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'Emilia Pérez' review: An incendiary transgender cartel musical

Jacques Audiard's gaudy, star-studded Cannes winner, "Emilia Pérez," is stirring and surprisingly philosophical. Review.






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Transgender activist commits theft, assault before Chloe Cole event at San Francisco State University

“A transgender activist at San Francisco State University assaulted a group of conservatives, including Chloe Cole, and stole a sign ahead of a Turning Point USA event last night,” reports The College Fix. By the end of the night, police arrested the activist after he showed up at Cole’s event. Cole had her breasts removed at […]

The post Transgender activist commits theft, assault before Chloe Cole event at San Francisco State University appeared first on Liberty Unyielding.




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2024 Transgender Day of Remembrance event to be held on Nov. 15

The Center for Sexual and Gender Diversity will hold its annual Transgender Day of Remembrance Vigil on Friday, Nov. 15, honoring the trans lives lost this year to violence.




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Transgender student bathroom bill clears Ohio legislature, heads to governor

The Ohio Senate on Wednesday approved a ban on transgender students using bathrooms that fit their gender identities and sent the measure to Republican Gov. Mike DeWine.




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Correspondence on 'Dispute arises over World Professional Association for Transgender Health’s involvement in WHO’s trans health guideline' by Jennifer Block




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Sri Lanka's first transgender candidate hopes to break political, social barriers

COLOMBO — Chanu Nimesha is contesting Sri Lanka's parliamentary election on Thursday (Nov 14) as the first openly transgender candidate, hoping to forge a more inclusive and tolerant political culture on the South Asian island. Transgender people are estimated to make up about one per cent of Sri Lanka's 22 million people, according to Equal Ground, a local civil society group. They frequently face social rejection, lack legal protection and have almost no representation in political parties. Nimesha, who is contesting from Kegalle — about 80km east of Colombo — said she was the first transgender person to run for a seat in the 225-strong parliament and that her message of social justice had been well received. "I'm not concerned about winning or losing," she said, sitting in her one-bedroom flat. "But it is important for me to be present in this space, to be seen, to inspire others like me. I want to help everyone, not just my community."




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Transgender and Non-Binary Child Custody – What Parents Need to Know

The issues surrounding minors who are exploring gender transition and relabeling their identity are numerous when it comes to custody. Often these discussions involve political and religious arguments, and there are ever-evolving public policy concerns despite seemingly little thought given to the actual interests of the children in question. The purpose of this article is […]





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NGO offers transgender people foreign scholarships

Programme will allow selected persons to attend month-long training in host country




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San Jose State volleyball assistant coach exits after reportedly filing transgender complaint

A San Jose State University women's volleyball assistant coach has left the team after reportedly filing a Title IX complaint about the squad's male-to-female transgender player.




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Tufts refutes report that it’s broken ties with Seth Moulton over transgender comments

A Tufts professor reportedly said they would no longer send students to Moulton's office for internships, but the university refuted the report.

The post Tufts refutes report that it’s broken ties with Seth Moulton over transgender comments appeared first on Boston.com.




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OSHA issues guidance on providing restroom access for transgender workers

Washington – Employers should provide transgender workers with access to restroom facilities based on workers’ gender identity, OSHA stated in a guidance document published June 1.




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'Dragon Age' game shows character apologizing, being punished for 'misgendering'

The latest entry in the fantasy role-playing franchise 'Dragon Age' allows players to make their character trans-identifying and features a scene where one character is forced to atone for “misgendering” someone by performing a series of push-ups. 




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A comprehensive characterization of thiophosgene in the solid state

Thio­phosgene is one of the principal C=S building blocks in synthetic chemistry. At room temperature, thio­phosgene is a red liquid. While its properties in the liquid and gaseous states are well known, a comprehensive characterization of thio­phosgene in its solid state is presented here. Differential scanning calorimetry shows that thio­phosgene forms a supercooled melt before rapidly crystallizing. Its melting point is 231.85 K (−41.3 °C). At 80 K, thio­phosgene crystallizes in space group P63/m [No. 174, a = b = 5.9645 (2), c = 6.2835 (3) Å, V = 193.59 (2) Å3]. The molecule shows a distinct rotational disorder: all S and Cl positions are of mixed occupancy and the disorder does not resolve at temperatures as low as 10 K, as was shown by neutron powder diffraction. Infrared, Raman and inelastic neutron scattering spectra were collected and assigned with the aid of quantum chemical calculations. A larger ordered structural model allowed for better agreement between the measured and calculated spectra, further indicating that disorder is an inherent feature of solid-state thio­phosgene.




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2021 Miss Nevada Will Be The First Openly Transgender Miss USA Contestant

Josie Fischels and Sarah McCammon | NPR

Wearing a rainbow sequin gown she designed herself in honor of Pride Month, Kataluna Enriquez made history last weekend when she was crowned Miss Nevada USA — the win will make her the first openly transgender contestant to compete in the upcoming Miss USA pageant this fall.

"My win is our win," she posted afterward on her Instagram in a message to the LGBTQ community. "We just made history. Happy pride."

Enriquez, who was also Miss Nevada USA's first trans contestant, beat out 21 other women for the top spot. She will represent the Silver State at the 2021 Miss USA pageant that will be held on Nov. 29 in Tulsa, Okla., where she will have a chance to be crowned Miss USA and advance to the Miss Universe pageant.

If crowned Miss USA, Enriquez will become the second trans contestant to compete for Miss Universe, after Angela Ponce, who represented Spain in the 2018 Miss Universe pageant. The pageant began allowing transgender contestants in 2012.

Enriquez began competing in pageants in 2015. Unable to afford custom designer gowns that fit her body at the time, she began designing her own to wear for competitions and eventually started her own line, Kataluna Kouture (@katalunakouture). In March, Enriquez became the first trans woman to win Miss Nevada's preliminary pageant, Miss Silver State USA.

The journey has not been easy, and Enriquez has faced discrimination. While competing in a pageant outside of Nevada, she had not been given a roommate when pageant organizers learned she was trans. A doctor had also been sent to certify that she was a woman before she could continue.

But Enriquez told NPR's Weekend All Things Considered that her determination to make history was what motivated her to keep competing.

"I had a purpose and I had a dream," she said. "I wanted to compete on the Miss USA stage. When I was young, I always wanted to see someone on the Miss USA stage — someone like me. And it just happened to be that I was the person that I needed to make history."

As she prepares for the Miss USA pageant, Enriquez said she plans to advocate for equality and mental health.

"My win is not just a win for the trans community," she said. "It's a win for all women to be represented."

Kalyani Saxena and Tinbete Ermyas produced and edited the audio version of this story. Josie Fischels produced for the web. Josie Fischels is an intern on NPR's News Desk.

Copyright 2021 NPR. To see more, visit https://www.npr.org.

This content is from Southern California Public Radio. View the original story at SCPR.org.




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Transgender People on Translr Find Equal and Friendly Connections Instead of Being Seen As Fetish

Translr, starting in 2018, has been one of the most famous trans dating apps in the United States which gathers 1M users now. It stops its users from seeing trans adults as fetishes since the release of the original version.




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Going Beyond IE&D 101: A Deeper Understanding of Being Transgender Today in America

As Pride Month comes to a close, we are celebrating with a very special podcast that features the personal stories and perspectives from two members of the Littler family.

Littler Knowledge Management Counsel, Betsy Cammarata (GSC – Kansas City) talks with Littler alum, Bennett Kaspar-Williams (Corporate Counsel for Labor Relations at Amazon Studios) about:




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Why employers should make sure health care plans are inclusive to transgender employees

The Supreme Court has ruled that transgender people are protected under the Civil Rights Act, and so Joycelyn Stevenson and Sarah Belchic say employers need to ensure that their health care plans are inclusive.

The Tennessean

View




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Federal Appeals Court Upholds Oregon District's Pro-Transgender 'Safety Plan'

A federal appeals court rejected a multi-pronged challenge to a school district plan allowing transgender students to use restrooms and other facilities that match their gender identity.




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OCR Letter Says Connecticut's Policy on Transgender Athletes Violates Title IX

The U.S. Department of Education's office for civil rights says that Connecticut's interscholastic sports governing body violates Title IX with its transgender participation policy.




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Education Dept.: High Court Ruling Does Not Support Transgender Athletes

The Trump administration argues that the U.S. Supreme Court's decision that federal law protects transgender employees does not apply to transgender athletes in school.




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U.S. Backs Idaho Law Limiting Sports Participation by Transgender Females

In a case involving a transgender track athlete, the Trump administration says female transgender athletes are seeking "special treatment" to compete in girls' or women's sports.




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Judge Blocks Idaho Law Limiting Sports Participation by Transgender Females

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.




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Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease




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Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease




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Generating and Validating Transgenic Mosquitoes with Transposon-Mediated Transgenesis

Transposon-mediated transgenesis has revolutionized both basic and applied studies of mosquito vectors of disease. Currently, techniques such as enhancer traps and transposon tagging, which rely on remobilizable insertional mutagenesis, are only possible with transposon-based vector systems. Here, we provide general descriptions of methods and applications of transposon-based mosquito transgenesis. The exact procedures must be adapted to each mosquito species and comparisons of some differences among different mosquito species are outlined. A number of excellent publications showing detailed and specific protocols and methods are featured and referenced.




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Mosquito Transposon-Mediated Transgenesis

Transposon-mediated transgenesis of mosquito vectors of disease pathogens followed the early success of transgenesis in the vinegar fly, Drosophila melanogaster. The P transposable element used in Drosophila does not function canonically in mosquitoes, and repeatable, routine transgenesis in mosquitoes was not accomplished until new transposable elements were discovered and validated. A number of distinct transposons were subsequently identified that mediate the introduction of exogenous DNA in a stable and heritable manner in mosquito species, including members of the genera Aedes, Anopheles, and Culex. The most versatile element, piggyBac, is functional in all of these mosquito genera, as well as in many other insects in diverse orders, and has been used extensively outside the class. Transposon-mediated transgenesis of recessive and dominant marker genes and reporter systems has been used to define functional fragments of gene control sequences, introduce exogenous DNA encoding products beneficial to medical interests, and act as "enhancer traps" to identify endogenous genes with specific expression characteristics.




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U.S. Backs Idaho Law Limiting Sports Participation by Transgender Females

In a case involving a transgender track athlete, the Trump administration says female transgender athletes are seeking "special treatment" to compete in girls' or women's sports.




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Judge Blocks Idaho Law Limiting Sports Participation by Transgender Females

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.




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Transgender Teachers Speak Out on What They Need From School Leaders

In a recent video message, transgender teachers urge school leaders to make schools more welcoming by examining their own biases and implementing inclusive policies.




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Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models [Articles]

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative of the indicated study population, and allow for appropriate dose adjustments to ensure safety in clinical trials. All of these factors contribute to a streamlined drug approval process and enhanced patient safety. Here we describe a new approach for early prediction of the magnitude of change in exposure for cytochrome P450 (P450) CYP3A4-related DDIs of small-molecule anticancer drugs based on the model-based extrapolation of human-CYP3A4-transgenic mice pharmacokinetics to humans. Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. Predictions of the magnitude of change in exposure deviated at most 0.99- to 1.31-fold from clinical trial results for inhibition with itraconazole, whereas exposure predictions for the induction with rifampicin were less accurate, with deviations of 0.22- to 0.48-fold. Results for the early prediction of DDIs and their clinical impact appear promising for CYP3A4 inhibition, but validation with more victim and perpetrator drugs is essential to evaluate the performance of the new method.

SIGNIFICANCE STATEMENT

The described method offers an alternative for the early detection and assessment of potential clinical impact of CYP3A4-related drug-drug interactions. The model was able to adequately describe the inhibition of CYP3A4 metabolism and the subsequent magnitude of change in exposure. However, it was unable to accurately predict the magnitude of change in exposure of victim drugs in combination with an inducer.






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British Athletics want 'open' category for transgender women to compete with men






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Transgender Kids Often Seek Support From Their School Teachers

medlinkTransgender/medlink students are more likely to seek help from teachers and not from their parents, finds a new study led by researchers at




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Mental Health Support: Transgender Students Prefer School Resources

Transgender students are less likely to seek help from their parents and more likely to seek support from their schoolteachers when compared to their cisgender classmates.




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Suicide Risk in 80% of Transgender Youth Uncovered

Transgender and gender diverse (TGD) youth are over five times more likely to screen positive for medlinksuicide risk/medlink compared to cisgender




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Donald Trump's second term worries Elon Musk's transgender daughter, says....

Wilson on Thursday announced her plans to leave America after Donald Trump reclaimed the US presidency. She said that she doesn't see a future in the country.




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Tailored BODIPY-based fluorogenic probes for phosgene detection: a comparative evaluation of recognition sites

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB02040E, Paper
Suay Dartar, Beraat Umur Kaya, Yanki Öncü Yayak, Ezgi Vural, Mustafa Emrullahoğlu
Rare examples of ICT-based fluorescent probes incorporating phosgene specific recognition units at the 2-position of the BODIPY core.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A rapid and selective “on-off” fluorescence detection of lethal pulmonary agent phosgene with theoretical approach: a cost-effective sensing tool for household bleach and soil analysis

New J. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4NJ00774C, Paper
Malavika S. Kumar, Malay Dolai, Avijit Kumar Das
A fluorescent probe, 4-(di-phenylamino)-benzaldehyde oxime (DPBO), has been developed comprising of 4-(diphenylamino) benzaldehyde as the fluorophore and hydroxyl amine, where the resutant oxime group leads to the formation of a...
The content of this RSS Feed (c) The Royal Society of Chemistry




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PIX: Spain's first transgender football team

Fenix's first game of the season on September 21 ended with a 19-0 defeat. But for its fans and players, trans men having the right to play their favourite sport on equal terms is far more important than the score.




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Eleven transgenders arrested for public nuisance in Cyberabad




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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Call to increase consultation days at transgender clinic at Government Rajaji Hospital in Madurai

Thousands of people have visited the clinic since its launch in 2022 thanks to friendly doctors; those coming from outstations find it difficult to make multiple trips; they also want a hostel for those visiting the clinic since they are not welcome at lodges, says an activist




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Who is Shameebha Patil, the lone transgender candidate in Maharashtra Assembly elections?




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Hisham Selim, famed Egyptian actor, praised over transgender son

When a famed Egyptian actor revealed his daughter had transitioned, the reaction was unconventional.