,” Shadow Transport Minister Susan Jackson said. Ms Jackson said, “Taxi owners expected the tax relief in September, but were met with resistance from TCD staff. Now there’s confusion […]

A woman was sent flying after she was hit by a car on Wednesday (Nov 13) morning. The incident occurred at the junction of Orchard Road and Handy Road. In a video posted to the SG Kaypoh Facebook group, the woman is seen crossing the road while the traffic light was not in her favour.   She appears to be looking down at her phone. The driver involved in the accident did not notice her till it was too late and collided with her head-on. In the video, the woman is sent flying and lands several metres in front of the car upon impact. She manages to sit up after landing, and looks stunned from the impact.   The driver and his passenger also rush out of the vehicle to assist.  Speaking to AsiaOne, the Singapore Civil Defence Force said that the female pedestrian was conveyed conscious to Tan Tock Seng Hospital. When contacted, the police said they were alerted to an accident involving a taxi and a pedestrian at the junction of Orchard Road and Handy Road on Nov 13 at about 3.15am.

This strategic investment comes from a diverse range of backers, including Micelio Mobility and Naval Ravikant

Local authorities in Phuket's Patong area are working to overhaul the city's motorcycle taxi service following a recent fight among drivers over passengers.

An OMer learning Turkish was encouraged when she shared the message of the gospel with a taxi driver in a city in Western Turkey.

Catégorie - HOMMES » Genre - Pop

The collision, involving a white BMW X6 and a black Kia Ceed taxi, happened on Cochrane Avenue at about 03:05.

Sharjeel Memon meets GAC and Dewan Motors to discuss electric taxi options, assuring full govt cooperation.

Los Angeles residents can now order robotaxis from their phones after Google's autonomous vehicle company Waymo ended its waitlist Tuesday.

The 54^th International Conference of the Association of German Taxidermists, organised by the Museum für Naturkunde, Berlin, wiill take place from 5 - 9 April 2016, in Berlin, Germany.

More information: http://www.praeparation.de/aktuelles/54_internationale_arbeitstagung 

Washington – The Federal Aviation Administration has published new guidance aimed at keeping airport workers safe as airplanes are taxied and towed.

The effect of boron in BxGa1−xN/SiC heteroepitaxy was established by X-ray diffraction reciprocal-space maps on symmetric 0002 and asymmetric 11 {overline 2} 4 reflections. The density of screw and edge threading dislocations was quantified in the framework of the mosaic model.

BGaN epilayers with boron contents up to 5.6% were grown on SiC substrates by metal–organic chemical vapor deposition. The effects of boron incorporation on the structural and optical properties were studied by high-resolution X-ray diffraction (XRD), atomic force microscopy (AFM), Raman spectroscopy and photoluminescence (PL) spectroscopy. XRD reciprocal-space maps around the symmetric 0002 and asymmetric 11 {overline 2} 4 reflections allowed evaluation of the lattice constants and lattice mismatch with respect to the underlying substrate. XRD rocking curves and AFM measurements indicated the mosaic microstructure of the epilayer. The impact of boron content on crystallite size, tilt and twist is evaluated and the correlation with threading dislocation density is discussed. The deterioration of optical properties with increasing boron content was assessed by Raman and PL spectroscopy.

X-ray diffraction from dislocation half-loops consisting of a misfit segment with two threading arms extending from it to the surface is calculated by the Monte Carlo method. The diffraction profiles and reciprocal space maps are controlled by the ratio of the total lengths of the misfit and the threading segments of the half-loops. A continuous transformation from the diffraction characteristic of misfit dislocations to that of threading dislocations with increasing thickness of epitaxial film is studied. Diffraction from dislocations with edge- and screw-type threading arms is considered and the contributions of the two types of dislocations are compared.

Airport Taxi Services

FRENZI APP, a trailblazing mobile application designed to transform the taxi booking experience in the UK, is thrilled to announce that the FRENZI DRIVER app is now available for download. With the customer-facing FRENZI APP set to launch soon.

New research shows the amount of carbon dioxide released into the atmosphere from private jets between 2019 and 2023.

U4SSC - Urban Mobility - Dubai: Mobile solutions for ordering taxis and other transportation services, 'E-hailing'

Mytaxi has quietly revealed that you may have to pay a bit more for every booking made through its app, starting from 21 September.

Read more: Irish Mytaxi users could now have to pay a little more for app bookings

El multimillonario ha afirmado que este vehículo revolucionará el transporte de personas porque su coste por kilómetro será 20 centavos, una quinta parte del de un autobús público Leer

Rolls-Royce pulls the plug on electric flying taxi project

Elon Musk unveiled the Cybercab on Thursday night at a highly anticipated event, where he also showed off new protoypes of a robovan and humanoid robot.

Dysfunctional neurons in the cerebellum, a brain region that controls motor functions, reduced REM sleep in mice.

New year, new career?

Panelistas consideran que la medida busca aliviar las finanzas de un sector golpeado, pero creen que puede tener un efecto sobre otros sectores que busquen el mismo beneficio.

http://www.musicxray.com/xrays/2672490 KadoMane - Im Taxin'em

La Luciérnaga se enciende para hablar del posible paro de taxistas. Además, le contamos cómo se prepara Bogotá para recibir el puente de reyes. Asimismo, el curioso cartel publicado por la policía de Santa Marta que se convirtió en un meme.

La Luciérnaga se enciende para hablar de cómo se desarrollaron las movilizaciones de taxistas a lo largo del país. Además, le contamos sobre lo qué pasa con una moción de censura contra la ministra de Minas. También, ¿El gabinete del presidente Petro está a punto de quedarse con vacantes?La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

La Luciérnaga se enciende para hablar de el Gobierno, pues se confirmó que antes de acabar el año se estabilizará el precio de la gasolina, que estará sobre los 15 mil pesos por galón, y comenzará  el alza del ACPM. Así mismo, más de 9.000 personas sufren hambruna por el paro armado del ELN en Chocó, asegura el gobernador Ariel Palacios. El mandatario solicitó incluir nuevamente al Clan del Golfo en los diálogos de paz. También, después de varias reuniones con el sector de taxistas en el país, el Ministerio de Transporte confirmó que en las próximas semanas se revisará y analizará las tarifas del servicio de taxi en el territorio nacional.  
La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Se detectó un plan criminal, terrorista de acuerdo con la información de inteligencia desde Venezuela por parte del Ejercito de Liberación Nacional para atentar contra la vida del Fiscal General de la Nación. Esto provocó en primer lugar, un rechazo generalizado en todos los estamentos del país así como una reunión de emergencia con el Gobierno Nacional para analizar la información de la Fiscalía. Así mismo, algunos bloqueos se mantuvieron en algunas ciudades del país como; Cúcuta, Medellín y Bucaramanga. Son al menos 1500 taxistas que salieron a las calles y carreteras, de esta manera se adelantaron 27 actividades en 13 municipios de 10 departamentos de Colombia. También, dos proyectos ley que se radicaron en el Congreso de La República, los cuales buscan beneficiar a los integrantes de las Fuerzas Militares como Policía Nacional, estos tuvieron algunos cambios positivos. 

La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este miércoles 25 de octubre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en su regreso a casa. 

Escuche el programa de este martes 20 de noviembre. La Luciérnaga, un espacio un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este martes 23 de julio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Hassan Fares, candidato a la Alcaldía de Barranquilla, dio detalles sobre las acusaciones a la Policía.

En Caracol Radio estuvo Gustavo Bolívar, director del Departamento de Prosperidad Social

Julián Sánchez, alcalde de Soacha, habló en 6AM sobre que representa para Soacha convertirse en la primera ciudad que hará transición enrgética en 300 taxis 

A 14-year-old boy is in hospital after being hit by a taxi at Greenacre on Monday.

Ride.bm said they are offering an “easy-to-access app that provides Bermudians and visitors alike with seamless, on-demand transportation.” A spokesperson said, “For decades, the number 295-4141 has been synonymous with safe and reliable transportation in Bermuda. Today, Ride.bm, powered by Central Dispatch, builds on that legacy, transforming a household number into a modern, easy-to-access app […]

Police are appealing for assistance in locating a female who, in what was apparently an intoxicated state, walked away from a taxi driver in the early hours of Saturday morning. A police spokesperson said, “Police responded to an incident that took place at 1am on Saturday February 14th on Harbour Road in the area of […]

His style complements the whimsical narrative of a woman taking an unconventional cab ride to the moon.

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Frederic Heihoff
Proc. Amer. Math. Soc. 152 (), 5229-5247.
Abstract, references and article information

NSun2 is an RNA methyltransferase introducing 5-methylcytosine into tRNAs, mRNAs, and noncoding RNAs, thereby influencing the levels or function of these RNAs. Autotaxin (ATX) is a secreted glycoprotein and is recognized as a key factor in converting lysophosphatidylcholine into lysophosphatidic acid (LPA). The ATX-LPA axis exerts multiple biological effects in cell survival, migration, proliferation, and differentiation. Here, we show that NSun2 is involved in the regulation of cell migration through methylating ATX mRNA. In the human glioma cell line U87, knockdown of NSun2 decreased ATX protein levels, whereas overexpression of NSun2 elevated ATX protein levels. However, neither overexpression nor knockdown of NSun2 altered ATX mRNA levels. Further studies revealed that NSun2 methylated the 3'-UTR of ATX mRNA at cytosine 2756 in vitro and in vivo. Methylation by NSun2 enhanced ATX mRNA translation. In addition, NSun2-mediated 5-methylcytosine methylation promoted the export of ATX mRNA from nucleus to cytoplasm in an ALYREF-dependent manner. Knockdown of NSun2 suppressed the migration of U87 cells, which was rescued by the addition of LPA. In summary, we identify NSun2-mediated methylation of ATX mRNA as a novel mechanism in the regulation of ATX.