Keep your Motorola Edge 2024 safe and protected with these amazing cases.

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PRZOOM - Newswire (press release) - Tue, 12 Nov 2024 00:00:00 -0500, Glasgow Scotland - £29.5 million investment in cloud-hosted solution to mobilise firefighters and help improve safety and security in Scotland - FireScotland.gov.uk

Use Your Mac Powerbook to Connect to the Internet using your Motorola Razr V3xx Bluetooth Phone and a 3G High Speed Internet Connection .
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(Telecompaper) Motorola Solutions has won a 7-year contract from the Scottish Fire and Rescue Service (SFRS) to provide a cloud-hosted Control Room Solution (CRS)...

According to the announcement, Motorola Solutions’ CommandCentral Aware unifies voice, video and data feeds from public safety, private enterprise and community-facing systems, leveraging AI to verify incident data and speed up response.

Karola Obermueller Composition Colloquium (Morrison 250) – Nov. 15time, timbre, and transformation  abstractMy creative research revolves around a collection of themes which I return to again and again in my composing. I will discuss these areas of inquiry, how they connect to each other, and in which ways they form / govern / appear in my compositions. short bioKarola Obermüller’s composing, described by the NYT as “hyperkinetic music”, is constantly in search of the unknown. Her unique voice began forming in collages of sound made with tape recorders and evolved later with composition degrees obtained in Nuremberg, Saarbrücken, and at the Mozarteum Salzburg. Her sense of rhythm and form was forever changed by studying Carnatic and Hindustani classical music in India. Since receiving a doctorate from Harvard, Obermüller taught composition and co-directed the composition area at the University of New Mexico before joining the Department of Music at UC San Diego in 2023. Her music can be heard on CD (WERGO, New Focus Recordings, Brilliant Classics) and at karolaobermueller.net.

Roland Keck is an expert in manufacturing engineering and operations with over 30 years of industry experience

Jose Rolando Amado brings exceptional leadership and expertise in post-acute care to his roles, including his current leadership at IMC Maddow Group.

Dr. Nicholas Franco Discusses Medicolegal Concerns Surrounding Surgical Devices and Mesh for Vaginal Prolapse and Urinary Incontinence

Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker | Communications Biology  Nature.com

El tribunal autonómico decreta la suspensión cautelar de una terna de proyectos en Ourense, Lugo y A Coruña, y eleva a 62 el número de parques paralizados cautelarmente en el territorio Leer

El viceprimer ministro ruso aterriza en La Habana para ayudar al régimen, acorralado por las crisis energética Leer

El fuego se inició en la sierra Ferrer de Tárbena y se extendió a los términos de Parcent y Xalò, y según la investigación, arrancó a raíz de una quema de rastrojos Leer

Las 30 personas que fueron evacuadas de una zona urbanizada no han podido regresar todavía a sus viviendas Leer

Joe Balchune, vice president and general manager of Federal Markets at Motorola, joins host John Gilroy on this week's Federal Tech Talk to explain how his company provides mission critical communications for many federal agencies. 

The post Innovations at the Edge: Motorola Solutions first appeared on Federal News Network.

Panelistas consideran que, si bien siempre han existido, fenómenos como cambio climático y la densidad poblacional influyen en las recientes apariciones masivas.

Aprenda a controlar el asma en tiempo de pandemia.

Escuche el programa de este viernes 24 de noviembre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Manfred Webster, pescador de la Isla Santa Catalina, denunció la presencia de barcos de pesca nicaragüenses en los cayos de Roncador y Quitasueño durante los últimos días. 

Óscar López, quien se desempeñó como subsecretario de Ambiente de Bogotá durante la administración de Enrique Peñalosa, defendió en 10AM la pertinencia de este proyecto; Ambientalistas alertaron sobre el impacto que tendría este proyecto

En Caracol Radio, Álvaro Farfán, capitán del cuerpo de Bomberos Cundinamarca, comentó que el incendio se ha logrado controlar y las viviendas en riesgo están protegidas,

Bogotá sigue siendo epicentro, casi a diario, de diferentes tomas. Pero ¿por qué las autoridades no han podido controlarlas?

Paula Ximena Henao, directora del Cuerpo Bomberos de Bogotá aseguró en 6AM que los ciudadanos deben tomar medidas para evitar nuevas conflagraciones que afecten los cerros orientales de la capital del país

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH that exhibits poor regioselectivity in the epoxide hydrolysis of fluostatin C (compound 1) and produces a pair of stereoisomers. Herein, we established the absolute configuration of the two stereoisomeric products and determined the crystal structure of Alp1U. A Trp-186/Trp-187/Tyr-247 oxirane oxygen hole was identified in Alp1U that replaced the canonical Tyr/Tyr pair in α/β-EHs. Mutation of residues in the atypical oxirane oxygen hole of Alp1U improved the regioselectivity for epoxide hydrolysis on 1. The single site Y247F mutation led to highly regioselective (98%) attack at C-3 of 1, whereas the double mutation W187F/Y247F resulted in regioselective (94%) nucleophilic attack at C-2. Furthermore, single-crystal X-ray structures of the two regioselective Alp1U variants in complex with 1 were determined. These findings allowed insights into the reaction details of Alp1U and provided a new approach for engineering regioselective epoxide hydrolases.

Animals can sense the presence of microbes in their tissues and mobilize their own defenses by recognizing and responding to conserved microbial structures (often called microbe-associated molecular patterns (MAMPs)). Successful host defenses may kill the invaders, yet the host animal may fail to restore homeostasis if the stimulatory microbial structures are not silenced. Although mice have many mechanisms for limiting their responses to lipopolysaccharide (LPS), a major Gram-negative bacterial MAMP, a highly conserved host lipase is required to extinguish LPS sensing in tissues and restore homeostasis. We review recent progress in understanding how this enzyme, acyloxyacyl hydrolase (AOAH), transforms LPS from stimulus to inhibitor, reduces tissue injury and death from infection, prevents prolonged post-infection immunosuppression, and keeps stimulatory LPS from entering the bloodstream. We also discuss how AOAH may increase sensitivity to pulmonary allergens. Better appreciation of how host enzymes modify LPS and other MAMPs may help prevent tissue injury and hasten recovery from infection.

α-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from different families. Terminal Galα1–3Gal motifs are found as a defining feature of different blood group and tissue antigens, as well as the building block of the marine algal galactan λ-carrageenan. The blood group B antigen and linear α-Gal epitope can be processed by glycoside hydrolases in family GH110, whereas the presence of genes encoding GH110 enzymes in polysaccharide utilization loci from marine bacteria suggests a role in processing λ-carrageenan. However, the structure–function relationships underpinning the α-1,3-galactosidase activity within family GH110 remain unknown. Here we focus on a GH110 enzyme (PdGH110B) from the carrageenolytic marine bacterium Pseudoalteromonas distincta U2A. We showed that the enzyme was active on Galα1–3Gal but not the blood group B antigen. X-ray crystal structures in complex with galactose and unhydrolyzed Galα1–3Gal revealed the parallel β-helix fold of the enzyme and the structural basis of its inverting catalytic mechanism. Moreover, an examination of the active site reveals likely adaptations that allow accommodation of fucose in blood group B active GH110 enzymes or, in the case of PdGH110, accommodation of the sulfate groups found on λ-carrageenan. Overall, this work provides insight into the first member of a predominantly marine clade of GH110 enzymes while also illuminating the structural basis of α-1,3-galactoside processing by the family as a whole.

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Hydrolases represent an essential class of enzymes indispensable for the metabolism of various clinically essential medications. Individuals exhibit marked differences in the expression and activation of hydrolases, resulting in significant variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs metabolized by these enzymes. The regulation of hydrolase expression and activity involves both genetic polymorphisms and nongenetic factors. This review examines the current understanding of genetic and nongenetic regulators of six clinically significant hydrolases, including carboxylesterase (CES)-1 CES2, arylacetamide deacetylase (AADAC), paraoxonase (PON)-1 PON3, and cathepsin A (CTSA). We explore genetic variants linked to the expression and activity of the hydrolases and their effects on the PK and PD of their substrate drugs. Regarding nongenetic regulators, we focus on the inhibitors and inducers of these enzymes. Additionally, we examine the developmental expression patterns and gender differences in the hydrolases when pertinent information was available. Many genetic and nongenetic regulators were found to be associated with the expression and activity of the hydrolases and PK and PD. However, hydrolases remain generally understudied compared with other drug-metabolizing enzymes, such as cytochrome P450s. The clinical significance of genetic and nongenetic regulators has not yet been firmly established for the majority of hydrolases. Comprehending the mechanisms that underpin the regulation of these enzymes holds the potential to refine therapeutic regimens, thereby enhancing the efficacy and safety of drugs metabolized by the hydrolases.

Highlights: Vaginal estrogen during prolapse surgery did not improve the outcomes of post-operative prolapse M

ಮೊಟೊರೊಲಾ ಕಂಪನಿಯ ಮೊಬೈಲ್‌ಗಳಿಗೆ ಮಾರುಕಟ್ಟೆಯಲ್ಲಿ ಭಾರೀ ಬೇಡಿಕೆಯಿದೆ. ಸ್ಮಾರ್ಟ್‌ಫೋನ್ ಪ್ರಿಯರು ಸಹ ಈ ಫೋನ್‌ಗಳನ್ನು ಇಷ್ಟಪಟ್ಟು ಖರೀದಿಸುತ್ತಾರೆ. ಅದರಂತೆ, ಕಂಪನಿಯು ಆಗಾಗ್ಗೆ ತನ್ನ ಅಭಿಮಾನಿಗಳಿಗೆ ಬೊಂಬಾಟ್ ಆಫರ್‌ಗಳನ್ನು ನೀಡುತ್ತದೆ. ಇದೀಗ, ಮೊಟೊರೊಲಾ ಎಡ್ಜ್‌ 50 ಪ್ರೊ 5G (Motorola Edge 50 Pro 5G) ಫೋನಿನ ಬೆಲೆ ಇಳಿಕೆ ಮಾಡಿದೆ. ನೀವು, 4 ಸಾವಿರ ರೂ. ರಿಯಾಯಿತಿಯೊಂದಿಗೆ

Honolulu : University of Hawaii Press, [2023]

Hamad Bin Khalifa Univerdity Press

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