Fr. Anthony and Fr. Gregory Jensen talk about how to live with - and even love - your limitations and then begin a discussion on the sorts of things that should be part of our annual check-up. Enjoy the show!

TECH-AI-OpenAI and rivals seek new path to smarter AI as current methods hit limitations

NANOFAENTECH's products have different features from the existing 2D cell culture methods and other 3D cell culture methods.

The statute of limitations for drug charges in Kentucky varies depending on the severity and classification of the offense.

Injury victims should not miss the chance to file a claim for damages.

An injured worker’s 2023 medical malpractice action was time-barred because more than three years had passed since she underwent the physical therapy that allegedly caused the additional injuries, a California…

The Connecticut Division of Criminal Justice said it ended an inquiry into a state senator who allegedly did not disclose that he was working while collecting workers’ compensation benefits, saying…

A divided Michigan Court of Appeals upheld the dismissal of a tort claim saying the injured worker agreed to a shorter statute of limitations in a contract he signed as…

While x-ray inspection of electronics has existed for several decades, the continuous shift in electronics design and manufacturing to smaller, more dense products, is driving x-ray technology forward.

Kylian Mbappe wasn't always the best footballing prospect. But he, and his family, had the clearest plan. Project Mbappe continues.

Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging.

Video of legally-blind photographer living his Whole Day, as he captures a celebration of senses and movement

Google Photos has introduced a new feature that allows users to back up folders directly from their PC to the cloud via its website, streamlining the process for those who want to store desktop images without using additional apps. While this

New York, NY : Routledge , 2024.

To overcome these challenges, researchers are exploring “test-time compute,” a technique that enhances existing AI models during the so-called “inference” phase, or when the model is being used

Elected rulers use heavy-handed authority to prevent being toppled by swings in opinion

MAX IV is a fourth-generation, or diffraction-limited, synchrotron light source with a number of state-of-the-art beamlines. The performance of a beamline is, to a high degree, set by the energy resolution it can achieve, which in turn is governed to a large extent by the monochromator. During the design phase of a monochromator, the mechanical requirements must be fully understood and met with margin. During commissioning, the performance must be verified and optimized. In this paper, six soft X-ray monochromators at MAX IV beamlines (Bloch, Veritas, HIPPIE, SPECIES, FinEstBeAMS and SoftiMAX) are examined with a focus on their resolving power, energy range and the time required to change measurement range, as those parameters are dependent on each other. The monochromators have a modern commercial design, planned and developed in close collaboration with the vendors. This paper aims to present the current status of the commissioning at MAX IV with emphasis on elucidating the mechanical limitations on the performance of the monochromators. It contains analysis of the outcome and our approach to achieve fast and high-resolution monochromators.

Global population growth since 1850 has been largely enabled by commercial phosphorus and nitrogen fertilisers. The availability of these nutrients for food production relies upon steadily diminishing resources of natural gas and phosphorus rock. A recent study suggests that to secure a long-term affordable food supply, policy intervention is needed to conserve these essential resources.

You can still be a proud sustainable foodie if you don’t grow your vegetables, raise your chickens or do it all yourself.

Dr. Shawn Dhillon, M.D. creates Anytime DRs to provide convenient, affordable concierge healthcare for the general working public.

Some Eastern Iowans are ready to go camping. With Gov. Kim Reynolds allowing campgrounds across the state to open Friday, some people wasted little time in heading outdoors. “They’re...

Some Eastern Iowans are ready to go camping.

With Gov. Kim Reynolds allowing campgrounds across the state to open Friday, some people wasted little time in heading outdoors.

“They’re already starting to fill up,” said Ryan Schlader of Linn County Conservation. “By about 7 this morning, we had a dozen at Squaw Creek Park. People were coming in bright and early to camp. We’re not surprised.”

Schlader said Linn County Conservation tried to have the campgrounds open at the county’s Squaw Creek, Morgan Creek and Pinicon Ridge parks at 5 a.m. Friday. He expected all of them would be busy.

“I think people were ready to go,” he said.

Lake Macbride State Park in Johnson County didn’t see quite as much of a rush for campsites, park manager Ron Puettmann reported Friday morning, saying he’d had six walk-ins for the park’s 42 campsites.

Camping this weekend will be done on a first-come, first-served basis. Sites won’t be available for reservations until next week, though online reservations can be made now, Puettmann said.

“I’m quite sure people were waiting anxiously to get on,” he said.

While Reynolds’ campground announcement came Wednesday, Schlader and Puettmann said they had no issues having the campgrounds ready for Friday.

Schlader said county staff have been in touch with the Iowa Department of Natural Resources and other county conservation boards to discuss protocols for reopening to ensure a safe experience for campers and employers.

“We anticipated at some point the order would be lifted,” Schlader said. “We were anticipating maybe May 15. The campgrounds were in good shape and ready to go.”

For now, camping comes with some limitations:

• Campers can camp only in a self-contained unit with a functioning restroom, such as a recreational vehicle.

• Shower houses with restrooms will remain closed for the time being.

• Campsites are limited to six people unless they are from the same household.

• No visitors are allowed at the campsites.

Puettmann said staffers and a DNR officer will be on hand to make sure guidelines are followed, but he didn’t anticipate enforcement would be an issue.

“For the most part, we’re going to allow people to police themselves,” he said.

It’s hard to gauge demand, Schlader said.

The weather isn’t yet deal for camping, and some people might not be ready to camp, given the continuing coronavirus.

“There is a lot of uncertainty,” he said. “Do people feel like they need to get out and enjoy a camping experience within their own campsite, or do people still feel under the weather and think it’s not a good idea for my family to go right now? ... We just want this to be an option for people.”

Comments: (319) 339-3155; lee.hermiston@thegazette.com

In her book, "You Look Like a Thing and I Love You," Janelle Shane poses the pitfalls of AI dependence

It is now decades since Todd Jefferis first raised the alarm about the sexual abuse atrocities carried out at Katanning's St Andrew's Hostel in Western Australia, but his fight for justice might finally be nearing an end.

Transcutaneous bilirubinometry was originally developed as a potential replacement for invasive blood sampling, but its clinical application is still limited to a screening method for hyperbilirubinemia. Reasons for this limited clinical value may be diverse.

This study provides insight into the reasons for the limited clinical value of transcutaneous bilirubinometry. This aids to both better interpretation of the measured TcB value from a patient and to possible improvement of the clinical value of the technique. (Read the full article)

Deep and lasting learning can best come from the relationship between teachers and their students.

ABSTRACT

Microbial pathogens exploit host nutrients to proliferate and cause disease. Intracellular pathogens, particularly those exclusively living in the phagosome such as Histoplasma capsulatum, must adapt and acquire nutrients within the nutrient-limited phagosomal environment. In this study, we investigated which host nutrients could be utilized by Histoplasma as carbon sources to proliferate within macrophages. Histoplasma yeasts can grow on hexoses and amino acids but not fatty acids as the carbon source in vitro. Transcriptional analysis and metabolism profiling showed that Histoplasma yeasts downregulate glycolysis and fatty acid utilization but upregulate gluconeogenesis within macrophages. Depletion of glycolysis or fatty acid utilization pathways does not prevent Histoplasma growth within macrophages or impair virulence in vivo. However, loss of function in Pck1, the enzyme catalyzing the first committed step of gluconeogenesis, impairs Histoplasma growth within macrophages and severely attenuates virulence in vivo, indicating that Histoplasma yeasts rely on catabolism of gluconeogenic substrates (e.g., amino acids) to proliferate within macrophages.

IMPORTANCE Histoplasma is a primary human fungal pathogen that survives and proliferates within host immune cells, particularly within the macrophage phagosome compartment. The phagosome compartment is a nutrient-limited environment, requiring Histoplasma yeasts to be able to assimilate available carbon sources within the phagosome to meet their nutritional needs. In this study, we showed that Histoplasma yeasts do not utilize fatty acids or hexoses for growth within macrophages. Instead, Histoplasma yeasts consume gluconeogenic substrates to proliferate in macrophages. These findings reveal the phagosome composition from a nutrient standpoint and highlight essential metabolic pathways that are required for a phagosomal pathogen to proliferate in this intracellular environment.

The bioprocessing industry uses recombinant mammalian cell lines to generate therapeutic biologic drugs. To ensure consistent product quality of the therapeutic proteins, it is imperative to have a controlled production process. Regulatory agencies and the biotechnology industry consider cell line "clonal origin" an important aspect of maintaining process control. Demonstration of clonal origin of the cell substrate, or production cell line, has received considerable attention in the past few years, and the industry has improved methods and devised standards to increase the probability and/or assurance of clonal derivation. However, older production cell lines developed before the implementation of these methods, herein referred to as "legacy cell lines," may not meet current regulatory expectations for demonstration of clonal derivation. In this article, the members of the IQ Consortium Working Group on Clonality present our position that the demonstration of process consistency and product comparability of critical quality attributes throughout the development life cycle should be sufficient to approve a license application without additional genetic analysis to support clonal origin, even for legacy cell lines that may not meet current day clonal derivation standards. With this commentary, we discuss advantages and limitations of genetic testing methods to support clonal derivation of legacy cell lines and wish to promote a mutual understanding with the regulatory authorities regarding their optional use during early drug development, subsequent to Investigational New Drug (IND) application and before demonstration of product and process consistency at Biologics License Applications (BLA) submission.

Dramatically rising costs in drug development are in large part because of the high failure rates in clinical phase trials. The poor correlation of animal studies to human toxicity and efficacy have led many developers to question the value of requiring animal studies in determining which drugs should enter in-human trials. Part 1 of this 2-part series examined some of the data regarding the lack of concordance between animal toxicity studies and human trials, as well as some of the potential reasons behind it. This second part of the series focuses on some alternatives to animal trials (hereafter referred to as animal research) as well as current regulatory discussions and developments regarding such alternatives.

We're resurfacing our interview from last month now that Mechner's book is out.

By Karla L. Palmer —

Severe and unexpected challenges generated by the COVID-19 pandemic force politicians, whether democratically elected or autocratically inclined, to make tough and unpopular choices. Russia is now one of the most affected countries, and President Vladimir Putin is compelled to abandon his recently reconfigured political agenda and take a sequence of decisions that he would rather…

Severe and unexpected challenges generated by the COVID-19 pandemic force politicians, whether democratically elected or autocratically inclined, to make tough and unpopular choices. Russia is now one of the most affected countries, and President Vladimir Putin is compelled to abandon his recently reconfigured political agenda and take a sequence of decisions that he would rather…

Severe and unexpected challenges generated by the COVID-19 pandemic force politicians, whether democratically elected or autocratically inclined, to make tough and unpopular choices. Russia is now one of the most affected countries, and President Vladimir Putin is compelled to abandon his recently reconfigured political agenda and take a sequence of decisions that he would rather…

Video of legally-blind photographer living his Whole Day, as he captures a celebration of senses and movement

A new review published in i Frontiers in Neuroscience /i explores the current literature and advancements in the applications of neuroscience in law.

This paper reviews the use of tax preferences to achieve environmental policy objectives. Tax preferences involve using the tax system to adjust relative prices with a view to influencing producer or consumer behaviour in favour of goods or services that are considered to be environmentally beneficial.

This article on public equity financing for SMEs complements earlier OECD work on market-based finance for SMEs. The development of this market segment could promote investment in SMEs and, together with securitisation and other non-bank debt financing instruments, encourage an enhanced allocation of risk and risk taking, and thus support growth.